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Una vida dedicada a la cocina

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今日中国（西文版） 2023年第9期 54-56页

作者： carmen GONZÁlEZ

Effect of dephytinization on bioavailability of iron,calcium and zinc from infant cereals assessed in the Caco-2 cell model

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World Journal of Gastroenterology 2009年第16期15卷 1977-1984页

作者： carmen Frontela Maria laura Scarino Simonetta Ferruzza Gaspar Ros carmen Martínez Department of Food Science and Nutrition Faculty of Veterinary Science and Food Science and TechnologyMurcia University INRAN National Research Institute for Food and Nutrition

AIM:To test the effect of the dephytinization of three different commercial infant cereals on iron, calcium, and zinc bioavailability by estimating the uptake, retention, and transport by Caco-2 ***:Both dephytinized (by adding an exogenous phytase) and non-dephytinized infant cereals were digested using an in vitro digestion protocol adapted to the gastrointestinal conditions of infants younger than 6 mo. Mineral cell retention, transport, and uptake from infant cereals were measured using the soluble fraction of the simulated digestion and the Caco-2 cells. RESUlTS: Dephytinization of infant cereals significantly increased (Pll uptake efficiency (from 0.66%-6.05% to 3.93%-13%), retention (from 6.04%-16.68% to 14.75%-20.14%) and transport efficiency (from 0.14%-2.21% to 1.47%-6.02%), of iron, and the uptake efficiency (from 5.0%-35.4% to 7.3%-41.6%) and retention (from 4.05%-20.53% to 14.45%-61.3%) of zinc, whereas calcium only cell uptake showed a significant increase (Ples analyzed. A positive relationship (Pl solubility and the cell uptake and transport efficiencies was ***: Removing phytate from infant cereals had a beneficial effect on iron and zinc bioavailability when infant cereals were reconstituted with water. Since in developing countries cereal-based complementary foods for infants are usually consumed mixed with water, exogenous phytase additions could improve the nutritional value of this weaning food.

关键词：生物利用度细胞模型婴儿谷物铁锌细胞吸收评估

Juvenile Play Behavior in Neonatally Underfed and Sensory Stimulated Wistar Rats

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Journal of Behavioral and Brain Science 2019年第10期9卷 362-374页

作者： Manuel Salas Mirelta Regalado carmen Torrero Minerva ortiz-Valladares Department of Developmental Neurobiology and Neurophysiology Institute of Neurobiology University of Mexico Campus UNAM Juriquilla Queretaro Mexico

Play development in juvenile rats depends on specific sensory signals integrated at cortical, limbic and brain stem levels to modulate motoric, metabolic, motivational and social responses. Neonatal undernourishment disrupts the morphological and functional organization of the brain for adaptive responses including play performance. These alterations may be restored by preweaning exposure to sensory-enriched environments. This study was designed to determine in four experimental groups, Control (lC), Underfed (lU), Control ligated/Stimulated (lCS), and Underfed ligated/Stimulated (lUS), whether changes in juvenile play of neonatally underfed male rats by the nipple-ligated procedure of F0 dams and/or the handling of F1 rats may restore the deficiencies in juvenile play performance. The pinning frequency values in lC, lCS and lUS groups consistently increased until reaching a significant peak between postnatal days (PDs) 25 and 50 and then gradually declining until PD 60, when the play in pairs was significantly higher compared with the play in groups that follows the same sequence but with lower values in the stimulated groups. The results may reflect poor maternal care and lower somatosensory stimulation;and the sensory massage of lU F1 pups compared with the lC, lUS, and lCS rats. Fewer dorsal body contacts occurred in lU and lUS rats when playing in pairs than in groups. Results suggest that although handling has salutary effects on neuronal play structures, the reduced levels of total pinning and dorsal contacts, mainly in the play of rat pairs in lCS vs. lUS groups, were not fully recovered.

关键词： Juvenile Play Early Handling Neonatal Undernutrition Rats

Stable Methylammonium-Free p-i-n Perovskite Solar Cells and Mini-Modules with Phenothiazine Dimers as Hole-Transporting Materials

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Carcinoid syndrome caused by a pulmonary carcinoid mimics intestinal manifestations of ulcerative colitis:A case report

能源与环境材料（英文） 2023年第6期6卷 383-392页

作者： luigi Angelo Castriotta Rossella Infantino luigi Vesce Maurizio Stefanelli Alessio Dessì carmen Coppola Massimo Calamante Gianna Reginato Alessandro Mordini Adalgisa Sinicropi Aldo Di Carlo lorenzo Zani Carlo Centre for Hybrid and Organic Solar Energy(C.H.O.S.E.) Department of Electronic EngineeringUniversity of Rome Tor Vergata00133 RomeItaly Institute of Chemistry of Organometallic Compounds(CNR-ICCOM Via Madonna del Piano 1050019 Sesto FiorentinoItaly Department of Biotechnology Chemistry and PharmacyUniversity of SienaVia Aldo Moro 253100 SienaItaly Institute of Chemistry of Organometallic Compounds(CNR-ICCOM Via Madonna del Piano 1050019 Sesto FiorentinoItaly Department of Biotechnology Chemistry and PharmacyUniversity of SienaVia Aldo Moro 253100 SienaItaly Dr.C.Coppola Prof.A.Sinicropi CSGIConsorzio per lo Sviluppo dei Sistemi a Grande InterfaseVia della Lastruccia 350019 Sesto FiorentinoItaly Institute of Chemistry of Organometallic Compounds(CNR-ICCOM Via Madonna del Piano 1050019 Sesto FiorentinoItaly Department of Chemistry"U.Schiff' University of FlorenceVia della Lastruccia 1350019 Sesto FiorentinoItaly Institute of Chemistry of Organometallic Compounds(CNR-ICCOM Via Madonna del Piano 1050019 Sesto FiorentinoItaly Department of Biotechnology Chemistry and PharmacyUniversity of SienaVia Aldo Moro 253100 SienaItaly Dr.C.Coppola Prof.A.Sinicropi CSGIConsorzio per lo Sviluppo dei Sistemi a Grande InterfaseVia della Lastruccia 350019 Sesto FiorentinoItaly Carlo Centre for Hybrid and Organic Solar Energy(C.H.O.S.E.) Department of Electronic EngineeringUniversity of Rome Tor Vergata00133 RomeItaly Institute of Structure of Matter(CNR-ISM) Via del Fosso del Cavaliere 10000133 RomeItaly

During the last decade,perovskite solar technologies underwent an impressive development,with power conversion efficiencies reaching 25.5％for single-junction devices and 29.8％for Silicon-Perovskite tandem *** though research mainly focused on improving the efficiency of perovskite photovoltaics(PV),stability and scalability remain fundamental aspects of a mature photovoltaics *** n-i-p structure perovskite solar cells,using poly-triaryl(amine)(PTAA)as hole transport layer(HTl)allowed to achieve marked improvements in device stability compared with other common hole *** p-i-n structure,poly-triaryl(amine)is also routinely used as dopant-free hole transport layer,but problems in perovskite film growth,and its limited resistance to stress and imperfect batch-to-batch reproducibility,hamper its use for device *** previous computational investigations,in this work,we report the synthesis of two small-molecule organic hole transport layers(BPT-1,2),aiming to solve the above-mentioned issues and allow upscale to the module *** using BPT-1 and methylammonium-free perovskite,*** conversion efficiencies of 17.26％and 15.42％on a small area(0.09 cm2)and mini-module size(2.25 cm2),respectively,were obtained,with a better reproducibility than with poly-triaryl(amine).Moreover,BPT-1 was demonstrated to yield more stable devices compared with poly-triaryl(amine)under ISOS-D1,T1,and l1 accelerated life-test protocols,reaching maximum T90 values＞1000 h on all tests.

关键词： methylammonium-free perovskite mini-modules organic hole-transporting layers perovskite solar cells stability studies

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世界胃肠病学杂志:英文版 2023年第33期29卷 5014-5019页

作者： carmen Mota Reyes Henriette Klein Fabian Stögbauer Henrik Einwächter Melanie Boxberg Moritz Schirren Seyer Safi Hans Hoffmann Department of Surgery Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Division of Thoracic Surgery Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Pathology Technical University of MunichMunich 81675Germany Department of Internal Medicine II Technical University of MunichMunich 81675Germany

BACKGROUND Pulmonary carcinoids are rare,low-grade malignant tumors characterized by neuroendocrine differentiation and relatively indolent clinical *** cases present as a slow-growing polypoidal mass in the major bronchi leading to hemoptysis and pulmonary infection due to blockage of the distal *** syndrome is a paraneoplastic syndrome caused by the systemic release of vasoactive substances that presents in 5%of patients with neuroendocrine *** to such nonspecific presentation,most patients are misdiagnosed or diagnosed late and may receive several courses of antibiotics to treat recurrent pneumonia before the tumor is *** SUMMARY We report the case of a 48-year-old male who presented with cough,dyspnea,a history of recurrent pneumonitis,and therapy-refractory ulcerative colitis that completely subsided after the resection of a pulmonary *** We report and emphasize pulmonary carcinoid as a differential diagnosis in patients with nonresponding inflammatory bowel diseases and recurrent pneumonia.

关键词： Carcinoid syndrome Paraneoplastic syndrome Pulmonary carcinoid Neuroendocrine tumor Ulcerative colitis Case report

GRID-INDEPENDENT CONSTRUCTION OF MUlTISTEP METHODS

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Journal of Computational Mathematics 2017年第5期35卷 672-692页

作者： carmen Arevalo Gustaf Soderlind Numerical Analysis Centre for Mathematical Sciences Box 118 SE-22100 Lund Sweden.

A new polynomial formulation of variable step size linear multistep methods is pre- sented, where each k-step method is characterized by a fixed set of k - 1 or k parameters. This construction includes all methods of maximal order （p = k for stiff, and p = k ＋ 1 for nonstiff problems）. Supporting time step adaptivity by construction, the new formulation is not based on extending classical fixed step size methods; instead classical methods are obtained as fixed step size restrictions within a unified framework. The methods are imple- mented in MATlAB, with local error estimation and a wide range of step size controllers. This provides a platform for investigating and comparing different multistep method in realistic operational conditions. Computational experiments show that the new multi- step method construction and implementation compares favorably to existing software, although variable order has not yet been included.

关键词： linear multistep methods Variable step size Adaptive step size Step sizecontrol Explicit methods Implicit methods Nonstiff methods Stiff methods Initial valueproblems Ordinary differential equations Differential-algebraic equations Implementa-tion.

Cardiovascular prevention in elderly patients

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Journal of Geriatric Cardiology 2022年第5期19卷 377-392页

作者： Clara Bonanad Rosa Fernández-Olmo Sergio García-Blas Jose Antonio Alarcon Pablo Díez-Villanueva carmen Rus Mansilla Héctor García-Pardo Pablo Toledo Ana Ayesta Eva Pereira Antoni Carol Almudena Castro-Conde carmen de Pablo-Zarzoso Manuel Martínez-Sellés Vicente Arrarte Raquel Campuzano Albert Ariza-Solé Servicio de Cardiología Hospital Clínico Universitario de ValenciaValenciaSpain Instituto de Investigación Sanitaria INClIVA ValenciaSpain Servicio Cardiología Hospital Universitario de Jaén Spain Servicio Cardiología Hospital de Donosti Spain Servicio de Cardiología Hospital Universitario La Princesa de MadridSpain Servicio de Cardiología Hospital Alto Gudalquivir de AndújarJaénSpain Servicio de Cardiología Hospital Rio Hortega de ValladolidSpain Servicio Cardiología Hospital Clínico San Cecilio de Granada Spain Servicio de Cardiología Hospital Universitario Central de AsturiasSpain Servicio de Cardiologia Hospital de LugoSpain Servicio de Cardiología Hospital Moisés Broggi de BarcelonaSpain Servicio de Cardiología Hospital Universitario de la Paz de Madrid Spain Servicio de Cardiología Hospital Ramón y Cajal de MadridSpain Department of Cardiology.Hospital Universitario Gregorio Marañón CIBERCV.Universidad EuropeaUniversidad Compluten Servicio de Cardiología del Hospital General de Alicante Spain Servicio de Cardiología Hospital Universitario Fundación de Alcorcón de MadridSpain Servicio de Cardiología Hospital Bellvitge de BarcelonaBioheartGrup de Malalties CardiovascularsInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatBarcelonaSpain

In recent decades,life expectancy has been increasing *** this scenario,health interventions are ne-cessary to improve prognosis and quality of life of elderly with cardiovascular risk factors and cardiovascular ***,the number of elderly patients included in clinical trials is low,thus current clinical practice guidelines do not include specific *** document aims to review prevention recommendations focused in patients≥75 years with high or very high cardiovascular risk,regarding objectives,medical treatment options and also including physical exercise and their inclusion in cardiac rehabilitation ***,we will show why geriatric syndromes such as frailty,dependence,cognitive impair-ment,and nutritional status,as well as comorbidities,ought to be considered in this population regarding their important pro-gnostic impact.

关键词： prevention patients cardiovascular

Effects of Pre-and Neonatal Undernutrition on long-Term Hearing Cognition of the Rat

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Journal of Behavioral and Brain Science 2022年第6期12卷 302-322页

作者： Manuel Salas carmen Torrero Mirelta Regalado Institute of Neurobiology Department of Developmental Neurobiology and Neurophysiology Universidad Nacional Autónoma de México Campus UNAM Juriquilla Querétaro México

Experimental evidence in the rat suggests that perinatal undernutrition, associated with sensory and hormonal deficiencies, interferes with brain network integrative actions. We review peripheral and central morpho-functional alterations related to early food restriction along with the auditory relays, and their connections with the limbic system, which are essential for motivation-emotional arousal. The findings indicated that different morpho-functional alterations in the auditory system permanently affect the brainstem, the reticular thalamic nucleus, and the prefrontal and auditory cortices. Moreover, data showed the noxious role of early food restriction and the external ear occlusion on the distal portions of dendritic arbor measurements, in the cochlea, nucleus ambiguous and motor cortical pyramids. These anatomical alterations also correlated with deficiencies in the dynamic motor and auditory cognitive brain plasticity. Food restriction-related deficiencies in the motor-emotional-behavioral arousal systems may be useful to understand long-term cognitive disorders in humans.

关键词： Perinatal Undernutrition Auditory Cognition Mother-litter Bonds Rats

Adjuvant treatment in biliary tract cancer: To treat or not to treat?

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World Journal of Gastroenterology 2012年第21期18卷 2591-2596页

作者： Stefano Cereda carmen Belli Michele Reni Department of Oncology San Raffaele Scientific Institute20132 Milan Italy

Biliary tract cancer is a rare malignant tumor. There is limited knowledge about biology and natural history of this disease and considerable uncertainty remains regarding its optimal diagnostic and therapeutic man- agement. The role of adjuvant therapy is object of debate and controversy. Although resection is identified as the most effective and the only potentially curative treatment, there is no consensus on the impact of ad- juvant chemotherapy and/or radiotherapy on the high incidence of disease recurrence and on survival. This is mainly due to the rarity of this disease and the consequent difficulty in performing randomized trials. The only two prospectively controlled trials concluded that adjuvant chemotherapy did not improve survival. Most of the retrospective trials, which had limited sample size and included heterogeneous patients population and non-standardized therapies, suggested a marginal benefit of chemoradiotherapy in reducing locoregional recurrence and an uncertain impact on survival. Welldesigned multi-institutional randomized trials are necessary to clarify the role of adjuvant therapy. Two ongoing phase Ⅲ trials may provide relevant information.

关键词：辅助治疗胆道随机试验癌治疗作用恶性肿瘤不确定性手术切除