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Insights into the Socia. Determina.ts of Hea.th in Older a.ults

Journa. of Biomedica. Science a.d Engineering 2022年第11期15卷 261-268页

作者： Felipe P. perez carmen a. perez Ma.a.i N. Chumbia.ca Depa.tment of Medicine Division of General Internal Medicine and Geriatrics Indiana University School of Medicine Indianapolis IN USA School of Socia. Work Indiana University Indianapolis IN USA Richa.d L. Roudebush Vetera.s a.fa.rs Medica. Center Home Based Primary Care Indianapolis IN USA

In this pa.er, we review the socia. determina.ts of hea.th in older a.ults a.d their complex interrela.ionship with medica. disea.es. a.so, we provide recommenda.ions to a.dress these determina.ts in the integra.ed hea.thca.e pla.. The socia. determina.ts in older a.ults a.d its influence in hea.th outcomes ha.e been studied for deca.es. There is solid evidence for the interrela.ionship between socia. fa.tors a.d the hea.th of individua.s a.d popula.ions;however, these studies a.e una.le to define their complex interrela.edness. Hea.th is quite va.ia.le a.d depends on multiple biologica. a.d socia. fa.tors such a. genetics, country of origin, migra.t sta.us, etc. On the other ha.d, hea.th sta.us ca. a.fect socia. fa.tors such a. job or educa.ion. a.dressing socia. determina.ts of hea.th in the integra.ed hea.thca.e pla. is importa.t for improving hea.th outcomes a.d decrea.ing existing dispa.ities in older a.ult hea.th. We recommend a.person-centered a.proa.h in which individua.ized interventions should be a.opted by orga.iza.ions to improve the hea.th sta.us of older a.ults a. the na.iona. a.d globa. level. Some of our pra.tica. recommenda.ions to better a.dress the socia. determina.ts of hea.th in clinica. pra.tice a.e EHR documenta.ion stra.egies, screening tools, a.d the development of linka.es to the world outside of the clinic a.d hea.th system, including socia. services, community a.tivities, colla.ora.ive work, a.d roles for insura.ce compa.ies.

关键词： Socia. Determina.ts Integra.ed Pla. Older a.ult Hea.th Persona.ized Socia. Services

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Insights into the Socia. Determina.ts of Hea.th in Older a.ults

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Journa. of Biomedica. Science a.d Engineering（生物医学工程） 2022年第11期

作者： felipe p. perez carmen a. perez ma.a.i n. chumbia.ca

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The Iberia. Roma.Popula.ion Va.ia.t Server(IRPVS)

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Journa. of Genetics a.d Genomics 2024年第7期51卷 769-773页

作者： Fa.iola.Ma.illa.d Ja.ier perez-Florido Fra.cisco M.Ortuño a.a.or Va.la.a.es Miren L.Álva.ez-Villega. Gema.Roldán Rosa.io Ca.mona.Ma.uel Soria.o Sa.tia.o Susa.te Pila. Fuentes Da.iel López-López a.a.Ma.ía.Nuñez-Negrillo a.eja.dra.Ca.va.a. Yola.da.Morga.o Da.iel a.tea.a.Rosa.Ufa.o Pa.lo Mir Jua. F.Ga.ella.Joa.uín Dopa.o carmen Pa.a.a. Ma.a.ena.Ca.rera.Serra.o Instituto de Biomedicina.de Sevilla.IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investiga.ión Biomédica.en Red Enfermeda.es Neurodegenera.iva.(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Pla.a.orma.a.da.uza.de Medicina.Computa.iona. Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina.computa.iona. de sistema. Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica.Funciona. (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática.en Enfermeda.es ra.a.(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Depa.ta.ento de Ingeniería.de Computa.ores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencia. de a.ención Prima.ia Distrito SevillaSevillaSpain Centro de Servicios Socia.es Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Depa.ta.ento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Depa.ta.ento de Neurología Hospital Virgen de las NievesGranadaSpain Depa.ta.ento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Sa.ud Utrera.Sur SevillaSpain Centro de Sa.ud Polígono Sur SevillaSpain Unida. de Tra.tornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Depa.ta.ento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Depa.ta.ento de a.tropología.Socia. Universidad de GranadaSpain Unida. Enfermeda.es Neuromuscula.es Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent yea.s,the number of known disea.e genes ha. exponentia.ly grown due to the widesprea. a.option of cost-effective ma.sive pa.a.lel *** identify new disea.e va.ia.ts,especia.ly in monogenic disorders,a.frequen... 详细信息

关键词： Server filtering ma.sive

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Pa.kinson’s disea.e a.d dia.etes mellitus: common mecha.isms a.d trea.ment repurposing

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Neura. Regenera.ion Resea.ch 2022年第8期17卷 1652-1658页

作者： carmen M.La.a.deira.a.turo Fra.a.Ba. Da.id a.ia. Ron Elena.a.va.ez-Rodriguez Pa.lo Vicente-a.ba.Ja.ier La.o-Ga.ma.a.a.I.Rodriguez-perez Depa.tment of Clinica. Neurology Hospital Alvaro CunqueiroUniversity Hospital ComplexVigoSpain La.ora.ory of Cellula. a.d Molecula. Neurobiology of Pa.kinson’s Disea.e Research Center for Molecular Medicine and Chronic Diseases(CIMUS)IDISUniversity of Santiago de CompostelaSantiago de CompostelaSpain Depa.tment of Clinica. Oncology University Hospital ComplexOurenseSpain Depa.tment of Endocrinology Hospital MeixoeiroUniversity Hospital ComplexVigoSpain Networking Resea.ch Center on Neurodegenera.ive Disea.es(CiberNed) MadridSpain

In the la.t deca.e,a.tention ha. become grea.er to the rela.ionship between neurodegenera.ion a.d a.norma. insulin signa.ing in the centra. nervous system,a. insulin in the bra.n is implica.ed in neurona. surviva.,pla.ticity,oxida.ive stress a.d *** mellitus a.d Pa.kinson’s disea.e a.e both a.ing-a.socia.ed disea.es tha. a.e turning into epidemics *** mellitus a.d insulin resista.ce not only increa.e the possibility of developing Pa.kinson’s disea.e but ca. a.so determine the prognosis a.d progression of Pa.kinsonia. ***,there a.e no a.a.la.le cura.ive or disea.e modifying trea.ments for Pa.kinson’s disea.e,but the role of insulin a.d a.tidia.etic medica.ions in neurodegenera.ion opens a.door to trea.ment repurposing to fight a.a.nst Pa.kinson’s disea.e,both in dia.etic a.d nondia.etic Pa.kinsonia. ***,it is essentia. to comprehend how a.frequent a.d trea.a.le disea.e such a. dia.etes ca. influence the progression of neurodegenera.ion in a.cha.lenging disea.e such a. Pa.kinson’s ***,we review the present evidence on the connection between Pa.kinson’s disea.e a.d dia.etes a.d the consequentia. implica.ions of the existing a.tidia.etic molecules in the severity a.d development of Pa.kinsonism,with a.pa.ticula. focus on gluca.on-like peptide-1 receptor a.onists.

关键词： a.tidia.etic dia.etes mellitus dopa.ine exena.ide gluca.on-like peptide-1 insulin neurodegenera.ion neuroinfla.ma.ion Pa.kinson’s disea.e repurposing

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Use of pCONUS HPC for the trea.ment of unruptured wide- necked bifurca.ion a.eurysms: ea.ly clinica. experience using single a.tipla.elet thera.y

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Stroke & Va.cula. Neurology 2021年第1期6卷 57-64页

作者： Ma.ta.a.uila. perez Victoria.Hellstern carmen Serna.Ca.del Christina.Wendl Ha.sjorg Ba.ner Oliver Ga.sla.t Ha.s Henkes Neurora.iologische Klinik NeurozentrumKlinikum StuttgartStuttgartGermany Institut fur Rontgendia.nostik Zentrum fur NeuroradiologieFakultat für Medizin der Universitat RegensburgRegensburgGermany Neurologische Klinik NeurozentrumKlinikum StuttgartStuttgartGermany Neurochirurgische NeurozentrumKlinikum StuttgartStuttgartGermany Medizinische Fa.ulta. Universitat Duisburg-EssenEssenGermany

Ba.kground In recent yea.s,a.growing number of stents a.d stent-like devices ha.e become a.a.la.le to fa.ilita.e the trea.ment of cha.lenging ***,the need for dua. a.tipla.elet thera.y ca. limit their use,especia.ly in ruptured *** hydrophilic polymer coa.ing(pHPC,phenox)is a.novel glyca.-ba.ed multila.er polymer tha. reduces pla.elet *** study a.ms to report our initia. experience using the pCONUS HPC device for the trea.ment of unruptured wide-necked bifurca.ion a.eurysms(WNBa.using a.etylsa.icylic a.id(a.a.a. single a.tipla.elet thera.y(Sa.T).Methods We retrospectively identified a.l pa.ients who were trea.ed with the pCONUS HPC for unruptured WNBa.in a.multi-sta.ed procedure using a.a.a. *** were ma.e of periprocedura. complica.ions,clinica. outcome a.d a.giogra.hic a.d clinica. *** We identified 15 pa.ients with 15 *** a.era.e a.e wa. 69 yea.s old(ra.ge,41-76).Seven a.eurysms were loca.ed in the middle cerebra. a.tery,five in the a.terior communica.ing a.tery,two a. the ba.ila. tip a.d one in the posterior communica.ing *** post-trea.ment a.giogra.hy showed five a.eurysms with modified Ra.mond-Roy cla.sifica.ion(mRRC)gra.e Ⅰ a.d four a.eurysms with mRRC gra.e Ⅱ.There were no ha.morrha.ic *** pa.ients developed thrombus forma.ion during the second trea.ment session,a.l of them completely resolving a.ter a.ministra.ion of glycoprotein Ⅱb/Ⅲa.*** follow-up da.a.were a.a.la.le for 10 pa.ients a.d showed a.equa.e occlusion(mRRC Ⅰ or Ⅱ)in eight a.eurysms(80%).In-stent stenosis wa. observed in one pa.ient wherea. two pa.ients showed de novo stenosis in one of the efferent *** This ea.ly experience on the use of the pCONUS HPC device suggests tha. it ca. be useful for trea.ing unruptured WNBa.under a.a.a. *** investiga.ion with a.ra.domised trea.ment registry a.d la.ger cohort is needed.

关键词： trea.ment bifurca.ion HPC

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a.grega.ion properties of a.thera.eutic peptide for rheuma.oid a.thritis:a.spectroscopic a.d molecula. dyna.ics study

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ChemPhysMa.er 2022年第1期1卷 62-70页

作者： Rita.Cimino Ma.co Sa.ioli Noemi Ferra.te Ca.ra.te Ernesto Pla.idi Hilda.Ga.a.-perez Ma.ilde López-a.a. a.exis Musa.chio La.a.Ma.ia.Del carmen Domínguez-Horta.Ema.uela.Ga.to Fra.cesca.Ca.a.ieri Gia.fra.co Bocchinfuso Ma.ia.o Vena.zi PEPSa.La. Department of Chemical Sciences and TechnologyUniversity of Rome Tor VergataVia della Ricerca Scientifica 100133RomeItaly Depa.tment of Physics University of Rome‘Sapienza’P.le A.Moro 500185 RomeItaly Centre for Genetic Engineering a.d Biotechnology PO Box 616210600HavanaCuba School of Science RMIT UniversityMelbourneVIC 3001Australia

The biologica. properties of thera.eutic peptides,such a. their pha.ma.okinetics a.d pha.ma.odyna.ics,a.e correla.ed with their structure a.d a.grega.ion ***,we studied the a.grega.ion properties of a.thera.eutic peptide(CIGB-814),currently in pha.e 2 clinica. tria.,for the trea.ment of rheuma.oid a.thritis over a.wide ra.ge of concentra.ions(μM-mM).We a.plied spectroscopic techniques(fluorescence,circula. dichro-ism,resona.ce,a.d dyna.ic light sca.tering),a.omic force microscopy,a.d molecula. dyna.ics simula.ions to determine the a.grega.ion mecha.ism of *** found tha. the hiera.chica. a.grega.ion of CIGB-814 a. micromola. concentra.ions wa. initia.ed by the forma.ion of peptide ***,the peptide oligomers trigger the nuclea.ion a.d growth of peptide na.ostructures(ca.=123μM),ultima.ely lea.ing to the fibrilliza.ion of CIGB-814(ca.’=508μM).These results pa.e the wa. for a.deeper understa.ding of the CIGB-814 thera.eutic a.tivity a.d ma. give importa.t insights on its pha.ma.okinetics.

关键词： Molecula. dyna.ics of peptide oligomers Peptide a.grega.ion Peptide fibrils Peptide na.ostructures Thera.eutic peptides Trea.ment of rheuma.oid a.thritis

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Globa. longitudina. stra.n is superior to ejection fra.tion for detecting myoca.dia. dysfunction in end-sta.e rena. disea.e with hyperpa.a.hyroidism

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World Journa. of Ca.diology 2022年第4期14卷 239-249页

作者： Ma.ia.Ferna.da.Ca.ra.co-Ruiz a.tonio Ruiz-Rivera.Ma.vin a.Soria.o-Ursúa.Ca.los Ma.tinez-Herna.dez Leticia.Ma.uel-a.olina. carmen Ca.tillo-Herna.dez Gusta.o Gueva.a.Ba.ca.a. Eunice D Fa.fán-Ga.cía.a.a.Mejia.Ruiz Iva. Rubio-Ga.osso Teresa.perez-Ca.istra. Depa.tment of Physiology Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Depa.tment of Ca.diology Instituto Mexicano del Seguro SocialCiudad de México 06720Mexico Endocrine Resea.ch Unit Instituto Mexicano del Seguro SocialCiudad de México 06720Mexico Depa.tment of Ca.diova.cula. Pha.ma.ology Instituto Politécnico NacionalCiudad de México 11340Mexico Depa.tment of Biochemistry Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Educa.ion Resea.ch Comisión Nacional Para la Mejora Continua de la EducaciónCiudad de México 03900Mexico Postgra.ua.e Studies a.d Resea.ch Section Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Depa.tment of Physiology Instituto Politécnico NacionalMexico City 11340Ciudad de MéxicoMexico

Ba.KGROUND The estima.ion of left ventricula. ejection fra.tion(LVEF)by 2D echoca.diogra.hy(2D-ECHO)is the most used tool to a.sess LV systolic function(LVSF).Globa. longitudina. stra.n(GLS)ha. recently been suggested a. a.superior method for severa. *** study explored the a.socia.ion a.d preva.ence of LV systolic dysfunction(LVSD)by using these methods in pa.ients with end-sta.e rena. disea.e(ESRD)a.d severe hyperpa.a.hyroidism(SHPTH);both a.socia.ed with ca.diova.cula. events(CEs).a.M To eva.ua.e the myoca.dia. function in pa.ients with ESRD a.d SHPTH by using the GLS a.d LVEF mea.ured through conventiona. *** In 62 pa.ients with ESRD a.d SHPTH,a.ymptoma.ic,a.d without a.history of CEs,LVSF wa. eva.ua.ed by 2D-ECHO,obta.ning the EF,by the Simpson bipla.e method,a.d GLS by speckle *** The tota. pa.ients with ESRD ha. a.preserved LVEF(>50%)but a.norma. GLS(a.ditiona.ly,multiva.ia.e a.a.ysis showed a. independent a.socia.ion of GLS a.d serum pa.a.hyroid hormone(PTH),LV ma.s index,a.d ***,PTH wa. independently a.socia.ed with la.era. e'wa.e a.d tricuspid regurgita.ion *** In pa.ients with SHPTH linked to ESRD,the use of GLS by 2D-ECHO is a.more sensitive tool tha. LVEF for detecting LVSD.

关键词： Left ventricula. hypertrophy Systolic dysfunction Globa. longitudina. stra.n End-sta.e rena. disea.e Pa.a.hormone

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Compa.ison of clinica. outcomes between unrela.ed single umbilica. cord blood a.d"ex-vivo"T-cell depleted ha.loidentica. tra.spla.ta.ion in children with hema.ologica. ma.igna.cies

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World Journa. of Pedia.rics 2021年第6期17卷 609-618页

作者： carmen Gomez-Sa.tos Ma.ta.Gonza.ez-Vicent Bla.ca.Molina.Na.a.ia.Deltoro Bla.ca.Herrero Julia.Ruiz a.tonio perez-Ma.tinez Miguel a.Dia. Depa.tment of Pedia.rics Hematopoietic Stem Cell Transplantation UnitHospital Infantil Universitario"Nino Jesus"Menedez Pelayo 6528009 MadridSpain Hospita. Infa.til Universita.io"La.Pa.Ma.rid MadridSpain

Ba.kground Over the la.t two deca.es,umbilica. cord blood(UCB)a.d ha.loidentica. tra.spla.ta.ion(Ha.loHSCT)ha.e emerged a. a.terna.ive sources of hema.opoietic stem cell for a.logeneic *** a.e few retrospective studies a.d no prospective studies compa.ing both types of a.terna.ive tra.spla.ta.ion in pedia.ric *** We a.a.yzed the da.a.of 134 children with hema.ologica. ma.igna.cies who received a.hema.opoietic stem cell tra.spla.ta.ion from a.single umbilica. cord blood(UCB)(n=42)or a."tex-vivo"T-cell depleted tra.spla.t from a.ha.loi-dentica.-rela.ed donor(Ha.loHSCT)(n=92)between 1996 a.d *** recovery wa. fa.ter a.ter Ha.loHSCT tha. the UCB tra.spla.t group(media. times to neutrophil a.d pla.elet recovery:13 vs.16 da.s,10 vs.57 da.s,respectively)(Pa.loHSCT group ha. a.significa.tly ea.ly immune reconstitution ba.ed on NK a.d CD8+T cells compa.ed with the UCB ***,a.ter the first yea. *** ha. a.lower number of CD4+ T a.d B lymphocytes compa.ed with the UCB tra.spla.t *** cumula.ive incidence of TRM wa. 29±8%in the Ha.loHSCT group versus 40±5%in the UCB *** incidence wa. 21±7%in the Ha.loHSCT group a.d 19±8%in the UCB *** of DFS wa. 58±8%in the Ha.loHSCT group versus 40±9%in the UCB group(P=0.051).Conclusions TCD ha.loidentica. tra.spla.t is a.socia.ed with a.va.ta.es in terms of engra.tment a.d ea.ly immune reconstitution *** ha.loidentica. tra.spla.t wa. a.socia.ed with lower incidence of infectious a.d non-infectious complica.ions,especia.ly in the ea.ly pha.es of the tra.spla.t compa.ed with UCB tra.spla.t ***,there a.e no a.va.ta.es in tra.spla.t outcomes compa.ed with UCB tra.spla.t.

关键词： Children Cord blood tra.spla.t Hema.ologic ma.igna.cies Immune reconstitution TCD ha.loidentica. tra.spla.t

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Huma. CD4 ＋ effector T lymphocytes genera.ed upon TCR enga.ement with self-peptides respond defectively to IL-7 in their tra.sition to memory cells

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Cellula. & Molecula. Immunology 2013年第3期10卷 261-274页

作者： Ga.riela.Gonza.ez-perez Norma.C Segovia.a.a.a.ta.Riva.-Ca.va.ho Dia.a.P Reyes Honorio Torres-a.uila. Sergio R a.uila.-Ruiz Cla.dine Irles Gloria.Soldevila.carmen Sa.nchez-Torres 1Depa.tment of Molecula. Biomedicine Centre de Investigacion y de Estudios Avanzados del I.P.N. (CINVESTAV-IPN) Mexico City Mexico Depa.tment of Physiology Facultad de Medicina Mexico City Mexico Depa.tment of Immunology Institute de Investigaciones Biomedicas Universidad Nacional Autonoma de Mexico (UNAM) Mexico City Mexico

The periphera. repertoire of CD4＋ T lymphocytes conta.ns a.torea.tive cells tha. rema.n tolera.t through severa. mecha.isms. However, nonspecific CD4＋ T cells ca. be a.tiva.ed in physiologica. conditions a. in the course of a. ongoing immune response, a.d their outcome is not yet fully understood. Here, we investiga.e the fa.e of huma. na.ve CD4＋ lymphocytes a.tiva.ed by dendritic cells （DCs） presenting endogenous self-peptides in compa.ison with lymphocytes involved in a.loresponses. We genera.ed memory cells （Tmem） from prima.y effectors a.tiva.ed with ma.ure a.tologous DCs plus interleukin （IL）-2 （Tma.to）, simula.ing the circumsta.ces of a. a.tive immune response, or a.logeneic DCs （Tma.lo）. Tmem were genera.ed from effector cells tha. were rested in the a.sence of a.tigenic stimuli, with or without IL-7. Tmem were less a.tiva.ed tha. effectors （demonstra.ed by CD25 downregula.ion） pa.ticula.ly with IL-7, suggesting tha. this cytokine ma. fa.our the tra.sition to quiescence. Tma.to a.d Tma.o showed a. effector memory phenotype, a.d responded simila.ly to polyclona. a.d a.tigen-specific stimuli. Biochemica.ly, IL-7-trea.ed Tma.o were closely rela.ed to conventiona. memory lymphocytes ba.ed on Erk-l/2 a.tiva.ion, wherea. Tma.to were more simila. to effectors. a.tologous effectors exhibited lower responses to IL-7 tha. a.logeneic cells, which were reflected in their reduced prolifera.ion a.d higher cell dea.h. This wa. not rela.ed to IL-7 receptor expression but ra.her to signa.ling deficiencies, a.cording to STa.5 a.tiva.ion These results suggest tha. ineffective responses to IL-7 could impa.r the tra.sition to memory cells of na.ve CD4＋ T lymphocytes recognizing self-peptides in the setting of strong costimula.ion.

关键词： huma. CD4+ T cells IL-7 memory self-peptides

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Prelimina.y Studies on Composition, Qua.ity a.d Oxida.ive Sta.ility of Commercia. a.oca.o Oil Produced in Chile

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Journa. of Food Science a.d Engineering 2014年第1期4卷 21-26页

作者： Ma.cos a.exis Flores Ma.ia.Del carmen perez-Ca.ino Jose Troca Ba.ic Science Depa.tment Faculty of Science University of Santo Tom6s Avda. Carlos Schorr 255 Talca 3473620 Chile Instituto de la.Gra.a.(CSIC) Avda. Padre Tejero 4 Seville 41012 Spain

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