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Review of the El Soplao Amber Outcrop,Early Cretaceous of Cantabria,Spain

Acta Geologica Sinica(English Edition) 2010年第4期84卷 959-976页

作者： María NAJARRO Enrique PENALVER Ricardo perez-DE LA FUENTE Jaime ORTEGA-BLANCO Cesar MENOR-SALVAN Eduardo BARRON carmen SORIANO Idoia ROSALES Rafael LOPEZ DEL VALLE Francisco VELASCO Fernando TORNOS Véronique DAVIERO-GOMEZ Bernard GOMEZ Xavier DELCLOS Instituto Geologico y Minero de Espana E-28003MadridSpain Departament d'Estratigrafia Paleontologia i Geociencies MarinesFacultat de GeologiaUniversitat de BarcelonaE-08071BarcelonaSpain Centro de Astrobiologia(CSIC-INTA) E-28850Torrejon de ArdozSpain European Synchrotron Radiation Facilities F-38000 GrenobleFrance/Geosciences Rennes-Universite de Rennes 1F-35042 RennesFrance El Soplao S.L. Prao El CollaoE-39553CantabriaSpain Universidad del Pais Vasco Dpto.Mineralogia y PetrologiaE-48080 BilbaoSpain CNRS-UMR 5125 PEPS Universite Lyon 1GeodeF-69622 VilleurbanneFrance

El Soplao outcrop, an Early Cretaceous amber deposit recently discovered in northern Spain （Cantabria）, has been shown to be the largest site of amber with arthropod inclusions that has been found in Spain so far. Relevant data provided herein for biogeochemistry of the amber, palynology, taphonomy and arthropod bioinclusions complement those previously published. This set of data suggests at least two botanical sources for the amber of El Soplao deposit. The first （type A amber） strongly supports a source related to Cheirolepidiaceae, and the second （type B amber） shows non-specific conifer biomarkers. Comparison of molecular composition of type A amber with Frenelopsis leaves （Cheirolepidiaceae） strongly suggests a biochemical affinity and a common botanical origin. A preliminary palynological study indicates a regional high taxonomical diversity, mainly of pteridophyte spores and gymnosperm pollen grains. According to the preliminary palynological data, the region was inhabited by conifer forests adapted to a dry season under a subtropical climate. The abundant charcoalified wood associated with the amber in the same beds is evidence of paleofires that most likely promoted both the resin production and an intensive erosion of the litter, and subsequent great accumulation of amber plus plant cuticles. In addition, for the first time in the fossil record, charcoalified plant fibers as bioinclnsions in amber are reported. Other relevant taphonomic data are the exceptional presence of serpulids and bryozoans on the surfaces of some amber pieces indicating both a long exposure on marine or brackish-water and a mixed assemblage of amber. Lastly, new findings of insect bioiuclusions, some of them uncommon in the fossil record or showing remarkable adaptations, are reported. In conclusion, a documented scenario for the origin of the El Soplao amber outcrop is provided.

关键词： fossil resin chemotaxonomy paleobotany charcoal arthropod bioinclusions taphonomy EarlyAlbian

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Heritage risk index:A multi-criteria decision-making tool to prioritize municipal historic preservation projects

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Frontiers of Architectural Research 2020年第2期9卷 403-418页

作者： Jonathan Ruiz-Jaramillo carmen Munoz-Gonzalez Maria Dolores Joyanes-Diaz Eduardo Jimenez-Morales Jose Manuel Lopez-Osorio Roberto Barrios-perez Carlos Rosa-Jimenez Department of Art and Architecture School of ArchitectureUniversidad de MalagaMalaga 29071Spain

The current pressure on the built historical heritage requires a global evaluation to develop strategies for its preservation.A combined vision of the state of conservation of architectural heritage is essential to highlight the vulnerabilities of the structure from which harmonized measures can be proposed for its *** study proposes a multi-criteria analysis methodology that considers a qualitative and quantitative approach to organize the global conservation state of heritage buildings hierarchically.A global index can be determined on the basis of the generation of an interoperable data matrix by defining a set of indicators to assess different components of a *** index describes the risk with respect to the stability,safety,and habitability of the *** methodology aims to achieve the state of the building in an integral way by obtaining a simple and objective index that enables efficient comparison among different *** application of this methodology to a historic area allows creating a hierarchical map of risk to stablish priorities for intervention and enable a sustainable and critical management and planning over the actions of maintenance,conservation,and *** this way,a holistic vision of the complex reality of built heritage and the urban landscape is obtained to identify critical areas of priority intervention.

关键词： Historic city State of conservation Risk index Intervention priority Architectural heritage

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Immunotherapy and immunoescape in colorectal cancer

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World Journal of Gastroenterology 2007年第44期13卷 5822-5831页

作者： Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta carmen Berasain José L perez-Gracia Alvaro Gonzalez Ignacio Melero Liver Unit Facultad de Ciencias Biomédicas Universidad Austral Presidente Perón 1500 (1635) Derqui-Pilar Buenos Aires Argentina Centro de Investigación Médica Aplicada and Clínica Universitaria Universidad de Navarra Pamplona Spain

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.

关键词：结肠癌免疫疗法基因疗法白介素

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Safety and Efficacy of Racotumomab-Alum Vaccine as Second-Line Therapy for Advanced Non-Small Cell Lung Cancer

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International Journal of Clinical Medicine 2014年第14期5卷 844-850页

作者： Eduardo Santiesteban Leslie perez Sailyn Alfonso Elia Neninger Soraida Acosta Yoana Flores Maurenis Hernandez carmen Viada Robin García Meylán Cepeda Daymys Estevez Yoisbel Moreno Amparo Macías Celestino Hernández Robau Hospital Villa Clara Cuba Center of Molecular Immunology Havana Cuba Hermanos Ameijeiras Hospital Havana Cuba José Ramón López Tabranes Hospital Matanzas Cuba National Institute of Oncology and Radiobiology Havana Cuba Saturnino Lora Hospital Santiago de Cuba Cuba

Despite extensive clinical research in non-small cell lung cancer (NSCLC), overall survival is still poor. Racotumomab-alum is an anti-idiotypic cancer vaccine that targets NeuGcGM3 tumor associated ganglioside. The aim of this study was to evaluate safety and efficacy of racotumomab-alum in advanced NSCLC patients with progressive disease. This expanded access program included 86 histologically confirmed NSCLC patients, 18 years or older age, with advanced disease and without therapeutic option, with ECOG performance status ≤3, adequate organ functions and signed informed consent. The primary endpoint was overall survival and toxicity was measure assessed treatment-related toxicity according CTCAEv3. The study was approved by ethical review boards of participant institutions. Racotumomab-alum treatment consisted in 5 biweekly intradermal doses (1 mg/mL) during the induction phase of treatment (2 months). The maintenance phase consisted in monthly re-immunizations until unacceptable toxicity or PS worsening. The median overall survival time of all patients treated with racotumomab-alum was 8.96 months. The survival rates at 12 and 24 months were 42.8% and 28.0%, respectively. Patients that completed the induction phase of treatment (five doses or more) reached a median OS of 12.1 months. The most common adverse events were injection site reaction, bone pain, cough and asthenia. Racotumomab-alum cancer vaccine could be considered an effective and safe treatment option as second-line therapy for advanced NSCLC. Further clinical studies should be conducted to confirm this result.

关键词： Non-Small Cell Lung Cancer Cancer Vaccine Second-Line Treatment

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Motor Effects of 1,3-Disubstituted 8-Styrylxanthines as A_(1) and A_(2) Adenosine-Receptor Antagonists in Rats

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Pharmacology & Pharmacy 2013年第3期4卷 303-311页

作者： Ilhuicamina Daniel Limon-perez de Leon Maria del carmen Parra-Cid Alejandro Munoz-Zurita Saul Alejandro Merino-Contreras Sara Montiel-Smith Socorro Meza-Reyes Gerardo Ramirez-Meja Jesus Sandoval-Ramirez Facultad de Ciencias Quimicas Benemerita Universidad Autonoma de PueblaPueblaMexico Instituto Nacional de Rehabili-tacion Unidad de Ingenieria de TejidosTerapia Celular y Medicina RegenerativaMexico DFMexico.

A series of 1,3-substituted 8-styrylxanthines (11a-d) was synthesized, under chemo- and regioselective conditions, in a good overall yield. The compounds showed affinity towards both A1 and A2A-adenosine receptors by radioligand binding by means of in vitro assays. The (E)-3-ethyl-1-propyl-8-styrylxanthine (11a) showed the greatest affinity towards the A2A receptor, whereas (E)-3-pentyl-1-propyl-8-styrylxanthine (11d) showed the greatest affinity for the A1 receptor. When the 8-styrylxanthines 11a (A15Et) and 11c (A15Bu) were administrated in rats, which were previously injured with 6-hydroxydopamine at the substantia nigra pars compacta (SNc), the turning behavior decreased 50%. Based on these results we propose to A15Et as a potential compound to treat some symptoms of Parkinson’s disease.

关键词： Xantines Adenosine Receptors Antagonists Turning Behavior Anti-Parkinsonian Drugs

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Satisfaction of the Service Provider with the Organization of the Timely Cervical Cancer Detection Program

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Health 2017年第2期9卷 289-298页

作者： Gutierrez-Enriquez Sandra Olimpia Teran-Figueroa Yolanda Gaytan-Hernandez Dario Diaz-Oviedo Aracely Zuniga-Martinez Ma.de Lourdes Hernandez-Nava Nereyda Cruz Ortiz Maribel perez Rodriguez Maria del carmen Ramirez-Ramirez Rocio Faculty of Nursing and Nutrition Autonomous University of San Luis PotosiSan Luis PotosiMexico Academic Coordination Altiplano Region Autonomous University of San Luis PotosiSan Luis PotosiMexico

Cervical cancer is a priority health problem in Mexico. The objective of this work was to know the degree of satisfaction of the service provider with the organization of the program of Timely Detection of Cervical Cancer, specifically in taking of the cervical cytology. The study design was observational, transversal and prospective conducted from January to May 2015 in Jurisdiction 1 of the Health Services of San Luis Potosí, Mexico, in 20 health centers. Participants were 87 service providers whose function is to take cervical cytology (Pap smears). A 32-question questionnaire was applied, with Likert scale with 5 levels of response: 1 (dissatisfied), 2 (little satisfied), 3 (indifferent), 4 (satisfied) and 5 (very satisfied). The score range was 32 points (minimum job satisfaction) up to 160 points (Maximum job satisfaction). We analyzed 2 dimensions: 1) intrinsic factors that have to do with motivation and professional recognition, and 2) extrinsic factors related to infrastructure, materials, remuneration and labor policies. Each factor consisted of four categories. Descriptive statistics and linear correlation of Pearson were applied for the analysis of data. Participants signed an informed consent letter. Of 4 categories, in the intrinsic dimension, the one with the highest percentage of satisfaction was “delegation of activities” with 28.8%. In the extrinsic dimension, the category with the highest percentage of satisfaction was “infrastructure and materials” with 49.4%;while satisfaction increase in intrinsic dimensions also does in extrinsic dimensions, such correlations are significant (p < 0.05), except between delegation of activities and remuneration (r = 0.074 and p = 0.497). The higher hierarchical level, the men, the bachelor academic level and older people showed the highest level of satisfaction.

关键词： Job Satisfaction Cervical Cancer Health Providers

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通过热致变分析研究工厂化加工奶的类别特征(Ⅱ)

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食品与机械 2001年第1期17卷 33-34页

作者： Francisco-J.Morales carmen Romero Salvio Jimenez-perez 成映波唐良荣 Departamento de Productos Lacteos

2结果与讨论2.1酸溶性乳清蛋白图1所示为原料奶和各热处理奶的典型色谱图.随着热处理强度的增加,主要乳清蛋白的峰面积响应值是减少的.酸溶性乳清蛋白水平(原奶中约54%β-LG,23%a-LA,6%BSA)的分析较分析其它指示物具有一定的优越性(Pear... 详细信息

2结果与讨论2.1酸溶性乳清蛋白图1所示为原料奶和各热处理奶的典型色谱图.随着热处理强度的增加,主要乳清蛋白的峰面积响应值是减少的.酸溶性乳清蛋白水平(原奶中约54%β-LG,23%a-LA,6%BSA)的分析较分析其它指示物具有一定的优越性(Pearce,1989),因为热变性在新鲜原奶中并不存在,而且其量相对于蛋白质总量来说是保持稳定比例的,因而无需在每一次检测热变性时还作一次原料奶的分析.

关键词：热致变分析工厂化加工奶类别特征乳制品

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Solvent-Free Synthesis of Carboxylic Acids and Amide Analogs of CAPE(Caffeic Acid Phenethyl Ester)under Infrared Irradiation Conditions

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Green and Sustainable Chemistry 2015年第2期5卷 81-91页

作者： Pablo A.Martínez-Soriano Jose R.Macías-perez Ana Maria Velazquez Brigida del carmen Camacho-Enriquez Gustavo Pretelin-Castillo Monica B.Ruiz-Sanchez Victor H.Abrego-Reyes Saul Villa-Trevino Enrique Angeles Laboratorio de Quimica Medicinal y Teorica Departamento de Ciencias QuimicasFES CuautitlanUniversidad Nacional Autonoma de MexicoCuautitlan IzcalliMexico Departamento de Biologia celular Centro de Investigacion y Estudios AvanzadosInstituto Politecnico NacionalMexicoD.F.Mexico Qsar Analytics S.A.de C.V.Ciudad Satelite Naucalpan de JuarezMexico

A convenient and easy method is described for the formation of carboxamides from carboxylic acids and primary amines in solventless conditions using infrared (IR) light. Thus, under IR light, cinnamic acid derivatives... 详细信息

关键词： Amides Carboxylic Acids Amines Infrared Light Solventless CAPE CAPA Cinnamic Acid Analogs

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Time to Progression of AFP(TPA)as a Predictor of Survival in Hepatocellular Carcinoma Treated with Sorafenib(SOR)

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Journal of Cancer Therapy 2014年第14期5卷 1332-1343页

作者： Maria Varela Olegario Castano-Fernandez Marcelo Garrido Lorena Blanco-García Pablo Martínez-Camblor Alicia Mesa-alvarez carmen Navascues Valle Cadahía-Rodrigo Rafael Menendez de Llano Ramon perez-alvarez Maria Luisa Gonzalez-Dieguez Manuel Rodríguez Liver Unit Department of Gastroenterology and HepatologyAsturias Central University HospitalOviedoSpain Hemato-Oncology Department Pontifical Catholic University of ChileSantiagoChile Research Support Unit Biosanitary Research Unit(OIB/Ficyt)OviedoSpain Autonoma University of Chile SantiagoChile Department of Radiology Hospital Universitario Central de AsturiasOviedoSpain

Background: The standard therapy in advanced hepatocellular carcinoma (HCC) is sorafenib (SOR), which has the inconvenience of toxicity and discontinuation. Patient selection and the use of early markers are critical for optimizing the potential benefit of SOR. Alpha-fetoprotein (AFP) has an established role in HCC prognosis. The objective was to evaluate whether AFP variation during SOR treatment reflects the lack of progression to SOR and can be used as a prognostic factor. Methods: AFP levels were prospectively analyzed in 114 patients to determine whether the time to progression of AFP (TPA) at 3 months had a prognostic value for survival. Results: Between July 2007 and October 2012, 114 patients were included (mean age 64 years, 97 male, 96 with cirrhosis). Etiology was alcohol 47 (41%) and hepatitis C virus (HCV) 31 (27%). According to the Barcelona Clinic Liver Cancer (BCLC) staging system: A (one case), B (24 cases) and C (89 cases). The Child-Pugh was Class A in 89 cases. The general condition of the patient according to ECOG-PS was 0 in 73 cases. The median duration of treatment was 5 months (3.47 - 6.53, 95% CI). The median overall survival (OS) was 9.23 months. The standard dose was maintained in 26 patients (22.8%). Sixty-seven percent of patients experienced at least one adverse event grade 3-4. The time to progression of AFP lower or higher than 3 months was an independent prognostic factor of OS (univariate and multivariate analysis): 8.10 vs. 18.85 months, P 3 months had longer OS, and TPA was an independent prognostic factor.

关键词： Hepatocellular Carcinoma Targeted Therapy AFP Sorafenib Prognostic Value Overall Survival

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旧地籍图的应用评估与门户网站开发--西班牙的实践

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数字人文研究 2023年第1期3卷 113-128页

作者：卡门·费梅尼亚-里贝拉加斯帕·莫拉-纳瓦罗路易斯·J.桑托斯·佩雷斯田清(译) 西班牙巴伦西亚理工大学制图工程、大地测量学与摄影测量学系西班牙地籍总局制图协调处复旦大学历史地理研究中心

社会对西班牙地籍总局所藏旧地籍图一直有很大需求。2012年,该机构决定从可用信息类型、存藏位置和状态几方面进行初步编目。随后,为评估地籍图的潜在用途而对这份目录进行审查,以调查这些地图是否能提供地理参照并在地理门户网站中发... 详细信息

社会对西班牙地籍总局所藏旧地籍图一直有很大需求。2012年,该机构决定从可用信息类型、存藏位置和状态几方面进行初步编目。随后,为评估地籍图的潜在用途而对这份目录进行审查,以调查这些地图是否能提供地理参照并在地理门户网站中发布。几年后,为更新这份编目(扩展字段使图片更加清晰、同质,更容易被软件处理),西班牙地籍总局向地产边界领域的技术专家们发放调查问卷,随后得出的主要结论为旧地籍图发挥着重要功用。支持更新地图编目的技术专家和法律专家们十分关注地籍图中蕴含的信息。旧地籍图数字化及在简单易用的地理门户中免费提供线上资源十分关键,图中信息有助于解决地产边界纠纷等问题。鉴于旧地籍图十分珍贵,为保护与发布这些地图而投入财力、人力至关重要。

关键词：地籍旧地图地图学地产标界历史地图地理门户

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