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Cytotoxic Properties of Lyophilized Beers in a Malignant Cell Line

Food and Nutrition Sciences 2014年第1期5卷 45-51页

作者： carmela spagnuolo Idolo Tedesco Maria Grazia Volpe Stefania Bilotto Maria Russo Gian Luigi Russo Institute of Food Sciences National Research Council Avellino Italy Institute of Food Sciences National Research Council Avellino Italy.

Moderate beer consumption can be considered as part of a healthy diet since it may protect against heart disease, cancer and osteoporosis. The protective effects of beer reside in its polyphenol content whose chemical composition appears extremely complex. In the present study, five commercial beers with different polyphenol content (ranging between 690 - 2400 μM equivalents of quercetin) were employed to investigate their cytotoxic effect in vitro on HL-60 cells derived from a human promyelocytic leukemia cell line. A significant reduction in cell viability was measured after 48 hours treatment. Lyophilized beers with higher polyphenol content showed the highest cytotoxicity compared to those with lower concentrations. However, when the assay was performed applying equal amounts of total polyphenols from different lyophilized beers, the sample possessing lowest amount of polyphenols (690 μM equivalents of quercetin) resulted the most effective in reducing cell viability. These data suggest that the biological activities of polyphenols present in beer are not simply dependent upon their total concentration, but qualitative profile and relative concentrations are even more important in determining their antiproliferative effects on cancer cells.

关键词： Beers Cytotoxicity Polyphenol Flavonoids HL-60

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Antiproliferative Activity of “<i>Lycopersicon esculentum</i>” Leaves (Var. Paul Robenson): Preliminary Study

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Food and Nutrition Sciences 2013年第6期4卷 632-635页

作者： carmela Saturnino Annalisa spagnuolo Chiara Palladino Ada Popolo Giuseppina Tommonaro Rocco De Prisco Aldo Pinto Council of National Research (CNR)—Institute of Biomolecular Chemistry Pozzuoli Italy Department of Pharmaceutical Sciences University of Salerno Via Ponte Don Melillo 84084 Fisciano Italy

Among plants, the Lycopersicon esculentum (Solanaceae) is the most important for its beneficial effects on health. Several epidemiological studies have shown the benefits of tomato consumption in the cancer and cardiovascular disease prevention. Tomato products constitute the major source of lycopene, the most potent antioxidant among carotenoids in vitro. In tomatoes leaves are also present many secondary metabolites including phenolic compounds, phytoalexins, protease inhibitors and glycoalkaloids who protect against adverse effects of hosts including fungi, bacteria, viruses, and insects and are involved in host-plant resistance. In this work we evaluated the antiproliferative activity of tomato leaves extract (var. Paul Robenson) in vitro.

关键词： Lycopersicon esculentum Antiproliferative Activity Glioma Cell Line

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