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Histopathological Analysis about Autopsies from HIV/AIDS Patients—About Two Decades of Research Comparing Results before and after Antiretroviral Therapy Advent

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World Journal of AIDS 2013年第3期3卷 207-215页

作者： Aline Domingos Pinto Ruppert Alexandre de Matos Soeiro Maria Carolina Fde Almeida Vera Luiza Capelozzi carlos vserrano jr Department of Pathology University of Sao Paulo Medical SchoolSao PauloBrazil Heart Institute University of Sao Paulo Medical SchoolSao PauloBrazil

Objectives: This study considers 489 autopsies of HIV/AIDS patients who died from acute respiratory failure and describes the demographic data, etiology, and histological pulmonary findings of HIV associated diseases, comparing results before and after introduction of antiretroviral therapy. Methods: The following data were obtained: age, sex, and major associated diseases (found at the autopsy). Pulmonary histopathology was categorized as: diffuse alveolar damage;pulmonary edema;alveolar hemorrhage;and acute interstitial pneumonia. Odds ratio of the HIV/AIDS-associated diseases developing a specific histopathological pattern was determined by logistic regression. Results: A total of 355 men were studied. The mean age was 37 years old. Bronchopneumonia presented in 43% and Pneumocystis jiroveci pneumonia in 38% of patients. Pulmonary histopathology showed diffuse alveolar damage in 31% and acute interstitial pneumonia in 23%. The multivariate analysis showed a significant and positive association between diffuse alveolar damage with disseminated tuberculosis, cirrhosis and sepsis;and acute interstitial pneumonia with Pneumocystis jiroveci pneumonia and cytomegalovirosis. After the introduction of antiretroviral therapy we observed an increase in the prevalence of bacterial bronchopneumonia, sepsis and cirrhosis;and a decrease in Pneumocystis jiroveci pneumonia and cytomegalovirosis. Conclusions: Coherent to literature, this study showed a decrease of respiratory failure mortality associated with some opportunistic infections after antiretroviral therapy introduction. But an increased prevalence of sepsis, bronchopneumonia and sepsis was observed too. The most prevalent pulmonary histopathological pattern was diffuse alveolar damage, which suggested a positive association with disseminated tuberculosis, sepsis and cirrhosis.

关键词： AIDS Acute Respiratory Failure Pathology

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A methodology for coffee price forecasting based on extreme learning machines

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Information Processing in Agriculture 2022年第4期9卷 556-565页

作者： Carolina Deina Matheus Henrique do Amaral Prates carlos Henrique Rodrigues Alves Marcella Scoczynski Ribeiro Martins Flavio Trojan Sergio Luiz Stevan jr Hugo Valadares Siqueira Department of Production Engineering Federal University of Rio Grande do Sul90.035-190Brazil Department of Electronics Federal University of TechnologyParana 84017-220Brazil Graduate Program in Production Engineering Federal University of TechnologyParana 84017-220Brazil

This work introduces a methodology to estimate coffee prices based on the use of Extreme Learning *** process is initiated by identifying the presence of nonstationary components,like seasonality and *** components are withdrawn if they are ***,the temporal lags are selected based on the response of the Partial Autocorre-lation Function *** predictors,we address the following models:Exponential Smooth-ing(ES),Autoregressive(AR)and Autoregressive Integrated and Moving Average(ARIMA)models,Multilayer Perceptron(MLP)and Extreme Learning Machines(ELMs)neural *** computational results based on three error metrics and two coffee types(Ara-bica and Robusta)showed that the neural networks,especially the ELM,can reach higher performance levels than the other *** methodology,which presents preprocess-ing stages,lag selection,and use of ELM,is a novelty that contributes to the coffee prices forecasting field.

关键词： Coffee price forecasting Linear models Artificial neural networks Computational intelligence

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Esophagogastric anastomosis with invagination into stomach:New technique to reduce fistula formation

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World Journal of Gastroenterology 2010年第45期16卷 5722-5726页

作者： Alexandre Cruz Henriques carlos Alberto Godinho Roberto Saad jr Daniel Reis Waisberg Aline Biral Zanon Manlio Basilio Speranzini Jaques Waisberg Department of Surgery University HospitalABC Medical SchoolSanto AndréSo Paulo09060-870Brazil

AIM: To present a new technique of cervical esophagogastric anastomosis to reduce the frequency of fistula formation. METHODS: A group of 31 patients with thoracic and abdominal esophageal cancer underwent cervical esophagogastric anastomosis with invagination of the proximal esophageal stump into the stomach tube. In the region elected for anastomosis, a transverse myotomy of the esophagus was carried out around the entire circumference of the esophagus. Afterwards, a 4-cm long segment of esophagus was invaginated into the stomach and anastomosed to the anterior and the posterior walls. RESULTS: Postoperative minor complications occurred in 22 (70.9%) patients. Four (12.9%) patients had serious complications that led to death. The discharge of saliva was at a lower region, while attempting to leave the anastomosis site out of the alimentary transit. Three (9.7%) patients had fistula at the esophagogastric anastomosis, with minimal leakage of air or saliva and with mild clinical repercussions. No patients had esophago- gastric fistula with intense saliva leakage from either the cervical incision or the thoracic drain. Fibrotic stenosis of anastomoses occurred in seven (22.6%) patients. All these patients obtained relief from their dysphagia with endoscopic dilatation of the ***: Cervical esophagogastric anastomosis with invagination of the proximal esophageal stump into the stomach tube presented a low rate of esophagogastric fistula with mild clinical repercussions.

关键词： Esophageal cancer Esophagectomy Constriction Pathologic Fistula Gastroplasty

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Leukocyte-technetium-99m uptake in Crohn's disease:Does it show subclinical disease?

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World Journal of Gastroenterology 2010年第3期16卷 365-371页

作者： Luciene G Mota Luiz GV Coelho carlos jr Simal Maria LA Ferrari Clodomiro Toledo Josep Martin-Comin Simone OF Diniz Valbert N Cardoso Nuclear Engineering Department Federal University of Minas Gerais Gastro-enterology ALFA Institute Clinical HospitalFederal University of Minas Gerais Nuclear Medicine Felício Rocho HospitalMedicine FacultyFederal University of Minas Gerais Medicine Nuclear Center Bellvitge Hospital Radioisotope Laboratory Pharmacy FacultyFederal University of Minas Gerais

AIM:To evaluate inflammatory activity in patients with Crohn's disease (CD) using technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) granulocyte ***: Twenty patients (7 male and 13 female) with CD and five healthy volunteers were selected for 99mTc-HMPAO granulocyte scintigraphy. The Crohn's Disease Activity Index (CDAI), blood tests and C-reactive protein (CRP) of each patient were performed 7 d before the scintigraphic images. The leukocytes were labeled according to the International Society of Radiolabeled Blood Elements (ISORBE) consensus protocol and the scintigraphic images, including single photon emission computed tomography, were obtained 30 min and 2 h after injection of the radiolabeled ***:The labeling yield of the leukocytes with the lipophilic complex 99mTc-HMPAO was 55.0%±10%. Six of the 20 patients (30%) presented congruent results for the three parameters investigated (CDAI, Scintigraphic Index and CRP). On the other hand, 14 patients (70%) did not show congruent results. There was no significant correlation between the indices analyzed according to the Spearman test (P>0.05,n=20).CONCLUSION: The results suggest that 99mTc-HMPAO-labeled leukocyte scintigraphy could be important for determining inflammatory activity in CD even in the absence of clinical symptoms.

关键词： Technetium-99m Hexamethylpropyleneamine oxime Leukocytes Inflammatory bowel disease Scintigraphy

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Comments on the Article “Improved Hemodynamics with the Use of Prophylactic Infusion of Epinephrine and or Norepinephrine during Transcatheter Aortic Valve Replacement (TAVR)”

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Open Journal of Anesthesiology 2015年第10期5卷 217-218页

作者： carlos Galhardo jr. carlos Darcy Alves Bersot Departament of Anesthesia at Unimed-Rio Hospital Rio de Janeiro Brazil Departament of Anesthesia at Lagoa Federal Hospital-SUS Rio de Janeiro Brazil

Transcatheter aortic valve replacement (TAVR) is a new therapeutic option to treat patients with symptomatic severe aortic stenosis, and a prohibitive mortality risk for conventional surgical AVR2. A thorough understanding of the procedural steps involved in TAVR is imperative for all components of the heart time. Balloon aortic valvuloplasty under rapid ventricular pacing is one of the main procedural steps, and is usually performed before valve insertion to enable passage of the prosthesis through the stenotic native aortic valve. Hemodynamic collapse necessitating prompt intervention may occur at different stages during the procedure.

关键词： Cardiovascular Anesthesia Surgery Hemodynamics Control

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Rationale for reconsidering current regulations restricting use of hybrids in orange juice

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Horticulture Research 2020年第1期7卷 2375-2381页

作者： Ed Stover Frederick G.Gmitter jr Jude Grosser Elizabeth Baldwin Guohong Albert Wu Jinhe Bai Yu Wang Peter Chaires Juan carlos Motamayor USDA/ARS US Horticultural Research Lab.2001 S Rock Rd.Ft.PierceFL 34945USA Citrus Research and Education Center Univ.Florida700 Experiment Station Rd.Lake AlfredFL 33850USA US Department of Energy Joint Genome InstituteLawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA New Varieties Development&Management Corp. PO Box 941058MaitlandFL 32794USA The Coca-Cola Company 2651 Orange Ave.ApopkaFL 32703USA

Huanglongbing(HLB)is a disease that has devastated the Florida citrus industry,threatens the entire *** industry,and globally is rapidly ***’s citrus production is 90%sweet orange,which is quite sensitive to *** heavy reliance on sweet orange for Florida citrus production makes the industry especially vulnerable to diseases that are damaging to this type of ***,90%of Florida oranges are used in producing orange juice that is defined by a federal regulation known as the“orange juice standard”,specifying that at least 90%of“orange juice”must be derived from Citrus *** analyses definitively reveal that sweet orange is not a true species,but just one of many introgression hybrids of *** and ***,with phenotypic diversity resulting from accumulated mutations in this single hybrid,the“sweet orange”.No other fruit industry is limited by law to such a narrow genetic ***,there are new citrus hybrids displaying reduced sensitivity to HLB,and in some cases they produce juice,alone or in blends,that consumers would recognize as“orange juice”.Reconsidering current regulations on orange juice standards may permit use of such hybrids in“orange juice”,providing greater latitude for commercialization of these hybrids,leading to higher-quality orange juice and a more sustainable Florida orange juice industry.

关键词： orange Rational stated

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Ascorbic acid improves impaired venous and arterial endotheliumdependent dilation in smokers

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Acta Pharmacologica Sinica 2005年第4期26卷 447-452页

作者： Márcio Goncalves de SOUSA Juan carlos YUGAR-TOLEDO Marcelo RUBIRA Sílvia Elaine FERREIRA-MELO Rodrigo PLENTZ Deise BARBIERI Fernanda CONSOLIM-COLOMBO Maria Cláudia IRIGOYEN Heitor MORENO jr Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Hypertension Unit InCor Clinical Hospital of S o Paulo Faculty of Medicine of S o Paulo University 05403-000 S o Paulo Brazil Cardiovascular Pharmacology and Cardiology Clinical Hospital of Campinas and Faculty of Medical Sciences State University of Campinas 13081-970 Campinas S o Paulo Brazil

Aim:To compare the acute effects of ascorbic acid on vasodilation of veins andarteries in ***:Twenty-six healthy non-smokers and 23 healthy moder-ate smokers were recruited in this *** dorsal hand vein compliance tech-nique and flow-mediated dilation were ***-response curves to bradykininand sodium nitroprusside were constructed to test the endothelium-dependentand-independent relaxation before and after acute infusion of ascorbic ***:Smokers had an impaired venodilation with bradykinin compared withnon-smokers(68.3%±13.2% vs 93.7%±20.1%,respectively;P<0.05).Ascorbic acidadministration in the dorsal hand vein significantly increased the venodilationwith bradykinin in smokers(68.3%±13.2% vs 89.5%±6.3% before and after infusion,respectively;P<0.05)but not in non-smokers(93.7%±20.1% vs 86.4%±12.4% be-fore and after infusion,respectively).Similarly,the arterial response in smokershad an impaired endothelium-dependent dilation compared with that in non-smok-ers(8.8%±2.7% vs 15.2%±2.3%,respectively;P<0.05)and ascorbic acid restoredthis response in smokers(8.8%±2.7% vs 18.7%±6.5% before and after infusion,respectively;P<0.05),but no difference was seen in non-smokers(15.2%±2.3% vs14.0%±4.4% before and after infusion,respectively).The endothelium-indepen-dent dilation did not differ in both the groups *** important hemody-namic change was detected using the Portapress ***:Smokershad impaired endothelium-dependent vasodilation responsiveness in both arte-rial and venous *** acid restores this responsiveness in smokers.

关键词： ascorbic acid vasodilation vascular endothelium arterioles venules dorsal hand vein flow-mediated dilation

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DYNAMICS OF EMERGENT AND RE-EMERGENT DISEASES INA GLOBAL VILLAGE

DYNAMICS OF EMERGENT AND RE-EMERGENT DISEASES INA GLOBAL VIL...

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第三世界生态高峰会

作者： carlos Castillo-Chavez Joaquin Bustoz jr. Arizona State University Arizona State University

The control and prevention of a growing number of diseases will only be effective if local and national public health policies adopt a global *** role of mass transportation,immigration,tourism, demographic growth,tourism and bioterrorism are but some of the engines behind disease dynamics and disease *** using recent epidemic outbreaks will be used to highlight not only the importance of these epidemic drivers but also to advance the importance of health policy perspectives without borders.

关键词： INA DYNAMICS OF EMERGENT AND RE-EMERGENT DISEASES INA GLOBAL VILLAGE

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Propensity-matched analysis of patients with intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma and hepatocellular carcinoma undergoing a liver transplant

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World Journal of Clinical Oncology 2022年第8期13卷 688-701页

作者： Ajacio Bandeira de Mello Brandão Santiago Rodriguez Alfeu de Medeiros Fleck jr Claudio Augusto Marroni Mário B Wagner Alex Hörbe Matheus V Fernandes carlos TS Cerski Gabriela Perdomo Coral Graduate Program in Medicine:Hepatology School of MedicineUniversidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050170RSBrazil Liver Transplantation Group Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020090RSBrazil Department of Hepatology Hospital Vozandes Quito-HVQQuito 170521Ecuador School of Medicine Universidade Federal do Rio Grande do Sul(UFRGS)Porto Alegre 90035002RSBrazil Interventional Radiology Unit Santa Casa de Misericórdia dePorto Alegre 90020090RSBrazil Department of Pathology School of MedicineUniversidade Federal do Rio Grande do SulPorto Alegre 90035002RSBrazil

BACKGROUND Cholangiocarcinoma(CC)is a rare tumor that arises from the epithelium of the bile *** is classified according to anatomic location as intrahepatic,perihilar,and *** CC(ICC)is rare in patients with cirrhosis due to causes other than primary sclerosing *** hepatocellular carcinoma-CC(HCC-CC)is a rare neoplasm that shows histologic findings of both HCC and ICC within the same tumor *** to the difficulties in arriving at the correct diagnosis,patients eventually undergo liver transplantation(LT)with a presumptive diagnosis of HCC on imaging when,in fact,they have ICC or *** To evaluate the outcomes of patients with intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma on pathological examination after liver *** Propensity score matching was used to analyze tumor recurrence(TR),overall mortality(OM),and recurrence-free survival(RFS)in LT recipients with pathologically confirmed ICC or HCC-CC matched 1:8 to those with ***-free survival and overall mortality rates were computed with the Kaplan-Meier method using Cox regression for *** Of 475 HCC LT recipients,1.7%had the diagnosis of ICC and 1.5%of HCC-CC on pathological examination of the *** recipients with ICC had higher TR(46%vs 11%;P=0.006),higher OM(63%vs 23%;P=0.002),and lower RFS(38%vs 89%;P=0.002)than those with HCC when matched for pretransplant tumor characteristics,as well as higher TR(46%vs 23%;P=0.083),higher OM(63%vs 35%;P=0.026),and lower RFS(38%vs 59%;P=0.037)when matched for posttransplant tumor *** pairings were performed to compare the outcomes of LT recipients with HCC-CC vs *** was no significant difference between the outcomes in either *** Patients with ICC had worse outcomes than patients undergoing LT for *** outcomes of patients with HCC-CC did not differ significantly from those of patients with HCC.

关键词： Cholangiocarcinoma Hepatocellular carcinoma Liver Prognosis Recurrence Survival analysis Transplantation

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Correction:Propensity-matched analysis of patients with intrahepatic cholangiocarcinoma or mixed hepatocellularcholangiocarcinoma and hepatocellular carcinoma undergoing a liver transplant

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World Journal of Clinical Oncology 2023年第6期14卷 227-229页

作者： Ajacio Bandeira de Mello Brandão Santiago Rodriguez Alfeu de Medeiros Fleck jr Claudio Augusto Marroni Mário B Wagner Alex Hörbe Matheus V Fernandes carlos TS Cerski Gabriela Perdomo Coral Graduate Program in Medicine:Hepatology School of MedicineUniversidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050170RSBrazil Liver Transplantation Group Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020090RSBrazil Department of Hepatology Hospital Vozandes Quito-HVQQuito 170521Ecuador School of Medicine Universidade Federal do Rio Grande do Sul(UFRGS)Porto Alegre 90035002RSBrazil Interventional Radiology Unit Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020090RSBrunei Darussalam Department of Pathology School of MedicineUniversidade Federal do Rio Grande do Sul(UFRGS)Porto Alegre 90035002RSBrazil

Rereading the article“Propensity-matched analysis of patients with intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma and hepatocellular carcinoma undergoing a liver transplant”(DOI:10.5306/wjco.v13.i8.688),published on August 24,we observe,with concern,that figures 3 and 4 are *** authors have attached the correct figures for correction.

关键词： Cholangiocarcinoma Hepatocellular carcinoma Liver Prognosis Recurrence Survival analysis Correction

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