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Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： carlos M Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LoC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LoC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LoC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LoC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LoC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LoC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip Microorganism identification Diagnostics Point-ofcare testing Biosensors

Combined U-Pb SHRIMP and Hf isotope study of the Late Paleozoic Yaminue Complex,Rio Negro Province,Argentina:Implications for the origin and evolution of the Patagonia composite terrane

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Geoscience Frontiers 2013年第1期4卷 37-56页

作者： carlos J.Chernicoff Eduardo o.Zappettini Joao o.S.santos Neal J.McNaughton Elena Belousova National Scientific and Technical Research Council(CoNICET) Argentina Argentine Geological-Mining Survey(SEGEMAR) Argentina Argentine Geological-Mining Survey(SEGEMAR).Argentina University of Western Australia PerthWA 6009Australia Redstone Resources.Perth.WA 6849.Australia John de Laeter Centre Curtin UniversityPerthWA 6102Australia ARC National Key Centre for Geochemical Evolution and Metallogeny of Continents(GEMoC) Macquarie UniversitySydneyNSW 2109Australia

We have carried out zircon U-Pb SHRIMP dating and Hf isotope determinations on a biotite paraschist and on a tonalitic orthogneiss of the Yaminué Complex, and re-evaluate this complex in the broader context of the tectonic evolution of the Patagonia composite terrane. In the metasedimentary unit （msuYC）, the youngest detrital zircon dated at 318 ± 5 Ma （Mississippian/Pennsylvanian boundary） indicates a Pennsylvanian （or younger） depositional age. The three main age populations peak at 474, 454 and 374 Ma. Preliminary Hf isotope data for two detrital zircons （447 and 655 Ma） yielded ε（Hf） values of -0.32 and 0.48, indicating that their primary sources contained small amounts of recycled crustal components （of Calymmian age; TDM 1.56 Ga）. Zircons from the orthogneiss （miuYC; intrusive into msuYC） show a crystallization age of 261.3 - 2.7 Ma （Capitanian; late middle Permian） which is broadly coeval with deformation, and Neoarchean-Paleoproterozoic inheritance. Meaningful core-rim relationship between Neoarchean zircon cores and late Permian rims is well defined, indicating the occurrence of Archean crust in this sector of Patagonia. Hf TDM of Permian zircons is mainly Meso-Paleoarchean （2.97-3.35 Ga）, with highly negative e（Hf） values （ca, -33）. Hf TDM of inherited Neoarchean zircon cores is also Meso-Paleoarchean （3.14-3.45 Ga） but more juvenile （ε（Hf） = -0.3）. Hf isotopes reinforce the presence of unexposed ancient crust in this area. Combining geological and isotope data, as well as geophysical models, we identify the Yaminué Complex within the La Esperanza-Yaminué crustal block flanked by two other, distinct crustal blocks： the Eastern block which forms part of the Patagonia terrane sensu stricto, located in the eastern Patagonian region, and the Western block forming part of the Southern Patagonia terrane. Their origins and timing of amalgamation to form the Patagonia composite terrane are also discussed.

关键词： Yaminue Complex U-Pb SHRIMP geochronology Hf isotopes Tectonics North Patagonian Massif Argentina

Existence of Semiclassical States for a Quasilinear Schr?dinger Equation on R^N with Exponential Critical Growth

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Acta Mathematica Sinica,English Series 2016年第11期32卷 1279-1296页

作者： Shao Jun LI carlos A. santos Min Bo YANG Department of Mathematics Zhejiang Normal UniversityJinhua 321004P.R.China Universidade de Brasilia Departamento de Matematica70910-900 BrasiliaDFBrazil

We study a quasilinear Schrodinger equation {-εN△Nu＋V（x）｜u｜N-2= Q（x）f（u） in R^N,0〈u∈W1,N（RN）,u（x）^｜x｜→∞0,where V, Q are two continuous real functions on R^N and c 〉 0 is a real parameter. Assume that the nonlinearity f is of exponential critical growth in the sense of Trudinger-Moser inequality, we are able to establish the existence and concentration of the semiclassical solutions by variational methods. Keywords Exponential critical growth, semiclassical solutions, variational methods

关键词： Exponential critical growth semiclassical solutions variational methods

Global multiplicity of solutions to a defocusing quasilinear Schrodinger equation with the singular term

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Science China Mathematics 2023年第8期66卷 1789-1812页

作者： Siyu Chen carlos Alberto santos Minbo Yang Jiazheng Zhou Department of Mathematics Zhejiang Normal UniversityJinhua 321004China Departamento de Matematica Universidade de BrasiliaBraslia 70910-900Brazil

We consider a class of modified quasilinear Schrodinger equations-△u+k/2u△u^(2)=λα(x)u^(-α)+b(x)u^(β) in Ω with u(x)=0 on■Ω,where Ω■R^(N)is a bounded domain with a regular boundary,N≥3,a and b are bounded mensurable functions,0o *** establish the global existence and multiplicity results of positive solutions in H^(1)_(0)(Ω)∩L^(∞)(Ω)for appropriate classes of parameters k andλand coefficients a(x)and b(x).

关键词： quasilinear Schrodinger equation singular term square diffusion term

The versatility of Fe(Ⅱ) in the synthesis of uniform citrate-stabilized plasmonic nanoparticles with tunable size at room temperature

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Nano Research 2020年第9期13卷 2351-2355页

作者： carlos Fernández-Lodeiro Javier Fernández-Lodeiro Enrique Carbó-Argibay carlos Lodeiro Jorge Pérez-Juste Isabel Pastoriza-santos CINBIo Universidade de VigoCampus universitario LagoasMarcosende36310 VigoSpain Galicia Sur Health Research Institute(IIS Galicia Sur) SERGAS-UVIGO36312 VigoSpain BIoSCoPE Group LAQV@REQUIMTEChemistry DepartmentNOVA School of Science and TechnologyNOVA University LisbonCaparica Campus2829-516 CaparicaPortugal PRoTEoMASS Scientific Society Rua dos InventoresMadam ParqueCaparica Campus2829-516 CaparicaPortugal International Iberian Nanotechnology Laboratory(INL) Av.Mestre Jose Veiga s/n4715-330 BragaPortugal

A highly versatile seed-mediated approach for the synthesis of citrate-stabilized gold,silver and palladium nanoparticles(NPs)with size control is *** use of iron(Ⅱ)as a reducing agent enables the fabrication of monodisperse NPs in a wide range of sizes(from 15 nm to at least 120 nm(90 nm for Pd))at room *** citrate as capping ligand on the NPs surface facilitates its further surface modification with proteins and thiolated molecules.

关键词： plasmonic nanoparticles gold silver palladium citrate-stabilized Fe(Ⅱ)

Is magnesium deficiency the major cause of needle chlorosis of Pinus taeda in Brazil?

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Journal of Forestry Research 2024年第2期35卷 209-221页

作者： Antônio carlos Vargas Motta Shizuo Maeda Valdécio dos santos dos santos Rodrigues Tamires Maiara Ercole Stephen Arthur Prior Ana Elisa Lyra Brumat Amanda Pacheco Cardoso Moura Julierme Zimmer Barbosa João Bosco Vasconcellos Gomes Department of Soil Sciences and Agriculture Engineering Federal University of ParanáR.dos Funcionários1540.CuritibaParanáCEP 80035‑050Brazil Brazilian Agricultural Research Company Embrapa FlorestasEstr.da Ribeira–Br‑476Km 111–Parque Monte Castelo.ColomboParanáCEP 83411‑000Brazil United States Department of Agriculture‑Agricultural Research Service USDA-ARS National Soil Dynamics Laboratory411 South Donahue DriveAuburnAL 36832USA Reforestation Remasa Rodovia PR 170–Km 522.BiturunaParanáCEP 84640‑000Brazil Federal Institute of Southeast of Minas Gerais R.Luz Interior360.Juiz de ForaMinas Gerais CEP 36030‑713Brazil

Needle chlorosis(NC)in Pinus taeda *** in Brazil becomes more frequent after second and third harvest rotation *** a study to identify factors contributing to yellowing needle chorosis(YNC),trees were grown in soils originating from contrasting parent materials,and soils and needles(whole,green and chlorotic portions)from 1-and 2-year-old branches and the first and second needle flush release at four sites with YNC on *** were analyzed for various elements and *** soils had very low base levels(Ca^(2+),Mg^(2+)and K^(+))and P,suggesting a possible lack of multiple *** symptoms started at needle tips,then extended toward the needle base with *** flush needles had longer portions with YNC than second flush needles *** from the lower crown also had more symptoms along their length than those higher in the *** were similar to those reported for *** chlorotic portions,Mg and Ca concentrations were well below critical values;in particular,Mg levels were only one third of the critical value of 0.3 g kg^(-1).Collectively,results suggest that Mg deficiency is the primary reason for NC of *** in various parent soils in Brazil.

关键词： Nutritional deficiency Forest management Soil depletion Pine foliar analysis Needle chlorosis

Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor

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World Journal of Gastroenterology 2008年第5期14卷 800-802页

作者： carlos Eduardo.paiva Francisco Alves Moraes Neto Abbas Agaimy Maria Aparecida Custódio Domingues Silvia Regina Rogatto oncological and Hemato-oncological Center So Paulo State University Botucatu So Paulo 18610-170 Brazil Department of Pathology Amaral Carvalho Hospital Jaú So Paulo Brazil Institute of Pathology Nuremberg Clinic Center Nuremberg Germany Department of Pathology So Paulo State University Botucatu So Paulo 18610-170 Brazil Department of Urology So Paulo State University Botucatu So Paulo 18610-170 Brazil

Approximately 10% of patients with gastrointestinal stromal tumors (GIST) develop other neoplasms, either synchronously or metachronously. In this report we describe coexistence of a gastrointestinal stromal tumor and a hepatic perivascular epithelioid cell tumor (PEComa) in a 51-year-old woman with no evidence of tuberous sclerosis. A subcapsular hepatic nodule (0.8 cm in diameter) was found during surgery for symptomatic gastric neoplasm (15 cm in diameter) arising from the lesser curvature. Both tumors revealed histomorphological and immunohistochemical features confirming a diagnosis of a small incidental hepatic PEComa and a high risky extramural gastric GIST, respectively. The patient remained disease-free 25 mo after surgery with no evidence of tumor recurrence or new neoplasms. To our knowledge, this is the first report of PEComa in a patient with GIST. Hepatic lesions detected synchronously or metachronously in patients with GISTs may represent histogenetically distinct lesions and should be sampled to confirm or exclude metastatic GISTs.

关键词： Gastrointestinal stromal tumors PEComa Coexistence Liver Synchronous

Unveiling an important interaction in forestry:Ectomyelois muriscis and Khaya grandifoliola cankers and tree growth

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Journal of Forestry Research 2021年第3期32卷 1287-1293页

作者： Lísias Coelho AndréRTerra Nascimento Jean carlos santos Vinícius Flabes Silva Instituto de Ciências Agrárias Universidade Federal de UberlandiaUberlandiaBrazil Instituto de Biologia Universidade Federal de UberlandiaUberlandiaBrazil Departamento de Ecologia Universidade Federal de SergipeSergipeBrazil

African mahogany,Khaya grandifoliola ***.,is the most planted mahogany species in Brazil,and became the choice species when plantations of Brazilian mahogany,Swietenia macrophyla King became unsustainable due to their susceptibility to the shoot borer Hypsipyla grandella *** study evaluated plantation growth and the occurrence of cankers associated with Ectomyelois muriscis Dyar *** recorded plantation volume,survival,and canker incidence of a plantation established in 2010 at 6 m×5.5 m *** were collected and reared on canker bark fragments until final adult *** were frequently associated with Ectomyelois muriscis *** average incidence of the moth(2.9%)was not a significant concern,however,an extreme incidence of 45%would indicate that management strategies should be *** is the first report of Ectomyelois muriscis attacking the bark of Khaya grandifoliola in the Cerrado biome.

关键词： African mahogany Stem cankers Potential pest Stand growth

Mercury in aquatic fauna contamination:A systematic review on its dynamics and potential health risks

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Journal of Environmental Sciences 2019年第10期31卷 205-218页

作者： Paloma de Almeida Rodrigues Rafaela Gomes Ferrari Luciano Neves dos santos carlos Adam Conte Junior Molecular and Analytical Laboratory Center Department of Food TechnologyFaculty of VeterinaryUniversidade Federal FluminenseNiteróiBrazil Chemistry Institute Food Science ProgramUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil National Institute of Health Quality Control Fundacaeo Oswaldo CruzRio de JaneiroBrazil Laboratory of Theoretical and Applied Ichthyology Department of Ecology and Marine ResourcesUniversidade Federal do Estado do Rio de JaneiroRio de JaneiroBrazil

Mercury is an important pollutant,released into aquatic ecosystems both naturally and by anthropogenic *** element is transferred to aquatic organisms in different ways,causing potential health *** addition,mercury can be accumulated by humans,especially through the consumption of contaminated *** systematic review aims to present mercury pathways,the major routes through which this element reaches the aquatic environment and its transformations until becoming available to living animals,leading to bioaccumulation and biomagnification *** key biotic and abiotic factors affecting such processes,the impact of mercury on animal and human health and the issue of seafood consumption as a source of chronic mercury contamination are also addressed.A total of 101 articles were retrieved from a standardized search on three databases(PubMed,Emabse,and Web of Science),in addition to 28 other studies not found on these databases but considered fundamental to this review(totaling 129 articles).Both biotic and abiotic factors display fundamental importance in mediating mercurial dynamics,i.e.,muscle tropism,and salinity,***,mercurial contamination in aquatic environments affects animal health,especially the risk of extinction species and also on human health,with methylmercury the main mercury species responsible for acute and chronic symptomatology.

关键词： Mercury levels Seafood Methylmercury Public health Aquatic environment