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Hypothalamic-pituitary-adrenal axis function during perinatal depression

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Neuroscience Bulletin 2015年第3期31卷 338-350页

作者： Phillipe Leff Gelman Mónica Flores-Ramos Margarita López-Martínez carlos cruz Fuentes Juan Pablo Reyes Grajeda National Institute of Perinatology Mexico City National Council of Sciences and Technology (CONACy T) Mexico City National Institute of Psychiatry Mexico City National Institute of Genomic Medicine Mexico City

Abnormal function of the hypothalamic-pituitary-adrenal （HPA） axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol pro- inflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 1113-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby.

关键词： brain depression neuroendocrine pregnancy stress glucocorticoids

Non-linear modeling of kinetic and equilibrium data for the adsorption of hexavalent chromium by carbon nanomaterials:Dimension and functionalization

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Chinese Journal of Chemical Engineering 2019年第4期27卷 912-919页

作者： Miguel de la Luz-Asunción Eduardo E.Pérez-Ramírez Ana L.Martínez-Hernández Victor M.Castano Víctor Sánchez-Mendieta carlos Velasco-Santos Facultad de Quimica Universidad Autonoma del Estado de Mexico Km. 12 de la carretera Toluca-Atlacomulco C.P. 50200 San Cayetano Toluca Estado de Mexico Mexico Tecnologico Nacional de Mexico-Instituto Tecnologico de Queretaro Division de Estudios de Posgrado e Investigacion Av. Tecnologico s/n esq. GraL Mariano Escobedo Col. Centro Historico C.P. 76000 Santiago de Queretaro Queretaro Mexico Centro de Fisica Aplicada y Tecnologia Avanzada Universidad Nacional Autonoma de Mexico Boulevard Juriquilla 3001 Queretaro 76230 Mexico

The adsorption capacities for the removal of hexavalent chromium from aqueous solutions by six carbon nanomaterials have been evaluated. Single-walled and multi-walled carbon nanotubes as received and after oxidation treatment, graphene oxide and reduced graphene oxide are the materials with different dimension and functionalization compared in this research. Carbon nanotubes have been modified using hydrogen peroxide as oxidizing agent under microwave radiation. The oxidation treatment on carbon nanotubes has a positive effect increasing the adsorbent–adsorbate interaction. Rate-controlling mechanisms and equilibrium data are analyzed using non-linear models. Non-linear method is proposed as the most suitable method for determining the kinetic and equilibrium parameters. The values of adsorption energy(E) obtained from the Dubinin–Radushkevich isotherm,have been found around 0.371 and 0.870 k J·mol-1, indicating physical adsorption. Therefore, the pseudo-second order model represents better the kinetic experimental data. The results show that the langmuir isotherm provides a slightly better fit to the experimental data compared with the Freundlich isotherm, indicating homogeneous distribution of active sites on carbon nanomaterials and monolayer adsorption. The separation factors Rlare found in the range of 0–1, suggesting that the adsorption process is suitable for all adsorbents. The mechanisms for hexavalent chromium removal have been proposed as electrostatic interactions and hydrogen bonding.

关键词： Carbon nanotubes Graphene Adsorption Hexavalent chromium Kinetic

3′-UTR of the SARS-CoV-2 genome as a possible source of piRNAs

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Genes & Diseases 2023年第3期10卷 668-670页

作者： María Teresa Hernández-Huerta laura Pérez-Campos Mayoral carlos Alberto Matias-Cervantes carlos Romero Díaz Eli cruz Parada Eduardo Pérez-Campos Mayoral Rafael Baltiérrez-Hoyos Margarito Martínez cruz Gabriel Mayoral Andrade Eduardo Pérez-Campos CONACyT Faculty of Medicine and SurgeryAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico Research Center Faculty of Medicine UNAM-UABJOAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 8020Mexico National Technology of Mexico/IT Oaxaca Oaxaca de JuárezOaxaca 68030Mexico

SARS-CoV-2 is the causal agent of the COVID-19 pandemic. This is a single-stranded RNA beta-coronavirus that is comprised of a 5′ and 3′-untranslated region (UTR) in its non-coding RNA (ncRNA) region. The P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are ncRNA sequences that bind to transposons and interfere with the translation of new genes. Here, we search for short sequences in the non-coding regions, corresponding to 28 nucleotides (nt). These start from a uracil and have a conserved region of at least 10 nt of homology with the previously reported piRNAs. The aim of this work was to identify piRNA-like sequences in the 3′-UTR of SARS-CoV-2 from the reported Wuhan Patient's genome sequence (GenBank: MN908947.3).

关键词： piRNA sequences piRNAs

Sleeve Gastrectomy with Duodenal Transit Bipartition (S-DTB): Preliminary Results and Technical Aspects of Its Metabolic Structure

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Effect of rare-earth oxides on properties of silicon nitride obtained by normal sintering and sinter-HIP

Surgical Science（外科学） 2024年第4期 244页

作者： Paulo Reis Esselin de Melo Ricardo Zorron Victor Ramos Mussa Dib carlos Augusto Scussel Madalosso Rui Ribeiro Thonya cruz Braga Paula Volpe carlos Eduardo Domene

来源：博看期刊评论

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Journal of Rare Earths 2012年第11期30卷 1177-1183页

作者： Cecilia C.Guedes-Silva Flávio Machado de Souza Carvalho José carlos Bressiani Nuclear and Energy Research Institute-IPEN/CNEN Geoscience Institute-IGC/USP

This paper presented the microstructure, mechanical properties and oxidation behavior of silicon nitride obtained by both conventional sintering and sintering followed by hot isostatic pressing （HIP）. Silicon nitride with additives such as 5 wt.% Al2O3 and 5 wt.% Ln203 （Ln= la, la concentrate, Gd or la＋Gd） were studied. The results revealed that Gd203 additions increased the formation of elongated grains of β-Si3N4, the fracture toughness and oxidation resistance. la2O3 additions led to higher densification and hardness values, while addition of la2O3 concentrate promoted the formation of materials with intermediate properties, compared to the other studied compositions. Hot isostatic pressing increased the hardness but decreased the fracture toughness of the material, mainly because it allowed residual pores to close and also reduced the average aspect ratio of β-Si3N4 grains.

关键词： rare earths silicon nitride properties normal sintering sinter-HIP

Safe Foods for Celiac People

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Food and Nutrition Sciences 2014年第9期5卷 787-800页

作者： carlos Osella Maria de la Torre Hugo Sánchez Instituto de Tecnología de Alimentos Facultad de Ingeniería Química Universidad Nacional del Litoral Santa Fe Argentina

Celiac Disease is a chronic entheropathy produced by gluten intolerance, more precisely to certain proteins called prolamines, which causes atrophy of intestinal villi, malabsorption and clinical symptoms that can appear in both childhood and adulthood. This pathogeny, results from the interaction of genetic, immunologic and environmental factors, which produce the lesions on the mucosa of the proximal small intestine. It is important to estimate the maximum gluten content that could be present in supposedly “gluten-free” foods, a limit of 20 mg/Kg is admitted. Rice flour, sorghum flour, starches, hydrocolloids, soy flour and dairy products are analyzed for carrying out the manufacture of gluten-free products, such as bread, noodles and others.

关键词： Celiac Disease Gluten-Free Products Raw Materials for Celiac People

Biodiversity responses to insular fragmentation in Amazonia: Two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： Ana Filipa Palmeirim Maíra Benchimol Danielle Storck-Tonon Anderson S.Bueno Isabel L.Jones Gilmar Klein carlos A.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental Sciences University of StirlingStirling FK94LAUK REBIO Uatumã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáInstitute ManausAmazonas 69057-060Brazil

As hydropower development expands across lowland tropical forests,flooding and concomitant insular fragmentation have become important threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these most iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Amazonia,occupying>400000 ha and comprising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragmentation at *** has largely concentrated on a set of 22 islands and three mainland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonomic group,island area was consistently included and played a pivotal role in 66.7%of all studies examining patterns of species *** persistence was further affected by species traits,mostly related to species capacity to use/traverse the aquatic matrix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to improve our understanding of such effects on wider ecosystem *** Impact Assessments must account for changes in both the remaining habitat amount and configuration,and subsequent long-term species losses.

关键词： Habitat loss Hydropower dams landbridge Local extinctions Species-area relationships Species diversity Tropical forests

Different patterns of intestinal response to injury after arterial,venous or arteriovenous occlusion in rats

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World Journal of Gastroenterology 2009年第31期15卷 3901-3907页

作者： Francisco Javier Guzmán-de la Garza carlos Rodrigo Cámara-Lemarroy Gabriela Alarcón-Galván Paula Cordero-Pérez Linda Elsa Muoz-Espinosa Nancy Esthela Fernández-Garza department of Physiology Autonomous University of Nuevo LeónSchool of Medicine Pathologic Anatomy and Cytopathology Service "José Eleuterio González" University Hospital Liver Unit Department of Internal MedicineAutonomous University of Nuevo LeónSchool of Medicine

AIM： To investigate the differences in injury patterns caused by arterial, venous or arteriovenous mesenteric occlusion. METHODS： Male Wistar rats were separated equally into four groups. Occlusion was performed by clamping the superior mesenteric artery （A）, the mesenteric vein （V） or both （AV） for 30 min, followed by 60 min of reperfusion. A control group received sham surgery only. Intestinal sections were examined for histological damage and serum tumor necrosis factor-α （TNF-α）, endothelin-1 （ET-1）, P-selectin, antithrombin Ⅲ （AT Ⅲ） and soluble intracellular adhesion molecule-1 （ICAM-1） concentrations were measured. RESULTS： All groups showed significant mucosal injury compared to controls. Furthermore, mucosal injury was significantly more severe in the V and AV groups compared to the A group （3.6 ± 0.55, 3.4 ± 0.55 and 2± 0.71, respectively, P = 0.01）. ICAM-1 was similarly elevated in all groups, with no significant differences between the groups. P-selectin levels were significantly elevated in the V and AV groups but not the A group （1.4 ± 0.5 ng/mL, 2.52 ± 0.9 ng/mL and 0.02± 0.01 ng/mL, respectively, P = 0.01） and ET-1 was significantly elevated in the A and V groups but not the AV group （0.32 ± 0.04 pg/mL, 0.36 ± 0.05 pg/mL and 0.29 ± 0.03 pg/mL, respectively, P = 0.01） compared to sham controls. ATⅢ levels were markedly depleted in the V and AV groups, but not in the A group （29.1 ± 5.2 pg/mL, 31.4 ±21.8 pg/mL and 55.8± 35.6 pg/mL, respectively, P = 0.01）, compared to controls. Serum TNF-α was significantly increased in all groups compared to sham controls （1.32 ± 0.87 ng/mL, 1.79 ± 0.20 ng/mL and 4.4 ± 0.69 ng/mL, for groups A, V and AV, respectively, P = 0.01）, with higher values in the AV group. CONCLUSION： Different patterns of response to ischemia/reperfusion are associated with venous, arterial or arteriovenous occlusion. Venous and arteriovenous occlusion was associated with the most severe alterations

关键词： Arterial occlusion Rat Intestine Ischemia/ reperfusion Venous occlusion

Hybrid heuristic and mathematical programming in oil pipelines networks: Use of immigrants

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第1期6卷 9-19页

作者： de la cruz J.M HERRáN-GONZáLEZ A RISCO-MARTíN J.L ANDRéS-TORO B department of Computer Architecture and Automatic Control Complutense University of Madrid 28040 Madrid SpainDepartment of Computer Architecture and Automatic Control Complutense University of Madrid 28040 Madrid SpainDepartment of Computer Science Engineering C.E.S. Felipe II (U.C.M.) 28300 Aranjuez SpainDepartment of Computer Architecture and Automatic Control Complutense University of Madrid 28040 Madrid Spain

We solve the problem of petroleum products distribution through oil pipelines networks. This problem is modelled and solved using two techniques: A heuristic method like a multiobjective evolutionary algorithm and Mathematical Programming. In the multiobjective evolutionary algorithm, several objective functions are defined to express the goals of the solutions as well as the preferences among them. Some constraints are included as hard objective functions and some are evaluated through a repairing function to avoid infeasible solutions. In the Mathematical Programming approach the multiobjective optimization is solved using the Constraint Method in Mixed Integer Linear Programming. Some constraints of the mathematical model are nonlinear, so they are linearized. The results obtained with both methods for one concrete network are presented. They are compared with a hybrid solution, where we use the results obtained by Mathematical Programming as the seed of the evolutionary algorithm.

关键词： MOEA MILP Hybrid algorithm Constraints