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The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

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Particuology 2024年第6期89卷 1-10页

作者： Juan Enrique Barranco-García Carolina Caicedo Enrique Javier Jiménez-Regalado carlos espinoza-González Graciela Morales Rocio Yaneli Aguirre-Loredo Abril Fonseca-García Tecnológico Nacional de México/Instituto Tecnológico de Oaxaca Departamento de Química y BioquímicaAvenida Ing.Víctor Bravo Ahuja No.125Esquina Calzada Tecnológico68030OaxacaMexico Faculty of Engineering Unidad Central del Valle del Cauca(UCEVA)Carrera 17a 48-144763022TuluáColombia Centro de Investigación en Química Aplicada(CIQA) Blvd.Enrique Reyna Hermosillo 14025294SaltilloCoahuilaMexico Investigadoras por México CONAHCYT-CIQA Av.Insurgentes Sur 1562Col.Crédito Constructor03940Alcaldía Benito JuárezCDMXMexico

Using biopolymers as wall materials in spray drying poses challenges,particularly in attaining flowability and thermal stability among their physicochemical *** paper addresses these challenges by preparing microparticles using a blend of starch–chitosan and a poloxamer,commercially named Pluronic®*** aimed to elucidate the effects of varying poloxamer concentrations on the resulting particles through the spray drying *** with a poloxamer concentration of 3%(w/v)demonstrated a notably higher yield,especially when compared to those with 0%and 1%*** with 3%and 5%(w/v)poloxamer displayed a narrower particle size distribution,with the 3%blend showing a superior yield attributed to arrangements of blend components that improve flowability.X-ray diffraction analysis showcased the characteristic peaks of A-type starch form,with shifts suggesting enhanced interactions between *** with increased poloxamer content showed elevated thermal degradation temperatures,with the 3%blend registering a significant rise,opening avenues for encapsulating heat-sensitive *** study primarily focuses on the preparation and basic characterization of *** underscores the potential of blends with optimal poloxamer concentrations in microencapsulation,emphasizing further research to harness their capabilities thoroughly.

关键词： Biopolymer Starch Chitosan Pluronic®F127 Microparticles Spray drying

Candelilla Wax as Natural Slow-Release Matrix for Fertilizers Encapsulated by Spray Chilling

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Journal of Renewable Materials 2018年第3期6卷 226-236页

作者： Noe Navarro-Guajardo Edgar Miguel Garcia-Carrillo carlos espinoza-Gonzalez Ruben Tellez-Zablah Fatima Davila-Hernandez Jorge Romero-Garcia Antonio Ledezma-Perez Jesus Alfonso Mercado-Silva Claudia Anahi Perez Torres Nicolaza Pariona Technological Institute of Saltillo Blvd.Venustiano Carranza 2400C.P.25280SaltilloCoahuilaMéxico Research Center for Applied Chemistry Sonomimetikos Research GroupBlvd.Enrique Reyna Hermosillo 140C.P.25294SaltilloCoahuilaMéxico Research Center for Applied Chemistry National Laboratory of GrapheneBlvd.Enrique Reyna Hermosillo 140C.P.25294SaltilloCoahuilaMéxico CONACyT–Institute of Ecology A.C. Carretera antigua a Coatepec 351El HayaC.P.91070XalapaVeracruzMéxico Network for Advanced Molecular Studies Institute of Ecology A.C.Carretera antigua a Coatepec 351El HayaC.P.91070XalapaVeracruzMéxico

Efforts to improve crop yields with efficient use of fertilizers are needed to guarantee global food *** slow-release fertilizer systems(SRFs)encapsulated in biodegradable matrices are being developed to address this global *** a wide range of strategies for SRFs development,we explored a natureinspired solution based on the plant cuticle model and its function as a membrane for water and nutrient transport ***,Candelilla wax,extracted from Candelilla wild plants(Euphorbia antisyphilitica),is studied as a renewable slow-release matrix for fertilizers encapsulated by a modified spray chilling *** this process,microencapsulates containing 40 wt%of phosphorus fertilizer are obtained with distinctive sizes and chemical characteristics,presenting a slow-release *** the abovementioned features,novel insights into fertilizer release mechanisms based on plant cuticle models are discussed.

关键词： Candelilla wax encapsulation phosphorus slow-release fertilizers(SRFs) spray chilling

“Magic” of our gastric cancer results on perioperative chemotherapy

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World Journal of Gastrointestinal Pathophysiology 2016年第3期7卷 283-287页

作者： carlos León-espinoza Fernando López-Mozos Roberto Marti-Obiol Marina Garces-Albir Joaquin Ortega-Serrano Department of Digestive and General Surgery Hospital Clínico Universitario de Valencia

AIM: To determine reproducibility of perioperative chemotherapy for gastric cancer(GC) on our settings by identifying patient's overall survival and comparing them to larger ***: Retrospective analysis of our series,where we present our eleven-year's experience on GC managed according to perioperative approach of three preoperative chemotherapy cycles followed by surgery and finally three postoperative chemotherapy *** scheme used was Xelox(Oxaliplatin and Capecitabine).Epidemiologic parameters as well as surgical variables were analysed,presented,and compared to other series with similar *** was estimated by Kaplan Meier/log rank method and also compared to these ***: Mean age was 65 years *** survival in our series was 37.7%,similar to other groups using perioperative *** was 4% and morbidity 30%,which are also similar to those *** curves were compared to larger studies,finding similarities on *** survival analysis between chemotherapy responders and non-responders didn't reach statically significant ***: Perioperative chemotherapic scheme can be reproduced on our setting with good results and without increasing morbidity or mortality.

关键词： Stomach neoplasms Perioperative period Chemotherapy

Does Adult Intestinal Invagination Need Surgery? Report of a Case and Review of Literature

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International Journal of Clinical Medicine 2011年第4期2卷 456-458页

作者： carlos Leon-espinoza Maria Gomez-Mateo Fernando Lopez-Mozos Roberto Marti-Obiol Juan Raga-Vazquez Joaquin Ortega-Serrano 不详

Benign intestinal tumors are the most frequent cause of small bowel intussusception in adults. This report presents a case of a 67-year-old male with abdominal pain, leukocytosis and C-reactive protein elevation. After ultrasonography and double contrast CT-scan consistent with ileal intussusception patient underwent laparoscopy, which confirmed diagnose. Intestinal resection and anastomosis were performed via minilaparotomy. Further histological study showed a fibroid inflammatory polyp or Vanek’s tumor as intussusception’s lead point.

关键词： Invagination Intussusception Vanek

Epidemics on networks: Reducing disease transmission using health emergency declarations and peer communication

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Infectious Disease Modelling 2020年第1期5卷 12-22页

作者： Asma Azizi Cesar Montalvo Baltazar espinoza Yun Kang carlos Castillo-Chavez School of Human Evolution and Social Change Simon A.Levin Mathematical Computational Modeling Science CenterArizona State UniversityTempeAZ85281USA Division of Applied Mathematics Brown UniversityProvidenceRI02906USA Sciences and Mathematics Faculty College of Integrative Sciences and ArtsArizona State UniversityMesaAZ85212USA

Understanding individual decisions in a world where communications and information move instantly via cell phones and the internet,contributes to the development and implementation of policies aimed at stopping or ameliorating the spread of *** this manuscript,the role of official social network perturbations generated by public health officials to slow down or stop a disease outbreak are studied over distinct classes of static social *** dynamics are stochastic in nature with individuals(nodes)being assigned fixed levels of education or *** may change their epidemiological status from susceptible,to infected and to *** importantly,it is assumed that when the prevalence reaches a pre-determined threshold level,P*,information,called awareness in our framework,starts to spread,a process triggered by public health *** is assumed to spread over the same static network and whether or not one becomes a temporary informer,is a function of his/her level of education or wealth and epidemiological *** simulations show that threshold selection Pand the value of the average basic reproduction number impact the final epidemic size *** the ErdÖos-Rényi and Small-world networks,an optimal choice for Pthat minimize the final epidemic size can be identified under some conditions while for Scalefree networks this is not case.

关键词： Awareness spread Behavior change Outbreak and epidemic threats ErdÖos-rényi network Small-world network Scale-free network

Role of short-term dispersal on the dynamics of Zika virus in an extreme idealized environment

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Infectious Disease Modelling 2017年第1期2卷 21-34页

作者： Victor M.Moreno Baltazar espinoza Derdei Bichara Susan A.Holechek carlos Castillo-Chavez Simon A.Levin Mathematical Computational and Modeling Sciences CenterArizona State UniversityP.O.Box 873901TempeAZ 85287-3901United States Biodesign Center for Infectious Diseases and Vaccinology Biodesign InstituteArizona State UniversityTempeAZ 85287-5401United States School of Life Sciences Arizona State UniversityTempeAZ 85287-4501United States Department of Mathematics and Center for Computational and Applied Mathematics California State UniversityFullertonCA 92831United States Departamento the Ingenieria Biomedica Universidad de Los AndesBogotaColombia Rector's Office Yachay Tech UniversityUrcuquiEcuador

In November 2015,El Salvador reported their first case of Zika virus(ZIKV)infection,an event followed by an explosive outbreak that generated over 6000 suspected cases in a period of two *** agencies began implementing control measures that included vector control and recommending an increased use of ***,in response to the alarming and growing number of microcephaly cases in Brazil,the importance of avoiding pregnancies for two years was *** this paper,we explore the role of mobility within communities characterized by extreme poverty,crime and ***,the role of short term mobility between two idealized interconnected highly distinct communities is explored in the context of ZIKV *** make use of a Lagrangian modeling approach within a two-patch setting in order to highlight the possible effects that short-term mobility,within highly distinct environments,may have on the dynamics of ZIKV outbreak when the overall goal is to reduce the number of cases not just in the most affluent areas but *** depend on existing mobility patterns,levels of disease risk,and the ability of federal or state public health services to invest in resource limited areas,particularly in those where violence is *** results of simulations in highly polarized and simplified scenarios are used to assess the role of *** quickly became evident that matching observed patterns of ZIKV outbreaks could not be captured without incorporating increasing levels of *** number of distinct patches and variations on patch connectivity structure required to match ZIKV patterns could not be met within the highly aggregated model that is used in the simulations.

关键词： Vector-borne diseases Zika virus Residence times Multi-patch model

Gauge Invariance of Gravitodynamical Potentials in the Jefimenko’s Generalized Theory of Gravitation

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Journal of Modern Physics 2016年第13期7卷 1617-1626页

作者： Augusto espinoza Andrew Chubykalo David Perez carlos Unidad Académica de Física Universidad Autónoma de Zacatecas Zacatecas México

In the Jefimenko’s generalized theory of gravitation, it is proposed the existence of certain potentials to help us to calculate the gravitational and cogravitational fields, such potentials are also presumed non-invariant under certain gauge transformations. In return, we propose that there is a way to perform the calculation of certain potentials that can be derived without using some kind of gauge transformation, and to achieve this we apply the Helmholtz’s theorem. This procedure leads to the conclusion that both gravitational and cogravitational fields propagate simultaneously in a delayed and in an instant manner. On the other hand, it is also concluded that these potentials thus obtained can be real physical quantities, unlike potentials obtained by Jefimenko, which are only used as a mathematical tool for calculating gravitational and cogravitational fields.

关键词： Gravitational Potentials Cogravitation Helmholtz’s Theorem

Conceptual Content of the Generalized Theory of Gravitation of Jefimenko

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Journal of Modern Physics 2018年第8期9卷 1522-1544页

作者： Andrew Chubykalo Augusto espinoza David Pérez carlos Unidad Académica de Física Universidad Autónoma de Zacatecas Zacatecas México

In this work, we make a brief exposition of the Jefimenko’s generalized theory of gravitation, describe its conceptual content, explain the mathematical apparatus used for the formulations of the theory and present the fundamental equations of the theory. We elucidate the main difference between Newton’s original theory of gravitation and the generalized theory of gravitation.

关键词： Cogravitation Gravitational Waves Gravikinetic Field

Role of Salmonella enterica exposure in Chilean Crohn's disease patients

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World Journal of Gastroenterology 2013年第35期19卷 5855-5862页

作者： Manuel Alvarez-Lobos Daniela P Pizarro Christian E Palavecino Abner espinoza Valentina P Sebastián Juan C Alvarado Patricio Ibaez carlos Quintana Orlando Díaz Alexis M Kalergis Susan M Bueno CAREI Group (Active Cohort Registry of Inflammatory Bowel Disease) Department of Gastroenterology Facultad de MedicinaPontificia Universidad Católica de Chile Departamento de Genética Molecular y Microbiología Facultad de Ciencias Biológicas Pontificia Universidad Católica de Chile School of Medicine Facultad de MedicinaPontificia Universidad Católica de Chile Department of Respiratory Diseases Facultad de Medicina Pontificia Universidad Católica de Chile

AIM:To study the association between exposure toSalmonella enterica(SE)and Crohn’s disease(CD)and its clinical implications in Chilean ***:Ninety-four unrelated Chilean CD patients from CAREI(Active Cohort Registry of Inflammatory Bowel Disease)presenting to a single inflammatory bowel disease(IBD)unit of a University Hospital were prospectively included in this study.A complete clinical evaluation,including smoking history,was performed at the initial visit,and all the important data of clinical evolution of CD were *** samples from these CD patients and 88 healthy sex-and agematched control subjects were analyzed for exposure to SE and for their NOD2/CARD15 gene status using the presence of anti-Salmonella lipopolysaccharide antibodies[immunoglobulin-G type(IgG)]and polymerase chain reaction(PCR),*** also evaluated exposure to SE in 90 sex-and age-matched patients without CD,but with known smoking status(30 smokers,30 non-smokers,and 30 former smokers).RESULTS:CD patients comprised 54 females and 40males,aged 35.5±15.2 years at diagnosis with a mean follow-up of 9.0±6.8 *** was inflammatory in 59 patients(62.7%),stricturing in 24(25.5%)and penetrating in 15(15.5%).Thirty cases(31.9%)had lesions in the ileum,29(30.8%)had ileocolonic lesions,32(34.0%)had colonic lesions and 23(24.4%)had perianal *** CD patients(17%)were exposed to SE compared to 15(17%)of 88 healthy control subjects(P=0.8).Thirty-one CD patients(32.9%)were smokers,and 7(7.4%)were former smokers at *** the group exposed to SE,10 of 16 patients(62.5%)were active smokers compared to 21 of 78 patients(26.9%)in the unexposed group(P=0.01).On the other hand,10 of 31 smoking patients(32%)were exposed to SE compared to 5 of 56 nonsmoking patients(9%),and one of the seven former smokers(14%)(P=0.01).In the group of 90 patients without CD,but whose smoking status was known,there was no differ-ence in exposure to SE[3 of 30 smokers(10%),5 of30 non-s

关键词： Crohn’s disease Salmonella Infection Tobacco Smoking Environmental factors