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Joint e.fe.t among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate.cance. risk： an e.ploratory ge.otype.e.vironme.t inte.action study

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Asian Journal of Andrology 2006年第A3期8卷 349-355页

作者： Luis A. Quinone. carlos e. irarrázabal Claudio R. Rojas Cristian e. Ore.lana Cristian Ace.e.o Christian Huidobro Ne.son e. Vare.a Dante.D. Cáice.e. Laboratory of Che.ical Carcinoge.e.is and Pharmacoge.e.ics Faculty of Medicine Biomedical Science Institute（ICBM） University of Chile lndependencia 1027 Santiago Chile De.artme.t of Urology National Cancer Corporation Chile Capellán Abarzúa 027 Providencia Santiago Chile e.ide.iology Division School of Public Health Faculty of Medicine University of Chile lndependencia 939Santiago Chile

Aim： To asse.s the.role.of se.e.al ge.e.ic factors in combination with an e.vironme.tal factor as modulators of prostate.cance. risk. We.focus on alle.e.variants of low-pe.e.rance.ge.e. associate. with ce.l control, the.de.oxification proce.se. and smoking. Me.hods： In a case.control study we.compare. pe.ple.carrying p53cd72 Pro alle.e. CYP1A1 M1 alle.e.and GSTM1 null ge.otype. with the.r prostate.cance. risk. Re.ults： The.joint risk for smoke.s carrying Pro^＊ and MI^＊, Pro^＊ and GSTM1null or GSTM1 null and CYP1A1 MI^＊ variants was significantly highe. （odds ratio [OR]： 13.13, 95% confide.ce.inte.val [CI]： 2.41-71.36; OR： 3.97, 95% CI： 1.13-13.95 and OR： 6.87, 95% CI： 1.68-27.97, re.pe.tive.y） compare. with that for the.re.e.e.ce.group, and for non-smoke.s was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M1 in smoke.s we.e.positive.y and significantly associate. with prostate.cance. risk compare. with non-smoke.s and compare. with the.putative.lowe.t risk group （OR： 8.87, 95% CI： 1.25-62.71）. Conclusion： Our re.ults sugge.t that a combination of p53cd72, CYP1A1, GSTM1 alle.e. and smoking plays a significant role.in modifie. prostate.cance. risk on the.study population, which me.ns that smoke.s carrying susce.tible.ge.otype. might have.a significantly highe. risk than those.carrying non-susce.tible.ge.otype..

关键词： p53cd72 GSTM1 CYP1A1 ge.e.ic polymorphism prostate.cance. risk smoking

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Avian re.ponse. to an e.tre.e.we.the. e.e.t:The.case.of the.Filome.a’snowstorm in Madrid(ce.tral Spain)

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Avian Re.e.rch 2024年第2期15卷 180-186页

作者： carlos Lazaro carlos Sanche.-García Fabian Casas e.Jorge.Tizado De.artme.t of Re.e.rch Fundacion Artemisan13001 Ciudad RealSpain De.artme.t of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain De.artme.t of Biodive.sity and e.vironme.tal Manage.e.t Universidad de Leon24401 PonferradaSpain

Cold spe.ls and se.e.e.we.the. may have.de.rime.tal e.fe.ts in wild birds,but owing to the.stochastic nature.of the.e.e.e.ts,it is not always possible.to me.sure.the.r *** January 2021,a strong snowstorm known as‘Filome.a’affe.te. Spain,mainly the.re.ion of Madrid(Ce.tral Spain),which was fully cove.e. with snow and suffe.e. fre.zing te.pe.ature. for a *** bird surve.s conducte. in the.winte.-spring of 2020 and 2021(be.ore.and afte. Filome.a)at same.locations,we.addre.se. the.possible.impact of the.cold spe.l in thre. wide.pre.d game.irds:Wood Pige.n(Columba palumbus),e.rasian Magpie.Pica pica)and Re.-le.ge. Partridge.Ale.toris rufa).No significant abundance.diffe.e.ce. we.e.found be.we.n ye.rs for none.of the.spe.ie. and hunting pre.sure.was only significantly re.uce. for Partridge.,he.ce.this spe.ie. may have.be.n ne.ative.y affe.te. by *** sugge.t that in re.ponse.to Filome.a,Pige.ns conducte. partial migration in se.rch of be.te. conditions,while.Magpie. aggre.ate. in ce.tain are.s of Madrid and Partridge. e.dure. the.harsh conditions within the.r home.*** re.ults highlight the.importance.to alle.iate.ne.ative.impacts of e.tre.e.we.the. e.e.ts in wild birds through manage.e.t actions,e.pe.ially for se.e.tary spe.ie..

关键词： Ale.toris rufa Climate.change Cold spe.l Columba palumbus Migration Pica pica Winte.

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Mortality rate.afte. total kne. arthroplasty or total hip arthroplasty in patie.ts with a history of live. transplant

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World Journal of Orthope.ics 2024年第4期15卷 310-311页

作者： e.carlos Rodrigue.-Me.chan De.artme.t of Orthope.ic Surge.y La Paz University Hospital-IdiPazMadrid 28046Spain

In this e.itorial I comme.t on the.article.by Ahme. e. al publishe. in a re.e.t issue.of the.World J Orthop 2023;14:*** is we.l known that patie.ts who have.unde.gone.a live. transplant(LT)may ne.d to have.a total hip arthroplasty(THA)or total kne. arthroplasty(TKA)*** e. al state. that the.mortality rate.in the.e.patie.ts was similar to the.one.of the.ge.e.al ***,the.e.are.thre. article. pre.iously publishe. that found highe. mortality in LT patie.ts who e.pe.ie.ce. THA/TKA than in the.ge.e.al population(individuals without LT).The.e.ore.in this e.itorial I would like.to point out that the.e.is controve.sy in the.lite.ature.re.arding whe.he. LT patie.ts unde.going THA/TKA have.highe. mortality than the.ge.e.al ***,future.re.e.rch should atte.pt to re.olve.this controve.sy.

关键词： Live. transplant Total kne. arthroplasty Total hip arthroplasty Re.ults Mortality

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How to fill the.biodive.sity data gap:Is it be.te. to inve.t in fie.dwork or curation?

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Plant Dive.sity 2024年第1期46卷 39-48页

作者： carlos A.Vargas Marius Bottin Tiina Sarkine. Jame. e.Richardson Marce.a Ce.is Boris Villanue.a Adriana Sanche. Programa de.Biología Facultad de Ciencias NaturalesUniversidad del RosarioBogotaD.C.Colombia Subdire.cion Cie.tífica Jardín Botanico de Bogota“Jose Celestino Mutis”BogotaD.C.Colombia Inde.e.de.t Re.e.rche. BogotaD.C.Colombia Tropical Dive.sity Se.tion Royal Botanic Garden EdinburghUK School of Biological Earth and Environmental SciencesUniversity College CorkCorkIreland De.artame.to de.Química y Biología Universidad del NorteKm.5 Vía Puerto ColombiaArea Metropolitana de Barranquilla 081007Colombia

Data gaps and biase. are.two important issue. that affe.t the.quality of biodive.sity information and downstre.m *** how be.t to fill e.isting gaps and account for biase. is ne.e.sary to improve.our curre.t information most *** curre.t main approache. for obtaining and improving data include.1)curation of biological colle.tions,and(2)***,the.comparative.e.fe.tive.e.s of the.e.approache. in improving biodive.sity data re.ains little.*** use. the.Flora de.Bogota proje.t to study the.magnitude.of change.in spe.ie. richne.s,spatial cove.age.and sample.cove.age.of plant re.ords base. on curation ve.sus *** proce.s of curation re.ulte. in a de.re.se.in spe.ie. richne.s(synonym and e.ror re.oval),but it significantly incre.se. the.numbe. of re.ords pe. *** contribute. to a slight incre.se.in spe.ie. richne.s,via accumulation of ne. ***,curation le. to incre.se. in spatial cove.age.spe.ie. obse.ve. by locality,the.numbe. of plant re.ords by spe.ie.,and localitie. by spe.ie. compare. to ***,curationwas more.e.ficie.t in producing ne. information compare. to fie.dwork,mainly be.ause.of the.large.numbe. of re.ords available.in *** re.omme.d inte.sive.curatorial work as the.first ste. in incre.sing biodive.sity data quality and quantity,to ide.tify bias and gaps at the.re.ional scale.that can the. be.targe.e. with *** ste.wise.strate.y would e.able.fie.dwork to be.planne. more.coste.fe.tive.y give. the.limite. re.ource. for biodive.sity e.ploration and characte.ization.

关键词： Colombia Flora de.Bogota Sample.cove.age Spe.ie. richne.s Tropical Ande.

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Analysis on the.Impact of Cattle.Fatte.ing Te.hnology on Farme. House.olds in Atabae.Timor-Le.te

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Agricultural Scie.ce. 2024年第4期15卷 399-407页

作者： Marcolino e.te.ão Fe.nande. e. Brito Vice.te.de.Paulo Corre.a carlos da Conce.cão de.De.s Mate.s de.Je.us Gome. Agro-Socio e.onomic Faculty of Agriculture National University of Timor Lorosa&#8217e Dili Timor-Leste

Agriculture.is one.of the.priority se.tors in Timor-Le.te. Introducing ne. agriculture.te.hnology is crucial to e.hance.agricultural production. Practicing cattle.fatte.ing can incre.se.be.f cattle.body we.ght and ge.e.ate.income.to the.be.f cattle.farme.s. As farme.s face.proble.s including agricultural production de.line. lack of forage. and information and we.the. unfavourable. The.study’s purpose.was to e.amine.the.impact of adoption of cattle.fatte.ing te.hnology on farme. house.olds in Atabae.administrative.post, Bobonaro municipality in Timor-Le.te. The.e.we.e.200 be.f cattle.farme.s house.olds whe.e.randomly se.e.te. in four village. in Atabae. It consiste. of 65 farme.s practicing cattle.fatte.ing and 135 farme.s non-practicing cattle.fatte.ing. Face.to face.inte.vie.s use. structure. que.tionnaire. Statistical analysis such as t-te.t and de.criptive.analysis we.e.use. to e.amine.impact adoption of cattle.fatte.ing te.hnology by farme.s and factor constraints of cattle.production and the.solutions of it. The.re.ults indicate. the.ave.age.value.of cattle.and profit we.e.significant diffe.e.t from ze.o and it is associate. with practicing of cattle.fatte.ing. The.ave.age.of labour use. on cattle.activitie., the.ave.age.of cattle.sold, and total cost spe.t on cattle.we.e.not significant diffe.e.t from ze.o. The.pe.ce.tage.of farme.s said that factors constraints cattle.production we.e.shortage.of wate. and forage.(53%) and spe.d time.on culture.ce.e.ony and lack of capital (33%). The.numbe. of farme.s said that the. colle.te. wate. from rive., fe.d cattle.with sago and forage.(55.3%) and cultivate. forage.(23.4%). This finding contribute. information to the.farme.s, trade.s, and Timore.e.gove.nme.t to continue.imple.e.ting cattle.fatte.ing activitie. as it e.hance. farme.s’ income.and de.e.oping cattle.production.

关键词： Cattle.Production Adoption of Cattle.Fatte.ing Te.hnology and Cattle.Farme. House.olds

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fRAP 2.0:a community e.gage.e.t me.hod applie. to ce.vical cance. disparitie. among Hispanic wome.

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Family Me.icine.and Community He.lth 2024年第S2期12卷 44-57页

作者： Autumn M Kie.e.-e.mons Susan e.Hanse. Michae. Topmille. Jaskaran Gre.al carlos Robe.to Jae. Be.jamin F Crabtre. William L Mille. De.artme.t of Family Me.icine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA Colle.e.of Me.icine USFTampaFloridaUSA Le.igh Valle. He.lth Ne.work AllentownPennsylvaniaUSA Ame.ican Acade.y of Family Physicians-He.lth Landscape CincinattiOHUSA Lafaye.te.Colle.e EastonPennsylvaniaUSA UT He.lth San Antonio San AntonioTexasUSA Rutge.s Robe.t Wood Johnson Me.ical School PiscatawayNew JerseyUSA Cance. Institute.of Ne. Je.se. New BrunswickNew JerseyUSA

focuse. Rapid Asse.sme.t Proce.s(fRAP)2.0 is a community e.gage.e.t approach combining ge.spatial mapping with rapid qualitative.asse.sme.t in cyclical fashion within communitie. to capture.multifactorial and multile.e. fe.ture. impacting primary care.*** 2.0 offe.s primary care.re.e.rche.s a me.hodology frame.ork for e.ploring comple. community fe.ture. that impact primary he.lthcare.de.ive.y and *** fRAP 2.0 study de.ign e.pands the.fRAP from a se.ue.tial de.ign to a cyclical proce.s of ge.spatial mapping and rapid qualitative.asse.sme.t in se.rch of modifiable.conte.tual *** participants are.stake.olde.s from various socioe.ological le.e.s whose.pe.spe.tive. inform study outcome. that the. may use.to the. be.ome.the.age.ts of change.for the.ve.y proble.s the. he.pe. ***,we.pre.e.t a proof-of-conce.t study for fRAP 2.0 e.amining disparitie. in ce.vical cance. mortality rate. among Hispanic wome. in *** primary outcome. of inte.e.t are.fe.ture. at the.community le.e.,me.ical he.lth syste. le.e. and re.ional gove.nme.t policy le.e.s that offe. opportunitie. for collaborative.inte.ve.tions to improve.ce.vical cance. *** this study,ge.spatial mapping of county and ZIP code.le.e. variable. impacting postdiagnosis ce.vical cance. care.at community,me.ical and policy le.e.s we.e.cre.te. using publicly available.data and the. ove.laid with maps cre.te. with Te.as Cance. Re.istry data for ce.vical cance. case. in thre. of the.large.t population *** disparate.are.s we.e.the. qualitative.y e.plore. using participant obse.vation and e.hnographic fie.d work,alongside.39 ke. informant *** discussion groups and stake.olde. e.gage.e.t e.iste. at e.e.y phase.of the.*** the.fRAP 2.0 me.hod,we.cre.te. an action-orie.te. roadmap of ne.t ste.s to improve.ce.vical cance. care.disparitie. in the.thre. Te.as countie. with e.phasis on the.high disparity *** ide.tifie. local change

关键词： ce.vical qualitative policy

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MAVS Antagonize. Human Ste. Ce.l Se.e.ce.ce.as a Mitochondrial Stabilize.

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Re.e.rch 2024年第2期2023卷 239-257页

作者： Cui Wang Kuan Yang Xiaoqian Liu Si Wang Moshi Song Juan carlos Izpisua Be.imonte.Jing Qu Guang-Hui Liu We.qi Zhang CAS Ke. Laboratory of Ge.omic and Pre.ision Me.icine Beijng Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Unive.sity of Chine.e.Acade.y of Scie.ce. Beijing 100049China Sino-Danish Colle.e University of Chinese Academy of SciencesBeijing 101408China State.Ke. Laboratory of Ste. Ce.l and Re.roductive.Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute.for Ste. Ce.l and Re.e.e.ation Chine.e.Acade.y of Scie.ce. Beijing 100101China Be.jing Institute.for Ste. Ce.l and Re.e.e.ative.Me.icine Bejing 100101China Advance. Innovation Ce.te. for Human Brain Prote.tion National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State.Ke. Laboratory of Me.brane.Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Mitochondrial dysfunction is a hallmark fe.ture.of ce.lular se.e.ce.ce.and organ ***,we.aske. whe.he. the.mitochondrial antiviral signaling prote.n(MAVS),which is e.se.tial for driving antiviral re.ponse.also re.ulate. human ste. ce.l *** answe. this que.tion,we.use. CRISPR/Cas9-me.iate. ge.e.e.iting and dire.te. diffe.e.tiation te.hnique. to ge.e.ate.various MAVS-knockout human ste. ce.l *** found that human me.e.chymal ste. ce.ls(hMSCs)we.e.se.sitive.to MAVS de.icie.cy,as manife.te. by acce.e.ate. se.e.ce.ce.*** uncove.e. that the.role.of MAVS in maintaining mitochondrial structural inte.rity and functional home.stasis de.e.ds on its inte.action with the.guanosine.triphosphatase.optic atrophy type.1(OPA1).De.le.ion of MAVS or OPA1 le. to the.dysfunction of mitochondria and ce.lular se.e.ce.ce.whe.e.s re.le.ishme.t of MAVS or OPA1 in MAVS-knockout hMSCs alle.iate. mitochondrial de.e.ts and pre.ature.se.e.ce.ce.*** toge.he.,our data unde.score.an uncanonical role.of MAVS in safe.uarding mitochondrial home.stasis and antagonizing human ste. ce.l se.e.ce.ce.

关键词： CRISPR/Cas9 home.stasis Mitochondrial

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HVOF-spraye. HAp/S53P4 BG composite.coatings on an AZ31 alloy for pote.tial applications in te.porary implants

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Journal of Magne.ium and Alloys 2024年第1期12卷 345-360页

作者： carlos A.Poblano-Salas John He.ao Astrid L.Giraldo-Be.ancur Paola Fore.o-Sossa Die.o Ge.man e.pinosa-Arbe.ae. Jorge.A.Gonzále.-Sánche. Luis R.Dzib-Pére. Susana T.e.trada-Moo Ide.fonso e.Pe.h-Pe.h CIATe. A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-CIATe. A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-Cinve.tav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Unive.sidad Te.nológica de.Que.étaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIDe.I Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Ce.te. for Corrosion Re.e.rch Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bioactive.the.mal spray coatings produce. via high-ve.ocity oxyge. fue. spray(HVOF)from hydroxyapatite.HAp)and bioactive.glasse.(BG)have.the.pote.tial to be.e.ploye. on te.porary implants due.to the.ability of both HAp and BG to dissolve.and promote.osse.inte.ration,conside.ing that both phase. have.diffe.e.t re.ction and dissolution rate. unde. in-vitro *** the.pre.e.t work,75%***-25%wt.S53P4 bioactive.glass powde.s we.e.HVOF-spraye. to obtain HAp/S53P4 BG composite.coatings on a biore.orbable.AZ31 *** study is focuse. on e.ploring the.e.fe.t of the.stand-off distance.and fue./oxyge. ratio variation as HVOF parame.e.s to obtain stable.structural coatings and to e.tablish the.r e.fe.t on the.phase. and microstructure.produce. in those.*** characte.ization te.hnique.,such as scanning e.e.tron microscopy,X-ray diffraction,and Fourie. transform infrare. spe.troscopy,we.e.e.ploye. to characte.ize.re.e.ant structural and microstructural prope.tie. of the.composite.*** re.ults showe. that the.mal gradie.ts during coating de.osition must be.manage. to avoid de.amination due.to the.high te.pe.ature.achie.e.(max 550℃)and the.diffe.e.ce. in coe.ficie.ts of the.mal *** was also found that both spraying distance.and oxyge./fue. ratio allowe. to ke.p the.hydroxyapatite.as the.main phase.in the.*** addition,in-vitro e.e.troche.ical studie. we.e.pe.forme. on the.obtaine. HAp/S53P4 BG composite.coatings and compare. against the.uncoate. AZ31 *** re.ults showe. a significant de.re.se.in hydroge. e.olution(at le.st 98%)whe. the.bioactive.coating was applie. on the.Mg alloy during e.aluation in simulate. body fluid(SBF).

关键词： Coatings Composite. The.mal spray Te.porary implants Hydroge. e.olution

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Towards an inte.rate. risk analysis se.urity frame.ork according to a syste.atic analysis of e.isting proposals

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Frontie.s of Compute. Scie.ce 2024年第3期18卷 199-216页

作者： Antonio SANTOS-OLMO Luis e.rique.SÁNCHe. David G.ROSADO Manue. A.Se.RANO carlos BLANCO Haralambos MOURATIDIS e.uardo Fe.NÁNDe.-Me.INA GSyA Re.e.rch Group University of Castilla-La ManchaCiudad Real 13071Spain Institute.for Analytics and Data Scie.ce University of EssexColchester CO43SQUK Alarcos Re.e.rch Group University of Castilla-La ManchaCiudad Real 13071Spain ISTR Re.e.rch group Department of Computer Science and ElectronicsUniversity of CantabriaSantander 39005Spain

The.information socie.y de.e.ds incre.singly on risk asse.sme.t and manage.e.t syste.s as me.ns to ade.uate.y prote.t its ke. information *** availability of the.e.syste.s is now vital for the.prote.tion and e.olution of ***,se.e.al factors have.le. to an incre.sing ne.d for more.accurate.risk analysis *** are.the.spe.d at which te.hnologie. e.olve.the.r global impact and the.growing re.uire.e.t for companie. to *** analysis proce.se. must conse.ue.tly adapt to the.e.ne. circumstance. and ne. te.hnological *** obje.tive.of this pape. is,the.e.ore.to pre.e.t the.re.ults of an e.haustive.analysis of the.te.hnique. and me.hods offe.e. by the.scie.tific community with the.aim of ide.tifying the.r main we.kne.se. and providing a ne. risk asse.sme.t and manage.e.t *** analysis was carrie. out using the.syste.atic re.ie. protocol and found that the.e.proposals do not fully me.t the.e.ne. *** pape. also pre.e.ts a summary of MARISMA,the.risk analysis and manage.e.t frame.ork de.igne. by our re.e.rch *** basis of our frame.ork is the.main e.isting risk standards and proposals,and it se.ks to addre.s the.we.kne.se. found in the.e.*** is in a proce.s of continuous improve.e.t,as is be.ng applie. by custome.s in se.e.al e.rope.n and Ame.ican *** consists of a risk data manage.e.t module.a me.hodology for its syste.atic application and a tool that automate. the.proce.s.

关键词： information se.urity manage.e.t se.urity syste. se.urity risk asse.sme.t and manage.e.t

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High-fre.ue.cy lacustrine.se.ue.ce.stratigraphy of clastic lake.: le.sons from ancie.t succe.sions

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Journal of Palae.ge.graphy 2024年第4期13卷 621-645页

作者： carlos Zavala Hua-Qing Liu Xiang-Bo Li Vale.tin Trobbiani Yang Li Mariano Arcuri Agustin Zorzano De.artame.to de.Ge.logía Universidad Nacional del Sur (UNS) GCS Consulting Se.vice..Bahía Blanca Re.e.rch Institute.of Pe.role.m e.ploration&De.e.opme.t-Northwe.t Conse.o Nacional de.Inve.tigacione. Cie.tíficas y T e.nicas (CONICe.) Shandong Unive.sity of Scie.ce.and Te.hnology

Se.ue.ce.stratigraphic conce.ts and me.hods provide.nove. tools for pe.forming stratigraphic analysis, allowing us to improve.our unde.standing of de.ositional mode.s and basin e.olution. Main controls and de.ositional e.e.e.ts(e.g., surface., syste.s tracts, parase.ue.ce., e.c.) re.ognize. in conve.tional se.ue.ce.stratigraphy are.de.igne. for marine.re.ate. syste.s. In contrast, the.se.ue.ce.stratigraphy of lacustrine.succe.sions is much more.comple. and poorly unde.stood, be.ause.it is not drive. by se.-le.e. change., but by a comple. inte.action be.we.n te.tonics and high-fre.ue.cy climatic cycle.. The.compre.e.sive.analysis of the.wate. balance.of lacustrine.syste.s allows the.re.ognition of thre. type. of lake.conditions: Unde.fille., balance.-fill and ove.fille. lake.. Unde.standing the.lake.conditions in ancie.t succe.sions is fundame.tal for unrave.ing lacustrine.se.ue.ce.stratigraphy, since.the.e.conditions e.fe.tive.y control wate. salinity, inte.nal stacking patte.n and the.characte.istics of syste.s tracts. Unde.fille. lake. are.hydrologically close. lake., and conse.ue.tly, the.lake.le.e. can highly fluctuate. drive. by high-fre.ue.cy we.-dry climatic cycle.. During we. pe.iods, rive.s supply wate. and se.ime.ts, re.ulting in fining-and thinning-upward e.e.e.tary de.ositional se.ue.ce.(e.S's) accumulate. during the.transgre.sive.syste.s tract(TST). In contrast, dry pe.iods are.characte.ize. by a re.ative.lake.le.e. fall with the.subae.ial e.posure.of lake.margin are.s during the.re.re.sive.syste.s tract(RST). Lake.wate. salinity can fluctuate.from brackish to hype.saline. Balance.-fill lake. are.partially close. lake., and conse.ue.tly, the. have.characte.istics of both unde.fille. and ove.fille. lake.. During the.TST, the.lake.is in unde.fille. condition, and conse.ue.tly, the.introduction of wate. and se.ime.t will accumulate.a fining-upward inte.val until re.ching the.spill point during the.maximum flooding. The.RST is accumulate. unde. an ove.fille

关键词： Lacustrine.se.ue.ce.stratigraphy Unde.fille. lake. Balance.-fill lake. Ove.fille. lake. Force. transgre.sion Force. re.re.sion

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