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Efficacy of morning-only 4 liter sulfa free polyethylene glycol vs 2 liter polyethylene glycol with ascorbic acid for afternoon colonoscopy

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World Journal of Gastroenterology 2014年第30期20卷 10620-10627页

作者： John M Rivas Alejro Perez Marlow Hernez Alison Schneider Ferno J castro Digestive Disease Center Cleveland Clinic FloridaWestonFL 33331United States Department of Gastroenterology University of Medicine and Dentistry of New JerseyStratfordNJ 08084United States Department of Internal Medicine Cleveland Clinic FloridaWestonFL 33331United States

AIM: To compare the bowel cleansing efficacy of same day ingestion of 4-L sulfa-free polyethylene glycol (4-L SF-PEG) vs 2-L polyethylene glycol solution with ascorbic acid (2-L PEG + Asc) in patients undergoing after... 详细信息

关键词： Bowel preparation Colonoscopy Screening colonoscopy Colon cancer screening

Priming the seed:Helicobacter pylori alters epithelial cell invasiveness in early gastric carcinogenesis

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World Journal of Gastrointestinal Oncology 2018年第9期10卷 231-243页

作者： Silvia Molina-castro Vanessa Ramírez-Mayorga Warner Alpízar-Alpízar Cancer Epidemiology Research Program Health Research InstituteUniversity of Costa RicaSan José2060Costa Rica Clinical Department School of MedicineUniversity of Costa RicaSan José2060Costa Rica Public Nutrition Section School of NutritionUniversity of Costa RicaSan José2060Costa Rica Center for Research in Microscopic Structures University of Costa RicaSan José2060Costa Rica Department of Biochemistry School of MedicineUniversity of Costa RicaSan José2060Costa Rica

Helicobacter pylori(H. pylori) infection is a wellestablished risk factor for the development of gastric cancer(GC), one of the most common and deadliest neoplasms worldwide. H. pylori infection induces chronic inflammation in the gastric mucosa that, in the absence of treatment, may progress through a series of steps to GC. GC is only one of several clinical outcomes associated with this bacterial infection, which may be at least partially attributed to the high genetic variability of H. pylori. The biological mechanisms underlying how and under what circumstances H. pylori alters normal physiological processes remain enigmatic. A key aspect of carcinogenesis is the acquisition of traits that equip preneoplastic cells with the ability to invade. Accumulating evidence implicates H. pylori in the manipulation of cellular and molecular programs that are crucial for conferring cells with invasive capabilities. We present here an overview of the main findings about the involvement of H. pylori in the acquisition of cell invasive behavior, specifically focusing on the epithelial-to-mesenchymal transition, changes in cell polarity, and deregulation of molecules that control extracellular matrix remodeling.

关键词： Helicobacter pylori Plasminogen activation system Invasion Epithelial-to-mesenchymal transition

Damage-associated molecular patterns in inflammatory bowel disease:From biomarkers to therapeutic targets

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World Journal of Gastroenterology 2018年第41期24卷 4622-4634页

作者： Hayandra Ferreira Nanini Claudio Bernardazzi Fernando castro Heitor Siffert Pereira de Souza Servico de Gastroenterologia e Laboratorio Multidisciplinar de Pesquisa Departamento de Clinica MedicaHospital Universitario Clementino Fraga FilhoUniversidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-913Brazil D’Or Institute for Research and Education(IDOR) Rua Diniz Cordeiro 30BotafogoRio de JaneiroRJ 22281-100Brazil

The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of several components in a genetically susceptible host. These components include environmental elements and gut microbiota a dysbiosis. For decades, immune abnormalities have been investigated as critically important in IBD pathogenesis, and attempts to develop effective therapies have predominantly targeted the immune system. Nevertheless, immune events represent only one of the constituents contributing to IBD pathogenesis within the context of the complex cellular and molecular network underlying chronic intestinal inflammation. These factors need to be appreciated within the milieu of nonimmune components. Damage-associated molecular patterns (DAMPs), which are essentially endogenous stress proteins expressed or released as a result of cell or tissue damage, have been shown to act as direct proinflammatory mediators. Excessive or persistent signalling mediated by such molecules can underlie several chronic inflammatory disorders, including IBD. The release of endogenous DAMPs amplifies the inflammatory response driven by immune and non-immune cells and promotes epigenetic reprogramming in *** effects determine pathologic changes,which may sustain chronic intestinal inflammation and also underlie specific disease *** addition to highlighting the potential use of DAMPs such as calprotectin as biomarkers,research on DAMPs may reveal novel mechanistic associations in IBD pathogenesis and is expected to uncover putative therapeutic targets.

关键词： Damage-associated molecular patterns Environmental factors Epigenetics Inflammatory bowel disease Therapeutic targets

Transfer of Machined Patterns on an Aluminum Plate to Pyrex Glass Using Reactive Ion Etching SF_(6) Plasma without Masks

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Journal of Surface Engineered Materials and Advanced Technology 2014年第5期4卷 262-269页

作者： carlos M.Ortiz-Lima Fernando J.Quinones-Novelo Alberto Jaramillo-Nunez Jorge castro-Ramos Insitituto Nacional de Astrofisica Optica y ElectronicaPueblaMexico

A method for etching the surface of a Pyrex glass substrate using the Reactive Ion Etching process without the use of masks is reported. Variations in the machined surface on an auxiliary plate, manufactured in aluminum and placed below a Pyrex glass slide, were transferred to the upper surface of the substrate. SF6 as etching gas and low pressure chamber to promote the increase of mean free path of ions were used. Two etching ratios were found, general, that affects the entire surface of the substrate, and differential, which generates the relief on the surface of the glass. Differential etching depth showed a linear behavior with respect to time;the mean differential etching rate obtained was 43 nm/min. The same phase between the auxiliary plate machining and the etched pattern on the substrate is preserved. With this technique it was possible to manufacture convex and concave surfaces;some examples are given. The arithmetic mean roughness achieved with the proposed method was found to be N1 class, ideal for the development of optical corrector plates.

关键词： Reactive Ion Etching No Masking RIE SF_(6) Plasma Etching

Ubiquitous Computing and Its Applications in the Disease Management in a Ubiquitous City

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Journal of Computer and Communications 2018年第3期6卷 19-42页

作者： Javier Cabo Salvador Jose Miguel Ramirez Uceda Veronica Cabo Muinos Javier Ramos Lopez carlos de castro Cátedra de Telemedicina Universidad Internacional de AndalucíaSevilleSpain CITEC Centro de Investigaciones Tecnológicas Universidad de CórdobaCórdobaSpain Cátedra de Gestión Sanitaria y Ciencias de la Salud UDIMAMadridSpain IHM-Medical Technology MadridSpain Fundación de Ingeniería Biomédica MadridSpain Escuela Técnica Superior de Ingenieros de Telecomunicación Universidad Rey Juan CarlosMadridSpain Departamento Cardiovascular Hospital Vithas NISA Pardo de Aravaca MadridSpain

The actual challenge in health is to manage patients with chronic diseases from a holistic approach where technology around the patient and at the city enhances their wellness. This paper deepens in the relations between health, devices, and models of technological cities and how these can be modeled to provide a more cost efficient solution while less invasive and more natural to the end users. In light of this, usable and accessible software and a wide range of devices, ranging from PC, smartphone, tablet and SmartTV have been tested. This manuscript will give good comprehension on how technology and disease management care models interact with the patient.

关键词： U-Health Ubiquitous Computing Internet of Things Spimes

The aryl hydrocarbon receptor and the gut–brain axis

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Cellular & Molecular Immunology 2021年第2期18卷 259-268页

作者： Andreia Barroso João Vitor Mahler Pedro Henrique Fonseca-castro Francisco J.Quintana Ann Romney Center for Neurologic Diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Faculdade de Medicina FMUSP Universidade de São PauloSão PauloSPBrazil Broad Institute of MIT and Harvard CambridgeMAUSA

The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for *** half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and *** this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.

关键词： Aryl hydrocarbon receptor Autoimmune diseases Infectious diseases cancer

Improving zinc recovery by thermoacidophilic archaeon Acidianus copahuensis using tetrathionate

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Transactions of Nonferrous Metals Society of China 2016年第11期26卷 3004-3014页

作者： Camila castro Edgardo R.DONATI CINDEFI (CCT La Plata-CONICET UNLP) Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP)

The attachment and bioleaching experiments were conducted to evaluate the zinc recovery from Hualilan ore by thethermoacidophilic archaeon Acidianus copahuensis. Cells of this species pregrown on tetrathionate showed higher capability ofattachment to the ore than cells pregrown on other energy sources and such attachment seemed to be mediated by the product ofextracellular polymeric substances. A. copahuensis achieved a successful bioleaching of the ore reaching 100% of zinc recoverywhen tetrathionate was added. Simultaneous addition of yeast extract and tetrathionate maintained the zinc extraction at higher *** dissolution kinetics was controlled by chemical reaction in cultures with the external addition of tetrathionate but by thediffusion through a product layer of jarosite in the other cultures.

关键词： bioleaching zinc tetrathionate microbial attachment Acidianus copahuensis thermophiles

A review of the risk of cholera outbreaks and urbanization in sub-Saharan Africa

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Journal of Biosafety and Biosecurity 2020年第2期2卷 71-76页

作者： Alexandre Zerbo Rafael castro Delgado Pedro Arcos Gonzalez Unit for Research in Emergency and Disaster Faculty of Medicine and Health SciencesUniversity of Oviedo33006 OviedoSpain

The sub-Saharan region of Africa is rapidly urbanizing,that has consequently spurred the development of specific challenges in terms of access to basic services and ***,exposure to waterborne diseases,including cholera,has been a recurrent problem for the people residing in these urban *** is important to understand the different risks faced by people in urban areas as it might aid in preventing and controlling the spread of the disease.A review of literature was conducted,using specific selection criteria to obtain relevant publications that described the risk factors for cholera outbreak in urban areas of sub-Saharan Africa.A perusal of available literature indicated that despite the heterogeneity in the urban areas of Africa,there are similarities with respect to the risk factors associated with the incidence of cholera *** risk factors include geographical location,hydroclimatic parameters,urban environment,genomics of the Vibrio cholerae virulence,sanitation,and human behavior.A succinct comprehension of the possible relationship between the different risk factors might prove to be helpful in managing the cholera epidemic.

关键词： Cholera Urban environment Sub-Saharan Africa

Kentish Plover(Charadrius alexandrinus) and Little Tern(Sternula albifrons) prefer shells for nesting:A field experiment

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Avian Research 2024年第1期15卷 55-59页

作者： Macarena castro Andrés De la Cruz Nuria Martin-Sanjuan Alejandro Pérez-Hurtado Instituto Universitario de Investigacion Marina(INMAR) Campus de Excelencia Internacional del Mar(CEIMAR)Departamento de BiologíaUniversidad de CadizPuerto RealSpain Servicios centrales de Investigacion Salinas de la Esperanza Universidad de CadizPuerto RealSpain

Shorebird populations are declining worldwide,mainly due to human disturbances and loss of coastal ***,supratidal habitats as saltpans could play a role in buffering human *** have shown to be important as feeding or breeding sites of some shorebird species.A potential conservation strategy to increase shorebird populations in saltpans is to manipulate the cues that birds use to select optimal breeding *** it is hypothesized that shorebirds are attracted to bivalve shells due to the advantages they *** this hypothesis,we supplemented a restored saltpan in 2019 and 2021 with bivalve shells,expecting an increase in the number of breeding birds’ *** than 75% of Kentish Plover(Charadrius alexandrinus) and Little Tern(Sternula albifrons) nests were found in patches with shells in both *** best model for both species indicates that the presence of shells is the factor that most correlates with the location of *** probability of choosing one place over another to settle their nest increases in areas with an abundance of shells,double in the case of the Kentish Plover and triple in the case of the Little *** result of this study may constitute a valuable tool for attracting birds to restored saltpans and could contribute to the success of expensive restoration projects where time is usually a constraint.

关键词： Habitat management Nest site selection Saltpan restoration Shell supplementation Shorebirds