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Effect of fosfomycin,Cynara scolymus extract,deoxynivalenol and their combinations on intestinal health of weaned piglets

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Animal Nutrition 2019年第4期5卷 386-395页

作者： Guadalupe martinez Susana N.Dieguez Maria B.Fernandez Paggi Maria B.Riccio Denisa S.perez Gaudio Edgardo Rodriguez Fabian A.Amanto Maria O.Tapia Alejandro L.Soraci Area Toxicología Departamento de FisiopatologíaFacultad de Ciencias VeterinariasUniversidad Nacional del Centro de la Provincia de Buenos AiresTandilB7000Buenos AiresArgentina Centro de Investigación Veterinaria de Tandil(CIVETAN) UNCPBA-CICPBA-CONICETFacultad de Ciencias VeterinariasCampus UniversitarioTandilB7000Buenos AiresArgentina Consejo Nacional de Investigaciónes Científicas-CONICET Buenos AiresC1425FQBArgentina Comisión de Investigaciónes Científicas de la Provincia de Buenos Aires(CIC-PBA) La PlataB1900Buenos AiresArgentina Area Producción Porcina Departamento de Producción AnimalFacultad de Ciencias VeterinariasUniversidad Nacional del Centro de La Provincia de Buenos AiresTandilB7000Buenos AiresArgentina Area Estadística Sanidad Animal y Medicina PreventivaFacultad de Ciencias VeterinariasUniversiclacl Nacional del Centro de la Provincia de Buenos AiresTandilB7000Buenos AiresArgentina

Weaning is a challenging stage of pig *** undergo environmental,social and dietary changes leading to weaning stress *** order to compensate for the detrimental effects of weaning stress,antibiotics and natural extracts are used as feed additives,sometimes without fully understanding the interactions between them or even with low concentrations of mycotoxins that are frequently present in *** aim of this study was to evaluate the effect of fosfomycin(FOS),Cynara scolymus extract(CSE),deoxynivalenol(DON) and their combined administration on intestinal health of weaned *** experiment was designed as a 2×2×2 factorial arrangement with 3 factors(FOS,CSE and DON treatments),2 levels each(presence and absence) and 3 *** piglets(n=24)were randomly divided in groups to receive the different treatments,namely DON administered in diet(50 μg/kg BW),FOS administered into the drinking water(30 mg/kg BW),CSE administered in diet(15 mg/kg BW) and all their *** 15 d,the animals were euthanized and gastrointestinal tract samples were immediately taken to evaluate gastrointestinal pH,Enterobacteriaceae to lactic acid bacteria(E:L) ratio,volatile fatty acid(VFA) concentrations,disaccharidase(lactase,sucrase and maltase)activity,histology(intestinal absorptive area [IAA] and goblet cells count) and mucus ability to adhere pathogenic Escherichia *** our results,FOS and CSE treatments,individually or combined,produced a lower E:L ratio,an enhanced production of butyrate,increased disaccharidase activity(particularly maltase),and a greater IAA and goblet cells count along with an increase in pathogenic bacteria adherence to intestinal *** did not show interactions with the other factors and its administration produced decreases on VFA,disaccharidase activity and goblet cells *** conclusion,weaning piglets receiving diets containing FOS,CSE or both exhibited evident beneficial intestinal effects compared

关键词： Fosfomycin Cynara scolymus extract Deoxynivalenol Intestinal health Weaned piglets

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The Institutionalization of Life Cycle Assessment in Mexico

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Journal of Environmental Protection 2015年第8期6卷 804-812页

作者： Nora Munguia Clara Rosalia Alvarez Rafael perez Alma Flores Francisco martinez Luis Velazquez Sustainability Graduate Program University of Sonora Hermosillo Mexico Institute of Agro-Livestock Sciences Autonomous University of Mexico State Toluca Mexico

This article presents a study of Life Cycle Assessment (LCA) at a slaughterhouse located in north-western Mexico with the purpose of testing the premise of a low degree of institutionalization of Industrial Ecology in Mexico. The article aims at analyzing the current role played by the Mexican academia in increasing the degree of institutionalization of the concept of LCA in northwestern Mexico. There was conducted a life cycle analysis study according to the standards ISO 14040: 2006, NMX-SAA-14040-IMNC-2008NOM in a Federally Inspected Type (TIF by Spanish acronym) Slaughterhouse in the state of Sonora in Northwest Mexico. The slaughter process was characterized by observing the production tasks during several walkthroughs the production lines and by having short interviews with workers, supervisors, and the manager. The CH4 emissions were calculated using the guidelines suggested by the Intergovernmental Panel on Climate Change (IPCC 2006). The present LCA case study revealed opportunities for improving the environmental performance of the slaughterhouse by taking measures such as the reduction of CH4 from enteric fermentation since methane was one of the main greenhouse gases responsible for climate change. Although, the LCA generated reliable information in terms of climate change or water eutrophication, the chances of implementing sustainable initiatives were unlikely because the benefits to reduce the impacts to climate change or to reduce the water crisis would be unnoticeable and unaffordable for companies. Findings in this study also confirmed the importance of Mexican universities for promoting and conducting more LCA studies among private and public organizations in order to guide firms towards this tool. The case study here presented gives insights to LCA stakeholders in Mexico to implement or improve the effectiveness of their potential LCA initiatives through the identification of strategies, opportunities, and barriers.

关键词： Institutionalization Academia LCA Sustainability Slaughterhouse Mexico

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SYNTHESIS AND SECOND ORDER NONLINEAR OPTICAL PROPERTIES OF NOVEL POLYMERS CONTAINING DIACETYLENES IN THE MAIN CHAINS AND POLAR CHROMOPHORS IN SIDE CHAINS

SYNTHESIS AND SECOND ORDER NONLINEAR OPTICAL PROPERTIES OF N...

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5th East-Asian Polymer Conference

作者： Ana Laura perez-martinez Takeshi Ogawa Tetsuya Aoyama Tatsuo Wada Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de México. Circuito Exterior Ciudad Universitaria México DF 04510 Mexico Spramolecular Science Laboratory RIKEN (The Institute of Physical and Chemical Research) Wako Saitama Japan

＜正＞Four isomeric poly（dipropargyloxybenzoates） containing Disperse Red 13 were synthesized and their second order nonlinear optical （2-NLO） susceptibities were investigated. There are 6 isomeric formes and it is

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Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients

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World Journal of Hepatology 2021年第2期13卷 218-232页

作者： Moises martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas Jose Luis perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-perez Linda Muñoz-Espinosa David Kershenobich Gabriela Gutierrez-Reyes Liver Pancreas and Motility LaboratoryUnit of Experimental MedicineSchool of MedicineGeneral Hospital of MexicoUniversidad Nacional Autonoma de MexicoMexico City 06726Mexico Department of Molecular Biology and Genomics Institute of Molecular Biology in Medicine and Gene TherapyHealth Science University CenterUniversity of GuadalajaraGuadalajara 06726Mexico Department of Gastroenterology General Hospital of Mexico“Dr.Eduardo Liceaga”Mexico City 06726Mexico Department of General Surgery General Hospital of Mexico“Dr.Eduardo Liceaga”School of MedicineUniversidad Nacional Autonoma de MexicoMexico City 06726Mexico Hepatology and Liver Transplant National Institute of Medical Sciences and Nutrition“Salvador Zubirán”Mexico City 06726Mexico University Hospital“Dr.JoséEleuterio González ”Autonomous University of Nuevo LeonMonterrey 06726Mexico

BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the ***,there are few studies on the regulation of liver MMPs in fibrosis progression in *** To assess the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C(CHC).METHODS A prospective,cross-sectional,multicenter study was *** patients were categorized in fibrosis grades through FibroTest®and/or FibroScan®.Serum MMP-2,-7,and-9 were determined by western blot and multiplex suspension array *** were validated by the Kruskal-Wallis and Mann-Whitney U *** Spearman correlation coefficient and area under the receiver operating characteristic curve were *** and gelatinase activity was determined through the Azocoll substrate and zymogram test,whereas tissue inhibitor of metalloproteinase-1 production was determined by dot blot *** Serum concentrations of the MMPs evaluated were higher in CHC patients than in healthy ***-7 distinguished early and advanced stages,with a correlation of 0.32(P<0.001),and the area under the receiver operating characteristic displayed moderate sensitivity and specificity for MMP-7 in F4(area under the receiver operating characteristic,0.705;95%confidence interval:0.605-0.805;P<0.001).Collagenolytic activity was detected at F0 and F1,whereas gelatinase activity was not detected at any fibrosis *** inhibitor of metalloproteinase-1 determination showed upregulation in F0 and F1 but downregulation in F2(P<0.001).CONCLUSION High concentrations of inactive MMPs were present in the serum of CHC patients,reflecting the impossibility to restrain liver fibrosis *** could be good diagnostic candidates and therapeutic targets for improving novel strategies to reverse liver fibrosis in CHC.

关键词： Extracellular matrix Matrix metalloproteinases Liver fibrosis Chronic hepatitis C Fibrogenesis Fibrolysis

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Self-care:A concept analysis

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International Journal of Nursing Sciences 2021年第4期8卷 418-425,I0004页

作者： Nicole martinez Cynthia D.Connelly Alexa perez Patricia Calero Hahn School of Nursing and Health Science Beyster Institute for Nursing ResearchUniversity of San DiegoUSA

Objectives:There is extensive literature from various disciplines on self-care,an important aspect of nursing intervention via evaluation and education,but its meaning remains unprecise due to the difficulty integrating the diverse definitions developed over time across ***,it is vital to clarify the meaning of self-care and formulate the defining attributes,antecedents,and consequences to ***:Walker and Avant’s concept analysis approach was used to analyze the concept of self-care.A search of the literature was completed using the databases CINAHL,PubMed,and EBSCOhost for years 1975e2020;literature search included peer-review articles,full-text publications,and available in English.A total of 31 articles were reviewed,and saturation was ***:An extensive review of the literature revealed salient characteristics that reflected the most frequently used terms associated with the *** byWalker and Avant’s method,three defining attributes emerged as common themes:awareness,self-control,and ***:A clarified definition was identified:the ability to care for oneself through awareness,selfcontrol,and self-reliance in order to achieve,maintain,or promote optimal health and well-being.

关键词： Concept analysis Chronic disease Delivery of health care Nursing theory Self care Self-control

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Applicability of in Vitro Models in Predicting the in Vivo Bioavailability of Lycopene and β-Carotene from Differently Processed Soups

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Food and Nutrition Sciences 2012年第4期3卷 477-489页

作者： Marie Alminger Cecilia Svelander Anna Wellner Rebeca.martinez-Tomas Lucy Bialek Elvira Larque Francisca perez-Llamas Department of Chemical and Biological Engineering Food ScienceChalmers University of TechnologyGoteborgSweden Physiology Department Faculty of BiologyUniversity of MurciaMurciaSpain Unilever Discover R&D Unilever Food and Health Research InstituteVlaardingenThe Netherlands

Presently, there is no clear consensus on the best approach to estimate carotenoid bioavailability. The best alternative would be to use human studies, but they are labour-intensive and expensive and can only be used to investigate a limited number of samples. Hence, a number of in vitro: models have been developed to study pre-absorptive processes and factors affecting bioavailability. The question is, however, how well the results obtained by the various methods correlate to each other and to the in vivo situation. In the present paper, we have compared in vivo data from two human studies on differently processed soups containing carrots, tomato and broccoli, with results obtained by in vitro characterisation of the same soups. In vitro bioaccessibility was estimated by a static in vitro digestion investigating matrix release and micellarization of carotenoids and by uptake studies in a human intestinal cell line (Caco-2). In vivo data was obtained from clinical studies measuring total plasma carotenoid concentrations in human subjects after 4 weeks daily consumption of the soups. Comparison of the in vitro and in vivo results indicate that the combination of a two-step in vitro digestion and Caco-2 cells seems to be a useful tool for estimation of β-carotene bioaccessibility and screening of factors governing the release of β-carotene from this type of food. For lycopene the in vitro and in vivo results were less consistent, suggesting that reliable prediction of lycopene bioavailability might be more problematic.

关键词： In Vitro Digestion Human Uptake Caco-2 Cells β-Carotene Lycopene Carotene Bioavailability

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Thermoluminescence Response and Its Deconvolution on Crystalline Higher Order Mixtures of Alkali Halides Exposed to Gamma-Rays for Dosimetric Use

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Journal of Chemistry and Chemical Engineering 2012年第12期6卷 1093-1098页

作者： Ricardo Rodriguez Mijangosl G. Vazquez-Polo R. perez-Salas1 P. Gonzalez-martinez Departamento de Investigaci6n en Fisica Universidad de Sonora. Hermosillo 83190 México Instituto de Fisica UNAM A. P. 20-364 01000 México D. F. Mdxico. Instituto Nacional de Investigaciones Nucleares A. P. 52750 Carretera México-Toluca s/n La Marquesa Estado de MéxicoMéxico

Alkali halides crystals have been the subject of intense research. High order crystalline one phase mixtures （high order： more that binary） studied by TL （thermoluminiscence technique） proved having persistent peaks along the time after the radiation to which they are exposed. In general in alkali halide crystals the traps associated with highest recorded temperature peaks in the TL due to radiation damage have greater permanence in time too. These features are useful for dosimetric applications. In this work, temperature thermoluminescence glow peaks of ternary and quaternary mixed alkali halide crystals have been studied. The study has been focused on their high temperature glow peaks after being subjected to thermal treatments at 373, 573, and 673 K. The glow peaks of high temperature were isolated and studied 24 h and 48 h after irradiation. The parameters of the recombination processes associated to these peaks were obtained using a glow peak shape method. Orders of kinetics were higher than 1.0 and the activation energy greater than 1.2 eV. The results suggest that such materials have a high potential as dosimeter and energy storage materials.

关键词： Thermoluminiscence alkali halide mixed crystals gamma radiation dosimetry.

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肯尼亚角羚谷散记

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博物 2022年第12期 48-57页

作者：王正阳 Christian perez-martinez(摄影) 不详

今年夏天,博士毕业那天,导师语重心长地对我说:“要想看真正的野生动物,肯定得跑趟肯尼亚。那边正好需要科研人手,你想不想去学习学习?”听导师这么一说,我扔下手中的论文,即刻前往肯尼亚角羚谷自然保护区,开展为期1个月的野外工作,在... 详细信息

今年夏天,博士毕业那天,导师语重心长地对我说:“要想看真正的野生动物,肯定得跑趟肯尼亚。那边正好需要科研人手,你想不想去学习学习?”听导师这么一说,我扔下手中的论文,即刻前往肯尼亚角羚谷自然保护区,开展为期1个月的野外工作,在东非草原度过了一个难忘的暑假……大草原上角羚谷角羚谷位于肯尼亚中部的热带草原上,地处东非大裂谷和肯尼亚山之间。

关键词：东非大裂谷肯尼亚山博士毕业野生动物野外工作导师自然保护区草原

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Fabrication of patterned graphitized carbon wires using low voltage near-field electrospinning, pyrolysis, electrodeposition, and chemical vapor deposition

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Microsystems & Nanoengineering 2020年第1期6卷 1341-1352页

作者： Derosh George Adrian Garcia Quang Pham Mario Ramos perez Jufeng Deng Michelle Trang Nguyen Tuo Zhou Sergio Omartinez-Chapa Yoonjin Won Chong Liu Roger CLo Regina Ragan Marc Madou Mechanical and Aerospace Engineering University of CaliforniaIrvineUSA Chemical Engineering and Materials Science University of CaliforniaIrvineUSA Materials and Manufacturing Technology University of CaliforniaIrvineUSA School of Engineering and Sciences Tecnologico de MonterreyMonterreyMexico Mechanical Engineering Dalian University of TechnologyDalianChina Chemical Engineering California State UniversityLong BeachUSA Present address:Mechanical Engineering Centro de Ensenanza Tecnica y Superior UniversidadMexicaliMexico

We herein report a high-resolution nanopatterning method using low voltage electromechanical spinning with a rotating collector to obtain aligned graphitized micro and nanowires for carbon nanomanufacturing.A small wire diameter and a small inter-wire spacing were obtained by controlling the electric field,the spinneret-to-collector distance,the pyrolysis parameters,the linear speed of the spinneret,the rotational speed of the *** a simple scaling analysis,we show how the straightness and the diameter of the wires can be controlled by the electric field and the distance of the spinneret to the collector.A small inter-wire spacing,as predicted by a simple model,was achieved by simultaneously controlling the linear speed of the spinneret and the rotational speed of the *** drying of the polymer nanowires enabled the facile fabrication of suspended wires over various *** polyacrylonitrile wires were carbonized using standard stabilization and pyrolysis to obtain carbon *** carbon nanowires with a diameter of<50 nm were *** also established a method for making patterned,highly graphitized structures by using the aforementioned carbon wire structures as a template for chemical vapor deposition of *** patterning technique offers high throughput for nano writing,which outperforms other existing nanopatterning techniques,making it a potential candidate for large-scale carbon nanomanufacturing.

关键词： nanowires carbon field

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XAANTAL2 （AGL14） Is an Important Component of the Complex Gene Regulatory Network that Underlies Arabidopsis Shoot Apical Meristem Transitions

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Molecular Plant 2015年第5期8卷 796-813页

作者： Rigoberto V. perez-R.u.iz Berenice Garcia-Ponce Nayelli Marsch-martinez Yamel Ugartechea-Chirino Mitzi Villajuana-Bonequi Stefan de Folter Eugenio Azpeitia Jose Davila-Velderrain David Cruz-Sanchez Adriana Garay-Arroyo Maria de la Paz Sanchez Juan M. Estevez-Palmas Elena R. Alvarez-Buylla Instituto de Ecologia Universidad Nacionat Autonoma de Moxico 3er Circuito Exterior s/no Junto al Jardin Bot~nico and Centro de Ciencias de la ComplejidadCiudad Universitaria Coyoacan 04510 Mexico D.F. Mexico Laboratorio Nacional de Genemica para la Biodiversidad (Langebio) Centro de Investigaci6n y de Estudios Avanzados del Instituto Polit~cnico Nacional(CINVESTAV-IPN) Km. 9.6 Carretera Irapuato - Leen AP 629 36821 Irapuato Guanajuato Mexico University of California 431 Koshland Hall Berkeley CA 94720 USA These authors contributed equally to this article. present address: Departamento de Biotecnologia y Biquimica Centro de )nvestigaci6n y de Estudios Avanzados del Instituto Polit6cnico Nacional(CINVESTAV-IPN) Km. 9.6 Libramiento Norte Carr. Irapuato-Leen 36821 Irapuato Guanajuato Mexico present address: Max Planck Institute for Plant Breeding Research D-50829 Cologne Germany Present address: INRIA Project-Team Virtual Plants/CIRAD/INRA UMR AGAP Campus St Priest - BAT 5 CC 05018 860 rue de St Priest 34095 Montpellier Cedex5 France

In Arabidopsis thaliana, multiple genes involved in shoot apical meristem （SAM） transitions have been char- acterized, but the mechanisms required for the dynamic attainment of vegetative, inflorescence, and floral meristem （VM, IM, FM） cell fates during SAM transitions are not well understood. Here we show that a MADS-box gene, XAANTAL2 （XAL2/AGL14）, is necessary and sufficient to induce flowering, and its regula- tion is important in FM maintenance and determinacy, xal2 mutants are late flowering, particularly under short-day （SD） condition, while XAL2 overexpressing plants are early flowering, but their flowers have vege- tative traits. Interestingly, inflorescences of the latter plants have higher expression levels of LFY, AP1, and TFL1 than wild-type plants. In addition we found that XAL2 is able to bind the TFL1 regulatory regions. On the other hand, the basipetal carpels of the 35S：：XAL2 lines lose determinacy and maintain high levels of WUS expression under SD condition. To provide a mechanistic explanation for the complex roles of XAL2 in SAM transitions and the apparently paradoxical phenotypes of XAL2 and other MADS-box （SOCl, AGL24） over- expressors, we conducted dynamic gene regulatory network （GRN） and epigenetic landscape modeling. We uncovered a GRN module that underlies VM, IM, and FM gene configurations and transition patterns in wild- type plants as well as loss and gain of function lines characterized here and previously. Our approach thus provides a novel mechanistic framework for understanding the complex basis of SAM development.

关键词： XAL2/AGL14 MADS-box TFL1 SAM transitions floral reversion gene regulatory networks,epigenetic landscape modeling

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