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Land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas Maria A.garcia-Lopez Jose M.Olano gabriel Sanguesa-Barreda Miguel garcia-Hidalgo Susana.g.mez-gonzalez Roberto Lopez-Rubio Jose M.Fernandez-Palacios Ignacio garcia-gonzalez Laura Lozano-Lopez Paula garcia-gonzalez Ana I.garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAgRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPLIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

Laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human *** the past,Canary laurel forests have been greatly altered by logging,livestock and *** remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic *** dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife *** cores were collected from over 80 trees per stand at three stands per *** used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed *** tree species were found in all stands,with Laurus novocanariensis,Ilex canariensis and Morella faya being the most common *** some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism *** trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past *** growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure Macaronesia Management cessation Tree rings

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HIV screening and retention in care in people who use drugs in Madrid, Spain: a prospective study

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Infectious Diseases of Poverty 2021年第4期10卷 77-85页

作者： Pablo Ryan Jorge Valencia guillermo Cuevas Jesus Troya Juan Torres-Macho Maria Jose Munoz-gomez Nuria Munoz-Rivas Isabel Canorea Sonia Vazquez-Moron Salvador Resino Hospital Universitario Infanta Leonor MadridSpain Universidad Complute nse de Madrid(UCM) MadridSpain Instituto de Investigacion Sanitaria gregorio Maranon(liSgM) MadridSpain Unidad de Reduccion de Darios"SMASD"Madrid Spain Unidad de Infeccion Viral e Inmunidad Centro Nacional de MicrobiologiaInstituto de Salud Carlos IIICarretera Majada-honda-PozueloKm 2.228220 MajadahondaMadridSpain

Background::The burden of human immunodeficiency virus(HIV)infection in people who use drugs(PWUD)is *** aimed to screen HIV infection among PWUD and describe their retention in HIV ***,we also screen for hepatitis C virus(HCV)infection among HIV-seropositive PWUD and describe their linkage to ***::We conducted a prospective study in 529 PWUD who visited the"Ca?ada Real galiana"(Madrid,Spain).The study period was from June 1,2017,to May 31,*** diagnosis was performed with a rapid antibody screening test at the point-of-care(POC)and HCV diagnosis with immunoassay and PCR tests on dried blood spot(DBS)in a central *** PWUD were referred to the *** used the Chi-square or Fisher’s exact tests,as appropriate,to compare rates between ***::Thirty-five(6.6%)participants were positive HIV antibodies,but 34 reported previous HIV diagnoses,and 27(76%)had prior antiretroviral *** patients with a positive HIV antibody test,we also found a higher prevalence of homeless(Pg use(PWID)(Pg use(P=0.002).All participants received HIV test results at the *** the 35 HIV positives,28(80%)were retained in HIV medical care at the end of the HIV screening study(2018),and only 22(62.9%)at the end of ***,12/35(34.3%)were positive for the HCV RNA *** the latter,10/12(83.3%)were contacted to deliver the HCV results test(delivery time of 19 days),5/12(41.7%)had an appointment and were attended at the hospital and started HCV therapy,and only 4/12(33.3%)cleared ***::We found almost no new HIV-infected PWUD,but their cascade of HIV care was low and remains a challenge in this population at *** high frequency of active hepatitis C in HIV-infected PWUD reflects the need for HCV screening and reinforcing the link to care.

关键词： HIV Point-of-care Screening People who use drugs Retention in care Hepatitis C Dried blood spot Antiviral treatment

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抗血栓治疗在二尖瓣狭窄伴心房纤颤患者中的作用:NASPEAF随机试验的亚分析

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 28-28页

作者： Pérez-gómez F. Salvador A. Zumalde J. 徐永城 Servicio de Cardiologa Hospital Clinico San CarlosProf.Martn Lagos s/n28040 MadridSpain

Aims: The randomized NASPEAF study included non-valvular with prior embolism and mitral stenosis patients in the same group. This is a sub-study to speciall y focus on the antithrombotic therapy in mitral stenosis. Methods and results: W e analysed 311 patients with mitral stenosis, compared with 175 non-valvular at rial fibrillation patients with prior embolism, stratified by a history of previ ous embolism and assigned to anticoagulant therapy [target international normali zed ratio(INR)=2.0-3.0] or combined antiplatelet plus moderate intensity antico agulant therapy. Median follow-up was 2.9 years. Outcomes were fatal and non-f atal embolism, stroke and myocardial infarction, sudden death, and death from bl eeding. Combined therapy in mitral stenosis patients, compared with anticoagulan t alone therapy, reduced the risk of vascular events by 58.3%. During equal the rapy, the outcome annual rates were essentially the same in non-valvular and va lvular patients [hazard ratio 0.90(95%confidence interval 0.37-2.16), P=0.81]. During anticoagulant alone therapy, the annual event rate in mitral stenosis pa tients without prior embolism was low(2.5%) and it was very high in patients wi th prior embolism(6.6%). Conclusion: Combined therapy was effective in mitral s tenosis patients. Prior embolism patients are not efficiently protected with ant icoagulant alone therapy for an INR of 2.0-3.0.

关键词：二尖瓣狭窄抗血栓治疗心房纤颤随机试验国际标准化比值抗凝治疗年发生率非致死性

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P2X4受体对活化的小胶质细胞的调控作用

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神经损伤与功能重建 2014年第1期9卷 50-50页

作者： Vázquez-Villoldo N Domercq M Martín A Llop J gómez-Vallejo V Matute C Departamento de Neurociencias Universidad del País Vasco-UPV/EHUBarrio Sarriena s/n 48940 Leioa Spain Achucarro Basque Center for Neuroscience-UPV/EHU Instituto de Salud carlos III. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)

小胶质细胞是中枢神经系统内的免疫细胞,当脑组织出现损伤时,小胶质细胞被激活,对脑组织起到保护作用。在自身免疫性脑脊髓炎模型大鼠和视神经脊髓炎患者体内,均观察到在脊髓炎性病灶及小胶质细胞内,P2X4受体表达上调。本课题组进行在... 详细信息

小胶质细胞是中枢神经系统内的免疫细胞,当脑组织出现损伤时,小胶质细胞被激活,对脑组织起到保护作用。在自身免疫性脑脊髓炎模型大鼠和视神经脊髓炎患者体内,均观察到在脊髓炎性病灶及小胶质细胞内,P2X4受体表达上调。本课题组进行在体和离体实验,用LPS活化小胶质细胞,观察P2X4受体在小胶质细胞炎性反应中的作用。膜片钳检测显示,在LPS激活的小胶质细胞内,P2X4受体活性增加。P2X4受体阻断剂可显著降低小胶质细胞的膜皱缩、TNFα的分泌、细胞形态的改变及LPS导致的小胶质细胞死亡。在体研究显示,LPS髓内注射后会诱发炎性反应,迅速导致小胶质细胞丢失;给予P2X4受体阻断剂可显著减少小胶质细胞的丢失,而P2X4受体激活剂则可显著增加小胶质细胞的丢失。海马齿状回的小胶质细胞特别容易被LPS诱导的炎症反应激活。注射LPS后2 h,位于海马齿状回的小胶质细胞即被激活,大约24 h后死亡,P2X4受体阻断剂可减少LPS诱导的小胶质细胞活化和死亡。上述数据提示,P2X4受体对于小胶质细胞的激活和存活有重要的调控作用。

关键词：实验性自身免疫性脑脊髓炎及多发性硬化 P2X4嘌呤受体细胞死亡小胶质细胞

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阿尔茨海默病小胶质细胞CX3CR1产物增加并受去甲肾上腺素的调节

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神经损伤与功能重建 2020年第7期15卷 F0003-F0003页

作者： Marta gonzález-Prieto Irene Lgutiérrez Borja garcía-Bueno Javier RCaso Juan CLeza Adriana Ortega-Hernández Dulcenombre gómez-garre JoséLMMadrigal 杜一星(编译) Department of Pharmacology and Toxicology School of MedicineUniversidad Complutense de Madrid(UCM)MadridSpain Centro de Investigación Biomédica en Red de Salud Mental(CIBERSAM) Instituto de Investigación Neuroquímica(IUINQ-UCM)Instituto de Investigación Sanitaria HospitalMadridSpain Vascular Biology Laboratory and Flow Cytometric Unit Hospital Clínico San Carlos-Instituto de Investigación Sanitaria San Carlos(IdISSC)MadridSpain Biomedical Research Networking Center in Cardiovascular Diseases(CIBERCV) MadridSpain 不详

去甲肾上腺素能神经元的丧失及其引起的脑去甲肾上腺素(NA)水平的降低与阿尔茨海默病(AD)的进展有关。这似乎主要是由于NA减少小胶质细胞活化的能力。我们以前观察到NA诱导神经元产生趋化因子Fractalkine/CX3CL1。小胶质细胞CX3CR1(CX3... 详细信息

去甲肾上腺素能神经元的丧失及其引起的脑去甲肾上腺素(NA)水平的降低与阿尔茨海默病(AD)的进展有关。这似乎主要是由于NA减少小胶质细胞活化的能力。我们以前观察到NA诱导神经元产生趋化因子Fractalkine/CX3CL1。小胶质细胞CX3CR1(CX3CL1的唯一受体)的激活会减少小胶质细胞的活化,已知这在很大程度上引起AD特征性的神经元损伤。因此,操控小胶质细胞中CX3CR1的产物可能转化为对CX3CL1抗炎作用的增强或抑制。为了确定小胶质细胞CX3CR1产物在AD中是否发生改变,以及NA是否可以控制这种改变,我们在5xFAD小鼠和人类AD脑样本中分析了CX3CR1的表达和合成。此外,我们分别在小胶质细胞培养物和小鼠中分析了NA及NA再摄取抑制剂瑞波西汀的作用。我们的结果表明,CX3CR1在AD大脑皮质中的产量增加,而给予瑞波西汀进一步增加了它的含量,并增强了小胶质对淀粉样β斑的反应性。然而,直接向原代大鼠小胶质细胞或人类HMC3细胞给予NA会抑制CX3CR1的产生,这表明小胶质细胞对NA的反应可能会在不存在产生CX3CL1的神经元或其他非小胶质外在因素的作用下发生改变。

关键词： (5-7)CX3C趋化因子受体1 表达5种人类AβPP和PS1突变的小鼠阿尔茨海默病 C-X3-C基序趋化因子配体1 不规则趋化因子去甲肾上腺素瑞波西汀

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