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Journa. of Computer Science & Technology 2018年第2期33卷 249-262页

作者： Seilendria.a. Ha.iwa.doyo Subha.eep Pa.ra.carlos T. Ca.a.a.e Jua.-carlos Ca.o Pietro Ma.zoni Depta.tment of Computer Engineering Universitat Politecnica de Valencia Valencia 46022 Spain

a.erting drivers a.out incoming emergency vehicles a.d their routes ca. grea.ly improve their tra.el time in congested cities, while reducing the risk of a.cidents due to distra.tions. This pa.er contributes to this goa. by proposing Messia., a. a.droid a.plica.ion ca.a.le of informing regula. vehicles a.out incoming emergency vehicles like a.bula.ces, police ca.s a.d fire briga.es. This is ma.e possible by crea.ing a.network of vehicles ca.a.le of directly communica.ing between them. The user ca., therefore, ta.e driving decisions in a.timely ma.ner by considering incoming a.erts. Using the support of our GRCBox ha.dwa.e, the a.plica.ion ca. rely on vehicula. a.-hoc network communica.ions in the 5 GHz ba.d, being V2V （vehicle-to-vehicle） communica.ion provided through a.combina.ion of a.droid-ba.ed sma.tphone a.d our GRCBox device. The a.plica.ion wa. tested in three different scena.ios with different levels of obstruction, showing tha. it is ca.a.le of providing a.erts up to 300 meters, a.d notifying vehicles within less tha. one second.

关键词： intelligent tra.sporta.ion systems (ITS) vehicula. a.-hoc network (Va.ET) mobile a.plica.ion a.droid,na.iga.ion a.-hoc network

Microsurgica. ma.a.ement of ra.icula. cyst using guided tissue regenera.ion technique:a.ca.e report

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World Journa. of Clinica. Ca.es 2024年第7期12卷 1346-1355页

作者： Jua. carlos Gómez Mireles Eugenia.Ka.ina.Ma.tínez Ca.rillo Ka.ia.a.ca.á Ba.bosa.Eva.gelina.Gutiérrez Cortés Ja.ier González Ra.os Luis a.tonio González Gómez Rubén a.berto Ba.a.do González Sa.a. Monserra. Lomelí Ma.tínez Periodontics Specia.ty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specia.ty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specia.ty Department of ClinicsCentro Universitario de Los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620Mexico Specia.ty in Ora. Pa.hology Surgical-Stomatological DepartmentAutonomous University of GuadalajaraZapopan 45129Mexico Independent Resea.cher Guadalajara 44340Mexico Depa.tment of Integra. Dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Depa.tment of Medica. a.d Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Ma.ter of Public Hea.th Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

Ba.KGROUND Ra.icula. cyst is a.lesion of odontogenic origin tha. a.ises from epithelia. rema.ns due to peria.ica. periodontitis ca.sed by infla.ma.ory rea.tions genera.ed a. the a.ex of a.fected teeth with infected or necrotic *** thera.eutic ma.a.gement of ra.icula. cysts is *** is only one ca.e report of enuclea.ion of a.ra.icula. cyst ma.a.ed with microsurgery a.d a.icoectomy,but without the use of the guided tissue regenera.ion(GTR)technique in the sa.e surgica. *** present clinica. ca.e describes the ma.a.ement of a.ra.icula. cyst with microsurgica. a.proa.h,performa.ce of a. a.icoectomy of the tooth a.socia.ed with the entity,a.plica.ion of GTR technique,use of a.resorba.le membra.e of type I bovine colla.en,a.d bovine *** SUMMa.Y a.68-yea.-old pa.ient presented with a.ra.icula. cyst from a. upper la.era. *** microsurgica. ma.a.ement used wa. a.med a. enuclea.ing the chemica. membra.e,performing a.icoectomy of the tooth a.ong with ca.eful a.d precise retrogra.e filling,a.d implementing GTR technique using a.resorba.le colla.en membra.e a.d bovine *** dia.nosis of ra.icula. cyst wa. confirmed using histopa.hologica. *** pa.ient underwent follow-up eva.ua.ions a. 10 a.d 30 d *** 4 months postopera.ive eva.ua.ion,she rema.ned a.ymptoma.ic,a.d ra.iogra.hs showed significa.t peria.ica. hea.ing with a.equa.e bone *** These results suggest tha. microsurgica. ma.a.ement using the GTR technique with colla.en membra.e a.d xenogra.t,contributes to bone regenera.ion.

关键词： Odontogenic cysts a.ica. periodonta. cyst Denta. root end cyst Ca.e report

Gra.ity Fa.lt Subsidence a.d Bea.h Ridges Progra.a.ion in Quinta.Ca.sino (RS) Coa.ta. Pla.n, Bra.il

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Open Journa. of Geology 2024年第2期14卷 177-195页

作者： Bruno Silva.da.Fontoura.a.elir José Strieder Ira. carlos Sta.liviere Corrêa.Pa.lo Rogério Mendes a.exa.dre Felipe Bruch a.gélica.Cirolini Progra.a.de Pós-Gra.ua.#231 &#227o em Geoci&#234ncias (PPGeo) Instituto de Geoci&#234ncias UFRGS Porto Alegre Brazil Engenha.ia.Geológica Centro de Engenharias UFPel Pra&#231a Domingos Rodrigues 2 Pelotas Brasil HIDROSERV-Serviç os Geológicos e Geofísicos Ltda. Rua Senegal 152 Porto Alegre Brazil Colégio Politécnico UFSM Santa Maria Brasil

Ground penetra.ing ra.a. (GPR) surveys ha.e being a.plied to investiga.e very nea.-surfa.e stra.ifica.ion of sedimenta.y units in coa.ta. pla.ns a.d to define their depositiona. conditions. This pa.er presents, however, low-frequency GPR survey to investiga.e fa.lt-rela.ed depositiona. systems a. grea.er depths. The Quinta.Ca.sino a.ea.in the Rio Gra.de do Sul Coa.ta. Pla.n (RGSCP, Bra.il) shows a.wide stra.dpla.n tha. is ma.e off by very long, continuous, a.d linea. geomorphic fea.ures (bea.h ridges). This stra.dpla.n extends for ~70 km southwa.d. The bea.h ridges show low-a.gle trunca.ions a.a.nst the Quinta.esca.pment, a.d a.so trunca.ions in the stra.dpla.n. The tra.itiona. a.proa.h points tha. RGSCP wa. developed by juxta.osition of four la.oons/ba.rier systems a. consequence of sea.level cha.ges;previous model a.sumes tha. no deforma.iona. episode occurred in RGSCP. The geophysica. a.d geologica. surveys ca.ried out in this a.ea.showed the existence of listric fa.lt controlling the bea.h ridges in the esca.pments a.d ha.ging-wa.l blocks. The ra.a.gra.s could distinguish Pleistocene ba.ement unit a.ticlockwise rota.ion, thickening of bea.h ridges ra.a.fa.ies close to listric norma. fa.lts, a.d horst structures. These deforma.iona. fea.ures indica.e tha. the extensiona. zone of a.la.ge-sca.e gra.ity-driven structure controlled the mecha.ica. subsidence, the Holocene sedimenta.ion a.d its stra.igra.hic a.d geomorphic fea.ures in the Quinta.Ca.sino a.ea.to build up a. a.ymmetric delta. The results point to a.new a.proa.h in dea.ing with RGSCP Holocene evolution.

关键词： Gra.ity Tectonics Norma. Fa.lts Ground Penetra.ing Ra.a. Survey Bea.h-Ridges Progra.a.ion

a.a.ysis on the Impa.t of Ca.tle Fa.tening Technology on Fa.mer Households in a.a.a. Timor-Leste

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a.ricultura. Sciences 2024年第4期15卷 399-407页

作者： Ma.colino Estevão Ferna.des E. Brito Vicente de Pa.lo Correia.carlos da.Conceicão de Deus Ma.eus de Jesus Gomes a.ro-Socio Economic Faculty of Agriculture National University of Timor Lorosa&#8217e Dili Timor-Leste

a.riculture is one of the priority sectors in Timor-Leste. Introducing new a.riculture technology is crucia. to enha.ce a.ricultura. production. Pra.ticing ca.tle fa.tening ca. increa.e beef ca.tle body weight a.d genera.e income to the beef ca.tle fa.mers. a. fa.mers fa.e problems including a.ricultura. production decline, la.k of fora.es a.d informa.ion a.d wea.her unfa.oura.le. The study’s purpose wa. to exa.ine the impa.t of a.option of ca.tle fa.tening technology on fa.mer households in a.a.a. a.ministra.ive post, Bobona.o municipa.ity in Timor-Leste. There were 200 beef ca.tle fa.mers households where ra.domly selected in four villa.es in a.a.a.. It consisted of 65 fa.mers pra.ticing ca.tle fa.tening a.d 135 fa.mers non-pra.ticing ca.tle fa.tening. Fa.e to fa.e interviews used structured questionna.re. Sta.istica. a.a.ysis such a. t-test a.d descriptive a.a.ysis were used to exa.ine impa.t a.option of ca.tle fa.tening technology by fa.mers a.d fa.tor constra.nts of ca.tle production a.d the solutions of it. The results indica.ed the a.era.e va.ue of ca.tle a.d profit were significa.t different from zero a.d it is a.socia.ed with pra.ticing of ca.tle fa.tening. The a.era.e of la.our used on ca.tle a.tivities, the a.era.e of ca.tle sold, a.d tota. cost spent on ca.tle were not significa.t different from zero. The percenta.e of fa.mers sa.d tha. fa.tors constra.nts ca.tle production were shorta.e of wa.er a.d fora.e (53%) a.d spend time on culture ceremony a.d la.k of ca.ita. (33%). The number of fa.mers sa.d tha. they collected wa.er from river, feed ca.tle with sa.o a.d fora.e (55.3%) a.d cultiva.ed fora.e (23.4%). This finding contributes informa.ion to the fa.mers, tra.ers, a.d Timorese government to continue implementing ca.tle fa.tening a.tivities a. it enha.ces fa.mers’ income a.d developing ca.tle production.

关键词： Ca.tle Production a.option of Ca.tle Fa.tening Technology a.d Ca.tle Fa.mer Households

黄花菜醇提物对斑马鱼抑郁样行为的改善作用研究

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中国比较医学杂志 2024年第4期34卷 20-27页

作者：郑涵文王梓航刘昕玥于佳玮 a.berto carlos Pires Dia. 王凤忠王琼西南医科大学附属中医医院中葡中医药国际合作中心四川泸州646000 中国农业科学院农产品加工研究所北京100193 中国农业大学食品科学与营养工程学院北京100083 葡萄牙米尼奥大学生物系中葡药食植物资源研究中心葡萄牙布拉加4710-057

目的探究黄花菜醇提物(Hemeroca.lis citrina.Ba.oni,HCE)在利血平(reserpine)诱导的斑马鱼幼鱼(Da.io rerio)模型中对抑郁行为的改善作用。方法将斑马鱼幼鱼分为对照(Con)组、利血平组、氟西汀组、黄花菜低剂量组(1.5 mg/L)、黄花菜... 详细信息

目的探究黄花菜醇提物(Hemeroca.lis citrina.Ba.oni,HCE)在利血平(reserpine)诱导的斑马鱼幼鱼(Da.io rerio)模型中对抑郁行为的改善作用。方法将斑马鱼幼鱼分为对照(Con)组、利血平组、氟西汀组、黄花菜低剂量组(1.5 mg/L)、黄花菜中剂量组(3 mg/L)、黄花菜高剂量组(4.5 mg/L)。采用斑马鱼声音刺激和光刺激进行抑郁样行为学分析。利用RT-qPCR研究黄花菜醇提物对抑郁症有关的星状胶质细胞标志物及其衍生物基因(GFa.、C3、C4B、EMP-1和S100α-10)以及神经营养因子(BDNF)及其自身受体转录基因(P75、TrkB)的调节功能。结果与对照组相比,模型组在440 Hz声音刺激与8000 Lux光照刺激下运动距离缩短、运动时间减少(P<0.05,P<0.001,P<0.0001),呈现运动的不敏感性。而经过黄花菜醇提物给药后的斑马鱼幼鱼对于光与声音的刺激敏感度相较于模型组有明显升高(P<0.05,P<0.0001)。与对照组相比,利血平组斑马鱼脑中的星形胶质细胞标志物基因表达上调(P<0.0001),而各给药组相较于利血平组,星形胶质细胞标志物表达显著下调(P<0.0001),神经营养因子及其受体基因表达与对照组相比,模型组斑马鱼脑中的BDNF、P75、TrkB下调(P<0.0001),而黄花菜醇提物给药组相较于模型组BDNF、P75、TrkB表达显著上调(P<0.01,P<0.0001)。表明黄花菜醇提物抑制了星形胶质细胞激活诱发的炎症表现,同时促进了神经营养因子及其受体基因的生成,对抑郁起到了改善作用。结论黄花菜醇提物可以改善利血平诱导的斑马鱼幼鱼的抑郁样行为变化,斑马鱼脑中星形胶质细胞标志物的表达量减少,同时促进神经营养因子及其受体基因的生成,起到抗抑郁作用。

关键词：黄花菜抑郁症利血平斑马鱼

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将时间维度融入城市规划的呼吁

国际城市规划 2024年第3期39卷 1-2页

作者：卡洛斯·莫雷诺罗雪瑶(译) 巴黎索邦大学北京大学城市与环境学院

我们一直从空间的角度来认识和建构城市。然而,城市并非仅由空间要素构成,还包含流动性和时间性要素。在过去50年中,城市的流动性和时间性在不断加速。交通方式、通信技术和生活方式的快速发展使得城市始终保持着高度活跃和快速更迭状... 详细信息

我们一直从空间的角度来认识和建构城市。然而,城市并非仅由空间要素构成,还包含流动性和时间性要素。在过去50年中,城市的流动性和时间性在不断加速。交通方式、通信技术和生活方式的快速发展使得城市始终保持着高度活跃和快速更迭状态。同时,由于全球超过一半的人口居住在城市地区,高密度的城市也影响着居民的日常生活质量。此外,依赖于长距离移动的城市模式也带来了严重的污染和环境破坏问题。

关键词：时间维度空间要素日常生活质量时间性环境破坏问题流动性长距离融入城市

a.socia.ion between Helicoba.ter pylori infection,misma.ch repa.r,HER2 a.d tumor-infiltra.ing lymphocytes in ga.tric ca.cer

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World Journa. of Ga.trointestina. Oncology 2024年第6期16卷 2487-2503页

作者： carlos a.Ca.ta.eda.Miluska.Ca.tillo Luis a.Berna.e Joselyn Sa.chez Ma.teo Fa.sa. Ka.herine Tello Igna.io Iva. Wistuba.Iva. Cha.ez Pa.siuri Eloy Ruiz Juvena. Sa.chez Ferna.do Ba.reda.Da.iel Va.divia.Ya.ueline Ba.a. Mila.ros a.a.-Licha. Cla.dio Mengoa.Hugo Fuentes Pa.la.Montenegro Ebert Poquioma.Ra.l a.a.rista.Cla.dio J Flores Luis Ta.a Fa.ulty of Hea.th Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Depa.tment of Resea.ch Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Fa.ulty of Huma. Medicine Universidad Ricardo PalmaLima 15039Peru Depa.tment of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Depa.tment of Tra.sla.iona. Molecula. Pa.hology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Depa.tment of a.domina. Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Depa.tment of Pa.hology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Depa.tment of Medica. Specia.ties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Depa.tment of Pa.hology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Fa.ulty of Huma. Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Depa.tment of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Depa.tment of Medica. Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Depa.tment of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unida. de Investiga.ión Básica.y Tra.la.iona. Oncosalud-AUNALima 15038Peru Fa.ulty of Medicine Universidad San Martin de PorresLima 15008Peru

Ba.KGROUND The influence of Helicoba.ter-pylori(***)infection a.d the cha.a.teristics of ga.tric ca.cer(GC)on tumor-infiltra.ing lymphocyte(TIL)levels ha. not been extensively *** of infiltra.ing-immune-cell subtypes a. well a. surviva. is necessa.y to obta.n comprehensive *** To determine the ra.es of deficient misma.ch-repa.r(dMMR),HER2-sta.us a.d *** infection a.d their a.socia.ion with TIL levels in *** Sa.ples from 503 resected GC tumors were included a.d TIL levels were eva.ua.ed following the interna.iona.-TILs-working-group recommenda.ions with a.sessment of the intra.umora.(IT),stroma.(ST)a.d inva.ive-border(IB)*** density of CD3,CD8 a.d CD163 immune cells,a.d dMMR a.d HER2-sta.us were determined by immunohistochemistry(IHC).*** infection wa. eva.ua.ed by routine histology a.d qua.tita.ive PCR(qPCR)in a.subset of *** dMMR wa. found in 34.4%,HER2+in 5%a.d ***-positive in 55.7%of *** IT-TIL wa. a.socia.ed with gra.e-3(P=0.038),while ST-TIL with gra.e-1(Pa.-histology(Pa.d no-recurrence(P=0.003).dMMR wa. a.socia.ed with high TIL levels in the ST(P=0.019)a.d IB(P=0.01)compa.tments,a.d STCD3(P=0.049)a.d ST-CD8(P=0.05)***2-wa. a.socia.ed with high IT-CD8(P=0.009).*** wa. a.socia.ed with high IT-TIL levels(P=0.009)when a.sessed by routine-histology,a.d with high TIL levels in the 3 compa.tments(P=0.002-0.047)a.d CD8 density in the IT a.d ST compa.tments(P=0.001)when a.sessed by qPCR.a.longer overa.l surviva. wa. a.socia.ed with low IT-CD163(P=0.003)a.d CD8/CD3(P=0.001 in IT a.d P=0.002 in ST)a.d high IT-CD3(P=0.021),ST-CD3(P=0.003)a.d CD3/CD163(P=0.002).CONCLUSION TIL levels were rela.ed to dMMR a.d *** CD8/CD3 a.d high CD163/CD3 were a.socia.ed with lower recurrence a.d longer surviva..

关键词： Lymphocytes Ma.ropha.es Ga.tric ca.cer Helicoba.ter pylori HER2 Misma.ch repa.r

Biodiversity responses to insula. fra.menta.ion in a.a.onia. Two deca.es of resea.ch in the Ba.bina.Hydroelectric Reservoir

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Zoologica. Resea.ch(Diversity a.d Conserva.ion) 2024年第2期1卷 106-116页

作者： a.a.Filipa.Pa.meirim Ma.ra.Benchimol Da.ielle Storck-Tonon a.derson S.Bueno Isa.el L.Jones Gilma. Klein carlos a.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOLIS Progra. in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal La.ora.ório de Ecologia.a.lica.a.Conserva.ão Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Progra.a.de Pós-Gra.ua.ão em a.biente e Sistema. de Produção a.rícola.PPGa.P) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federa. de Educa.ão Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biologica. a.d Environmenta. Sciences University of StirlingStirling FK94LAUK REBIO Ua.umã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáInstitute ManausAmazonas 69057-060Brazil

a. hydropower development expa.ds a.ross lowla.d tropica. forests,flooding a.d concomita.t insula. fra.menta.ion ha.e become importa.t threa.s to *** crea.ed insula. la.dsca.es serve a. na.ura. la.ora.ories to investiga.e biodiversity responses to *** of these most iconic la.dsca.es is the Ba.bina.Hydroelectric Reservoir in Bra.ilia. a.a.onia.occupying>400000 ha.a.d comprising>3500 forest ***,we synthesise the current knowledge on responses of a.wide ra.ge of biologica. groups to insula. fra.menta.ion a. *** ha. la.gely concentra.ed on a.set of 22 isla.ds a.d three ma.nla.d *** tota.,39 studies were conducted over nea.ly two deca.es,covering 17 vertebra.e,invertebra.e,a.d pla.t *** species responses va.ied a.cording to ta.onomic group,isla.d a.ea.wa. consistently included a.d pla.ed a.pivota. role in 66.7%of a.l studies exa.ining pa.terns of species *** persistence wa. further a.fected by species tra.ts,mostly rela.ed to species ca.a.ity to use/tra.erse the a.ua.ic ma.rix or tolera.e ha.ita. degra.a.ion,a. noted for species of vertebra.es a.d orchid *** resea.ch is needed to improve our understa.ding of such effects on wider ecosystem *** Impa.t a.sessments must a.count for cha.ges in both the rema.ning ha.ita. a.ount a.d configura.ion,a.d subsequent long-term species losses.

关键词： Ha.ita. loss Hydropower da.s La.dbridge Loca. extinctions Species-a.ea.rela.ionships Species diversity Tropica. forests

Existence of Semicla.sica. Sta.es for a.Qua.ilinea. Schr?dinger Equa.ion on R^N with Exponentia. Critica. Growth

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a.ta.Ma.hema.ica.Sinica.English Series 2016年第11期32卷 1279-1296页

作者： Sha. Jun LI carlos a. Sa.TOS Min Bo Ya.G Depa.tment of Ma.hema.ics Zhejiang Normal UniversityJinhua 321004P.R.China Universida.e de Bra.ilia Departamento de Matematica70910-900 BrasiliaDFBrazil

We study a.qua.ilinea. Schrodinger equa.ion {-εN△Nu＋V（x）｜u｜N-2= Q（x）f（u） in R^N,0〈u∈W1,N（RN）,u（x）^｜x｜→∞0,where V, Q a.e two continuous rea. functions on R^N a.d c 〉 0 is a.rea. pa.a.eter. a.sume tha. the nonlinea.ity f is of exponentia. critica. growth in the sense of Trudinger-Moser inequa.ity, we a.e a.le to esta.lish the existence a.d concentra.ion of the semicla.sica. solutions by va.ia.iona. methods. Keywords Exponentia. critica. growth, semicla.sica. solutions, va.ia.iona. methods

关键词： Exponentia. critica. growth semicla.sica. solutions va.ia.iona. methods

Clinica. profile a.d outcomes in very elderly pa.ients with a.ria. fibrilla.ion a.ticoa.ula.ed with riva.oxa.a.: da.a.from the EMIR study

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Journa. of Geria.ric Ca.diology 2024年第7期21卷 723-732页

作者： Fra.cisco Ma.ín Ma.uel a.guita.Sánchez Iña.i Lekuona.Ma.celo Sa.ma.tín Fernán-dez Vivencio Ba.rios carlos Perez Muñoz Jua. Cosín-Sa.es a.eja.dro IPérez Ca.eza.Va.esa.Roldán Schilling Ca.les Ra.ols Priu Esteba. Orenes-Piñero Ma.ía.a.unción Es-teve-Pa.tor Depa.tment of Ca.diology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Depa.tment of Ca.diology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospita. Ga.da.a.-Usa.solo BizkaiaSpain Depa.tment of Ca.diology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Depa.tment of Ca.diology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medica. Center La.Ca.illita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Depa.tment of Ca.diology Hospital Arnau de VilanovaValenciaSpain Depa.tment of Ca.-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Depa.tment of Ha.ma.ology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Depa.tment of Medica. a.fa.rs Bayer HispaniaBarcelonaSpain Depa.tment of Biochemistry a.d Molecula. Biology-A University of MurciaMurciaSpain

Objectives To a.a.yze the clinica. profile,a.equa.y of trea.ment with riva.oxa.a. a.d outcomes in octogena.ia.s with a.ria.(a.),ta.ing riva.oxa.a. in clinica. *** Out of 1433 pa.ients,453(31.6%)were octogena.ia.s a. *** to younger pa.ients,octogena.ia.s ha. more comorbidities,higher CHa.DS2-Va.c(4.5±1.3vs.3.0±1.4;Pa.d Ha.-BLED scores(2.0±1.0vs.1.4±1.0;Pa.l,the dose of riva.oxa.a. wa. a.equa.ely prescribed in 83.4%of pa.ients,but more frequently in the younger popula.ion(71.1%vs.89.1%;P=0.039).a.ter a.mea. follow-up of 2.2±0.6 yea.s,a.nua. ra.es of stroke+systemic embolism+tra.sient ische-mic a.ta.k,Ma.E,ca.diova.cula. dea.h a.d ma.or bleeding were 1.03%,1.24%,1.03%a.d 1.75%,respectively,in octogena.ia. *** for progressive hea.t fa.lure dea.h a.d ma.or bleeding,ra.es of outcomes in octogena.ia.s were simila. com-pa.ed to younger *** octogena.ia.s,the concomita.t use of a.tipla.elet a.ents a.d non-severe dementia.were independ-ently a.socia.ed with the development of ischemic stroke,wherea. previous corona.y reva.cula.iza.ion a.d hea.t fa.lure with a.d higher Ha.-BLED score with ma.or ***,Conclusions In clinica. pra.tice,a.ound one third of pa.ients ta.ing riva.oxa.a. a.e *** pa.ients ha.e ma.y comorbidities a.d a.high thromboembolic *** tha.,ra.es of a.verse events rema.n *** is a.equa.ely pre-scribed in the ma.ority of octogena.ia.s.

关键词： pa.ients a.ria. bleeding