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Infla.ma.ory ma.kers,oxida.ive stress,a.d mitochondria. dyna.ics:Repercussions on corona.y a.tery disea.e in dia.etes

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World Journa. of Dia.etes 2024年第9期15卷 1853-1857页

作者： Josécarlos Ta.ma.su-Rocha.Lua. santos Mendes-Costa College of Medicine Postgraduate Program in Physiotherapy and FunctionalityFederal University of Ceará-UFCFortaleza 60430-450CearáBrazil Physica. Thera.y Federal University of CearáFortaleza 60000-000CearáBrazil

Infla.ma.ory ma.kers a.d media.ors tha. a.fect the development of ca.diova.cula. disea.es ha.e been the focus of recent scientific ***,the purpose of this editoria. is to promote a.critica. deba.e a.out the a.ticle titled“Nε-ca.boxymethyl-lysine a.d infla.ma.ory cytokines,ma.kers,a.d media.ors of corona.y a.tery disea.e progression in dia.etes”,published in the World Journa. of Dia.etes in *** work directs us to reflect on the role of a.va.ced glyca.ion end products,which a.e pro-infla.ma.ory products a.ising from the meta.olism of fa.ty a.ids a.d suga.s whose ma.n ma.ker in tissues is Nε-ca.boxymethyllysine(NML).Recent studies ha.e linked high levels of pro-infla.ma.ory a.ents with the development of corona.y a.tery disea.e(Ca.),especia.ly tumor necrosis fa.tor a.pha.interleukins,a.d C-rea.tive *** infla.ma.ory a.ents increa.e the production of rea.tive oxygen species(ROS),of which people with dia.etes a.e known to ha.e a. increa.ed *** increa.e in ROS promotes lipid peroxida.ion,which ca.ses da.a.e to myocytes,promoting myoca.dia. ***,oxida.ive stress induces the binding of NML to its receptor Ra.E,which in turn a.tiva.es the nuclea. fa.tor-kB,a.d consequently,infla.ma.ory *** infla.ma.ory cytokines induce endothelia. dysfunction,with increa.ed expression of a.hesion molecules,cha.ges in endothelia. permea.ility a.d cha.ges in the expression of nitric *** this sense,the thera.eutic use of monoclona. a.tibodies(infla.ma.ory reducers such a. sta.ins a.d sodium-glucose tra.sport inhibitors)ha. demonstra.ed positive results in the regression of a.herogenic pla.ues a.d consequently *** the other ha.d,ma.y studies ha.e demonstra.ed a.rela.ionship between mitochondria. dyna.ics,dia.etes,a.d ca.diova.cula. *** link occurs since ROS ha.e their origin in the imba.a.ce in glucose meta.olism tha. occurs in the mitochondria. ma.rix,a.d this imba.a.ce ca. ha.e its origin in ina.equa.e diet a. well a.

关键词： Mitochondria. dyna.ics Dia.etes Oxida.ive stress Corona.y a.tery disea.e Nε-ca.boxymethyl-lysine

Eleva.ion tra.sition of a.ua.ic insects closely ma.ches a.therma. fea.ure in the Yunga. of Northwestern a.gentina

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Journa. of Mounta.n Science 2024年第2期21卷 433-448页

作者： a.exa.dra.BUITRa.O-GUa.a.a.E carlos MOLINERI a.drés LIRa.NORIEGa.Da.iel a.drés DOS santos Neotropica. Biodiversity Institute(CONICET-UNT) UNT-DomesHorco Molle S/N4107 TucumánArgentina CONa.YT Resea.ch Fellow Network of Advanced Molecular StudiesInstitute of Ecology A.COld Road to Coatepec 351El HayaCP 91073XalapaVeracruzMexico Biosta.istics Cha.r Faculty of Natural Sciences and IMLNational University of TucumánSan Miguel de TucumánMiguel Lillo 2054000 TucumánArgentina

Tempera.ure is a.key fa.tor tha. sha.es the distribution of *** knowledge a.out how species respond to tempera.ure is releva.t to devise stra.egies for a.dressing the impa.ts of clima.e *** insects a.e pa.ticula.ly vulnera.le to clima.e cha.ge,yet there is still much to lea.n a.out their ecology a.d *** the Yunga. ecoregion of Northwestern a.gentina.cold-a.d wa.m-a.a.ted species of the orders Ephemeroptera.Plecoptera.a.d Trichoptera.EPT)a.e segrega.ed by *** modeled the ecologica. niche of South a.erica. EPT species in this region using a.a.la.le da.a.a.d projected their potentia. distribution in geogra.hic *** were grouped ba.ed on their ecogeogra.hic simila.ity,a.d we a.a.yzed their repla.ement pa.tern a.ong eleva.ion gra.ients,focusing on the ecotone where opposing therma. preferences *** this interfa.e,we identified critica. points where the combined incidence of cold a.d wa.m a.sembla.es ma.imizes,indica.ing a.significa.t tra.sition *** found tha. the Monta.e Cloud Forest holds the interfa.e,with a.pa.ticula.ly grea.er suita.ility a. its lower *** ma.n a.is of the interfa.e runs in a.N-S direction a.d fa.ls between 14°C-16°C mea. a.nua. *** proba.ility of a.pa.ticula. loca.ion within a.ba.in being cla.sified a. pa.t of the interfa.e increa.es a. Kira.s wa.mth index a.proa.hes a.score a.ound *** the interfa.e is critica. for defining the therma. limits of species distribution a.d designing biomonitoring *** in the loca.ion of therma. consta.ts rela.ed to mounta.nous ecotones ma. ca.se vertica. displa.ement of a.ua.ic insects a.d vegeta.ion *** ha.e recognized significa.t tempera.ure thresholds tha. serve a. indica.ors of suita.ility for the *** globa. wa.ming is a.ticipa.ed to shift these indica.ors,we suggest using them to monitor the imprints of clima.e cha.ge on mounta.n ecosystems.

关键词： a.stra. Yunga. Ecologica. Niche Model Ephemeroptera Kira.s wa.mth index Plecoptera Trichoptera

Towa.ds a. integra.ed risk a.a.ysis security fra.ework a.cording to a.systema.ic a.a.ysis of existing proposa.s

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Frontiers of Computer Science 2024年第3期18卷 199-216页

作者： a.tonio santos-OLMO Luis Enrique SÁNCHEZ Da.id G.ROSa.O Ma.uel a.SERRa.O carlos BLa.CO Ha.a.a.bos MOURa.IDIS Edua.do FERNÁNDEZ-MEDINA GSya.Resea.ch Group University of Castilla-La ManchaCiudad Real 13071Spain Institute for a.a.ytics a.d Da.a.Science University of EssexColchester CO43SQUK a.a.cos Resea.ch Group University of Castilla-La ManchaCiudad Real 13071Spain ISTR Resea.ch group Department of Computer Science and ElectronicsUniversity of CantabriaSantander 39005Spain

The informa.ion society depends increa.ingly on risk a.sessment a.d ma.a.ement systems a. mea.s to a.equa.ely protect its key informa.ion *** a.a.la.ility of these systems is now vita. for the protection a.d evolution of ***,severa. fa.tors ha.e led to a. increa.ing need for more a.cura.e risk a.a.ysis *** a.e:the speed a. which technologies evolve,their globa. impa.t a.d the growing requirement for compa.ies to *** a.a.ysis processes must consequently a.a.t to these new circumsta.ces a.d new technologica. *** objective of this pa.er is,therefore,to present the results of a. exha.stive a.a.ysis of the techniques a.d methods offered by the scientific community with the a.m of identifying their ma.n wea.nesses a.d providing a.new risk a.sessment a.d ma.a.ement *** a.a.ysis wa. ca.ried out using the systema.ic review protocol a.d found tha. these proposa.s do not fully meet these new *** pa.er a.so presents a.summa.y of Ma.ISMa.the risk a.a.ysis a.d ma.a.ement fra.ework designed by our resea.ch *** ba.is of our fra.ework is the ma.n existing risk sta.da.ds a.d proposa.s,a.d it seeks to a.dress the wea.nesses found in these *** is in a.process of continuous improvement,a. is being a.plied by customers in severa. Europea. a.d a.erica. *** consists of a.risk da.a.ma.a.ement module,a.methodology for its systema.ic a.plica.ion a.d a.tool tha. a.toma.es the process.

关键词： informa.ion security ma.a.ement security system security risk a.sessment a.d ma.a.ement

a.temisia.vulga.is Induces Tumor-Selective Ferroptosis a.d Necroptosis via.Lysosoma. Ca.(2+) Signa.ing

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Chinese Journa. of Integra.ive Medicine 2024年第6期30卷 525-533页

作者： Luca. dos santos Za.a.ioli Michele Rosa.a.Ma.a.santos a.olfo Ga.cia.Erustes Va.essa.Ma.ques Mecca.ti Tha.s Cristine Pereira.Sora.a.S Sma.li Ma.ia.Cristina.Ma.cucci carlos Rocha.Oliveira.Gusta.o JS Pereira.Cla.dia.Bincoletto Depa.tment of Pha.ma.ology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Resea.ch Group on Phytocomplexes a.d Cell Signa.ing School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Depa.tment of Biosciences a.d Ora. Dia.nosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To eva.ua.e the chemica. composition a.d effects of a.temisia.vulga.is(a.)hydroa.coholic extra.t(HEa.)on brea.t ca.cer cells(MCF-7 a.d SKBR-3),chronic myeloid leukemia.K562)a.d NIH/3T3 *** Phytochemica. a.a.ysis of HEa. wa. done by high-performa.ce liquid chroma.ogra.hy-ma.s(HPLC)*** a.d cell dea.h studies were performed using trypa. blue a.d a.nexin/FITC-7a.D,***-1(Fer-1)a.d necrosta.in-1(Nec-1)were used to a.sess the mode of HEa.-induced cell dea.h a.d a.etoxymethylester(Ba.Ta.a.)wa. used to verify the involvement of cytosolic ca.cium in this *** ca.cium mea.urements were ma.e using *** HEa. decrea.ed the via.ility of MCF-7,SKBR-3 a.d K562 cells(Pa.ility of HEa.-trea.ed K562 cells wa. reduced compa.ed to HEa.-exposed fibrobla.ts(Pa.ment of K562 cells with HEa. induced cell dea.h prima.ily by la.e a.optosis a.d necrosis in a.sa.s using a.nexin V-FITC/7-a.D(Pa.d Fer-1 increa.ed the via.ility of K562 cells trea.ed with HEa. rela.ive to cells exposed to HEa. a.one(Pa.-induced Ca.(2+)relea.e ma.nly from lysosomes in K562 cells(Pa.Ta.a.,a. intra.ellula. Ca.(2+)chela.or,decrea.ed the number of non-via.le cells trea.ed with HEa.(Pa. is cytotoxic a.d a.tiva.es severa. moda.ities of cell dea.h,which a.e pa.tia.ly dependent on lysosoma. relea.e of Ca.(2+).These effects ma. be rela.ed to a.temisinin a.d ca.feoylquinic a.ids,the ma.n compounds identified in HEa..

关键词： a.temisia.vulga.is necroptosis ferroptosis la.e a.optosis Ca.(2+)signa.ing

Is ma.nesium deficiency the ma.or ca.se of needle chlorosis of Pinus ta.da.in Bra.il?

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Journa. of Forestry Resea.ch 2024年第2期35卷 209-221页

作者： a.tônio carlos Va.ga. Motta.Shizuo Ma.da.Va.décio dos santos dos santos Rodrigues Ta.ires Ma.a.a.Ercole Stephen a.thur Prior a.a.Elisa.Lyra.Bruma. a.a.da.Pa.heco Ca.doso Moura.Julierme Zimmer Ba.bosa.João Bosco Va.concellos Gomes Depa.tment of Soil Sciences a.d a.riculture Engineering Federal University of ParanáR.dos Funcionários1540.CuritibaParanáCEP 80035‑050Brazil Bra.ilia. a.ricultura. Resea.ch Compa.y Embrapa FlorestasEstr.da Ribeira–Br‑476Km 111–Parque Monte Castelo.ColomboParanáCEP 83411‑000Brazil United Sta.es Depa.tment of a.riculture‑a.ricultura. Resea.ch Service USDA-ARS National Soil Dynamics Laboratory411 South Donahue DriveAuburnAL 36832USA Reforesta.ion Rema.a Rodovia PR 170–Km 522.BiturunaParanáCEP 84640‑000Brazil Federa. Institute of Southea.t of Mina. Gera.s R.Luz Interior360.Juiz de ForaMinas Gerais CEP 36030‑713Brazil

Needle chlorosis(NC)in Pinus ta.da.*** in Bra.il becomes more frequent a.ter second a.d third ha.vest rota.ion *** a.study to identify fa.tors contributing to yellowing needle chorosis(YNC),trees were grown in soils origina.ing from contra.ting pa.ent ma.eria.s,a.d soils a.d needles(whole,green a.d chlorotic portions)from 1-a.d 2-yea.-old bra.ches a.d the first a.d second needle flush relea.e a. four sites with YNC on *** were a.a.yzed for va.ious elements a.d *** soils ha. very low ba.e levels(Ca.(2+),Mg^(2+)a.d K^(+))a.d P,suggesting a.possible la.k of multiple *** symptoms sta.ted a. needle tips,then extended towa.d the needle ba.e with *** flush needles ha. longer portions with YNC tha. second flush needles *** from the lower crown a.so ha. more symptoms a.ong their length tha. those higher in the *** were simila. to those reported for *** chlorotic portions,Mg a.d Ca.concentra.ions were well below critica. va.ues;in pa.ticula.,Mg levels were only one third of the critica. va.ue of 0.3 g kg^(-1).Collectively,results suggest tha. Mg deficiency is the prima.y rea.on for NC of *** in va.ious pa.ent soils in Bra.il.

关键词： Nutritiona. deficiency Forest ma.a.ement Soil depletion Pine folia. a.a.ysis Needle chlorosis

Complexed a.ino a.id minera.s ***-glycina.e chela.ed minera.s:Impa.t on the performa.ce of old la.ing hens

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a.ima. Nutrition 2024年第1期16卷 395-408页

作者： Ma.cos J.B.santos Ma.ia.C.M.M.Ludke Lea.dro M.Silva.carlos B.V.Ra.ello Mércia.R.Ba.ros Fa.ia.o S.Costa.Cla.ia.a.S.santos Ja.ille S.S.Wa.derley Depa.tment of a.ima. Science Rural Federal University of PernambucoRecifePEBrazil Depa.tment of Veterina.y Science Rural Federal University of PernambucoRecifePEBrazil

The present study wa. to eva.ua.e the effect of tra.e minera.s(Zn,Mn,a.d Cu)from complexed a.ino a.id minera.s(ZMCa.)a.d bis-glycina.e chela.ed minera.s(ZMCGly)in la.ing hen diets on performa.ce,interna. a.d externa. egg qua.ity,yolk minera. deposition,intestina. morphometry,a.d bone *** 78 to 98 weeks of a.e,400 White LSL-Lite stra.n la.ing hens were distributed in a.ra.domized design with 4 trea.ments with 10 replica.es per *** were distributed in a.2×2 fa.toria. a.ra.gement using either Zn,Mn,a.d Cu of ZMCa. or ZMCGly source a. 2 levels:low(20,20,a.d 3.5 mg/kg of Zn,Mn,a.d Cu,respectively)or high(40,40,a.d 7 mg/kg of Zn,Mn,a.d Cu,respectively).The a.a.ysis of va.ia.ce wa. performed,a.d in ca.es where differences were observed,the mea.s were compa.ed using Tukey?s test(Pa.d level of tra.e minera. supplementa.ion ha. a.significa.t impa.t on the performa.ce of la.ing *** fed ZMCa. ha. higher egg production(P=0.01),egg weight(P=0.02),egg ma.s(P=0.01),a.d lower feed conversion ra.io(P=0.05)compa.ed to those fed *** ZMCa. supplementa.ion showed higher a.bumen height(P=0.01),a.bumen weight(P=0.01),a.d eggshell thickness(Pa.d Cu(Pa. grea.er for hens received *** weight(P=0.04)a.d bone densitometry(Pa.were higher with ZMCa. *** the sma.l intestine,ZMCa. resulted in longer villi(P=0.02)a.d shorter crypt depth(P=0.01)in the *** a.d ileum mea.urements were influenced by the level a.d source of tra.e minera.s(Pa.ing hens fed ZMCa. exhibited superior performa.ce,egg qua.ity,deposition of tra.e minera.s in the egg yolk,a.d bone density compa.ed to hens fed *** this study,older la.ing hens supplemented with ZMCa. a. lower levels demonstra.ed a.equa.e levels of supplementa.ion.

关键词： Bis-glycina.es Meta.-a.ino a.ids Ra.iodensity Tra.e minera.s

Liquid crysta. immunosensors for the selective detection of Escherichia.coli with a.fa.t a.a.ysis tool

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Photonics Resea.ch 2024年第7期12卷 1564-1573页

作者： Sa.DRO C.OLIVEIRa.Ma.Ia.S.SOa.ES BÁRBa.a.V.GONÇa.VES a.DREIa.C.M.RODRIGUES a.a.EU M.V.M.SOa.ES RITa.G.SOBRa. NUNO F.santos Ja. NEDOMa.PEDRO L.a.MEIDa.carlos Ma.QUES CICECO-a.eiro Institute of Ma.eria.s Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal i3N Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal a.socia.e La.ora.ory i4HB-Institute for Hea.th a.d Bioeconomy School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal CESa.-Centre for Environmenta. a.d Ma.ine Studies a.d Depa.tment of Biology University of Aveiro3810-193 AveiroPortugal Depa.tment of Telecommunica.ions VSB-Technical University of OstravaOstrava 70800Czech Republic i3N-CENIMa. School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal UnIRE ISELPolytechnic Institute of Lisbon1549-020 LisbonPortugal Depa.tment of Physics VSB-Technical University of OstravaOstrava 70800Czech Republic

The consumption of conta.ina.ed food ma. ca.se serious illnesses,a.d tra.itiona. methods to detect Escherichia.coli a.e still a.socia.ed with long wa.ting times a.d high costs given the necessity to tra.sport sa.ples to specia.ized *** is a.need to develop new technologies tha. a.low chea.,fa.t,a.d direct monitoring a. the site of ***,in this work,we developed optica. immunosensors for the selective detection of ***,ba.ed on liquid crysta. technology,whose molecules ca. a.ign in different ma.ners depending on the bounda.y conditions (such a. substra.es) a. well a. the environment tha. they *** gla.s substra.e wa. functiona.ized with *** a.tibody using cystea.ine a. a. intermedia.e,a.d a.vertica. a.ignment wa. imposed on the liquid crysta. molecules by using DMOa. during *** presence of ba.teria.disrupts the a.ignment of the liquid crysta. molecules,cha.ging the intensity of light emerging between cross pola.izers,mea.ured using a.pola.ized optica. microscope a.d a.*** wa. possible to detect *** in suspensions in the concentra.ion ra.ge from 2.8 cells/mL to 2.8×10^(9) cells∕*** wa. a.so eva.ua.ed,a.d the sensors were used to a.a.yze conta.ina.ed wa.er sa.ples.a.prototype wa. developed to a.low fa.ter,in-situ,a.d ea.ier a.a.ysis a.oiding bulky instruments.

关键词： crysta. a.ignment a.a.ysis

Unveiling the silent crisis:globa. burden of suicide‑rela.ed dea.hs a.ong children a.ed 10–14 yea.s

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World Journa. of Pedia.rics 2024年第4期20卷 371-391页

作者： Irmina.Ma.ia.Micha.ek Pa.el Koczkoda. Ma.zena.Micha.ek Florentino Lucia.o Ca.ta.o dos santos Depa.tment of Ca.cer Epidemiology a.d Prima.y Prevention Maria Sklodowska-Curie National Research Institute of Oncologyul.Wawelska 15 BWarsawPoland Priva.e Psychia.ric Pra.tice-Ma.zena.Micha.ek MDSiedlcePoland Ha.va.d Business School Harvard UniversityBostonMAUSA

Ba.kground The rise in suicides a.ong children a.ed 10–14 yea.s dema.ds urgent a.tention *** study a.ms to a.sess the globa. burden of suicide-rela.ed dea.hs in this a.e group from 1990 to 2019,considering fa.tors such a. sex,geogra.hy,a.d sociodemogra.hics,to inform prevention stra.egies a.d *** The da.a.from Globa. Burden of Disea.e 2019,encompa.sing 204 countries a.d territories,were a.a.yzed to investiga.e dea.hs a.d yea.s of life lost(YLLs)due to suicide a.ong children a.ed 10–14 *** a.a.yses,including morta.ity ra.es,YLLs,a.d the sociodemogra.hic index(SDI),were conducted using sta.da.dized *** In 2019,a.tota. of 8327[95%uncerta.nty interva.(UI)=7073–9685]children a.ed 10–14 yea.s died globa.ly due to suicide,with a.morta.ity ra.e of 1.30(95%UI=1.10–1.51)per 100,*** ra.es va.ied a.ross countries/territories ra.ging between 0.05(95%UI=0.02–0.10)in South a.rica.a.d 7.49(95%UI=5.13–10.57)in *** contribution of suicide-rela.ed dea.hs to a.l-ca.se morta.ity ra.ged from 0.07%(95%UI=0.04%–0.15%)in South a.rica.to 33.02%(95%UI=24.36%–41.53%)in ***,there were a.proxima.ely 636,196(95%UI=540,383–740,009)YLLs due to suicide,with a.ra.e of 99.07(95%UI=84.15–115.23)per 100,*** a.socia.ion between SDI a.d suicide-rela.ed dea.hs wa. evident,with higher contributions observed in countries with higher *** This study revea.s a.concerning globa. burden of suicide-rela.ed dea.hs a.ong children a.ed 10–14 *** progress in reducing morta.ity ra.es,suicide rema.ns a.significa.t *** overa.l ra.es ha.e declined,the percenta.e of dea.hs ca.sed by suicide in this a.e group is increa.ing.

关键词： Ea.ly a.olescent Globa. Burden of Disea.e Incidence Suicide Yea.s of life lost

Tempora. a.d spa.ia. differences in huma. a.tivities performed in Urba. Green Spa.es of Vilnius(Lithua.ia.

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Geogra.hy a.d Susta.na.ility 2024年第2期5卷 302-317页

作者： Luís Va.ença.Pinto Ca.la.Sofia.santos Ferreira.Pa.lo Pereira Resea.ch Centre for Na.ura. Resources Environment a.d Society(CERNa.) Polytechnic Institute of CoimbraBencanta3045-601 CoimbraPortugal Environmenta. Ma.a.ement La.ora.ory Mykolas Romeris UniversityVilniusLithuania Polytechnic Institute of Coimbra Applied Research InstituteRua da MisericórdiaLagar dos Cortiços-S.Martinho do Bispo3045-093 CoimbraPortugal

Urba. green spa.es(UGS)a.e releva.t to city well-being,a. recognized by the United Na.ions’Susta.na.le Development Goa.s(SDGs).However,few studies ha.e studied the tempora. use of *** work a.sessed the sea.ona.,weekly,a.d da.ly use of three urba. green spa.es(Vingis Pa.k,Berna.dino Ga.den,a.d Joma.ta. Pa.k)in Vilnius(Lithua.ia..The study is ba.ed on a. on-site observa.ion-ba.ed survey,which recorded users’cha.a.teristics,a.tivities,a.d wea.her conditions during summer a.d *** results showed tha. UGS’s sea.ona.,weekly,a.d da.ly use differed a.cording to pa.k a.d users’*** with a.higher diversity of fa.ilities ha. a.high sea.ona. difference in the number of observed *** numbers were higher in the summer for a.tivities with children,socia. a.tivities,sports,a.d wa.er a.tivities tha. in the *** Pa.k ha. the lowest va.ia.ility in user *** va.ia.les were linked to cha.ges in users’*** precipita.ion a.d lower tempera.ure were a.socia.ed with reducing the number of users a.d the diversity of registered *** of the sta.iona.y a.tivities were observed during *** diversity of the observed a.tivities wa. a.socia.ed with the a.a.la.le fa.ilities ra.her tha. the pa.k *** distribution of sta.iona.y a.tivities wa. spa.ia.ly correla.ed with fa.ility/equipment(benches,pla.grounds,sports,a.d fitness equipment)a.d proximity to wa.er *** results of this study a.e releva.t for UGS design,pla.ning,a.d ma.a.ement.

关键词： Urba. pa.ks Sea.ona. differences Tempora. use Time of da. Spa.ia. distribution of UGS users