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Occult hepatitis B virus and hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第20期20卷 5951-5961页

作者： Teresa Pollicino carlo Saitta Department of Pediatric Gynecologic Microbiological and Biomedical Sciences University Hospital of Messina 98124 Messina Italy Department of Clinical and Experimental Medicine University Hospital of Messina 98124 Messina Italy

Occult hepatitis B virus(HBV)infection(OBI)is a challenging pathobiological and clinical issue that has been widely debated for several *** definition,OBI is characterized by the persistence of HBV DNA in the liver tissue(and in some cases also in the serum)in the absence of circulating HBV surface antigen(HBsAg).Many epidemiological and molecular studies have indicated that OBI is an important risk factor for hepatocellular carcinoma(HCC)*** may exert direct pro-oncogenic effects through the activation of the same oncogenic mechanisms that are activated in the course of an HBsAg-positive ***,in OBI as in HBV-positive infection,HBV DNA can persist in the hepatocytes both integrated into the host genome as well as free episome,and may maintain the capacity to produce proteins-mainly X protein and truncated preS-S protein-provided with potential transforming ***,OBI may indirectly favor HCC *** has been shown that the persistence of very low viral replicative activity during OBI may induce mild liver necro-inflammation continuing for life,and substantial clinical evidence indicates that OBI canaccelerate the progression of liver disease towards cirrhosis that is considered the most important risk factor for HCC development.

关键词： Hepatitis B virus Hepatitis B virus surface antigen Hepatitis B virus DNA HBx protein Hepatocellular carcinoma Occult hepatitis B virus infection

Intensity-curvature functional based digital high pass filter of the bivariate cubic B-spline model polynomial function

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Visual Computing for Industry,Biomedicine,and Art 2019年第1期2卷 75-92页

作者： carlo Ciulla Grace Agyapong Faculty of Information Systems VisualizationMultimediaand AnimationUniversity of Information Science and TechnologySt.Paul the ApostlePartizanska B.B.Ohrid 6000Republic of North Macedonia Faculty of Communication Networks and Security University of Information Science and TechnologySt.Paul the ApostlePartizanska B.B.Ohrid 6000Republic of North Macedonia

This research addresses the design of intensity-curvature functional(ICF)based digital high pass filter(HPF).ICF is calculated from bivariate cubic B-spline model polynomial function and is called ICF-based *** order to calculate ICF,the model function needs to be second order differentiable and to have non-null classic-curvature calculated at the origin(0,0)of the pixel coordinate *** theoretical basis of this research is called intensitycurvature *** concept envisions to replace signal intensity with the product between signal intensity and sum of second order partial derivatives of the model *** of the concept in two-dimensions(2D)makes it possible to calculate the ICF of an *** treatise is presented to demonstrate the hypothesis that ICF is HPF *** evidence then validates the assumption and also extends the comparison between ICF-based HPF and ten different HPFs among which is traditional HPF and particle swarm optimization(PSO)based *** comparison of image space and k-space magnitude,results indicate that HPFs behave *** HPF filtering and ICF-based filtering are superior to PSO-based *** filtered with traditional HPF are sharper than images filtered with ICF-based *** contribution of this research can be summarized as follows:(1)Math description of the constraints that ICF need to obey to in order to function as HPF;(2)Math of ICF-based HPF of bivariate cubic B-spline;(3)Image space comparisons between HPFs;(4)K-space magnitude comparisons between *** research provides confirmation on the math procedure to use in order to design 2D HPF from a model bivariate polynomial function.

关键词： Intensity-curvature functional High pass filter B-spline Particle swarm optimization K-space

DZ Lyn:a contact binary with components in poor thermal contact

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Research in Astronomy and Astrophysics 2009年第11期9卷 1270-1276页

作者： Massimiliano Martignoni Francesco Acerbi carlo Barani Via Don G. Minzoni 26/D 20020 Magnago(MI)Italy Via Zoncada 51 26845 Codogno(LO)Italy Via Molinetto 35 26845 Triulza di Codogno(LO)Italy

CCD photometric observations of the short-period eclipsing binary DZ Lyn were obtained during seven nights in March-April 2008 in the B, V, Rc and Ic bands; these observations confirm the short-period （P = 0.378 d） of the system. The presented light curves are analyzed by means of the 2003 version of the Wilson-Devinney （WD） program. A grid of solutions for several fixed values of mass ratio was calculated. The best fitting possible is for a mass ratio of q -- 0.885, a degree of contact f = 0.18 and a low orbital inclination of i = 57.6°. The results show that DZ Lyn is an A-subtype W Ursae Majoris contact binary in poor thermal contact; in fact the difference between the mean temperatures of the components is about 1800 K. The star DZ Lyn seems to be another member of the class of poorly understood close binaries in or near geometrical contact but far from thermal contact. The absolute dimensions are estimated and its dynamical evolution is inferred.

关键词： binaries eclipsing -- stars fundamental parameters -- stars individual DZ Lyn

Modelling Strategy and Parametric Study of Metal Gaskets for Automotive Applications

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 51-64页

作者： Fabio Bruzzone Cristiana Delprete carlo Rosso Politecnico di Torino Corso Duca degli Abruzzi 24Torino10129Italy

This paper is focused on finite element simulation of cylinder head *** element codes support several methodologies,each of which has its own strengths and *** of the key points lies in the influence of the gasket geometry on its final *** a contribution can come from the detailed modelling of the gasket or by defining a global non-linear behaviour in which material and geometry non-linearities are *** approaches were used to simulate the gasket *** first one consists in using a 2D approach,which allows to model through-thickness non-linear behaviour of *** second one consists in using conventional 3D finite element *** numerical methods have been discussed and compared in relation to the accordance with experimental data,amount of information supplied and computational time ***,a parametric study shows how some geometric parameters influence the compressive load and the elastic recovery of a single-layer steel gasket.

关键词： Gaskets finite elements parametric study

BACE1 role in Alzheimer’s disease and other dementias:from the theory to the practice

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Neural Regeneration Research 2021年第12期16卷 2407-2408页

作者： carlo Cervellati Giuseppe Valacchi Giovanni Zuliani Department of Translational Medicine and for Romagna University of FerraraFerraraItaly Department of Biomedical and Specialist Surgical Sciences University of FerraraFerraraItalyPlants for Human Health InstituteAnimal Science DepartmentNC State UniversityKannapolisNCUSA

Beta-site amyloid precursor protein(APP)cleaving enzyme-1(BACE1):brief overview on the biology and its role in Alzheimer’s disease(AD)pathogenesis:AD is a multifactorial and multifaceted disease,with a complex and still not completely understood pathogenesis(Cervellati et al.,2016;Iturria-Medina et al.,2016).Multiple hypotheses have been proposed to explain the pathobiology of the disease.

关键词： BACE1 Alzheimer al.

OxInflammation in Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2709-2710页

作者： carlo Cervellati Giovanni Zuliani Giuseppe Valacchi Department of Translational Medicine and for Romagna University of FerraraFerraraItaly Department of Environmental Sciences and Prevention University of FerraraFerraraItaly Plants for Human Health Institute Animal Science DepartmentNC State UniversityKannapolisNCUSA Department of Food and Nutrition Kyung Hee UniversitySeoulSouth Korea

Oxlnflammation:definition and role in disease:Oxlnflammation has been introduced as a new term in the biomedical field to highlight the deep and mutual relationship between the dysregulation of redox and immune homeostasis(Valacchi et al.,2018).Regardless of which is the initial spark,inflammation cannot take place without a concomitant oxidative stress response and *** other words,they are sides of the same coin.

关键词： al. homeostasis inflammation

Why did life develop on the surface of the Earth in the Cambrian？

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Geoscience Frontiers 2016年第6期7卷 865-873页

作者： carlo Doglioni Johannes Pignatti Max Coleman Department of Earth Sciences Sapienza University 00185 Rome Italy NASA Jet Propulsion Laboratory California Institute of Technology Pasadena CA 91109 USA NASA Astrobiology Institute USA

Life was limited for most of Earth＇s history, remaining at a primitive stage and mostly marine until about 0.55 Ga. In the Paleozoic, life eventually exploded and colonized the continental realm. Why had there been such a long period of delayed evolution of life？ Early life was dominated by Archaea and Bacteria, which can survive ionizing radiation better than other organisms. The magnetic field preserves the atmosphere, which is the main shield of UV radiation. We explore the hypothesis that the Cambrian explosion of life could have been enabled by the increase of the magnetic field dipole intensity due to the solidification of the inner core, caused by the cooling of the Earth, and the concomitant decrease with time of the high-energy solar flux since the birth of the solar system. Therefore, the two phenomena could be responsible for the growth and thickening of the atmosphere and the development of land surface life.

关键词： Origin of lifeInner core solidificationSolar ionizing radiations

The promise of neuroprotection by dietary restriction in glaucoma

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Neural Regeneration Research 2022年第1期17卷 45-47页

作者： Rossella Russo carlo Nucci Annagrazia Adornetto Preclinical and Translational Pharmacology Department of PharmacyHealth and Nutritional SciencesUniversity of CalabriaRendeItaly Ophthalmology Unit Department of Experimental MedicineUniversity of Rome Tor VergataRomeItaly

Glaucoma,a progressive age-related optic neuropathy characterized by the death of retinal ganglion cells,is the most common neurodegenerative cause of irreversible blindness *** therapeutic management of glaucoma,which is limited to lowering intraocular pressure,is still a challenge since visual loss progresses in a significant percentage of treated *** dietary regimens have received considerable attention as adjuvant strategy for attenuating or delaying the progression of neurodegenerative *** we discuss the literature exploring the effects of modified eating patterns on retinal aging and resistance to stressor stimuli.

关键词： aging caloric restriction fasting glaucoma neurodegeneration retina retinal ganglion cells

From the Far Side of the Moon: Delay/DisruptionTolerant Networking Communications via Lunar Satellites

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China Communications 2013年第10期10卷 12-25页

作者： Pietrofrancesco Apollonio carlo Caini Vincenzo Fiore Department of Electrical Electronics and Information Engineering "Guglielmo Marconi" University of Bologna

Delay/Disruption-Tolerant Networking(DTN) originated from research on Interplanetary Internet and still today space applications are the most important application field and research stimulus. This paper investigates DTN communications between the Earth and the far side of the Moon, by means of a lunar orbiter acting as relay. After an introductory part, the paper presents a comprehensive analysis of the DTN performance that can be achieved on the identified communication scenario. The focus is on the evaluation of the stateof-the-art ability of Interplanetary Overlay Network(ION), the NASA DTN implementation of Bundle Protocol(BP) and Contact Graph Routing(CGR), to meet the many challenges of the space communication scenario investigated(and more generally of a future interplaynetary Internet): intermittent links, network partitioning, scarce bandwidth, long delays, dynamic routing, handling of high priority and emergency traffic, interoperability issues. A study of security threats and Bundle Security Protocol(BSP) countermeasures complete the *** many results provided, confirm the essential role of DTN in future space communications.

关键词： DTN Earth to Moon communications interplanetary Interact satellite communications space communications