Occult hepatitis B virus and hepatocellular carcinoma
Occult hepatitis B virus and hepatocellular carcinoma作者机构：Department of Pediatric Gynecologic Microbiological and Biomedical Sciences University Hospital of Messina 98124 Messina Italy Department of Clinical and Experimental Medicine University Hospital of Messina 98124 Messina Italy
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第20期
页 面：5951-5961页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Hepatitis B virus Hepatitis B virus surface antigen Hepatitis B virus DNA HBx protein Hepatocellular carcinoma Occult hepatitis B virus infection
摘 要：Occult hepatitis B virus(HBV)infection(OBI)is a challenging pathobiological and clinical issue that has been widely debated for several *** definition,OBI is characterized by the persistence of HBV DNA in the liver tissue(and in some cases also in the serum)in the absence of circulating HBV surface antigen(HBsAg).Many epidemiological and molecular studies have indicated that OBI is an important risk factor for hepatocellular carcinoma(HCC)*** may exert direct pro-oncogenic effects through the activation of the same oncogenic mechanisms that are activated in the course of an HBsAg-positive ***,in OBI as in HBV-positive infection,HBV DNA can persist in the hepatocytes both integrated into the host genome as well as free episome,and may maintain the capacity to produce proteins-mainly X protein and truncated preS-S protein-provided with potential transforming ***,OBI may indirectly favor HCC *** has been shown that the persistence of very low viral replicative activity during OBI may induce mild liver necro-inflammation continuing for life,and substantial clinical evidence indicates that OBI canaccelerate the progression of liver disease towards cirrhosis that is considered the most important risk factor for HCC development.
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