检索结果-南通市图书馆

Hepatitis C virus and diffuse large B-cell lymphoma: Pathogenesis, behavior and treatment

World Journal of Gastroenterology 2014年第32期20卷 11054-11061页

作者： carlo Visco Silvia Finotto Department of Hematology and Cell Therapy San Bortolo Hospital

A significant association between hepatitis C virus (HCV) infection and B-cell lymphoma has been reported by epidemiological studies, most of them describing a strong relationship between indolent lymphomas and HCV. Furthermore, the curative potential of antiviral therapy on HCV related indolent lymphomas supports a specific role for the virus in lymphomagenesis. These observations are reinforced by numerous laboratory experiments that led to several hypothetical models of B-cell transformation by HCV. Diffuse large B-cell lymphoma (DLBCL), the most common lymphoma subtype in the western countries, has been associated to HCV infection despite its aggressive nature. This association seems particularly prominent in some geographical areas. Clinical presentation of HCV-associated DLBCL has consistently been reported to differ from the HCV-negative counterpart. Nevertheless, histopathology, tolerance to standard-of-care chemo-immunotherapy (R-CHOP or CHOP-like regimens) and final outcome of HCV-positive DLBCL patients is still matter of debate. Addition of rituximab has been described to enhance viral replication but the probability of severe hepatic complications remains low, with some exceptions (i.e., hepatitis B virus or immune immunodeficiency virus co-infected patients, presence of grade > 2 transaminases elevation, cirrhosis or hepatocarcinoma). HCV viral load in this setting is not necessarily directly associated with liver damage. Overall, treatment of HCV associated DLBCL should be performed in an interdisciplinary approach with hepatologists and hematologists with close monitoring of liver function. Available reports reveal that the final outcome of HCV-positive DLBCL that receive standard immunochemotherapy is not inferior to their HCV-negative counterpart. This review summarizes data on epidemiology, pathogenesis and therapeutic approach on HCV-associated DLBCL. Several issues that are matter of debate like clinical management of patients with trans

关键词： Hepatitis C virus Non-Hodgkin lymphoma Liver Toxicity Diffuse large B-cell lymphoma Rituximab Cyclophosphamide Hydroxydaunorubicin Vincristine Prednisolone Immuno-chemotherapy Antiviral treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Editorial Note on the 10-Year Anniversary of the International Journal of Disaster Risk Science:A Thank You Letter

引用

International Journal of Disaster Risk Science 2020年第4期11卷 411-413页

作者： Peijun Shi carlo Jaeger Academy of Disaster Reduction and Emergency Management Ministry of Emergency Management and Ministry of EducationFaculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Global Climate Forum 10178 BerlinGermany

This year marks the 10-year anniversary of the International Journal of Disaster Risk Science(IJDRS).On this occasion,as Editors-in-Chief,we are deeply grateful for the support and contribution of many who have enable... 详细信息

关键词： journal contributing deeply

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Occult hepatitis B virus and hepatocellular carcinoma

引用

World Journal of Gastroenterology 2014年第20期20卷 5951-5961页

作者： Teresa Pollicino carlo Saitta Department of Pediatric Gynecologic Microbiological and Biomedical Sciences University Hospital of Messina 98124 Messina Italy Department of Clinical and Experimental Medicine University Hospital of Messina 98124 Messina Italy

Occult hepatitis B virus(HBV)infection(OBI)is a challenging pathobiological and clinical issue that has been widely debated for several *** definition,OBI is characterized by the persistence of HBV DNA in the liver tissue(and in some cases also in the serum)in the absence of circulating HBV surface antigen(HBsAg).Many epidemiological and molecular studies have indicated that OBI is an important risk factor for hepatocellular carcinoma(HCC)*** may exert direct pro-oncogenic effects through the activation of the same oncogenic mechanisms that are activated in the course of an HBsAg-positive ***,in OBI as in HBV-positive infection,HBV DNA can persist in the hepatocytes both integrated into the host genome as well as free episome,and may maintain the capacity to produce proteins-mainly X protein and truncated preS-S protein-provided with potential transforming ***,OBI may indirectly favor HCC *** has been shown that the persistence of very low viral replicative activity during OBI may induce mild liver necro-inflammation continuing for life,and substantial clinical evidence indicates that OBI canaccelerate the progression of liver disease towards cirrhosis that is considered the most important risk factor for HCC development.

关键词： Hepatitis B virus Hepatitis B virus surface antigen Hepatitis B virus DNA HBx protein Hepatocellular carcinoma Occult hepatitis B virus infection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modeling the antigen recognition by B-cell and T-cell receptors through thermostatted kinetic theory methods

引用

International Journal of Biomathematics 2017年第5期10卷 263-299页

作者： carlo Bianca Louis Brezin Laboratoire de Recherche en Eco-innovation Industrielle el Energetique ECAM-EPMI 13 Boulevard de l'Hautil 95092 Cergy Pontoise Cedex France Laboratoire de Physique Statistique Ecole Normale Supdrieure PSL Research University Universite Paris Diderot Sorbonne Paris-Cite Sorbonne Universites UPMC Univ Paris 06 CNRS 24 rue Lhomond 75005 Paris France Institut Universitaire de Cancdrologie Facultg de Medecine Universite Pierre et Marie Curie-Paris 6 91 Bd de l'Hopital 75013 Paris France

The activation and the resulting response of the immune system to antigens comprise different complex processes and cells. This paper aims at modeling the processes of recognition and learning of the immune system by means of the thermostatted kinetic theory methods. Specifically, the thermostatted kinetic framework is firstly generalized for taking into account that in some processes of proliferation of the cells, the rate is also function of the degree of information exchanged amongst cells. In particular, within the new framework, a mathematical model is proposed for miming the recognition process of the immune system through the definition of interactions between the cytoto^ic and humoral components of the adaptive immune system via T- and B-cells. The model validation is obtained by performing a sensitivity analysis on the parameters which depicts the main emerging phenomena and the different phases of the recognition and learning of the immune system.

关键词： Thermostatted kinetic theory integro-differential models learning and memory biological complexity immune system.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intensity-curvature functional based digital high pass filter of the bivariate cubic B-spline model polynomial function

引用

Visual Computing for Industry,Biomedicine,and Art 2019年第1期2卷 75-92页

作者： carlo Ciulla Grace Agyapong Faculty of Information Systems VisualizationMultimediaand AnimationUniversity of Information Science and TechnologySt.Paul the ApostlePartizanska B.B.Ohrid 6000Republic of North Macedonia Faculty of Communication Networks and Security University of Information Science and TechnologySt.Paul the ApostlePartizanska B.B.Ohrid 6000Republic of North Macedonia

This research addresses the design of intensity-curvature functional(ICF)based digital high pass filter(HPF).ICF is calculated from bivariate cubic B-spline model polynomial function and is called ICF-based *** order to calculate ICF,the model function needs to be second order differentiable and to have non-null classic-curvature calculated at the origin(0,0)of the pixel coordinate *** theoretical basis of this research is called intensitycurvature *** concept envisions to replace signal intensity with the product between signal intensity and sum of second order partial derivatives of the model *** of the concept in two-dimensions(2D)makes it possible to calculate the ICF of an *** treatise is presented to demonstrate the hypothesis that ICF is HPF *** evidence then validates the assumption and also extends the comparison between ICF-based HPF and ten different HPFs among which is traditional HPF and particle swarm optimization(PSO)based *** comparison of image space and k-space magnitude,results indicate that HPFs behave *** HPF filtering and ICF-based filtering are superior to PSO-based *** filtered with traditional HPF are sharper than images filtered with ICF-based *** contribution of this research can be summarized as follows:(1)Math description of the constraints that ICF need to obey to in order to function as HPF;(2)Math of ICF-based HPF of bivariate cubic B-spline;(3)Image space comparisons between HPFs;(4)K-space magnitude comparisons between *** research provides confirmation on the math procedure to use in order to design 2D HPF from a model bivariate polynomial function.

关键词： Intensity-curvature functional High pass filter B-spline Particle swarm optimization K-space

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

DZ Lyn:a contact binary with components in poor thermal contact

引用

Research in Astronomy and Astrophysics 2009年第11期9卷 1270-1276页

作者： Massimiliano Martignoni Francesco Acerbi carlo Barani Via Don G. Minzoni 26/D 20020 Magnago(MI)Italy Via Zoncada 51 26845 Codogno(LO)Italy Via Molinetto 35 26845 Triulza di Codogno(LO)Italy

CCD photometric observations of the short-period eclipsing binary DZ Lyn were obtained during seven nights in March-April 2008 in the B, V, Rc and Ic bands; these observations confirm the short-period （P = 0.378 d） of the system. The presented light curves are analyzed by means of the 2003 version of the Wilson-Devinney （WD） program. A grid of solutions for several fixed values of mass ratio was calculated. The best fitting possible is for a mass ratio of q -- 0.885, a degree of contact f = 0.18 and a low orbital inclination of i = 57.6°. The results show that DZ Lyn is an A-subtype W Ursae Majoris contact binary in poor thermal contact; in fact the difference between the mean temperatures of the components is about 1800 K. The star DZ Lyn seems to be another member of the class of poorly understood close binaries in or near geometrical contact but far from thermal contact. The absolute dimensions are estimated and its dynamical evolution is inferred.

关键词： binaries eclipsing -- stars fundamental parameters -- stars individual DZ Lyn

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

BACE1 role in Alzheimer’s disease and other dementias:from the theory to the practice

引用

Neural Regeneration Research 2021年第12期16卷 2407-2408页

作者： carlo Cervellati Giuseppe Valacchi Giovanni Zuliani Department of Translational Medicine and for Romagna University of FerraraFerraraItaly Department of Biomedical and Specialist Surgical Sciences University of FerraraFerraraItalyPlants for Human Health InstituteAnimal Science DepartmentNC State UniversityKannapolisNCUSA

Beta-site amyloid precursor protein(APP)cleaving enzyme-1(BACE1):brief overview on the biology and its role in Alzheimer’s disease(AD)pathogenesis:AD is a multifactorial and multifaceted disease,with a complex and still not completely understood pathogenesis(Cervellati et al.,2016;Iturria-Medina et al.,2016).Multiple hypotheses have been proposed to explain the pathobiology of the disease.

关键词： BACE1 Alzheimer al.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modelling Strategy and Parametric Study of Metal Gaskets for Automotive Applications

引用

Computer Modeling in Engineering & Sciences 2020年第10期125卷 51-64页

作者： Fabio Bruzzone Cristiana Delprete carlo Rosso Politecnico di Torino Corso Duca degli Abruzzi 24Torino10129Italy

This paper is focused on finite element simulation of cylinder head *** element codes support several methodologies,each of which has its own strengths and *** of the key points lies in the influence of the gasket geometry on its final *** a contribution can come from the detailed modelling of the gasket or by defining a global non-linear behaviour in which material and geometry non-linearities are *** approaches were used to simulate the gasket *** first one consists in using a 2D approach,which allows to model through-thickness non-linear behaviour of *** second one consists in using conventional 3D finite element *** numerical methods have been discussed and compared in relation to the accordance with experimental data,amount of information supplied and computational time ***,a parametric study shows how some geometric parameters influence the compressive load and the elastic recovery of a single-layer steel gasket.

关键词： Gaskets finite elements parametric study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

OxInflammation in Alzheimer's disease

引用

Neural Regeneration Research 2023年第12期18卷 2709-2710页

作者： carlo Cervellati Giovanni Zuliani Giuseppe Valacchi Department of Translational Medicine and for Romagna University of FerraraFerraraItaly Department of Environmental Sciences and Prevention University of FerraraFerraraItaly Plants for Human Health Institute Animal Science DepartmentNC State UniversityKannapolisNCUSA Department of Food and Nutrition Kyung Hee UniversitySeoulSouth Korea

Oxlnflammation:definition and role in disease:Oxlnflammation has been introduced as a new term in the biomedical field to highlight the deep and mutual relationship between the dysregulation of redox and immune homeostasis(Valacchi et al.,2018).Regardless of which is the initial spark,inflammation cannot take place without a concomitant oxidative stress response and *** other words,they are sides of the same coin.

关键词： al. homeostasis inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Why did life develop on the surface of the Earth in the Cambrian？

引用

Geoscience Frontiers 2016年第6期7卷 865-873页

作者： carlo Doglioni Johannes Pignatti Max Coleman Department of Earth Sciences Sapienza University 00185 Rome Italy NASA Jet Propulsion Laboratory California Institute of Technology Pasadena CA 91109 USA NASA Astrobiology Institute USA

Life was limited for most of Earth＇s history, remaining at a primitive stage and mostly marine until about 0.55 Ga. In the Paleozoic, life eventually exploded and colonized the continental realm. Why had there been such a long period of delayed evolution of life？ Early life was dominated by Archaea and Bacteria, which can survive ionizing radiation better than other organisms. The magnetic field preserves the atmosphere, which is the main shield of UV radiation. We explore the hypothesis that the Cambrian explosion of life could have been enabled by the increase of the magnetic field dipole intensity due to the solidification of the inner core, caused by the cooling of the Earth, and the concomitant decrease with time of the high-energy solar flux since the birth of the solar system. Therefore, the two phenomena could be responsible for the growth and thickening of the atmosphere and the development of land surface life.

关键词： Origin of lifeInner core solidificationSolar ionizing radiations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：