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Venous thromboembolism in patients with inflammatory bowel disease:Focus on prevention and treatment

World Journal of Gastroenterology 2014年第12期20卷 3173-3179页

作者： Alfredo Papa Viviana Gerardi Manuela Marzo carla felice Gian Lodovico Rapaccini Antonio Gasbarrini Internal Medicine and Gastroenterology Unit Catholic University

Inflammatory bowel disease(IBD)patients have an increased risk of venous thromboembolism(VTE),which represents a significant cause of morbidity and *** most common sites of VTE in IBD patients are the deep veins of the legs and pulmonary system,followed by the portal and mesenteric ***,other sites may also be involved,such as the cerebrovascular and retinal *** aetiology of VTE is multifactorial,including both inherited and acquired risk factors that,when simultaneously present,multiply the risk to the *** prevention involves correcting modifiable risk factors,such as disease activity,vitamin deficiency,dehydration and prolonged *** role of mechanical and pharmacological prophylaxis against VTE using anticoagulants is also ***,although guidelines recommend thromboprophylaxis for IBD patients,this method is still poorly implemented because of concerns about its safety and a lack of awareness of the magnitude of thrombotic risk in these *** efforts are required to increase the rate of pharmacological prevention of VTE in IBD patients to avoid preventable morbidity and mortality.

关键词： Inflammatory bowel disease Venous thromboembolism Thromboembolic prophylaxis Anticoagulants Unfractionated heparin Low molecular weight heparin

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Management of perianal fistulas in Crohn's disease:An upto-date review

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World Journal of Gastroenterology 2015年第5期21卷 1394-1403页

作者： Manuela Marzo carla felice Daniela Pugliese Gianluca Andrisani Giammarco Mocci Alessandro Armuzzi Luisa Guidi IBD Unit Complesso Integrato ColumbusUniversità Cattolica del Sacro Cuore00168 RomeItaly

Perianal disease is one of the most disabling manifestations of Crohn's disease.A multidisciplinary approach of gastroenterologist,colorectal surgeon and radiologist is necessary for its management.A correct diagnosis,based on endoscopy,magnetic resonance imaging,endoanal ultrasound and examination under anesthesia,is crucial for perianal fistula *** medical and surgical therapies are discussedin this review,including new local treatment modalities that are under investigation.

关键词： Crohn’s disease Perianal fistula Surgery Drug ther

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What is the best way to manage screening for infections and vaccination of inflammatory bowel disease patients?

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第3期7卷 387-396页

作者： Gianluca Andrisani Alessandro Armuzzi Manuela Marzo carla felice Daniela Pugliese Alfredo Papa Luisa Guidi IBD Unit Complesso Integrato Columbus Università Cattolica del Sacro Cuore

The use of biological agents and immunomodulators for inflammatory bowel disease(IBD) is associated with an increased risk of opportunistic infections, in particular of viral or bacterial etiology. Despite the existence of international guidelines, many gastroenterologists have not adopted routine screening and vaccination in those patients with IBD, which are candidate for biologic therapy. Available strategies to screen, diagnose and prevent bacterial and viral infections in patients with IBD prior to start biological therapy are discussed in this review.

关键词： Inflammatory bowel disease Opportunistic infections Immunomodulators Corticosteroids Anti-tumor necrosis factor agents

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