Venous thromboembolism in patients with inflammatory bowel disease:Focus on prevention and treatment

作     者：Alfredo Papa Viviana Gerardi Manuela Marzo Carla Felice Gian Lodovico Rapaccini Antonio Gasbarrini 

作者机构：Internal Medicine and Gastroenterology UnitCatholic University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第12期

页      面：3173-3179页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Inflammatory bowel disease Venous thromboembolism Thromboembolic prophylaxis Anticoagulants Unfractionated heparin Low molecular weight heparin 

摘      要：Inflammatory bowel disease(IBD)patients have an increased risk of venous thromboembolism(VTE),which represents a significant cause of morbidity and *** most common sites of VTE in IBD patients are the deep veins of the legs and pulmonary system,followed by the portal and mesenteric ***,other sites may also be involved,such as the cerebrovascular and retinal *** aetiology of VTE is multifactorial,including both inherited and acquired risk factors that,when simultaneously present,multiply the risk to the *** prevention involves correcting modifiable risk factors,such as disease activity,vitamin deficiency,dehydration and prolonged *** role of mechanical and pharmacological prophylaxis against VTE using anticoagulants is also ***,although guidelines recommend thromboprophylaxis for IBD patients,this method is still poorly implemented because of concerns about its safety and a lack of awareness of the magnitude of thrombotic risk in these *** efforts are required to increase the rate of pharmacological prevention of VTE in IBD patients to avoid preventable morbidity and mortality.