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Hepatitis B vaccine in celiac disease:Yesterday,today and tomorrow

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World Journal of Gastroenterology 2013年第6期19卷 838-845页

作者： Giovanna Vitaliti Andrea Domenico Praticò carla Cimino Giovanna Di Dio Elena Lionetti Mario La Rosa Salvatore Leonardi Department of Pediatrics University of Catania

Some studies showed that in celiac patients the immunological response to vaccination is similar to that one found in general population except for vaccine against hepatitis B virus (HBV).The non-responsiveness to HBV vaccine has also been described in healthy people,nevertheless the number of non-responders has been demonstrated to be higher in celiac disease (CD) patients than in healthy *** hypothesis explaining this higher rate of unresponsiveness to HBV vaccine in CD patients have been described,such as the genetic hypothesis,according with CD patients carrying the disease-specific haplotype HLA-B8,DR3,and DQ2,show a lower response to HBV vaccine both in clinical expressed CD patients and in healthy people carrying the same *** the other hand,it has been demonstrated that the gluten intake during the vaccination seems to influence the response to the same ***,it has been demonstrated a possible genetic predisposition to hepatitis B vaccine nonresponsiveness likely due to the presence of specific human leukocyte antigen haplotypes and specific single nucleotide polymorphism in genes of cytokine/cytokinereceptors and toll like receptors,but the pathogenic mechanism responsible for this low responsiveness still remains *** aim of this review is to focus on the possible pathogenic causes of unresponsiveness to HBV vaccine in CD patients and to propose an alternative vaccination schedule in order to improve the responsiveness to HBV vaccine in this at-risk patients.

关键词： Celiac disease Non responders Hepatitis B vaccine Vaccination schedules

Longitudinal assessment of liver stiffness by transient elastography for chronic hepatitis C patients

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World Journal of Clinical Cases 2022年第17期10卷 5566-5576页

作者： Anya Mezina Arunkumar Krishnan Tinsay A Woreta Kevin B Rubenstein Eric Watson Po-Hung Chen carla Rodriguez-Watson Department of Medicine Johns Hopkins School of MedicineBaltimoreMD 21287United States Division of Gastroenterology and Hepatology Johns Hopkins School of MedicineBaltimoreMD 21231United States Mid-Atlantic Permanente Research Institute Kaiser Permanente Mid-Atlantic StatesRockville 20852United States Department of Health Policy and Management Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21287United States Innovation in Medical Evidence Development and Surveillance(IMEDS)Program Reagan-Udall Foundation for the FDAWashington20036United States

BACKGROUND Liver fibrosis is a common pathway of liver injury and is a feature of most chronic liver *** progression varies markedly in patients with hepatitis C virus(HCV).Liver stiffness has been recommended as a parameter of fibrosis progression/regression in patients with *** To investigate changes in liver stiffness measured by transient elastography(TE)in a large,racially diverse cohort of United States patients with chronic hepatitis C(CHC).METHODS We evaluated the differences in liver stiffness between patients treated with direct-acting antiviral(DAA)therapy and untreated *** had≥2 TE measurements and no prior DAA *** used linear regression to measure the change in liver stiffness between first and last TE in response to treatment,controlling for age,sex,race,diabetes,smoking status,human immunodeficiency virus status,baseline alanine aminotransferase,and baseline liver *** regression models analyzed the change in liver stiffness as measured by kPa,stratified by cirrhosis *** Of 813 patients,419(52%)initiated DAA *** liver stiffness was 12 kPa in 127(16%).Median time between first and last TE was 11.7 and 12.7 mo among treated and untreated patients,*** was no significant change in liver stiffness observed over time in either the group initiating DAA treatment(0.016 kPa/month;CI:-0.051,0.084)or in the untreated group(0.001 kPa/mo;CI:-0.090,0.092),controlling for covariates.A higher baseline kPa score was independently associated with decreased liver *** DAA treatment was not associated with a differential change in liver stiffness over time in patients with CHC compared to untreated patients.

关键词： Chronic hepatitis C Liver stiffness Cirrhosis Transient elastography Direct-acting antiviral therapy

Reply to"Six-minute walking test performance is associated with survival in cirrhotic patients"to the editor

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World Journal of Hepatology 2022年第5期14卷 1047-1049页

作者： carla Malaguti Carlos Alberto Mourão-Junior Júlio Maria Chebli Departament of Cardiorespiratory and Skeletal Muscle Universidade Federal de Juiz de ForaJuiz de Fora 36036-634Minas GeraisBrazil Department of Physiology Universidade Federal de Juiz de ForaJuiz de Fora 36036-634Minas GeraisBrazil Department of Medicine Universidade Federal de Juiz de ForaJuiz de Fora 36036-634Minas GeraisBrazil

Use of the six-minute walk test has been proposed as a prognostic marker in liver *** the Letter to the Editor presented here,the authors highlight some important points,which were raised after the article was publish... 详细信息

关键词： Six-minute walking test Liver cirrhosis Hospital admission and mortality

The use of liquid biopsy in early breast cancer:clinical evidence and future perspectives

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 33-48页

作者： Paolo D’Amico carla Corvaja Lorenzo Gerratana Carolina Reduzzi Giuseppe Curigliano Massimo Cristofanilli Division of Hematology and Oncology Department of MedicineNorthwestern University Feinberg School of MedicineChicagoIL 60611USA Division of Early Drug Development for Innovative Therapies IEOEuropean Institute of Oncology IRCCSMilan 20132Italy Department of Oncology and Hemato-Oncology University of MilanoMilan 20122Italy Department of Oncology ASUFCUniversity Hospital of UdineUdine 33100Italy Department of Medicine University of UdineUdine 33100Italy Department of Medical Oncology Centro di Riferimento Oncologico(CRO)IRCCSPordenone 33081Italy

Liquid biopsy,including both circulating tumor cells and circulating tumor DNA,is gaining momentum as a diagnostic modality adopted in the clinical management of breast *** studies testing several technologies demonstrated clinical validity and,in some cases,achieved the United States Food and Drug Administration *** initial testing and clinical application of liquid biopsy focused primarily on the diagnosis,while molecular characterization and monitoring of metastatic disease,with larger data from prospective studies,came in the last two *** its role in metastatic setting is thus widely recognized,the current evidence does not provide support for the routine clinical use of liquid biopsy methods for the earlier stage of this *** the relevance of early detection,characterization,and management of breast cancer in the early-stage,this clinical setting is the most suitable to increase the chances for effective treatment selection and improved prognosis,and a better understanding of the main application of liquid biopsy tools in the earlier stage of breast cancer is therefore *** aim of this review is to provide an overview of the clinical evidence and subsequent potential applications of liquid biopsy in early breast cancer,identifying the main existing caveats and the possible future scenarios.

关键词： Liquid biopsy early breast cancer circulating tumor cells circulating tumor DNA clinical trials screening early detection minimal residual disease

Energy and Sustainability in Museums. The Plant Refurbishment of the Medieval Building of Palagio di Parte Guelfa in Florence

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Open Journal of Energy Efficiency 2012年第3期1卷 31-47页

作者： carla Balocco Enrico Marmonti Dipartimento di Energetica Università degli Studi di Firenze Firenze Italy

This paper presents a performance-based design of a HVAC plant and controller system of the “Palagio di Parte Guelfa” Palace, a medieval building converted into a museum in the city of Firenze. Transient simulations to evaluate the internal microclimate conditions during the year for the building and the different system plant were carried out. A comparison between the indoor microclimatic parameters obtained and the values suggested by the standards on protection and conservation of historical works of art, suggested a non-invasive and reversible plant system solution. The MuseumofHistorical Footballbuilding portion is the case study. The proposed plant, a constant air flow system coupled with radiant panels dry mounted above the existing flooring, was simulated throughout the year under transient conditions to evaluate its energy performance. This solution ensures indoor temperature and humidity values suitable for the conservation of works of art and visitor comfort. It is an example of a possible course of action for a plant refurbishment in a historic building converted into a museum, located in climatic regions characterized by high thermal and solar loads. The present paper concerns the study of an integrated and reversible architectural-plant solution proposed: reversibility of the proposed system is understood as the possibility for the present conditions being easily restored.

关键词： Energy Efficiency Retrofit Solution Conservation Museum Reversible Plant Systems

Revisiting Stoker＇s Dracula： No Brave Good Villains Left

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Journal of Literature and Art Studies 2014年第8期4卷 653-660页

作者： carla Ferreira de Castro University of Evora Evora Portugal

This article considers the implication of the main character, Count Dracula, the villain/anti-hero in Stoker＇s text, as a starting point to analysing the approaches deployed in the novel that introduce new stratagems to uncover the motives which allow the readers to find excuses to deny ＂pure＂ evilness. Stoker＇s Dracula （1897） introduced the plausibility--in the realm of the gothic horror novel--of finding heroes in modem day ＂villains＂. This paper will argue this influence by introducing connections with modem ＂pop＂ vampires： from the teenage vampires in the Twilight saga both the texts （2005, 2006, 2007, ＆ 2008） and the film versions （ 2008, 2009, 2010, ＆ 2012）, to the grown-up fantasies of Charlaine Harris in the True Blood saga （both the 13 books published between 2001 and 2012 and the Home Box Office TV series that started in 2008 and, so far is in its 7th season in 2014） and Tim Button＇s Dark Shadows （2012）, the remake of the 70s American Broadcasting Company Gothic soap opera （which ran between june 1966 to April 1977）. Bearing in mind the history of the vampire, through a brief account of its constant presence in the contemporary film and television industry, we will attempt to unveil the cultural reasons that bring light to the fact that modem society is out of brave good villains. The presentation will retrieve some theoretical support from Cristopher Frayling＇s analysis of the vampire myth, David Punters＇ ideas on the modem gothic and Maggie Kilgour＇s assumptions on the rise of the gothic.

关键词： Dracula villains pop-culture postmodern gothic

Biomarkers of hypoxic-ischemic encephalopathy:a systematic review

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World Journal of Pediatrics 2023年第6期19卷 505-548页

作者： Ines Caramelo Margarida Coelho Miguel Rosado carla M.P.Cardoso Alexandra Dinis Carlos B.Duarte Mario Graos Bruno Manadas CNC-Center for Neuroscience and Cell Biology University of Coimbra3004‑504 CoimbraPortugal PhD Programme in Experimental Biology and Biomedicine Institute for Interdisciplinary Research(IIIUC)University of CoimbraCasa Costa Alemão3030‑789 CoimbraPortugal Chemistry Department Faculty of Sciences and TechnologyUniversity of Coimbra3004‑535 CoimbraPortugal Stemlab SA 3060‑197 CantanhedePortugal Pediatric Intensive Care Unit Hospital PediátricoCentro Hospitalar E Universitário de Coimbra3000‑075 CoimbraPortugal Department of Life Sciences University of Coimbra3001‑401 CoimbraPortugal Biocant Technology Transfer Association3060‑197 CantanhedePortugal Institute for Interdisciplinary Research University of Coimbra(IIIUC)3030‑789 CoimbraPortugal

Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement ***,this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice(PROSPERO ID:CRD42021272610).Data sources Searches were performed in PubMed,Web of Science,and Science Direct databases until November *** original papers analyzing samples from newborns>36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were *** was assessed by the Newcastle–Ottawa *** search and data extraction were verified by two authors *** From 373 papers,30 met the inclusion *** from samples collected in the first 72 hours were extracted,and increased serum levels of neuron-specific enolase and S100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal *** addition,the levels of glial fibrillary acidic protein,ubiquitin carboxyl terminal hydrolase isozyme-L1,glutamic pyruvic transaminase-2,lactate,and glucose were elevated in newborns diagnosed with hypoxic–ischemic ***,pathway analysis revealed insulin-like growth factor signaling and alanine,aspartate and glutamate metabolism to be involved in the early molecular response to *** Neuron-specific enolase and S100-calcium-binding protein-B are potential biomarkers,since they are correlated with an unfavorable outcome of hypoxic-ischemic encephalopathy ***,more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice.

关键词： Biomarker Hypoxic-ischemic encephalopathy Neonatal brain injury Newborn Neuron-specific enolase S100-calcium-binding protein-B

Construction and Demolition Debris Management for Sustainable Reconstruction after Disasters： Italian Case Studies

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Journal of Environmental Science and Engineering(B) 2012年第7期1卷 865-873页

作者： carla Furcas Ginevra Balletto Department of Civil and Environmental Engineering and Architecture Universi(y of Cagliari Cagliari 09123 Italy

The Italian earthquakes of recent decades created an emergency situation that required immediate post-earthquake reconstruction policies, which led to an increase in the demand for construction minerals. In particular, extraction in active quarries has been intensified, and new quarries opened according to extraordinary procedures notwithstanding current regulations. The objective of this work is to investigate the consequences that a seismic event may produce on both the built-up environment, i.e. the totality of urban and suburban settlements and infrastructure, and the natural environment, which is often compromised by hasty emergency procedures aimed at mineral extraction. As a result, correct evaluation of the demand for minerals and the recycling of earthquake debris are the fundamental elements of coherent post seismic reconstruction, by means of which post-earthquake policies could be reconciled with environmental protection.

关键词： Reconstruction construction and demolition waste debris recycling earthquake.

A prospective study on radiofrequency ablation locally advanced pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2010年第3期9卷 306-311页

作者： Riccardo Casadei Claudio Ricci Raffaele Pezzilli carla Serra Lucia Calculli Antonio Maria Morselli-Labate Donatella Santini Francesco Minni Department of Surgery S.Orsola-Malpighi Hospital University of Bologna Department of Internal Medicine and Gastroenterology S.Orsola-Malpighi Hospital University of Bologna Department of Radiology S.Orsola-Malpighi Hospital University of Bologna Department of Internal Medicine and Gastroenterology Department of Pathology S.Orsola-Malpighi Hospital University of Bologna

BACKGROUND:Radiofrequency ablation(RFA)has been suggested as a new treatment option for patients with locally advanced *** study aimed to prospectively evaluate the efficacy and safety of intraoperative RFA in patients with unresectable,locally advanced,non-metastatic carcinoma of the pancreatic ***:RFA was the first step of the surgical procedure and was carried out on the mobilized pancreatic head followed by biliary by-pass and ***-and post-operative morbidity and mortality,performance status, pain control,quality of life,and survival at 24 months were ***:Seven patients(3 men and 4 women;median age 66 years,range 47-80 years)were studied and 4 were eligible for *** RFA procedure was carried out in 3 of the 4 patients;in one patient it was not carried out because of the upstaging of the *** all 3 patients RFA achieved complete necrosis of the lesion.A biliary fistula developed 7 days after the procedure in one patient;all 3 patients developed ascites 8.6 days(range 7-9 days)on average after *** patients died respectively,at 3,4,and 5 months after the ***:In our experience,RFA is a feasible procedure, but it presents a very high rate of postoperative ***,pain control,life quality and survival rate are *** few data suggest no impact on survival.

关键词： pancreatic neoplasms radiofrequency ablation survival efficacy safety