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Oxidative stress,the blood-brain barrier and neurodegenerative diseases:The critical beneficial role of dietary antioxidants

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Acta Pharmaceutica Sinica B 2023年第10期13卷 3988-4024页

作者： Jin Feng Youle Zheng Mingyue Guo Irma Ares Marta Martínez Bernardo Lopez-torres María-Rosa Martínez-Larran aga Xu Wang Arturo Anadon María-Aranzazu Martínez National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan 430070China MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products Huazhong Agricultural UniversityWuhan 430070China department of Pharmacology and Toxicology Faculty of Veterinary MedicineUniversidad Complutense de Madrid(UCM)And Research Institute Hospital 12 de Octubre(i+12)Madrid 28040Spain

In recent years,growing awareness of the role of oxidative stress in brain health has prompted antioxidants,especially dietary antioxidants,to receive growing attention as possible treatments strategies for patients with neurodegenerative diseases(NDs).The most widely studied dietary antioxidants include active substances such as vitamins,carotenoids,flavonoids and *** antioxidants are found in usually consumed foods such as fresh fruits,vegetables,nuts and oils and are gaining popularity due to recently growing awareness of their potential for preventive and protective agents against NDs,as well as their abundant natural sources,generally non-toxic nature,and ease of long-term *** review article examines the role of oxidative stress in the development of NDs,explores the‘two-sidedness’of the blood-brain barrier(BBB)as a protective barrier to the nervous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of ***,current challenges and future directions for the prevention and treatment of NDs using dietary antioxidants are discussed,and useful information on the prevention and treatment of NDs is provided.

关键词： Dietary antioxidant supplements Oxidative stress Blood-brain barrier Neurodegenerative diseases Vitamins Carotenoids Flavonoids Polyphenols

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Microstructural and photocatalytic characterization of cement-paste sol-gel synthesized titanium dioxide

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Frontiers of Structural and Civil Engineering 2016年第2期10卷 189-197页

作者： Elena CERRO-PRADA Miguel MANSO Vicente torres Jesfs SORIANO Civil Engineering department Universidad Politecnica de Madrid Alfonso XII 3 Madrid 28014 Spain Applied Physics department Universidad Aut6noma de Madrid Ciudad Universitaria de Cantoblanco Madrid 28049 Spain Laboratory of Materials CEDEX Ministerio de Fomento de Espana Alfonso XIL Madrid 28014 Spain

ABSTRACT A routte for the in paste synthesis of TiO2 loaded cement is described. TiO2 sols are blended with fresh cement paste as an alternative process to add photocatalytic functionality to cement. The modification of cement paste structure after the addition ofTiO2 sols is analyzed by XRD, SEM and TGA. As a particular microstructural feature, TiO2 containing calcium silicate hydrate （C-H-S） particles are identified as networking centers ofa C-S-H gel fiber matrix. The increase of the TiO2 sol concentration induces a decrease of pore size and an increase in the specific surface area in the cement composites. The photocatalytic activity of the TiO2/cement system is evaluated from the degradation of Methylene Blue （MB） under UV irradiation, monitored through the absorbance at 665 nm. The results show that, although TiO2 phases reveal no long range order structure, the cement paste exothermal treatment in presence of hydrate products and alkaline conditions leads to a photocatalytic composite. Such new cement matrix may be twofold advantageous since it additionally promotes the formation of C-S-H gel, main determinant of cement mechanical properties.

关键词： cement composites photocatalytic TiO2 sol-gel C-S-H gel microstructure

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Two mitochondrial haplotypes in Pterochloroides persicae （Hemiptera： Aphididae： Lachninae） associated with different feeding sites

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Insect Science 2013年第5期20卷 637-642页

作者： Mdellel Lassaad David Martinez-torres Ben Halima Kamel Monia Hight Institute of Agronomy Chott Mariem 4042 Sousse Tunisia Institut Cavanilles de Biodiversitat i Biologia Evolutiva Universitat de Valencia Apdo. Correos 22085 46071 Valencia Spain

Pterochloroides persicae （Cholodkovsky） is an aphid species belonging to the subfamily Lachninae that uses different members of Rosaceae （specially Prunus spp.） as hosts. Partial sequences from the mitochondrial cytochrome c oxidase 1 （COI） and the nuclear long-wave opsin genes were obtained for approximately 100 P. persicae aphid individuals sampled from 34 colonies collected mainly in Tunisia and other Mediterranean locations. The variability found at the mitochondrial locus revealed the presence of two maternal haplotypes in the studied area that differed in a single nucleotide. The nuclear gene analyzed, however, failed to reveal any variability in this species. The variability found at the COI locus was related to the season of aphid sampling and with the site of feeding, with haplotype I mostly detected in samples collected in spring and summer on trunks and branches and haplotype II only detected in aphids collected in autumn on roots. The observed pattern of molecular variation suggests the presence of two clonal races of P. persicae coexisting in the studied area differentially adapted to conditions prevalent in the alternative seasons and/or to different feeding sites.

关键词： aphids COI Lachninae life cycle Pterochloroides variability

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Albumin-bilirubin score in non-malignant liver diseases should be properly validated

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World Journal of Gastroenterology 2023年第46期29卷 6089-6091页

作者： Andrea Pasta Francesco Calabrese Maria Corina Plaz torres Giorgia Bodini Manuele Furnari EdoardoVincenzo Savarino Vincenzo Savarino Edoardo Giovanni Giannini Elisa Marabotto Gastroenterology Unit Department of Internal MedicineUniversity of GenoaIRCCS‐Ospedale Policlinico San MartinoGenoa 16132Italy department of Surgery Oncology and GastroenterologyUniversity Hospital of PaduaPadua 35128Italy

The albumin-bilirubin(ALBI)score to assess the risk of decompensation in patients with initially compensated cirrhosis may improve their prognostic *** letter critically evaluates the research,which utilizes the ALBI score to forecast decompensation in cirrhosis patients over a three-year *** score was initially developed to assess liver function in hepatocellular carcinoma,its prognostic utility for non-malignant liver diseases has now been explored,recognizing decompensation as a pivotal event that significantly affects patient’s *** concerns regarding the methodology of this research may be raised,particularly the exclusive use of radiological diagnosis,potentially including patients without definite cirrhosis and thus skewing the decompensation risk *** reported predominance of variceal bleeding as a decompensating event conflicts with established literature,that often reports ascites as the initial decompensation *** letter highlights the absence of details on esophageal varices and their management,which could introduce bias in evaluating the ALBI score's predictive ***,the letter points out the small sample size of patients with high-risk ALBI grades,potentially compromising the score's validity in this *** suggest prospective future research to investigate the dynamic changes in the ALBI score over time to reinforce the validity of the ALBI score as a predictor of decompensation in non-malignant liver disease.

关键词： Albumin-bilirubin score decompensated cirrhosis Liver disease Nonmalignant liver disease Portal hypertension

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RANS simulations of the U and V grooves effect in the subcritical flow over four rotated circular cylinders

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Journal of Hydrodynamics 2015年第4期27卷 569-578页

作者： ALONZO-GARCIA A. GUTIERREZ-torres C.del C. JIMENEZ BERNAL J.A. MOLLINEDO-PONCE de LEON H.R. MARTINEZ-deLGADILLO S.A. BARBOSA-SALDANA J.G. Instituto Politécnico Nacional SEPI ESIME ZacatencoLABINTHAP U.P.Adolfo López Mateos Edif.5 3er.PisoMéxicoD.F.México Instituto Politécnico Nacional UPIITAAv.IPN 2580C.P.07340MéxicoD.F.México Universidad Autónoma Metropolitana-Azcapotzalco Depto.Ciencias BásicasAv.San Pablo 180Azcapotzalco C.P 07740MéxicoD.F.México

This paper presents a CFD study about the effect of the V and U grooves in the flow over four cylinders in diamond shape configuration at subcritical flow conditions（Re= 41 000）. The k- ε Realizable turbulence model was implemented to fully structured hexahedral grids with near-wall refinements. Results showed that the numerical model was able to reproduce the impinging flow pattern and the repulsive forces present in the lateral cylinders of the smooth cylinder array. As a consequence of the flow alignment induced by the grooves, a jet-flow is formed between the lateral cylinders, which could cause an important vortex induced vibration effect especially in the rear cylinder. The magnitudes of the shear stresses at the valleys and peaks for the V grooved cylinders were lower than those of the U grooved cylinders, but the separation points were delayed due the U grooves presence. It is discussed the presence of a blowing effect caused by counter-rotating eddies located near the grooves peaks that cause a decrease of the shear stresses in the valleys, and promote them at the peaks.

关键词： RANS model grooved cylinder four cylinders subcritical flow impinging flow

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Sample Size dependence of Second Magnetizaion Peak in Type-ⅡSuperconductors

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Tsinghua Science and Technology 2003年第3期8卷 370-378页

作者： J.H.S.torres Y.Kopelevich Institute de fisica"Gleb Wataghin" Universitade Estadual de CampinasUnicamp 13083-970CampinasSao PauloBrasilInstitute de fisica"Gleb Wataghin"Universitade Estadual de CampinasUnicamp 13083-970CampinasSao PauloBrasil

We show that the second magnetization peak(SMP),i.e.,an increase in the magnetization hysteresis loop width in type-11 superconductors,vanishes for samples smaller than a critical size,We argue that the SMP is not related to the critical current enhancement but can be well explainde within a frameword of the thermomagenetic flux-jump in stability theory,where flux jumps reduce the absolute irreversible magnetization relative to the isothermal critical state value at low enough magnetic *** recovering of the isothermal critical sate with increasing field leads to the *** low-field SMP takes place in both *** and high**** *** results show that the rsstoration of the isothermal critical state is rsponsible for the SMP occurrence in both cases.

关键词： Superconductor flux pinning and creep peekeffect phase transityons

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Reducing bacterial adhesion to titanium surfaces using low intensity alternating electrical pulses

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World Journal of Orthopedics 2022年第6期13卷 578-586页

作者： Marti Bernaus Jordi Guillem-Marti Adrian Bermúdez-Castel Jose Antonio Calero Diego torres Margarita Veloso Lluís Font-Vizcarra department of Orthopedics and Traumatology Osteoarticular Infection UnitHospital Universitari Mutua TerrassaTerrassa 08221Spain department of Materials Science and Metallurgical Engineering Universitat Politecnica de CatalunyaBarcelona 08930Spain Barcelona Research Center in Multiscale Science and Engineering Universitat Politecnica de CatalunyaBarcelona 08930Spain Innovative Minds S.L.Terrassa 08224Spain AMES PM Tech Center Sant Vicençdels Horts 08980Spain

BACKGROUND Orthopedic implant-related infection remains one of the most serious complications after orthopedic *** recent years,there has been an increased scientific interest to improve prevention and treatment ***,many of these strategies have focused on chemical *** To analyze the effect of alternating current electrical fields on bacterial adherence to titanium *** Staphylococcus aureus(***)and Escherichia coli(***)were exposed to 6.5 V electrical currents at different frequencies:0.5 Hz,0.1 Hz,and 0.05 *** exposure,a bacterial count was then performed and compared to the control *** variables registered included the presence of electrocoagulation of the medium,electrode oxidation and/or corrosion,and changes in pH of the *** The most effective electrical model for reducing *** adhesion was 6.5 V alternating current at 0.05 Hz achieving a 90%adhesion reduction *** ***,the 0.05 Hz frequency model also showed the most effective results with a 53%adhesion reduction rate,although these were significantly lower than *** adhesion reduction rates were observed for *** and *** in the studied ***,the presence of electrode oxidation makes us presume these conditions are not optimal for in vivo *** Although our findings suggest electrical currents may be useful in preventing bacterial adhesion to metal surfaces,further research using other electrical conditions must be examined to consider their use for in vivo trials.

关键词： Electrical fields Bacterial adhesion Orthopedic infection Titanium Metal surfaces

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Distribution of Malpighia mexicana in Mexico and its implications for Barranca del Río Santiago

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Journal of Forestry Research 2021年第3期32卷 1095-1103页

作者： Martín Tena Meza Rafael MaNavarro-Cerrillo Diego Brizuela torres Instituto de Botánica Centro Universitario de Ciencias Biológicas y AgropecuariasUniversidad de GuadalajaraMéxicoCamino Ramón Padilla Sánchez No.2100.Nextipac45200 ZapopanJaliscoMexico depto.Ingeniería Forestal Laboratorio de SelviculturaDendrocronología y Cambio ClimáticoDendrodatLab-ERSAFUniversidad de CórdobaCampus de RabanalesCtra.N-IVkm.39614071 CórdobaSpain departamento de Producción Forestal Centro Universitario de CienciasBiológicas y AgropecuariasUniversidad de GuadalajaraMéxicoCamino Ramón Padilla Sánchez No.2100 Nextipac45200 ZapopanJaliscoMexico

Wild plants represent relatively unexplored resource of high economic potential,especially as an alternative to developing new crops and,even more relevant,for improving existing crops and contributing to nutrition and *** wild species M alpighia mexicana(manzanita)has a wide tradition of food,medicinal and ornamental use in *** is part of the American-origin group of tropical shrubs that produce edible red fruits,such as A cerola,which is considered the most important natural source of vitamin C in the *** the role played by *** in Mexico,and particularly in Barranca del Río Santiago(Santiago River Canyon),we modelled its potential distribution in both geographical *** used species'records from databases,local herbaria and records collected by the authors as well as climatic variables representing long term average,variability and extreme conditions of temperature and *** fit the models we used the modelling algorithm Maxent and selected an adequate configuration by testing a range of model complexity *** results indicate a clear species preference for warm-dry tropical forest,most extensively in the Balsas river depression and the central valleys of *** probability of the species presence in the western region was also high,although the probability was also high for smaller surface areas,such as the region of Santiago river canyons,which are covered by warm-dry tropical forests.

关键词： Malpighia mexicana Maxent Warmdry tropical forest Río Santiago Genetic resources Ecological niche model Manzanita

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Relationship between PON-1 enzymatic activity and risk factors for pesticide poisoning in farmers from the Cienega,Jalisco,Mexico

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BIOCELL 2021年第5期45卷 1241-1250页

作者： HAZAEL RAMIRO CEJA-GALVEZ ERANDIS DHENI torres-SÁNCHEZ JUAN HERIBERTO torres-JASSO EMMANUEL REYESURIBE JOEL SALAZAR-FLORES department of Medical and Life Sciences University Center of La CienegaUniversity of Guadalajara(CUCI-UdeG)OcotlánCP 47810Mexico department of Biological Sciences University Center of the CoastUniversity of Guadalajara(CUCosta-UdeG)Puerto VallartaCP 48280Mexico

Paraoxonase-1(PON-1)is an enzyme that hydrolyzes organophosphate *** presence of polymorphisms in PON-1(L55M and Q192R)decreases its enzyme activity and increases the risk of central nervous system(CNS)toxicity in occupationally exposed farmers,leading to chronic degenerative diseases and *** studied 103 farmers in the region of Cienega Jalisco,Mexico,which were exposed mainly to organophosphate *** used serum and plasma samples to assay PON-1 activity and perform polymorphism analysis(L55M and Q192R)using qPCR and TaqMan probes,*** both polymorphisms,there was high percentage of heterozygosity(55 LL=0.19,LM=0.75,MM=0.06;192 QQ=0.12,QR=0.72,RR=0.16),while the allelic frequencies were more balanced(L=0.56,M=0.44;Q=0.48,R=0.52).There were no significant differences in enzyme activity of L55M polymorphism genotypes(LL=179.27;LM=192.11;MM=122.11;QQ=135.74;QR=187.90;RR=209;p>0.05).But there was a slight decrease in enzyme activity for the Q192R polymorphism *** genotype and alcohol consumption associated with slight increases in enzyme ***,genotype and tobacco consumption did not have a significant effect on PON-1 activity(μU/mL)(p>0.05).Overall,alcohol and tobacco consumption affected PON-1 enzyme activity(μU/mL)up to 21.1%.The data obtained in this study reveal that PON-1 activity is affected by genetic variants such as Q192R and alcohol *** may influence the susceptibility of populations to organophosphate poisoning.

关键词： Paraoxonase-1 Pesticides Organophosphates Polymorphisms

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The number of alignments between two DNA sequences

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International Journal of Biomathematics 2016年第4期9卷 75-80页

作者： Helena Andrade Juan J. Nieto Angela torres departamento de Andlisis Matemdtico Facultad de Matemdticas Universidad de Santiago de Compostela Spain department of Mathematics Faculty of ScienceKing Abdulaziz University Jeddah 21589 Saudi Arabia departamento de Psiquiatrla Radiologla y Salud Publica Facultad de Medicina Universidad de Santiago de Compostela Spain

We consider two DNA sequences and compare both sequences. One of the crucial issues in bioinformatics is to measure the similarity of two DNA sequences. To this purpose one has to consider different alignments between both sequences. The number of alignments grows very rapidly with the length of the sequences. In this paper we give exact, explicit and computable formulas for the number of different possible alignments and for some classes of reduced alignments. We provide a new insight into the theory of DNA sequence alignment.

关键词： DNA序列比对生物信息学相似性路线

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