Reducing bacterial adhesion to titanium surfaces using low intensity alternating electrical pulses
作者机构：Department of Orthopedics and TraumatologyOsteoarticular Infection UnitHospital Universitari Mutua TerrassaTerrassa 08221Spain Department of Materials Science and Metallurgical EngineeringUniversitat Politecnica de CatalunyaBarcelona 08930Spain Barcelona Research Center in Multiscale Science and EngineeringUniversitat Politecnica de CatalunyaBarcelona 08930Spain Innovative MindsS.L.Terrassa 08224Spain AMES PM Tech CenterSant Vicençdels Horts 08980Spain
出 版 物：《World Journal of Orthopedics》 (世界骨科杂志（英文版）)
年 卷 期：2022年第13卷第6期
页 面：578-586页
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：the DIRECT project (Desarrollo de Nuevos Dispositivos Biomimé ticos Mejorados Superficialmente con Nuevos Recubrimientos y Tratamientos Físicos) which has been funded with a grant from the Centre for Development of Industrial Technology (CDTI)
主 题：Electrical fields Bacterial adhesion Orthopedic infection Titanium Metal surfaces
摘 要：BACKGROUND Orthopedic implant-related infection remains one of the most serious complications after orthopedic *** recent years,there has been an increased scientific interest to improve prevention and treatment ***,many of these strategies have focused on chemical *** To analyze the effect of alternating current electrical fields on bacterial adherence to titanium *** Staphylococcus aureus(***)and Escherichia coli(***)were exposed to 6.5 V electrical currents at different frequencies:0.5 Hz,0.1 Hz,and 0.05 *** exposure,a bacterial count was then performed and compared to the control *** variables registered included the presence of electrocoagulation of the medium,electrode oxidation and/or corrosion,and changes in pH of the *** The most effective electrical model for reducing *** adhesion was 6.5 V alternating current at 0.05 Hz achieving a 90%adhesion reduction *** ***,the 0.05 Hz frequency model also showed the most effective results with a 53%adhesion reduction rate,although these were significantly lower than *** adhesion reduction rates were observed for *** and *** in the studied ***,the presence of electrode oxidation makes us presume these conditions are not optimal for in vivo *** Although our findings suggest electrical currents may be useful in preventing bacterial adhesion to metal surfaces,further research using other electrical conditions must be examined to consider their use for in vivo trials.
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