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紫贻贝(Mytilus edulis)对疏水有机污染物在波罗的海本体循环中所起的作用

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人类环境杂志 1997年第4期26卷 198-205页

作者： Michael Gilek Dag Broman nils Kautsky Ulrik Kautsky carina nf 沈丽赛 Department of Systems Ecology Stockholm UniversityS-106 91 StockholmSweden Institute of Applied Environmental Research Stockholm UnivrsityS-106 91 Stockholm.Sweden Department of Systems Ecology Stockholm UniversityS-106 91 StockholmSweden。 Aquati Chemical Ecotoxicology Department of ZoologyStockholm UniversityS-106 91 StockholmSweden。

作者通过栖息在瑞典波罗的海沿岸密集的紫贻贝群落为三类重要的疏水有机污染物(HOCs)建立了流动的年度收支表,它们是多环芳烃(PAHs)、多氯联苯(PCBs)以及多氯二苯并-p-二噁(口英)和二苯并呋喃(PCDD/fs)。这收支表清楚地表明紫贻贝显著... 详细信息

作者通过栖息在瑞典波罗的海沿岸密集的紫贻贝群落为三类重要的疏水有机污染物(HOCs)建立了流动的年度收支表,它们是多环芳烃(PAHs)、多氯联苯(PCBs)以及多氯二苯并-p-二噁(口英)和二苯并呋喃(PCDD/fs)。这收支表清楚地表明紫贻贝显著地改变了所研究的这三类HOCs的流动,表现在:①使 HOCs向海底的净沉降增加13%～19%,从而使这些污染物更容易被底栖生物吸收;②通过被动排泄作用,使大量HOCs重新流回远洋系统,从而增加了HOCs在水体中的保留时间;③生物蓄积大量的HOCs,形成对以贻贝为食的底栖鱼类及雁鸭类的重要污染源;④通过产卵向波罗的海沿岸水域释放大量HOCs,可能显著增加了鲱鱼幼体及其他浮游动物受HOC污染的机会。

关键词：紫贻贝本体循环 HOCs 波罗的海疏水有机污染物

Evaluating foot reflexology as a proposed treatment for sensorineural hearing loss:A critical review

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World Journal of Clinical Cases 2025年第4期13卷 15-17页

作者： carina McClean Brandon Lucke-Wold College of Medicine University of FloridaGainesvilleFL 32610United States Lillian S.Wells Department of neurosurgery University of FloridaGainesvilleFL 32608United States

This editorial critically evaluates the application of foot reflexology as a treatment for sensorineural hearing loss(SnHL)in infants,as proposed in a case report published in the World of Clinical *** is a condition characterized by damage to the cochlea or the neural pathways that transmit auditory information to the *** etiology of SnHL is often complex,involving genetic mutations,prenatal factors,or perinatal ***,an alternative therapy involving the application of pressure to specific points on the feet,is based on the hypothesis that these points correspond to different organs and systems in the body,including the auditory ***,the biological plausibility and clinical efficacy of foot reflexology in addressing SnHL lack empirical *** editorial examines the pathophysiology of SnHL,assesses the clinical claims of reflexology practitioners,and emphasizes the necessity of evidence-based approaches in treating infant hearing *** complementary therapies may provide ancillary benefits,they should not supplant validated medical treatments in managing SnHL in *** research is needed to evaluate the safety and efficacy of foot reflexology and other alternative therapies in pediatric audiology.

关键词： Sensorineural hearing loss Reflexology Congenital hearing loss Alternative medicine Audiology

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia nürnberger Barbara Schaedl James ferguson nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). However, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Laparoscopic complete mesocolic excision: West meets East

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World Journal of Gastroenterology 2014年第39期20卷 14301-14307页

作者： carina f K Chow Seon Hahn Kim Division of Colorectal Surgery Departmentof SurgeryRoyal Brisbane and Women’s HospitalBrisbaneQueensland 4029 Australia Department of General Surgery Mater Hospital South Brisbane Brisbane Queensland 4101 Australia Department of Surgery University of Queensland Brisbane Queensland 4072 Australia Colorectal Division Department of SurgeryKorea University Anam Hospital Anam-dongSeongbuk-gu Seoul 136-705 South Korea

Complete mesocolic excision is a relatively new concept in western literature. It follows the same concept of total mesorectal excision and units’ routinely performing complete mesocolic excisions have good pathological results as well as good improvements in overall survival, disease free survival and local recurrence. And yet unlike total mesorectal excision, uptake in the West has been relatively slow with many units sceptical of the true benefits gained by taking up a more technically challenging and potentially more morbid procedure when there is a paucity of literature to support these claims. This article reviews complete mesocolic excision for colon cancer, attempting to identify the risks and benefits of the technique and particularly looking at the reasons why its uptake has not been universal. It also discusses the similarities of a complete mesocolic excision to a colon resection with a D3 lymphadenectomy as well as the role of a laparoscopic approach to this technique. Considering a D3 lymphadenectomy has been the standard of care for stage II and III colon cancers in many of our Asian neighbours for over 20 years, combining this data with data on complete mesocolic excision may provide enough evidence to support or refute the need for complete mesocolic excisions. Maybe there might be lessons to be learnt from our colleagues in the east.

关键词： Complete mesocolic excision Colorectal surgery Laparoscopy Colonic neoplasms D3 lymphadenectomy

Screening chloroplast regions in Calophyllum brasiliense (Calophyllaceae) for suitability for population genetic analyses

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Journal of forestry Research 2018年第4期29卷 978-985页

作者： Cecilia B. Percuoco Lucas G. Gimenez Liliana n. Talavera Stefani Jorge V. Crisci carina f. Argüelles Laboratorio GIGA Instituto de Biologia Subtropical Nodo Posadas Universidad Nacional de Misiones (UNaM) Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) Jujuy 1745 N3300NFK Posadas Misiones Argentina Catedra de Genetica Molecular Facultad de Ciencias Exactas Quimicas y Naturales (FCEQyN) Universidad Nacional de Misiones (UNaM) Felix de Azara 1552 N3300LQH Posadas Misiones Argentina Laboratorio de Sistematica y Biologia Evolutiva (LASBE) facultad de Ciencias naturales y Museo (fCnyM) Universidad Nacional de La Plata-(UNLP) Avenida 122 y 60 1900 La Plata Buenos Aires Argentina

The uniparental inheritance and conserved structure of the chloroplast genome among many angiosperms makes it suitable for constructing gene lineages and inferring population histories based on these relationships. However, the analysis of a single chloroplast region to solve population issues has not yielded the desired amount of variability due to the low mutation rate. Therefore, it is necessary to screen and carefully analyze chloroplast intergenic or intronic regions to select the most appropriate for studying the genetic variability in the chloroplast genome of a particular taxon. In this context, the aim of this work was to characterize 8 regions in Calophyllum brasiliense using 11 selected primer pairs and to evaluate their usefulness for phylogeographic analysis. Intergenic spacers petA-psbJ, petG-trnP and rp132-trnL and the trnL intron demonstrated potentially informative sites. The combination of these 4 regions will allow the analysis of genetic population structure and the integration of historical aspects to inform strategies for conserving C. brasiliense, especially for highly impacted populations and those at risk of local extinction.

关键词： cpDnA cpSSRs noncoding regions

Preliminary examination of early neuroconnectivity features in the R6/1 mouse model of Huntington's disease by ultra-high field diffusion MRI

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neural Regeneration Research 2022年第5期17卷 983-986页

作者： Rodolfo G.Gatto carina Weissmann Department of Bioengineering the University of Illinois at ChicagoChicagoILUSA Instituto de fisiología Biología Molecular y neurociencias-IfIBYnECOnICET Universidad de Buenos AiresBuenos AiresArgentina

During the last decades,advances in the understanding of genetic,cellular,and microstructural alterations associated to Huntington's disease(HD)have improved the understanding of this progressive and fatal ***,events related to early neuropathological events,neuroinflammation,deterioration of neuronal connectivity and compensatory mechanisms still remain vastly ***-high field diffusion MRI(UHfD-MRI)techniques can contribute to a more comprehensive analysis of the early microstructural changes observed in *** addition,it is possible to evaluate if early imaging microstructural parameters might be linked to histological ***,qualitative studies analyzing histological complexity in brain areas susceptible to neurodegeneration could provide information on inflammatory events,compensatory increase of neuroconnectivity and mechanisms of brain repair and *** application of ultra-high field diffusion-MRI technology in animal models,particularly the R6/1 mice(a common preclinical mammalian model of HD),provide the opportunity to analyze alterations in a physiologically intact model of the *** some disparities in volumetric changes across different brain structures between preclinical and clinical models has been documented,further application of different diffusion MRI techniques used in combination like diffusion tensor imaging,and neurite orientation dispersion and density imaging have proved effective in characterizing early parameters associated to alteration in water diffusion exchange within intracellular and extracellular compartments in brain white and grey ***,the combination of diffusion MRI imaging techniques and more complex neuropathological analysis could accelerate the discovery of new imaging biomarkers and the early diagnosis and neuromonitoring of patients affected with HD.

关键词： brain repair diffusion tensor imaging Huntington's disease neurite orientation dispersion and density imaging neuroconnectivity neuroinflammation neuroplasticity neuroregeneration R6/1 mice ultra-high field diffusion MRI

novel experimental techniques to assess the time-dependent deformations of geosynthetics under soil confinement

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第2期13卷 410-419页

作者： carina Maia Lins Costa Jorge Gabriel Zornberg Department of Civil Engineering Federal University of Rio Grande do NorteAv.Senador Salgado Filho 3000NatalRio Grande do Norte59078-970Brazil Department of Civil Architectural and Environmental Engineering The University of Texas at Austin301 E.Dean KeetonAustinTX78712-0280USA

A new experimental approach to assess the impact of soil confinement on the long-term behavior of geosynthetics is presented in this *** experimental technique described herein includes a novel laboratory apparatus and the use of different types of tests that allow generation of experimental data suitable for evaluation of the time-dependent behavior of geosynthetics under soil *** soil-geosynthetic interaction equipment involves a rigid box capable of accommodating a cubic soil mass under plane strain conditions.A geosynthetic specimen placed horizontally at the mid-height of the soil mass is subjected to sustained vertical pressures that,in turn,induce reinforcement axial loads applied from the soil to the *** previously reported studies on geosynthetic behavior under soil confinement,the equipment was found to be particularly *** minor setup modifications,not only interaction tests but also in-isolation geosynthetic stress relaxation tests and soil-only tests under a constant strain rate can be conducted using the same ***,the time histories of the reinforcement loads and corresponding strains are generated throughout the *** from typical tests conducted using sand and a polypropylene woven geotextile are presented to illustrate the proposed experimental *** testing procedure was found to provide adequate measurements during tests,including good repeatability of test *** soilegeosynthetic interaction tests were found to lead to increasing geotextile strains with time and decreasing reinforcement tension with *** test results highlighted the importance of measuring not only the time history of displacements but also that of reinforcement loads during *** approach of using different types of tests to analyze the soilegeosynthetic interaction behavior is an innovation that provides relevant insight into the impact of soil confinement on the time-dependent deformations of geos

关键词： Geosynthetics Geotextile Creep Stress relaxation Reinforced soil Long-term deformation

foot reflexology in autoimmune diseases:Effectiveness and mechanisms

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World Journal of Clinical Cases 2025年第7期13卷 1-5页

作者： Jozélio freire de Carvalho Aaron Lerner carina Benzvi núcleo de Pesquisa em Doenças Crônicas não Transmissíveis Federal University of BahiaSalvador 40231-300BahiaBrazil Department of Research Chaim Sheba Medical CenterThe Zabludowicz Research Center for Autoimmune DiseasesRamat Gan 52621Israel

foot reflexology(fR)is a Chinese-originated and non-invasive complementary therapy increasingly used by functional,alternative and para-medical *** attempts are made to study fR in non-functional organic *** present invited Editorial discusses the application of fR in autoimmune diseases(AD),highlighting a few successful studies demonstrating symptomatic relief and objective *** promising results,the fR domain remains under-investigated and an urgent need to confirm and understand the effect of fR in chronic diseases,including AD,is highly recommended.

关键词： Reflexology foot reflexology Sensorineural hearing loss Autoimmune diseases Autoimmunity

Environmental enrichment as a promising strategy for aiding multiple sclerosis treatment

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neural Regeneration Research 2020年第9期15卷 1660-1661页

作者： Berenice Anabel Silva carina Cintia ferrari Instituto de Medicina Translacional e Ingenieria Biomedica del Hospital italiano(IMTIB-COnICET) Leloir Institute foundation Institute for Biochemical InvestigationsIIBBA-CONICETBuenos AiresArgentina

Multiple sclerosis(MS)is a complex chronic disease of the central nervous system(CnS)which includes three main anatomopathological characteristics:inflammation,demyelination,*** pathology induces many clinical symptoms,depending on the site of the lesions,such as motor,sensitive,visual,urinary and cognitive *** addition,MS is a very heterogeneous disease that displays different clinical courses or phenotypes(relapsing/remitting MS,primary progressive MS(PPMS)and secondary progressive MS(SPMS).Both neurodegeneration and inflammation are present along the natural history of the ***,the balance of both phenomena varies according to the course of the *** relapsing/remitting MS form,the acute inflammation,mainly adaptive immunity,predominates over the neurodegeneration,being the main cause of the *** SPMS and PPMS,the neurodegeneration predominates over the inflammation,which appears as chronic inflammation,being innate immunity(microglia and astroglia)the main feature in the neurodegenerative process.

关键词： inflammation immunity sclerosis