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Phenolic and nutritional profiles,and antioxidant activity of grape pomaces and seeds from Lacrima di Morro d’Alba and Verdicchio varieties

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Food Bioscience 2023年第3期53卷 2731-2740页

作者： Doaa Abouelenein Ahmed M.Mustafa giovanni caprioli Massimo Ricciutelli Gianni Sagratini Sauro Vittori School of Pharmacy University of CamerinoCHemistry Interdisciplinary Project(CHIP)via Madonna delle Carceri62032CamerinoItaly Department of Pharmacognosy Faculty of PharmacyZagazig UniversityZagazig44519Egypt

Grape pomace contains high amounts of bioactive compounds,mainly polyphenols,with different concentrations depending on several factors:grape variety,vinification procedures,even within the same cultivar variation may be due to the geographic regions and wine ***,phenolic,antioxidant,macro-and micro-nutritional composition of wine waste(pomace and seed)originating from Lacrima di Morro d’Alba red grape variety and pomace of Verdicchio white variety were evaluated for the first ***-MS/MS analysis showed the presence of 32 phenolic *** phenolic profile was different in pomace of both varieties:white grape pomaces showed the predominance of flavan-3-ols,while anthocyanins were predominant in red *** seeds and pomace of Lacrima di Morro d’Alba,catechin and epicatechin are representative com-pounds in red grape seeds,while malvidin-3-galactoside and petunidin-3-glucoside are the most abundant compounds in pomace of all *** TPC and antioxidant activities determined by UV-vis spectro-photometer were observed in seed *** dietary fibers,polyunsaturated fatty acids,minerals and protein contents were observed in all *** byproducts of both grape varieties appeared to be a good source of phenolic and nutritional compounds;therefore,they could be a cheap alternative for phenolics production and development of new functional foods.

关键词： Lacrima di Morro d’Alba Red grape variety White grape variety Verdicchio Grape pomace Grape seeds Phenolic profile Nutritional profile Antioxidant

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Integration of in vitro and in silico approaches to assess three Astragalus species from Turkey flora:A novel spotlight from lab bench to functional applications

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Food Bioscience 2022年第5期49卷 1183-1194页

作者： Gokhan Zengin Abdullahi Ibrahim Uba Mustafa Ocal Majid Sharifi-Rad giovanni caprioli Simone Angeloni Yasemin Celik Altunoglu Mehmet Cengiz Baloglu Evren Yıldıztugay Department of Biology Science FacultySelcuk University42130KonyaTurkey Department of Molecular Biology and Genetics Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul34083Turkey Department of Genetics and Bioengineering Faculty of Engineering and ArchitectureKastamonu UniversityKastamonuTurkey Department of Range and Watershed Management Faculty of Water and SoilUniversity of ZabolIran School of Pharmacy University of CamerinoVia Sant’Agostino 1I-62032CamerinoMCItaly Department of Biotechnology Science FacultySelcuk University42130KonyaTurkey

Members of the genus Astragalus have a great interest as a source of natural bioactive compounds on a scientific *** provide multidirectional insights into three Astragalus species(***,***,and ***),the current work focused on the chemical characterization and biological properties of their extracts(aerial parts and roots).The chemical characterization of the extracts was detected by HPLC-MS/MS *** biological properties were evaluated by antioxidant,enzyme inhibitory,and cytotoxic *** for radical quenching,reducing capacity,and metal chelation were also used to evaluate antioxidant *** test the enzyme inhibitory effects of the extracts,cholinesterases,tyrosinase,α-amylase,andα-glucosidase were utilized as target *** cancer cell lines,(MCF-7(human breast cancer cell line)and HeLa(Human cervix cancer cell line),were selected to evaluate cytotoxic ***,5-caffeoylquinic acid(2.43-283.92μg/g extract),hyperoside(4.33-216.22μg/g extract)and rutin(1.09-184.98μg/g extract)were the main *** extracts from aerial parts and roots of *** showed stronger radical scavenging and reducing power abilities compared to *** and *** best AChE and BChE inhibitory effects were determined in the aerial parts of ***(2.18 mg GALAE/g)and roots of ***(4.76 mg GALAE/g),*** extracts of *** had the highest tyrosinase inhibitory *** extract from aerial parts of *** showed stronger cytotoxic effects compared to other ***’s correlation analysis revealed that the presence of some compounds(resveratrol,p-coumaric,5-caffeoylquinic,and ferulic acids,etc)was linked to the observed biological *** docking was also provided for the possible interaction of enzymes as well as protein targets of the tested cell *** findings provide a scientific basis for the Astragalus species,which may serve as a source

关键词： Astragalus Phenolics Cytotoxic effect Molecular docking Bioactive agents

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Evaluation of the chemical constituents,antioxidant and enzyme inhibitory activities of six Yemeni green coffee beans varieties

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Food Bioscience 2022年第2期46卷 1006-1013页

作者： Ammar Mohammed Ahmed Ali Sakina Yagi Ahmed A.Qahtan Abdurrahman A.Alatar Simone Angeloni Filippo Maggi giovanni caprioli Eslam M.Abdel-Salam Kouadio Ibrahime Sinan Gokhan Zengin Department of Biology Faculty of EducationHajji UniversityHajjahYemen Botany Department Faculty of ScienceUniversity of KhartoumSudan Department of Botany&Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia Chemistry Interdisciplinary Project(ChIP) School of PharmacyUniversity of CamerinoVia Madonna delle Carceri 9/BI62032CamerinoMCItaly Physiology and Biochemistry Laboratory Department of BiologyScience FacultySelcuk UniversityCampus42103KonyaTurkey

Coffee arabica *** an economical crop cultivated in many countries including *** present study evaluated the phytochemical contents of the methanolic extracts,prepared by maceration,of six Yemeni green coffee beans varieties namely Esmaeli,Hamadi,Harazi,Mattari,Odaini and ***(phosphomolybdenum,antiradical,reducing power and ferrous chelating),and enzyme inhibition activity of the extracts against acetylcholinesterase butyrylcholinesterase,tyrosinase,α-glucosidase,andα-amylase were also *** of total phenols revealed that all green beans varieties were richer in their total polyphenolic(63.77-110.98 mg gallic acid equivalent per g of extract)content than their flavonoids one(2.86-5.57 mg rutin equivalent per g of extract).HPLC-MS/MS analysis of 30 selected bioactive compounds showed that all varieties had the same types of phytoconstituents with differences in their relative ***(1613.89-2466.38μg/g)followed by 5-caffeoylquinic acid(1017.63-1313.39μg/g)were the dominant compounds in all varieties with caffeine more abundant in Esmaeli variety while 5-caffeoylquinic acid in Odaini *** varieties displayed a pronounced antioxidant property in all the in vitro assays with Odaini variety significantly(p<0.05)exerted the highest anti-DPPH radicals(253.96 mg Trolox equivalent(TE)/g),metal chelating(19.73 mg Disodium edetate equivalents/g),Cu^(2+)(441.11 mg TE/g)and Fe3+(221.04 mg TE/g)reducing ***,the majority of green coffee beans varieties showed comparable enzyme inhibition property with highest activity recorded against tyrosinase(39.35-46.96 mg kojic acid equivalents/g)and acetylcholinesterase(1.80-2.17 mg galanthamine equivalents/g)*** conclusion,all Yemeni green coffee beans varieties have proven to be rich source of biochemicals with beneficial impact on human health and could be of significant applications in food,pharmaceutical and cosmetics industry.

关键词： Yemeni coffee Phytoconstituents Green coffee HPLC-MS/MS Antioxidants Enzyme inhibitory properties

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Conversion of ergosterol into vitamin D2 and other photoisomers in Agaricus bisporus mushrooms under UV-C irradiation

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Food Bioscience 2022年第6期50卷 1625-1633页

作者： Yue Sun Franks Kamgang Nzekoue Sauro Vittori Gianni Sagratini giovanni caprioli Chemistry Interdisciplinary Project (CHip) School of PharmacyUniversity of CamerinoVia Madonna delle Carceri62032CamerinoItaly

Agaricus bisporus mushrooms contain high levels of ergosterol(3–8 mg/g dw),which can be converted into vitamin D2(VD2)under ultraviolet irradiation(UV).However,the photoconversion of ergosterol can also lead to the production of inactive photoisomers decreasing the production yield of *** study assesses the impact of UV irradiation conditions on the conversion of ergosterol into vitamin *** effects of various parameters were tested including the mushroom form(powder,extract,suspension),irradiation time(0–240 min),temperature(20–40°C),intensity(0.16–0.48 mW/cm2),and agitation during UV-C *** mushroom extract was the most suitable mushroom form for VD2 *** VD2,other photoisomers(tachysterol and lumisterol),were detected through HPLC-APCI-MS and their levels increased with deep and prolonged *** highest VD2 levels(0.95–1.03 mg/g dw)were obtained by irradiating mushroom extracts with an intensity of 0.31 mW/cm2 for 10 *** results highlight the potential of mushrooms for VD2 production through UV-C irradiation,which is accompanied by the formation of biologically-active photo-isomers.

关键词： Mushrooms Vitamin D2 Ergosterol Tachysterol Lumisterol UV-C irradiation Photo-conversion Champignons HPLC-APCI-MS Mushroom wastes

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Grapevine leaves(Vitis vinifera):Chemical characterization of bioactive compounds and antioxidant activity during leave development

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Food Bioscience 2022年第6期50卷 1579-1586页

作者： Franks Kamgang Nzekoue Manuella Lesly Kouamo Nguefang Laura Alessandroni Ahmed M.Mustafa Sauro Vittori giovanni caprioli CHemistry Interdisciplinary Project (CHIP) School of PharmacyUniversity of CamerinoVia Madonna delle Carceri62032CamerinoItaly Department of Pharmacognosy Faculty of PharmacyZagazig UniversityZagazig44519Egypt

Leaves from Vitis vinifera *** the less studied and valorized wastes of grape crops and the winery *** study aims thus to perform for the first time a deepened assessment of the bioactive compounds in grapevine *** detailed composition of main phytochemicals involved in the high antioxidant of grape leaves(2.20 g TE/100 g)was determined including carotenoids(lutein,β-carotene),tocopherols(αandɣ-tocopherol),polyphenols(phenolics acids,flavonoids),and phytosterols(β-sitosterol).In particular,high levels of lutein(0.3–1.0 g/kg)andα-tocopherol(0.2–1.2 g/kg)were ***,the evolution of bioactive compounds during 7 harvesting times from July to October was also studied showing that the content of phytochemicals fluctuates according to the development stage of grape *** for example reached their highest levels in leaves in the later stage of maturation(T6–T7)with values around 169±40 mg/kg.

关键词： Grape leaves Polyphenols Carotenoids Tocopherols Phytosterols Antioxidants Waste valorization

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Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

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Neural Regeneration Research 2025年第6期20卷 1701-1702页

作者： giovanni Ribaudo Matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli Department of Molecular and Translational Medicine University of BresciaBresciaItaly

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关键词： gateway homeostasis preserve

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High voltage direct current transmission cables to help decarbonisation in Europe:Recent achievements and issues

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High Voltage 2022年第4期7卷 633-644页

作者： giovanni Mazzanti Department of Electrical Electronic and Information EngineeringUniversity of BolognaBolognaItaly

High Voltage Direct Current(HVDC)underground and submarine cables constitute an essential technology for the long-distance transmission of renewable electrical power with low losses,thereby fostering *** the past 2 decades,all this yielded a quasi-exponential rise of HVDC cable systems installed worldwide,but has also made the working conditions of HVDC cables *** this paper,the contribution of HVDC cables to decarbonisation is tackled,with particular reference to the situation in Europe,and a few simple calculations showing in general terms the quantitative contribution provided by HVDC cable systems to decarbonisation are ***,the major issues towards long-lasting and reliable HVDC cable systems are summarised briefly,focussing-for the sake of brevity-on the influence of the main HVDC cable technologies,of cable laying environment and of duty *** hints are also provided at the chances given by multiterminal HVDC systems.

关键词： cable submarine thereby

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Imaging of Proteins in Tissue Sections Using Mass Spectrometry as a Discovery Tool

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质谱学报 2004年第B10期25卷 119-120页

作者： RichardM.caprioli DepartmentofBiochemistry VanderbiltUniversitySchoolofMedicineNashvilleTNUSA

The Mass Spectrometry Group of Richard M. caprioli at Vanderbilt University is evaluating Macromizer^TM for their MALDI-imaging application. The expectation is to see more high mass proteins due to the increased high ... 详细信息

关键词：质谱分析蛋白质缩氨酸基质辅助激光解吸电离

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Deep learning to develop zero-equation based turbulence model for CFD simulations of the built environment

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Building Simulation 2024年第3期17卷 399-414页

作者： giovanni Calzolari Wei Liu Division of Sustainable Buildings Department of Civil and Architectural EngineeringKTH Royal Institute of TechnologyBrinnelvägen 23Stockholm11428Sweden

This study aims to improve the accuracy and speed of predictions for thermal comfort and air quality in built environments by creating a coupled framework between computational fluid dynamics(CFD)simulations and deep learning *** coupling approach is showcased by the development of a data-driven turbulence *** new turbulence model is built using a deep learning neural network,whose mapping structure is based on a zero-equation turbulence model for built environment simulations,and is coupled with the CFD software OpenFOAM to create a hybrid *** neural network is a standard shallow multi-layer *** number of hidden layers and nodes per layer was optimized using Bayesan optimization *** framework is trained on an indoor environment case study,as well as tested on an indoor office simulation and an outdoor building array *** show that the deep learning based turbulence model is more robust and faster than traditional two-equation Reynolds average Navier-Stokes(RANS)turbulence models,while maintaining a similar level of *** model also outperforms the standard algebraic zero-equation model due to its superior ability to generalize to various flow *** some challenges,namely the mapping constraint,the limited training dataset size and the source of generation of training data,the hybrid framework demonstrates the viability of the coupling technique and serves as a starting point for future development of more reliable and advanced models.

关键词： neural networks computational fluid dynamics(CFD) turbulence model OpenFOAM

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Numerical modeling of deep-seated landslides interacting with man-made structures

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第6期10卷 1020-1036页

作者： giovanni Barla Politecnico di Torino TorinoItaly

This paper describes the interaction between deep-seated landslides and man-made structures such as dams, penstocks, viaducts, and tunnels. Selected case studies are reported first with the intent to gain insights into the complexities associated with the interaction of these structures with deep-seated landslides(generally referred to as deep-seated gravity slope deformations, DSGSDs). The main features, which characterize these landslides, are mentioned together with the interaction problems encountered in each case. Given the main objective of this paper, the numerical modeling methods adopted are outlined as means for increase in the understanding of the interaction problems being investigated. With the above in mind, the attention moves to an important and unique case history dealing with the interaction of a large-size twin-tunnel excavated with an earth pressure balance(EPB)tunnel boring machine(TBM) and a deep-seated landslide, which was reactivated due to the stress changes induced by tunnel excavation in landslide shear zone. The geological and geotechnical conditions are described together with the available monitoring data on the landslide movements, based on the advanced and conventional monitoring tools used. Numerical modeling is illustrated as an aid to back-analyze the monitored surface and subsurface deformations and to assist in finding the appropriate engineering solution for putting the tunnel into service and as a follow-up means for future understanding and control of the interaction problems. The simulation is based on a novel time-dependent model representing the landslide behavior.

关键词： Deep-seated landslides Man-made structures Landslide-structure interaction Monitoring of landslide movement Numerical modeling

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