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Distribution of per-and polyfluoroalkyl substances in blood,serum,and urine of patients with liver cancer and associations with liver function biomarkers

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Journal of Environmental Sciences 2024年第5期139卷 418-427页

作者： cao dai Lin Peng Yanjie Li Zhendong Li Da Chen Fei Wang Nan Lin Department of Hepatobiliary Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China School of Environment Guangdong Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China South China Institute of Environmental Sciences MEEGuangzhou 510655China

Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or ***,data on clinical epidemiology are very *** this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood ***,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers *** example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with *** addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(p<0.05).Our results provide epidemiological support for the future study on the potential clinical hepatotoxicity of PFAS.

关键词： Per-and polyfluoroalkyl substances(PFASs) Liver cancer Serum Blood Urine Liver function biomarkers

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航空信息网络服务功能链请求调度策略

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兵工学报 2024年第7期45卷 2306-2317页

作者：曹代詹思瑜郝鑫胜关楷付皓通电子科技大学信息与通信工程学院四川成都611731 电子科技大学智能计算研究院四川成都611731 93303部队辽宁沈阳110000 95859部队甘肃酒泉735000

为解决航空信息网络场景下业务突发、拓扑结构动态变化以及资源有限所带来的资源利用效率低下问题,针对服务功能链请求(Service Function Chain Requirement,SFCR)高效调度的难题,提出一种网络功能虚拟化的服务功能链调度算法。算法依据... 详细信息

为解决航空信息网络场景下业务突发、拓扑结构动态变化以及资源有限所带来的资源利用效率低下问题,针对服务功能链请求(Service Function Chain Requirement,SFCR)高效调度的难题,提出一种网络功能虚拟化的服务功能链调度算法。算法依据SFCR与平台的相关性进行映射,提高服务器处理效率并有效减少虚拟网络功能实例化数量及整合平台资源;综合考虑时延和流量影响对网络功能实例进行整合迁移,降低网络能耗同时提升网络资源利用率。仿真结果表明,在满足时延需求条件下,新方法在运行平台数量、SFCR接受率、网络资源消耗等方面具有较好的优化性能,适用于解决航空信息网络场景下的SFCR调度问题。

关键词：航空信息网络网络功能虚拟化服务功能链服务功能链请求调度网络功能实例

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Nonlinear dynamics of a circular curved cantilevered pipe conveying pulsating fluid based on the geometrically exact model

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 261-276页

作者： Runqing cao Zilong GUO Wei CHEN Huliang dai Lin WANG Department of Engineering Mechanics School of Aerospace EngineeringHuazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074China State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Due to the novel applications of flexible pipes conveying fluid in the field of soft robotics and biomedicine,the investigations on the mechanical responses of the pipes have attracted considerable *** fluid-structure interaction(FSI)between the pipe with a curved shape and the time-varying internal fluid flow brings a great challenge to the revelation of the dynamical behaviors of flexible pipes,especially when the pipe is highly flexible and usually undergoes large *** this work,the geometrically exact model(GEM)for a curved cantilevered pipe conveying pulsating fluid is developed based on the extended Hamilton's *** stability of the curved pipe with three different subtended angles is examined with the consideration of steady fluid *** attention is concentrated on the large-deformation resonance of circular pipes conveying pulsating fluid,which is often encountered in practical *** constructing bifurcation diagrams,oscillating shapes,phase portraits,time traces,and Poincarémaps,the dynamic responses of the curved pipe under various system parameters are *** mean flow velocity of the pulsating fluid is chosen to be either subcritical or *** numerical results show that the curved pipe conveying pulsating fluid can exhibit rich dynamical behaviors,including periodic and quasi-periodic *** is also found that the preferred instability type of a cantilevered curved pipe conveying steady fluid is mainly in the flutter of the second *** a moderate value of the mass ratio,however,a third-mode flutter may occur,which is quite different from that of a straight pipe system.

关键词： curved pipe conveying fluid pulsating fluid geometrically exact model(GEM) nonlinear dynamics parametric vibration flutter

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Residual levels and health risk assessment of trace metals in Chinese resident diet

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Journal of Environmental Sciences 2024年第2期136卷 451-459页

作者： Yubing dai Shuai Sun Rong cao Haijun Zhang Jiping Chen Ningbo Geng CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Shenyang Pharmaceutical University Shenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

Large-scale metal contamination across the food web is an intractable problem due to increasing pollutant emissions,atmospheric transport,and dry and wet deposition of *** present study focus on several trace metals that are rarely studied but have special toxicity,including tin(Sn),antimony(Sb),gold(Au),hafnium(Hf),palladium(Pd),platinum(Pt),ruthenium(Ru),tellurium(Te)and iridium(Ir).We investigated trace metals residues and distribution characteristics,and further evaluated the potential health risks from major daily food intakes in 33 cities in ***,Sb,Ir,Hf,and Au were frequently detected in food samples with the concentrations ranged from ND(not detected)to 24.78μg/kg ww(wet weight).Eggs exhibited the highest residual level of all detected metals(13.70±14.70μg/kg ww in sum),while the lowest concentrations were observed in vegetables(0.53±0.17μg/kg ww in sum).Sn accounting for more than 50%of the total trace metals concentration in both terrestrial and aquatic animal origin *** terrestrial plant origin foods,Sn and Ir were the most abundant *** and Au were the most abundant elements in egg *** addition,Sb and Ir showed a clear trophic dilution effect in terrestrial environments,while in aquatic ecosystems,Sn,Hf,and Au exhibited obvious trophic amplification *** calculated average estimated daily intake(EDI)via food consumption in five regions of China was 0.09μg/(kg·day),implying the health risk of aforementioned elements was acceptable.

关键词： Trace metals Accumulation characteristics Dietary exposure Estimated daily intake(EDI)

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Effects of acid mine drainage on photochemical and biological degradation of dissolved organic matter in karst river water

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Journal of Environmental Sciences 2024年第1期135卷 26-38页

作者： Linwei Li Xingxing cao Chujie Bu Pan Wu Biao Tian Yongheng dai Yeye Ren College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China Key Laboratory of Karst Georesources and Environment Ministry of EducationGuizhou UniversityGuiyang 550025China Guizhou Karst Environmental Ecosystems Observation and Research Station Ministry of EducationGuizhou UniversityGuiyang 550025China

Dissolved organic matter(DOM)can be removed or transformed by photochemical and biological processes,producing the negative effect of transforming organic carbon into inorganic carbon,which plays a vital role in the karst carbon ***,acid mine drainage(AMD)will affect this process,so the degradation of DOM in karst river water(KRW)needs to be studied in this *** this study,to reveal the evolution processes of DOM under photochemical and biological conditions in AMD-impacted KRW,AMD and KRW were mixed in different ratios under conditions of visible light irradiation(VL),biodegradation(BD),ultraviolet irradiation(UV)and ultraviolet irradiation+biodegradation(UV+BD).The average DOC concentrations in samples after mixing AMD and KRW in different proportions decreased significantly(by 23%)in UV+BD,which was 1.2–1.4 times higher than under the other conditions and would lead to a significant release of inorganic *** analysis of the fluorescence parameters via parallel factor analysis(PARAFAC)revealed that the DOM fluorescence components in AMD comprised mainly protein-like substances derived from autochthonous components,while the DOM fluorescence components in KRW were mainly humic-like substances with both autochthonous and allochthonous ***,AMD could promote both the photochemical and biological degradation of DOM in karst receiving streams,resulting in the conversion of DOC to inorganic *** results showed that the synergistic effects of UV+BD and AMD accelerated the degradation of DOM and the release of inorganic carbon in KRW,thus affecting the stability of the karst carbon cycle.

关键词： Acid mine drainage Dissolved organic matter Karst river water Photochemical degradation Biological degradation

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Implementation of a particle-in-cell method for the energy solver in 3D spherical geodynamic modeling

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Earth and Planetary Physics 2024年第3期8卷 549-563页

作者： Hao Dong ZeBin cao LiJun Liu YanChong Li SanZhong Li LiMing dai XinYu Li Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Laboratory of Submarine Geosciences and Prospecting TechniquesMinistry of Education and College of Marine GeosciencesOcean University of ChinaQingdao 266100China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Laboratory for Marine Geology Laoshan LaboratoryQingdao 266237China Department of Earth Science&Environmental Change University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Laboratory of Seismology and Physics of Earth’s Interior School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China

The thermal evolution of the Earth’s interior and its dynamic effects are the focus of Earth ***,the commonly adopted grid-based temperature solver is usually prone to numerical oscillations,especially in the presence of sharp thermal gradients,such as when modeling subducting slabs and rising *** phenomenon prohibits the correct representation of thermal evolution and may cause incorrect implications of geodynamic *** examining several approaches for removing these numerical oscillations,we show that the Lagrangian method provides an ideal way to solve this *** this study,we propose a particle-in-cell method as a strategy for improving the solution to the energy equation and demonstrate its effectiveness in both one-dimensional and three-dimensional thermal problems,as well as in a global spherical simulation with data *** have implemented this method in the open-source finite-element code CitcomS,which features a spherical coordinate system,distributed memory parallel computing,and data assimilation algorithms.

关键词： numerical oscillation overshooting and undershooting particle-in-cell method three-dimensional spherical geodynamic modeling energy solver finite element method

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Silicon photonic spectrometer with multiple customized wavelength bands

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Photonics Research 2024年第5期12卷 1016-1023页

作者： LONG ZHANG XIAOLIN YI DAJIAN LIU SHIHAN HONG GAOPENG WANG HENGZHEN cao YAOCHENG SHI DAOXIN dai State Key Laboratory for Modern Optical Instrumentation Center for Optical&Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityZjingang CampusHangzhou 310058China Intelligent Optics and Photonics Research Center Jiaxing Research InstituteZhejiang UniversityJiaxing 314000China Ningbo Research Institute Zhejiang UniversityNingbo 315100China

A silicon photonic spectrometer with multiple customized wavelength bands is developed by introducing multiple channels of wideband optical filters based on multimode waveguide gratings(MWGs)for pre-filtering and the corresponding thermally tunable narrowband filter for high *** these multiple customized wavelength bands,the central wavelengths,bandwidths,and resolutions are designed flexibly as desired,so that the system is simplified and the footprint is minimized for several practical applications(e.g.,gas sensing).A customized silicon photonic spectrometer is designed and demonstrated experimentally with four wavelength bands centered around1310 nm,1560 nm,1570 nm,and 1930 nm,which is,to the best of our knowledge,the first on-chip spectrometer available for sensing multiple gas components like HF,CO,H_(2)S,and CO_(2).The spectral resolutions of the four wavelength bands are 0.11 nm,0.08 nm,0.08 nm,and 0.37 nm,*** a customized silicon photonic spectrometer shows great potential for various applications,including gas monitors,wearable biosensors,and portable spectral-domain optical coherence tomography.

关键词： waveguide bands multiple

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Research on 3D Distribution of Meandering River Sand Body Using Sedimentary Facies Method and 3D Geological Modeling

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Journal of China University of Mining and Technology 2006年第3期16卷 349-352页

作者： WU Jian cao dai-yong Key Laboratory of Coal Resources Ministry of Education Beijing 100083 China

Sedimentary facies study is an important method in describing the property and distribution of reservoir. 3D geological modeling is a powerful tool in 3D characterization of geological bodies. By combining the sedimentary facies study with 3D geological modeling to generate 3D sedimentary facies model, the 3D geometry and distribution feature of sand bodies can be more accurately characterized, particularly in 3D view. In Liuchu oilfield of Jizhong depression, the Ed2IV formation was recognized as meandering river deposition facies and five sedimentary facies were identified, which include point bar sand, levee, channel margin, abandoned channel and floodplain. All the 24 sand body facies in Ed2IV were mapped and the 3D sedimentary facies model established based on 2D facies maps. The result shows that the 3D sedimentary facies model is well matched for the research result of sedimentary facies. Being an extension of traditional sedimentary study, the 3D sedimentary facies model can be used to describe the 3D geometry and distribution orders of a single sand body more reliably and more accurately.

关键词：沉积相曲流河三维模拟地质模型数学勘探

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A Skin-Inspired Self-Adaptive System for Temperature Control During Dynamic Wound Healing

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Nano-Micro Letters 2024年第8期16卷 211-224页

作者： Yaqi Geng Guoyin Chen Ran cao Hongmei dai Zexu Hu Senlong Yu Le Wang Liping Zhu Hengxue Xiang Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University2999 North Renmin RoadShanghai 201620People’s Republic of China

The thermoregulating function of skin that is capable of maintaining body temperature within a thermostatic state is ***,patients suffering from skin damage are struggling with the surrounding scene and situational ***,we report an interactive self-regulation electronic system by mimicking the human thermos-reception *** skin-inspired self-adaptive system is composed of two highly sensitive thermistors(thermal-response composite materials),and a low-power temperature control unit(Laserinduced graphene array).The biomimetic skin can realize self-adjusting in the range of 35–42℃,which is around physiological *** thermoregulation system also contributed to skin barrier formation and wound *** wound models,the treatment group healed~10%more rapidly compared with the control group,and showed reduced inflammation,thus enhancing skin tissue *** skin-inspired self-adaptive system holds substantial promise for nextgeneration robotic and medical devices.

关键词： Thermo-reception Self-regulation Flexible electronic system Wound healing

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Structural Isomers:Small Change with Big Difference in Anion Storage

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Nano-Micro Letters 2024年第1期16卷 222-234页

作者： Huichao dai Yuan Chen Yueyue cao Manli Fu Linnan Guan Guoqun Zhang Lei Gong Mi Tang Kun Fan Chengliang Wang School of Integrated Circuits Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Wenzhou Advanced Manufacturing Institute Huazhong University of Science and TechnologyWenzhou 325035People’s Republic of China Hubei Key Laboratory of Polymer Materials School of Materials Science and EngineeringHubei UniversityWuhan 430062People’s Republic of China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430073People’s Republic of China

Organic electrode materials are promising for ***,the reported organic electrodes are often facing the challenges of low specific capacity,low voltage,poor rate capability and vague charge storage mechanisms,*** are good platform to investigate the charge storage mechanisms and enhance the performance of batteries,which,however,have not been focused in ***,two isomers are reported for *** a result,the isomer tetrathiafulvalene(TTF)could store two monovalent anions reversibly,deriving an average discharge voltage of 1.05 V and a specific capacity of 220 mAh g−1 at a current density of 2 *** the other hand,the other isomer tetrathianaphthalene could only reversibly store one monovalent anion and upon further oxidation,it would undergo an irreversible solid-state molecular rearrangement to *** molecular rearrangement was confirmed by electrochemical performances,X-ray diffraction patterns,nuclear magnetic resonance spectra,and 1H detected heteronuclear multiple bond correlation *** results suggested the small structural change could lead to a big difference in anion storage,and we hope this work will stimulate more attention to the structural design for boosting the performance of organic batteries.

关键词： Zinc-organic batteries Isomers Solid-state molecular rearrangement Anion storage P-type organic electrode materials

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