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Tissue distribution of perfluoroalkyl acids and health status in wild Mozambique tilapia(Oreochromis mossambicus) from Loskop Dam, Mpumalanga, South Africa

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Journal of Environmental Sciences 2017年第11期29卷 59-67页

作者： Jacqueline T.Bangma Jessica L.Reiner Hannes Botha Theresa M.cantu Marco A.gouws Matthew P.guillette Jeremy P.Koelmel Wilmien J.Luus-Powell Jan Myburgh Olivia Rynders Joseph R.Sara Willem J.Smit John A.Bowden Medical University of South Carolina Department of Obstetrics and Gynecology Charleston SC 29412 United States National Institute of Standards and Technology Chemical Sciences Division Hollings Marine Laboratory Charleston SC 29412 United States Department of Biodiuersity University of Limpopo Souenga South Africa Scientific Services Mpumalanga Tourism and Parks Agency Nelspruit 1200 South Africa Department of Science School of Natural Resource Management Nelson Mandela Metropolitan University George 6529 South Africa Uniuersity of Florida Department of Chemistry Gainesville FL 32611 United States Department of ParaclinieaI Sciences Faculty of Veterinary Science University of Pretoria Onderstepoort South Africa

This study examined concentrations of 15 perfluoroalkyl acids（PFAAs） in tissues from male Mozambique tilapia（Oreochromis mossambicus） collected at Loskop Dam, Mpumalanga,South Africa in 2014 and 2016. Nine of the 15 PFAAs were detected frequently and were included in statistical analysis and included two of the most commonly known PFAAs,perfluorooctanesulfonic acid（PFOS）（median, 41.6 ng/g） and perfluorooctanoic acid（PFOA）（median, 0.0825 ng/g）. Of the tissues measured, plasma（2016 and 2014 median, 22.2 ng/g）contained the highest PFAA burden followed by（in descending order）： liver（median,11.6 ng/g）, kidney（median, 9.04 ng/g）, spleen（median, 5.92 ng/g）, adipose（median, 2.54 ng/g）, and muscle（median, 1.11 ng/g）. Loskop Dam tilapia have been affected by an inflammatory disease of the adipose tissue known as pansteatitis, so this study also aimed to investigate relationships between PFAA tissue concentrations and incidence of pansteatitis or fish health status. Results revealed that healthy tilapia exhibited an overall higher（p-value 〈 0.05） PFAA burden than pansteatitis-affected tilapia across all *** analysis showed that organs previously noted in the literature to contain the highest PFAA concentrations, such as kidney, liver, and plasma, were the organs driving the difference in PFAA burden between the two tilapia groups. Care must be taken in the interpretations we draw from not only the results of our study, but also other PFAA measurements made on populations（human and wildlife alike） under differing health status.

关键词： Perfluoroalkyl acids Liquid chromatography mass spectrometry Pansteatitis Perfluorooctanesulfonic acid Tissue distribution

Effects of Electrical Stimulation in People with Post-Concussion Syndromes: A Pilot Study

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Health 2018年第4期10卷 381-395页

作者： Yi-Ning Wu Jessica gravel Naseem Chatiwala Terrie Enis Caroline Stark Robert C. cantu Department of Physical Therapy University of Massachusetts Lowell Lowell MA USA Dr. Robert C. cantu Concussion Center Emerson Hospital Concord MA USA Center for Rehabilitative and Sports Therapies Emerson Hospital Concord MA USA Department of Neurosurgery and Neurology Boston University School of Medicine Boston MA USA

Post-concussion syndrome (PCS) is a complex disorder with various symptoms. There is limited evidence to support that any intervention enhances recovery after a concussion. This pilot study aimed to examine the efficacy of neck paraspinal muscles electrical stimulation (ES) in conjunction with physical therapy (PT) on reducing the severity of post concussive symptoms. Twenty-four individuals with PCS were randomly assigned to the ES group (PT + ES) or the control group (PT only). Both groups received the intervention twice a week for eight weeks. Clinical measures including the Concussion Signs/Symptoms Checklist, balance error scoring system, King-Devick test, ImPACT, and the Standardized Assessment of Concussion were used to evaluate the symptoms. We investigated the recovery rate by calculating slopes of changes over time for each participant. A changing slope was derived by linearly fitting the symptoms severity over time with the initial severity score as the intercept. Significant overall improvement was observed in both groups after the interventions. There was no significant difference seen in total symptom recovery rate between two groups (-1.49 ± 1.59 versus -1.2 ± 1.56, p = 0.32). The cognitive symptoms recovery rate of the ES group was faster than the control group (-0.5 ± 0.49 and -0.13 ± 0.46 respectively, p = 0.04). Physical therapy targeting the cervical region is beneficial for persons with PCS. Moreover, peripheral electrical stimulation on the paraspinal muscles surrounding the neck region could potentially advance the cognitive function recovery of persons with PCS.

关键词： Post-Concussion Syndrome Cognitive Function Physical Therapy Electrical Stimulation

ELECTRICAL AND STRUCTURAL PROPERTIES OF ALgAN/ALgAN SUPERLATTICE STRUCTURES gROWN BY METAL-ORgANIC CHEMICAL VAPOR DEPOSITION

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ELECTRICAL AND STRUCTURAL PROPERTIES OF ALGAN/ALGAN SUPERLAT...

A conserved Puccinia striiformis effector interacts with wheat NPR1 and reduces induction of pathogenesis-relatedgenes in response to pathogens

第8届国际材联电子材料国际研讨会

作者： S.Keller P.cantu U.K.Mishra S.P.DenBaars Electrical & Computer Engineering and Materials Departments University of California Santa Barbara CA 93106 USA

In this study we investigated the electrical and structural properties of 280 nm thick silicon doped AlgaN/AlgaN superiattice (SL) structures with various well and barrier layer thickness, which were grown on 1.2 μm thick AlgaN-on-sapphire films by metal-organic chemical vapor deposition. Whereas un-intentionally doped samples were highly resistive, Si doped structures exhibited sheet carrier densities up to 5.5×10cm, determined by Hall measurements after van der Pauw at 300 K. The electron

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A conserved Puccinia striiformis effector interacts with whe...

Dilation assisted stone extraction for complex biliary lithiasis:Technical aspects and practical principles

中国植物病理学会2016年学术年会

作者： WANg Xiao-dong YANg Bao-ju LI Kun KANg Zhen-sheng Dario cantu Jorge Dubcovsky Department of Plant Science University of California State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest Agriculture and Forestry University Department of Plant Pathology Agriculture University of Hebei Department of Viticulture and Enology University of CaliforniaDavisCA 95616USA.5.Howard Hughes Medical Institute(HHMI)Chevy Chase

In Arabidopsis,NPR1 is a key transcriptional co-regulator of systemic acquired *** pathogen challenge,NPR1 translocates from the cytoplasm to the nucleus,where it interacts with TgA-bZIP transcription factors to activate the expression of several pathogenesis-related *** a screen of a yeast two-hybrid library from wheat leaves infected with ***,we identified a conserved rust effector that interacts with wheat NPR1 and named it Puccinia NPR1 interactor（PNPi）.PNPi interacts with the NPR1/NIM1-like domain of NPR1 via its C-terminal *** bimolecular fluorescence complementation assays,we detected the interaction between PNPi and wheat NPR1 in the nucleus of Nicotiana benthamiana protoplasts.A yeast three-hybrid assay showed that PNPi interaction with NPR1 competes with the interaction between wheat NPR1 and *** barley transgenic lines over expressing PNPi,we observed reduced induction of multiple PR genes in the region adjacent to Pseudomonas *** DC3000 *** on these results,we hypothesize that PNPi has a role in manipulating wheat defense response via its interactions with NPR1.

关键词： Wheat Stripe rust NPR1 Pathogen effector Yeast two-hybrid Bimolecular fluorescence complementation Transgenic barley

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World Journal of gastrointestinal Endoscopy 2021年第2期13卷 33-44页

作者： giuseppe grande Silvia Cocca Helga Bertani Angelo Caruso Flavia Pigo' Santi Mangiafico Salvatore Russo Marinella Lupo graziella Masciangelo Paolo cantu' Raffaele Manta Rita Conigliaro gastroenterology and Digestive Endoscopy Unit Azienda Ospedaliero Universitaria di ModenaModena 41126Italy gastroenterology and Endoscopy Unit Department of Pathophysiology and TransplantationFondazione IRCCS Ca’GrandaOspedale Maggiore Policlinico and Universitàdegli Studi di MilanoMilano 20122Italy gastroenterology and Digestive Endoscopy Unit General Hospital of PerugiaPerugia 06129Italy

Common bile duct stones are frequently diagnosed worldwide and are one of the main indications for endoscopic retrograde *** sphincterotomy(EST)has been used for the removal of bile duct stones for the past 40 years,providing a wide opening to allow *** to 15%of patients present with complicated *** this context,additional therapeutic approaches have been proposed such as endoscopic mechanical lithotripsy,intraductal or extracorporeal lithotripsy,or endoscopic papillary large balloon dilation(EPLBD).EPLBD combined with EST was introduced in 2003 to facilitate the passage of large or multiple bile duct stones using a balloon greater than 12 mm in *** without EST was introduced as a simplified technique in ***-assisted stone extraction(DASE)is the combination of two techniques:EPLBD and sub-maximal *** studies have reported this technique as safe and effective in patients with large bile duct stones,without any increased risk of adverse events such as pancreatitis,bleeding,or ***,it is difficult to analyze the outcomes of DASE because there are no standard techniques and definitions between *** purpose of this paper is to provide technical guidance and specific information about the main issues regarding DASE,based on current literature and daily clinical experience in biliary referral centers.

关键词： Dilation-assisted stone extraction Endoscopic papillary large balloon dilation Macrolithiasis Difficult choledochiolithiasis Stone treatment Common bile duct stones Endoscopic retrograde cholangiopancreatography

Comparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew

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Horticulture Research 2015年第1期2卷 143-153页

作者： Katherine C H Amrine Barbara Blanco-Ulate Summaira Riaz Dániel Pap Laura Jones Rosa Figueroa-Balderas M Andrew Walker Dario cantu Department of Viticulture and Enology University of CaliforniaDavisDavis95616CAUSA Department of genetics and Plant Breeding Corvinus University of BudapestVillányiút 29-341118BudapestHungary

grape powdery mildew(PM),caused by the biotrophic ascomycete Erysiphe necator,is a devastating fungal disease that affects most Vitis vinifera *** have previously identified a panel of *** accessions from Central Asia with partial resistance to PM that possess a Ren1-like local *** this study,we show that in addition to the typical Ren1-associated late post-penetration resistance,these accessions display a range of different levels of disease development suggesting that alternative alleles or additional genes contribute to determining the outcome of the interaction with the *** identify potential Ren1-dependent transcriptional responses and functions associated with the different levels of resistance,we sequenced and analyzed the transcriptomes of these Central Asian accessions at two time points of PM *** were compared to identify constitutive differences and PM-inducible responses that may underlie their disease resistant *** to *** in all resistant accessions were characterized by an early up-regulation of 13 genes,most encoding putative defense functions,and a late down-regulation of 32 genes,enriched in transcriptional regulators and protein *** Ren1-dependent responses included a hotspot of co-regulated genes on chromosome *** also identified 81 genes whose expression levels and dynamics correlated with the phenotypic differences between the most resistant accessions‘Karadzhandahal’,DVIT3351.27,and O34-16 and the other *** study provides a first exploration of the functions associated with varying levels of partial resistance to PM in *** accessions that can be exploited as sources of genetic resistance in grape breeding programs.

关键词： breeding mildew cultivar

基于数据挖掘的中医药治疗鼻咽癌放疗后口干用药规律分析

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山东中医杂志 2022年第1期41卷 37-43页

作者：陈婷方灿途中山市中医院广东中山528400

目的:使用中医传承辅助系统(TCMISS)对中医内服方药治疗鼻咽癌放疗后口干用药、证型规律等进行分析。方法:检索并筛选1990年1月至2020年5月中国知网(CNKI)、维普资讯中文期刊服务平台及万方数据知识服务平台中关于中医药治疗鼻咽癌放疗... 详细信息

目的:使用中医传承辅助系统(TCMISS)对中医内服方药治疗鼻咽癌放疗后口干用药、证型规律等进行分析。方法:检索并筛选1990年1月至2020年5月中国知网(CNKI)、维普资讯中文期刊服务平台及万方数据知识服务平台中关于中医药治疗鼻咽癌放疗后口干临床研究中的中药处方,利用TCMISS构建数据库后,运用关联规则及复杂系统的熵聚类等方法统计药物的使用频次,分析遣方规律并演算新方剂。结果:对筛选出的58首治疗鼻咽癌放疗后口干的中药方剂中136味中药进行分析,主要为滋阴药、清热药、益气药等,从中挖掘出10个核心中药组合并演算出5则新处方。结论:利用TCMISS对中医药治疗鼻咽癌放疗后口干用药规律及证型分析可知,中医药治疗本病常用滋阴清热法,其中麦冬、生地黄使用最多,使用药物多归肺、胃二经,多为苦、寒之品。常见的证型可归纳为肺燥津伤、阴虚内热、气阴两虚、痰瘀热结四型。演算出治疗核心中药组合及新方剂,对中医药治疗鼻咽癌放疗后口干有一定的参考意义。

关键词：鼻咽癌放射性口干中医药熵聚类算法中医传承辅助系统

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创新良种推广模式实现“迷你甘薯”产业化

农业科技管理 2011年第2期30卷 62-65页

作者：季志仙成灿土浙江省农业科学院作物与核技术利用研究所杭州310021 浙江省优质农产品开发服务中心杭州310020

甘薯被世界卫生组织誉为"冠军蔬菜"。21世纪以来,为满足我国人民膳食新要求而成功研究的"迷你甘薯",深受广大消费者喜爱。文章论述了采用优选甘薯新品种、配套高效新技术、创新推广新模式、包装销售新品牌、建立盈利新机制等方式,使"小... 详细信息

甘薯被世界卫生组织誉为"冠军蔬菜"。21世纪以来,为满足我国人民膳食新要求而成功研究的"迷你甘薯",深受广大消费者喜爱。文章论述了采用优选甘薯新品种、配套高效新技术、创新推广新模式、包装销售新品牌、建立盈利新机制等方式,使"小甘薯"创出"高效益",提升了现代甘薯产业技术水平,并提出了谋划"迷你甘薯"产业发展的新对策。

关键词：甘薯良种推广创新模式包装品牌高盈利产业化

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与戴接触镜有关的镰孢菌性角膜炎暴发

世界核心医学期刊文摘(眼科学分册) 2006年第12期 11-12页

作者： Alfonso E.C. cantu-Dibildox J. Munir W.M. 王静波 Bascom Palmer Eye Institute 900 NW 17th St Miami FL 33136 United StatesDr.

Objective: To describe the clinical presentation and course of patients who developed keratitis due to Fusarium while wearing nontherapeutic soft contact lenses. Methods: A retrospective review of microbiologic records from January 1, 2004, through April 15, 2006, was performed, identifying all patients with corneal ulceration and a culture positive for Fusarium species. Medical records of 34 patients were reviewed for clinical characteristics, treatment regimens, and microbiologic features. Results: The most common antimicrobial medications administered prior to Fusarium diagnosis were antibacterials in 31 of 34 patients. No distinct preponderance of any one brand of either contact lens or solution was identified. The microbiologic corneal cultures found Fusarium oxysporum in 20 cases, Fusarium solani in 3 cases, Fusarium species not further identifiable in 10 cases, and no growth in 1 case. Patients with a delayed onset of treatment had a tendency for prolonged treatment until cure. Conclusions: Fusarium has previously been an unusual organism in the etiology of infectious keratitis in the setting of nontherapeutic soft contact lens wear. A delay in proper diagnosis and intervention may contribute to a prolonged treatment course. The microbial spectrum of contact lens-related keratitis may be evolving with higher participation of Fusarium species compared with prior reports.

关键词：角膜炎聚星障角膜疾病接触镜镰孢菌