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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel candela caballero-eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

Getting started in mapping-by-sequencing

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Journal of Integrative Plant Biology 2015年第7期57卷 606-612页

作者： Héctor candela Rubén Casanova-Sáez José Luis Micol Instituto de Bioingeniería Universidad Miguel Hernández Department of Forest Genetics and Plant Physiology Umea Plant Science CenterSwedish University of Agricultural Sciences

Next-generation sequencing （NGS） technologies allow the cost-effective sequencing of whole genomes and have expanded the scope of genomics to novel applications, such as the genome-wide characterization of intraspecific polymorphisms and the rapid mapping and identification of point mutations. Next-generation sequencing platforms, such as the Illumina HiSeq2ooo platform, are now commercially available at affordable prices and routinely produce an enormous amount of sequence data, but their wide use is often hindered by a lack of knowledge on how to manipulateand process the information produced. In this review, we focus on the strategies that are available to geneticists who wish to incorporate these novel approaches into their research but who are not familiar with the necessary bioinformatic concepts and computational tools. In particular, we comprehensively summarize case studies where the use of NGS technologies has led to the identification of point mutations, a strategy that has been dubbed ＂mapping-by-sequencing＇, and review examples from plants and other model species such as Caenorhabditis elegans, Saccharomyces cerevisiae, and Drosophila mela- nogaster. As these technologies are becoming cheaper and more powerful, their use is also expanding to allow mutation identification in species with larger genomes, such as many crop plants.

关键词： Mapping-by-sequencing massively parallel sequencing mutation identification SHOREmapping whole-genome re-sequencing

Antibiotics and probiotics in chronic pouchitis:A comparative proteomic approach

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World Journal of Gastroenterology 2010年第1期16卷 30-41页

作者： Silvia Turroni Beatrice Vitali Marco candela Paolo Gionchetti Fernando Rizzello Massimo Campieri Patrizia Brigidi Department of Pharmaceutical Sciences University of Bologna Department of Internal Medicine and Gastroenterology University of BolognaPolyclinic S.Orsola

AIM:To profile protein expression in mucosal biopsies from patients with chronic refractory pouchitis following antibiotic or probiotic treatment,using a comparative proteomic approach. METHODS:Two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ ionization-time of flight mass spectrometry were used to characterize the changes related to antibiotic therapy in the protein expression profiles of biopsy samples from patients with chronic refractory *** same proteomic approach was applied to identify differentially expressed proteins in the non-inflamed pouch before and after probiotic administration. RESULTS:In the first set of 2D gels,26 different proteins with at least 2-fold changes in their expression levels between the pouchitis condition and antibiotic-induced remission were *** the second set of analysis,the comparison between mucosal biopsy proteomes in the normal and probiotic-treated pouch resulted in 17 significantly differently expressed *** these,8 exhibited the same pattern of deregulation as in the pouchitis/pouch remission group. CONCLUSION:For the first time,2D protein maps of mucosal biopsies from patients with ileal pouch-anal anastomosis were provided,and differentially expressed proteins following antibiotic/probiotic treatment were identified.

关键词： Chronic disease Pouchitis Antibiotics Probiotics Proteins Gene expression

Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia

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World Journal of Gastroenterology 2017年第3期23卷 406-413页

作者： Claudia Sisa Silvia Turroni Roberto Amici Patrizia Brigidi Marco candela Matteo Cerri Department of Biomedical and Neuromotor Sciences University of Bologna40126 BolognaItaly Unit of Microbial Ecology of Health Department of Pharmacy and BiotechnologyUniversity of Bologna40126 BolognaItaly

Therapeutic hypothermia is today used in several clinical settings, among them the gut related diseases that are influenced by ischemia/reperfusion injury. This perspective paved the way to the study of hibernation physiology, in natural hibernators, highlighting an unexpected importance of the gut microbial ecosystem in hibernation and torpor. In natural hibernators, intestinal microbes adaptively reorganize their structural configuration during torpor, and maintain a mutualistic configuration regardless of long periods of fasting and cold temperatures. This allows the gut microbiome to provide the host with metabolites, which are essential to keep the host immunological and metabolic homeostasis during hibernation. The emerging role of the gut microbiota in the hibernation process suggests the importance of maintaining a mutualistic gut microbiota configuration in the application of therapeutic hypothermia as well as in the development of new strategy such as the use of synthetic torpor in humans. The possible utilization of tailored probiotics to mold the gut ecosystem during therapeutic hypothermia can also be taken into consideration as new therapeutic strategy.

关键词： Therapeutic hypothermia Gut microbiota Hibernation Dysbiosis Synthetictorpor

Grid-connected Converters with Virtual Electromechanical Characteristics:Experimental Verification

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CSEE Journal of Power and Energy Systems 2017年第3期3卷 286-295页

作者： Weiyi Zhang Daniel Remon Ignacio candela Alvaro Luna Pedro Rodriguez Electrical Engineering Department Technical University of CataloniaBarcelona 08222Spain Department of Engineering University Loyola Andaluc´ıaSeville 41014Spain

Grid-connected power converters,which are frequently used to link renewable generation plants with the grid,are required to provide a better functionality for large scale integration of *** are expected to be gridfriendly,or even grid-supportive,instead of simply grid-feeding or *** paper designs a synchronous power controller for grid-connected converters in detail,emulating the electromechanical characteristics of synchronous machines and improving even its actual performance,as it is based on a virtual *** on this design,the grid-interfacing units are capable of showing inertia,damping,and droop characteristics as synchronous machines and presenting thus a grid-supporting *** detailed control design and experimental validation on a 10 kW laboratory setup acts as the main contribution of this paper,compared with the existing studies on generator emulation controls.

关键词： DC-AC power conversion power generation control synchronous power controller virtual electromechanical characteristics

Simultaneous expression analysis of deleted in azoospermia-family genes and CDC25A. their potential as a predictor for successful testicular sperm extraction

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Asian Journal of Andrology 2017年第6期19卷 715-716页

作者： candela Rocio Gonzailez Cristian Alvarez Sedo Florencia Nodar Sergio Papier Alfredo Daniel Vitullo Research Center of Biomedical Biotechnology Environmental and Diagnostic Studies Maim6nides University Hidalgo 775 1405 Buenos Aires Argentina National Scientific and Technical Research Council (CONICET) Argentina Laboratory of Reproductive Biology and Genetics (CEGyR) Viamonte 1432 1055 Buenos Aires Argentina.

Dear Editor, Infertility is a major health problem affecting 10%-15% of couples seeking to have children, and a male factor can be identified in about half of these cases.1 Nonobstructive azoospermia is one of the causes of male infertility （10%）, resulting from testicular failure？ The most common histological patterns in these patients are hypospermatogenesis （HS）, maturation arrest （MA）, and Sertoli cell-only syndrome （SCO）.3

关键词： Simultaneous azoospermia-family testicular

Inflammation and colorectal cancer, when microbiota-host mutualism breaks

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World Journal of Gastroenterology 2014年第4期20卷 908-922页

作者： Marco candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli Carla Fiorentini Patrizia Brigidi Department of Pharmacy and Biotechnology University of Bologna Department of Food Science University of Arkansas Department of Therapeutic Research and Medicines Evaluation

Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal *** this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic *** possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically *** the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is *** a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory *** inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting *** this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset.

关键词： Colorectal cancer Inflammation Gut microbiome Co-abundance groups

Substances of abuse consumption among patients seeking medical help for uro-andrological purposes:a sociobehavioral survey in the real-life scenario

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Asian Journal of Andrology 2021年第5期23卷 456-461页

作者： Federico Belladelli Luca Boeri Paolo Capogrosso Walter Cazzaniga Eugenio Ventimiglia Luigi candela Edoardo Pozzi Andrea Baudo Massimo Alfano Costantino Abbate Francesco Montorsi Andrea Salonia Division of Experimental Oncology/Unit of Urology URIIRCCS Ospedale San Raffaelevia Olgettina 60Milan 20131Italy University Vita-Salute San Raffaele via Olgettina 60Milan 20131Italy Department of Urology Foundation IRCCS Ca'Granda-Ospedale Maggiore PoliclinicoUniversity of Milanvia Della Commenda 15Milan 20122Italy

Substances of abuse(SoA),as well as smoking and alcohol consumption,are well known for their impact on male fertility status,erectile function,and *** assessed SoA consumption habits in a cohort of men seeking medical attention for uro-andrological *** from 7447 men seeking medical attention for the first time for uro-andrological purposes were analyzed.A complete medical and sexual history was collected for each ***,alcohol,and SoA consumption were *** statistics was used to describe the whole *** primary motivations for their evaluation were lower urinary tract symptoms(LUTS),erectile dysfunction(ED),and infertility in 1912(25.7%),2944(39.5%),and 2591(34.8%)men,*** use of SoA was reported by 378(5.1%)men,and 190(2.6%)individuals were current *** seeking medical attention for infertility were more frequently current SoA users(107;4.1%)than men with ED(66;2.2%)and LUTS(17;0.9%)(both P<0.001).Current users of SoA were younger than those with past or no SoA history(P<0.001).Current SoA users were more frequently smokers(P<0.001)and alcohol consumers(P<0.001)than those with a previous history or those who had never tried *** conclusion,approximately 3%of men seeking medical attention for uro-andrological purposes were current SoA *** men reported a higher use of SoA than those with ED or *** SoA users were younger and more frequently concomitant smokers and alcohol consumers compared to those who did or had never used SoA.

关键词： cannabis cocaine erectile dysfunction male infertility risk factors substances of abuse

Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice

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World Journal of Gastroenterology 2014年第8期20卷 2051-2061页

作者： Luigia De Fazio Elena Cavazza Enzo Spisni Antonio Strillacci Manuela Centanni Marco candela Chiara Praticò Massimo Campieri Chiara Ricci Maria Chiara Valerii Department of Biological Geological and Environmental SciencesBiology UnitUniversity of BolognaVia Selmi 340126 BolognaItaly Department of Pharmacy and Biotechnology University of BolognaVia 640126 BolognaItaly Department of Medical and Surgical Sciences University of BolognaVia Massarenti 940138 BolognaItaly Department of Clinical and Experimental Sciences University of BresciaSpedali Civili 125121 BresciaItaly

AIM: To characterize longitudinally the inflammation and the gut microbiota dynamics in a mouse model of dextran sulfate sodium (DSS)-induced colitis.

关键词： Colitis, Dysbiosis Dextran sulfate sodium Inflammation Cyclooxygenase 2