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Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations

Zoological Research 2024年第1期45卷 69-78页

作者： Shun Wang Peng Zhang Fan Fei Tianyang Tong Xiujuan Zhou Yajie Zhou Jing Zhang Mengke Wei Yanqi Zhang Lei Zhang Yulong Huang Lin Zhang Xin Zhang Tiantian Cai can Xie Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Department of Anatomy Anhui Medical UniversityHefeiAnhui 230032China Department of Mechanical and Aerospace Engineering University at BuffaloState University of New YorkBuffaloNY 14260 USA International Magnetobiology Frontier Research Center Science IslandHefeiAnhui 230031China

Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance *** species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same *** highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate ***,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly *** the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence ***,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic *** findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions.

关键词： Homing and migration Animal navigation Magnetoreceptor(MagR) Diverse navigation pattern Conserved protein

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The role of reactive oxygen species in gastric cancer

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cancer Biology & Medicine 2024年第9期 740-753页

作者： Yuqi Wang Jingli Xu Zhenjie Fu Ruolan Zhang Weiwei Zhu Qianyu Zhao Ping Wang can Hu Xiangdong Cheng College of Pharmaceutical Sciences Zhejiang University of Technology Department of Gastric Surgery Zhejiang Cancer Hospital Key Laboratory of Prevention Zhejiang Provincial Research Center for Upper Gastrointestinal Tract cancer Zhejiang Cancer Hospital

Gastric cancer(GC) ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide. Reactive oxygen species(ROS) are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance. ROS are closely associated with the occurrence, development, and treatment of GC. This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction. In addition, the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized. The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.

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Iron and ferritin effects on intensive care unit mortality:A metaanalysis

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World Journal of Clinical Cases 2024年第16期12卷 2803-2812页

作者： Deng-can Yang Bo-Jun Zheng Jian Li Yi Yu Department of Anesthesiology The Central Hospital of ShaoyangShaoyang 422000Hunan ProvinceChina Department of Critical Care Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Critical Care Medicine Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND The effect of serum iron or ferritin parameters on mortality among critically ill patients is not well *** To determine the association between serum iron or ferritin parameters and mortality among critically ill *** Web of Science,Embase,PubMed,and Cochrane Library databases were searched for studies on serum iron or ferritin parameters and mortality among critically ill *** reviewers independently assessed,selected,and abstracted data from studies reporting on serum iron or ferritin parameters and mortality among critically ill *** on serum iron or ferritin levels,mortality,and demographics were *** Nineteen studies comprising 125490 patients were eligible for *** observed a slight negative effect of serum ferritin on mortality in the United States population[relative risk(RR)1.002;95%CI:1.002-1.004].In patients with sepsis,serum iron had a significant negative effect on mortality(RR=1.567;95%CI:1.208-1.925).CONCLUSION This systematic review presents evidence of a negative correlation between serum iron levels and mortality among patients with ***,it reveals a minor yet adverse impact of serum ferritin on mortality among the United States population.

关键词： Iron Ferritin Mortality Critically ill Meta analysis

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Anisotropic etching mechanisms of 4H-SiC:Experimental and first-principles insights

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Journal of Semiconductors 2024年第1期45卷 42-47页

作者： Guang Yang Lingbo Xu can Cui Xiaodong Pi Deren Yang Rong Wang Key Laboratory of Optical Field Manipulation of Zhejiang Province Department of PhysicsZhejiang Sci-Tech UniversityHangzhou 310018China State Key Laboratory of Silicon and Advanced Semiconductor Materials&School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Institute of Advanced Semiconductors&Zhejiang Provincial Key Laboratory of Power Semiconductor Materials and Devices HangzhoIun novation CenterZhejiang UniversityHangzhou 311200China

Molten-alkali etching has been widely used to reveal dislocations in 4H silicon carbide(4H-SiC),which has promoted the identification and statistics of dislocation density in 4H-SiC single ***,the etching mechanism of 4H-SiC is limited *** this letter,we reveal the anisotropic etching mechanism of the Si face and C face of 4H-SiC by combining molten-KOH etching,X-ray photoelectron spectroscopy(XPS)and first-principles *** activation energies for the molten-KOH etching of the C face and Si face of 4H-SiC are calculated to be 25.09 and 35.75 kcal/mol,*** molten-KOH etching rate of the C face is higher than the Si *** XPS analysis and first-principles calculations,we find that the molten-KOH etching of 4H-SiC is proceeded by the cycling of the oxidation of 4H-SiC by the dissolved oxygen and the removal of oxides by molten *** faster etching rate of the C face is caused by the fact that the oxides on the C face are unstable,and easier to be removed with molten alkali,rather than the C face being easier to be oxidized.

关键词： principles alkali etching

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个人信息权立法完善的路径与选择

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信息安全研究 2024年第3期10卷 263-267页

作者：王璨中南财经政法大学刑事司法学院武汉430073

当前,信息泄露已成为全球性问题,各国纷纷就个人信息权进行立法保护.尽管《中华人民共和国个人信息保护法》的出台优化了我国对个人信息权的立法保护,但我国相关规范性文件未能有效衔接,某些规范性文件位阶不明,特殊领域的个人信息权立... 详细信息

当前,信息泄露已成为全球性问题,各国纷纷就个人信息权进行立法保护.尽管《中华人民共和国个人信息保护法》的出台优化了我国对个人信息权的立法保护,但我国相关规范性文件未能有效衔接,某些规范性文件位阶不明,特殊领域的个人信息权立法保护不成体系,部分地方缺乏立法能动性,对公权力的监管规定存在漏洞.相较而言,美国在个人信息权保护方面积累了较多经验和教训.通过比较分析法,对美国就个人信息权保护的立法优势、劣势加以辨别,对我国个人信息权保护的立法提出建议,以期完善我国对个人信息权的立法保护.

关键词：个人信息权《个人信息保护法》特殊领域立法完善美国经验

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Research Progress on Career Development of Nursing Staff

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Journal of Clinical and Nursing Research 2024年第5期8卷 180-187页

作者： Jie Liu Yuying Hao Rui Song Li Cao can Deng School of Nursing Shaanxi University of Traditional Chinese MedicineXianyang 712046Shaanxi ProvinceChina Department of Nursing Affiliated Hospital of Shaanxi University of Traditional Chinese MedicineXianyang 712000Shaanxi ProvinceChina

There are few studies on career development as an exclusive concept in the field of nursing in ***,research related to the career development of nursing staff primarily relies on inductive evaluation tools,and there is less systematic summarization of this *** paper reviews the concept,evaluation tools,and influencing factors of nursing career development,aiming to provide a reference for future research in this area.

关键词： Career development Nursing staff Summary

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用于高风险环境安全监测和可调热管理的具有分层核壳结构的耐化学品纱线

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Engineering 2024年第1期32卷 217-225页

作者： Duo Xu Yingcun Liu can Ge Chong Gao Ze Chen Ziyi Su Haoran Gong Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China

Chemical resistant textiles are vital for safeguarding humans against chemical hazards in various *** as industrialproduction,chemicalaccidents,laboratory activities,and road ***,the ideal integration of chemical resistance,thermal and moisture management,and wearer condition monitoring in conventional chemically protective textiles remains ***,the design,manufacturing,and use of stretchable hierarchical core-shell yarns(HCSYs)for integrated chemical resistance,moisture regulation,and smart sensing textiles are *** yarns con-tain helically elastic spandex,wrapped silver-plated nylon,and surface-structuredpolytetrafluo-roethylene(PTFE)yarns and are designed and manufactured based on a scalable fabrication *** addition to their ideal chemical resistance performance,HCSYs can function as multifunctional stretch-able electronics for real-time human motion monitoring and as the basic element of intelligent ***,a desirable dynamic thermoregulation function is achieved by exploiting the fabric structure with stretching *** HCSYs may provide prospective opportunities for the future development of smart protective textiles with high durability,flexibility,and scalability.

关键词： Hierarchical core-shell structure Chemical resistant yam Wearable strain sensor Thermoregulation

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Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

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World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li Qian-Jun Ren can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-Qiu Liang Bin Wen Ming-Kun Liang Xiao-Fang Zhao Department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional Chinese Medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular *** pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic ***,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic *** To explore the effect of taurine on aHSC proliferation and the mechanisms *** Human HSCs(LX-2)were randomly divided into five groups:Normal control group,platelet-derived growth factor-BB(PDGF-BB)(20 ng/mL)treated group,mmol/L,respectively)with PDGF-BB(20 ng/mL)treated *** Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of ***-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron *** electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in *** real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2,SLC7A11,and *** Taurine promoted the death of aHSCs and reduced the deposition of the *** with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62 protein ***,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized b

关键词： Hepatic stellate cells Autophagy Ferroptosis Molecular docking Taurine

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Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2038-2059页

作者： Xiang-Hui Wan Guo-Bing Jin Qun Yang Ji-Long Hu Zhi-Liang Liu Jun Rao can Wen Peng-Ling Li Xi-Mei Yang Bo Huang Xiao-Zhong Wang Jiangxi Medical College Nanchang UniversityNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Jiangxi Key Laboratory of Translational Research for cancer Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Abdominal Surgery Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Pathology Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Science and Education Section Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Children’s HospitalNanchang 330006Jiangxi ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Province Key Laboratory of Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Heterogeneous ribonucleoprotein A1(hnRNPA1)has been reported to enhance the Warburg effect and promote colon cancer(CC)cell proliferation,but the role and mechanism of the miR-490-3p/hnRNPA1-b/PKM2 axis in CC have not yet been *** To investigate the role and mechanism of a novel miR-490-3p/hnRNPA1-b/PKM2 axis in enhancing the Warburg effect and promoting CC cell proliferation through the PI3K/AKT *** Paraffin-embedded pathological sections from 220 CC patients were collected and subjected to immunohistochemical analysis to determine the expression of *** relationship between the expression values and the clinicopathological features of the patients was *** in mRNA expression were analyzed using quantitative real-time polymerase chain reaction,while differences in protein expression were analyzed using western *** proliferation was evaluated using the cell counting kit-8 and 5-ethynyl-2’-deoxyuridine assays,and cell cycle and apoptosis were detected using flow cytometric *** targeted binding of miR-490-3p to hnRNPA1-b was validated using a dual luciferase reporter *** Warburg effect was evaluated by glucose uptake and lactic acid production *** The expression of hnRNPA1-b was significantly increased in CC tissues and cells compared to normal controls(Pcant variations in the expression of the hnRNPA1-b antigen in different stages of CC,including stage I,II-III,and ***,the clinicopathologic characterization revealed a significant correlation between hnRNPA1-b expression and clinical stage as well as T ***1-b was found to enhance the Warburg effect through the PI3K/AKT pathway,thereby promoting proliferation of HCT116 and SW620 ***,the proliferation of HCT116 and SW620 cells was inhibited when miR-490-3p targeted and bound to hnRNPA1-b,effectively blocking the Warburg ***

关键词： Heterogeneous ribonucleoprotein A1-b MiR-490-3p Colon cancer Alternative splicing Warburg effect

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服务贸易网络、信息传递与OFDI

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世界经济研究 2024年第4期 41-56,M0003页

作者：宋灿孙浦阳南京邮电大学经济学院中国人民大学经济学院

文章立足于服务经济的非实体化特征,利用2007~2020年的OECD双边服务贸易数据库和上市公司数据库,从理论与实证两个层面探讨了服务贸易网络对服务企业OFDI的影响与作用机制。研究发现:服务贸易网络对服务企业OFDI决策具有显著的直接效应... 详细信息

文章立足于服务经济的非实体化特征,利用2007~2020年的OECD双边服务贸易数据库和上市公司数据库,从理论与实证两个层面探讨了服务贸易网络对服务企业OFDI的影响与作用机制。研究发现:服务贸易网络对服务企业OFDI决策具有显著的直接效应与网络效应;贸易网络中心度较高的服务企业可以有效地运用信息优势整合服务要素资源提高服务质量,并通过降低信息壁垒克服对外投资过程中的“外来者劣势”,因此,服务质量提升及信息壁垒降低是服务贸易网络作用于OFDI的有效途径;区分贸易方向和投资模式发现,由于服务外包主要通过进口实现,而不同投资模式的服务企业对当地市场信息的依赖度存在显著差别,因此,进口网络对服务企业OFDI的影响显著大于出口网络,且服务贸易网络对绿地投资的影响显著大于跨国并购。进一步研究发现,企业管理效率及数字化程度的提升均有利于增强服务贸易网络对服务企业OFDI的边际作用效果。

关键词：服务贸易服务企业OFDI 网络中心度服务质量信息壁垒

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