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Forensic Sciences Research 2021年第2期6卷 148-151页

作者： camille jantzi Alexandre perrin University centre of Legal Medicine(cUrML) University of GenevaGenevaswitzerland

the mediatization of the CoVID-19 pandemic has created a lot of stress leading sometimes to mental health issues.We present a case of a thirty-year-old woman with no history of psychotic disease but some vulnerabilities and no criminal record,who attempted to kill her seven-year-old son during a brief delusional episode in the context of fear of the coronavirus.she was successfully treated by pharmacotherapy and psychotherapy.she was examined by forensic psychiatrists leading to the conclusion that her responsibility was highly diminished,and her reoffending risk was low.We add to the literature that the CoVID-19 pandemic has been such a stressor for mentally vulnerable people that it could lead to severe psychiatric decompensation and even criminal acts.

关键词： Forensic sciences forensic psychiatry CoVID-19 infanticide psychosis criminal responsibility forensic evaluation

Two hits are better than one:rational dual strategy efficiently fights neuroblastoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1802-1804页

作者： Jacques Zimmer camille Rolin Markus Ollert Department of Infection and Immunity Luxembourg Institute of HealthEsch-sur-AlzetteLuxembourg University of Luxembourg Esch-sur-AlzetteLuxembourg Department of Dermatology and Allergy Center Odense Research Center for Anaphylaxis(ORCA)University of Southern DenmarkOdenseDenmark

The recently published landmark paper by Bergaggio et al.from Roberto Chiarle’s group in Cancer Cell1 investigates an elegant double-hit strategy to improve anti-cancer immunotherapy.This important approach demonstrates in a preclinical model that chimeric antigen receptor(CAR)-T cell treatment can be rendered more efficient by increasing the cell surface expression of the CAR target structure via a small molecule.

关键词： neuroblastoma al. Cancer

Incidental and secondary findings in trio exome sequencing

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Genes & Diseases 2024年第4期11卷 152-154页

作者： camille Cohen Emeline Bellanger Jeremie Mortreux Laure Raymond Francois Vialard Rodolphe Dard Department of Genetics Centre Hospitalier Intercommunal de Poissy-Saint-Germain-en-LayePoissy 78300France RHuMA UMR-BREEDINRA-ENVA-UVSQMontigny le Bretonneux 78180France Service de Genetique Laboratoire Eurofins BiomnisLyon 69007France

Exome sequencing(ES)generates secondary findings(SFs)in 2%of tested individuals if one follows the American College of Medical Genetics and Genomics(ACMG)guide-lines.i,z2 However,the rate of incidental and secondary findings(ISFs)is higher in routine clinical practice because of(i)the use of trio ES instead of solo sequencing and(i)the exclusion of the incidental findings(IFs)of medical value concerning genes in the ACMG list.Hence,it is not clear how sufficient is a restricted list of genes to detect every ISF of major clinical value;and what is the amount of additional workload for the laboratory.

关键词： routine clinical finding

Characterisation of the Bacteria and Archaea Community Associated with Wild Oysters, At Three Possible Restoration Sites in the North Sea

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Open Journal of Marine Science 2024年第2期14卷 19-40页

作者： Natacha M. S. Juste-Poinapen Yang Lu Blanca Bolaños De Hoyos George C. Birch camille Saurel Oyster Heaven Rotterdam Netherlands Nucleus Rotterdam Netherlands Microbial Ecology and Wastewater Microbiology Queensland University of Technology Brisbane Australia National Institute of Aquatic Resources Technical University of Denmark Lyngby Denmark

With 85% of the global oyster reefs destroyed, there is an urgent need for large scale restoration to benefit from the ecosystem services provided by biogenic oyster reefs and their associated biodiversity, including microorganisms that drive marine biogeochemical cycles. This experiment established a baseline for the monitoring of the bacterial and archaeal community associated with wild oysters, using samples from their immediate environment of the Voordelta, with cohabiting Crassostrea gigas and Ostrea edulis, Duikplaats with only C. gigas attached to rocks, and the Dansk Skaldyrcentre, with no onsite oysters. The microbial profiling was carried out through DNA analysis of samples collected from the surfaces of oyster shells and their substrate, the sediment and seawater. Following 16S rRNA amplicon sequencing and bioinformatics, alpha indices implied high species abundance and diversity in sediment but low abundance in seawater. As expected, Proteobacteria, Bacteroidetes, Firmicutes and Thaumarchaeota dominated the top 20 OTUs. In the Voordelta, OTUs related to Colwellia, Shewanella and Psychrobium differentiated the oysters collected from a reef with those attached to rocks. Duikplaats were distinct for sulfur-oxidizers Sulfurimonas and sulfate-reducers from the Sva 0081 sediment group. Archaea were found mainly in sediments and the oyster associated microbiome, with greater abundance at the reef site, consisting mostly of Thaumarchaeota from the family Nitrosopumilaceae. The oyster free site displayed archaea in sediments only, and algal bloom indicator microorganisms from the Rhodobacteraceae, Flavobacteriaceae family and genus [Polaribacter] huanghezhanensis, in addition to the ascidian symbiotic partner, Synechococcus. This study suggests site specific microbiome shifts, influenced by the presence of oysters and the type of substrate.

关键词： Oyster Reefs Microbiome Marine Bacteria Marine Archaea Restoration

Bioremediation Potential of the Macroalga Ulva lactuca (Chlorophyta) for Ammonium Removal in Elastomer Industry Wastewater

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Advances in Bioscience and Biotechnology 2024年第6期15卷 325-343页

作者： Diego Lelis Alex Enrich-Prast camille R. Chaves Thuane Mendes Anacleto Roberta R. C. Pereira Vinicius P. de Oliveira Programa de Ps-Graduao em Biotecnologia Vegetal e Bioprocessos Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Unidade Multiusurio de Anlises Ambientais Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Institute of Marine Science Federal University of So Paulo (IMar/UNIFESP) Santos Brazil Department of Thematic StudiesEnvironmental Change and Biogas Solutions Research Center (BSRC) Linkping University Linkping Sweden Department of Marine Biology Institute of Biology Federal University of Rio de Janeiro Rio de Janeiro Brazil

During the production of nitrile rubber, significant amounts of nitrogen in the form of ammonium are generated in the wastewater. The discharge of this high-nitrogen wastewater can lead to serious environmental issues, including eutrophication, disruption of aquatic ecosystems, and groundwater contamination. To mitigate these impacts, this research explored the bioremediation capabilities of the macroalgae Ulva lactuca (Chlorophyta) for removing nitrogen from nitrile rubber production wastewater. The study employed single-phase and Michaelis-Menten decay models based on ammonium consumption, using various dilutions of wastewater to identify the optimal concentration for treatment. The physiological state of the macroalgae was monitored by measuring the photosynthetic capacity and specific growth rate during the experiments. In the presence of U. lactuca, ammonium concentrations decreased in all treatment groups, confirming that the ammonium kinetics conformed to both applied models. Our results show that U. lactuca effectively reduces ammonium concentrations, with an approximate removal rate of 0.020 µM·g−1·min−1 across different wastewater concentrations (70%, 80%, 90%, and 100%). Notably, the treatments with 70%, 80%, and 90% wastewater strength achieved about 67% reduction in ammonium, demonstrating the alga’s capacity to treat high-nitrogen wastewater. The photosynthetic performance of U. lactuca initially declined in control conditions but stabilized across all treatments, highlighting its adaptability. The kinetic analysis using the Michaelis-Menten model indicated a Vmax of 1342 μM·g−1·DMh−1, suggesting a robust capacity for ammonium uptake when fully saturated. Our study underscores the potential of Ulva lactuca as a cost-effective and efficient agent for wastewater bioremediation, particularly in settings with high nitrogen loads.

关键词： Photosynthetic Quantum Yield One-Phase Decay Model Michaelis-Menten Model Nitrogen Physiological Parameters Elastomers

Coverage and Factors Associated with Acceptance and Satisfaction of Seasonal Malaria Chemoprevention in Six Health Zones in Benin

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Open Journal of Preventive Medicine 2024年第3期14卷 49-60页

作者： Cyriaque Affoukou Georgia Damien Thibaud Lègba Olarewadjou Richard Biaou Boni Géraud Padonou Rock Aïkpon William Houndjo camille Houetohossou Elysé Sohizoun Aurore Ogouyemi Badirou Aguèmon Community Health and Epidemiology Unit Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin National Malaria Control Program of Benin Cotonou Benin Ministry of Health Cotonou Benin Laboratory of Epidemiology of Chronic and Neurological Diseases (LEMACEN) Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin

Introduction: Seasonal malaria chemoprevention (SMC) was adopted in 2019 in two health zones in Benin where malaria transmission is very high. Positive results led to the extension of the intervention to other zones with additional financial support. Annual SMC campaigns from 2021 to 2023 were carried out in all six health zones in the Atacora and Alibori departments. In five years of implementation, various approaches have been developed on the basis of a communication plan facilitating buy-in and acceptance by all stakeholders. The aim of this study was to assess the effective coverage and acceptance of the SMC by their beneficiary populations in 2023. Methods: It was a cross-sectional study with an analytical focus. Data collection took place from November 30 to December 13, 2023. The study population consisted of children under 5 years of age residing in the departments of Atacora and Alibori in northern Benin. A total of 3573 children under 5 years of age were included in the study, and their parents or guardians were interviewed. Results: During the 2023 campaign, 87.7% of targets were reached by SMC administration and 100.00% of children had received at least one dose of SMC by the fourth visit. Effective therapeutic coverage of SMC was 70.55%, with 99.60% in BNK, 69.40% in KGS, 16.20% in MK, 56.10% in 2KP, 92.40% in NBT and 89.60% in TMC. This coverage was statistically related to child and respondent ages (p Conclusion: SMC is a strategy accepted by the population, and the main reasons for non-participation in SMC were dominated by the absence of mothers or babysitters when the agents visited.

关键词： Coverage Acceptance SMC Benin

Proximal tibiofibular stabilization by anatomical ligamentoplasty and diaphyseal osteotomy of the fibula

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Chinese Journal of Traumatology 2022年第3期25卷 177-180页

作者： Choufani camille Barbier Olivier Clinic of Orthopedics and Traumatology Military Teaching Hospital Sainte-Anne2 Boulevard Sainte-Anne83000ToulonFrance Toulon Mediterranean Orthopedic and Sport Trauma 83000ToulonFrance

Proximal tibiofibular instability is a rare condition for which treatment is poorly codified.A 21-year-old patient,a leisure sportswoman,presented a post-traumatic anterolateral instability of the proximal tibiofibular articulation without cartilage lesion.We propose an original surgical technique based on a review of the literature that combines an anatomical ligamentoplasty of the proximal tibiofibular joint and a proximal fibular diaphyseal osteotomy to reduce the distal tibiofibular mechanical stresses.This original technique allows a favorable evolution with recovery of professional and sports activities at 6 months.

关键词： Joint instability Proximal tibiofibular instability Ligamentoplasty Fibular osteotomy

Should proximal ruptures of the anterior rectus femoris muscle be treated surgically?

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Chinese Journal of Traumatology 2022年第4期25卷 232-236页

作者： camille Choufani Frederic Khiami Olivier Barbier Orthopaedic Surgery and Traumatology Department Saint-Anne Military Teaching HospitalToulon83000France Toulon Mediterranean Orthopedic and Sport Trauma Toulon83000France Orthopaedic Surgery Department Pitie-Salp^etriere HospitalParisFrance

Purpose:No therapeutic consensus has been established about proximal ruptures of the rectus femoris muscle.The objective of this literature review is to determine a therapeutic course of action.Methods:We conducted a literature review on the PubMed database using the following keywords(in French and English,respectively):"quadriceps/quadriceps","droit antérieur/rectus femoris","proximal/proximal","chirurgie/surgical","avulsion/avulsion".We collected 266 articles,36 of them were selected,which were related to our topic:proximal rupture of the anterior rectus femoris.Patients with a proximal rupture of the rectus femoris,minor or major patient of traumatic origin were included in this study.Patients injured at another lesion level,or non-traumatic lesions of the proximal rectus femoris(tendinitis without ruptures,tumor or others)were excluded.For each patient,the indications,the type of treatment and the functional result were analyzed,with the time to recovery and the level of recovery from sports and professional activities(same sport/profession or not,same level or not)as the main criterion of judgment.Fisher exact test was used for statistical comparison.Results:The aims of conservative treatment are to be pain free for the patient,to fight hematoma and to rehabilitate the injury as quickly as possible.The surgical techniques are varied,with most consisting of either a reinsertion of the musculo-tendon stump or a resection of the scar tissue with myo-tendinoaponeurotic suture in place.The functional results are good for the majority of the treatments proposed,but the conservative treatment has a shorter recovery time(3 months vs.4 months for the best surgical results).Highly displaced bone avulsion is the only indication for first-line surgical treatment.Conslusion:The main disadvantage of conservative treatment is the risk of residual pain beyond 3 months(10%),justifying an MRI to guide secondary surgical treatment.We propose a treatment plan for proximal rupture of the proximal rectus femoris rupture.

关键词： Avulsion fractures Quadriceps muscle Surgery

Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1β

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Cellular & Molecular Immunology 2023年第1期20卷 8-10页

作者： camille Chauvin Sruthi Vijaya Retnakumar Jagadeesh Bayry Institut National de la Santéet de la Recherche Médicale Centre de Recherche des CordeliersSorbonne UniversitéUniversitéde Paris75006ParisFrance Department of Biological Sciences&Engineering Indian Institute of Technology PalakkadPalakkad678623India

Interleukin(IL)-33 is a nuclear cytokine in the IL-1 family that is constitutively expressed in the epithelial cells of environmentally exposed tissues(skin,gastrointestinal tract and lungs)and endothelial cells.IL-33 is involved in type 2 innate immunity via the activation of eosinophils,basophils,mast cells,group 2 innate lymphoid cells and macrophages through its receptor ST2(also called IL1RL1)[1].Due to the absence of a secretory signal sequence,IL-33 was thought to be passively released during cell necrosis,physical stress or tissue damage and was accordingly considered an alarmin[2].

关键词： immunity Interleukin damage

Roles of macrophages in tumor development: a spatiotemporalperspective

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Cellular & Molecular Immunology 2023年第9期20卷 983-992页

作者： Mathilde Bied William W.Ho Florent Ginhoux camille Blériot Institut Gustave Roussy INSERM U1015VillejuifFrance Singapore Immunology Network(SIgN) Agency for ScienceTechnology and Research(A∗STAR)SingaporeSingapore Shanghai Institute of Immunology Shanghai JiaoTong University School of MedicineShanghaiChina Translational Immunology Institute SingHealth Duke-NUSSingaporeSingapore Institut Necker des Enfants Malades INSERMCNRSUniversitéParis CitéParisFrance

Macrophages are critical regulators of tissue homeostasis but are also abundant in the tumor microenvironment (TME). In bothprimary tumors and metastases, such tumor-associated macrophages (TAMs) seem to support tumor development. While we knowthat TAMs are the dominant immune cells in the TME, their vast heterogeneity and associated functions are only just beingunraveled. In this review, we outline the various known TAM populations found thus far and delineate their specialized rolesassociated with the main stages of cancer progression. We discuss how macrophages may prime the premetastatic niche to enablethe growth of a metastasis and then how subsequent metastasis-associated macrophages can support secondary tumor growth.Finally, we speculate on the challenges that remain to be overcome in TAM research.

关键词： Macrophages Tumor associated macrophages Tumor microenvironment Metastasis