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New avenues for the treatment of immunotherapy-resistant pancreatic cancer

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1134-1153页

作者： Luis Guilherme de Oliveira silva Fabian Fellipe Bueno Lemos Marcel silva Luz Samuel Luca Rocha Pinheiro Mariana dos santos Calmon Gabriel Lima Correa santos Gabriel reis Rocha Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Pancreatic cancer(PC)is characterized by its extremely aggressive nature and ranks 14th in the number of new cancer cases ***,due to its complexity,it ranks 7th in the list of the most lethal cancers *** pathogenesis of PC involves several complex processes,including familial genetic factors associated with risk factors such as obesity,diabetes mellitus,chronic pancreatitis,and *** in genes such as KRAS,TP53,and SMAD4 are linked to the appearance of malignant cells that generate pancreatic lesions and,consequently,*** this context,some therapies are used for PC,one of which is immunotherapy,which is extremely promising in various other types of cancer but has shown little response in the treatment of PC due to various resistance mechanisms that contribute to a drop in immunotherapy *** is therefore clear that the tumor microenvironment(TME)has a huge impact on the resistance process,since cellular and non-cellular elements create an immunosuppressive environment,characterized by a dense desmoplastic stroma with cancerassociated fibroblasts,pancreatic stellate cells,extracellular matrix,and immunosuppressive *** to this are genetic mutations in TP53 and immunosuppressive factors that act on T cells,resulting in a shortage of CD8+T cells and limited expression of activation markers such as *** this way,finding new strategies that make it possible to manipulate resistance mechanisms is ***,techniques such as the use of TME modulators that block receptors and stromal molecules that generate resistance,the use of genetic manipulation in specific regions,such as microRNAs,the modulation of extrinsic and intrinsic factors associated with T cells,and,above all,therapeutic models that combine these modulation techniques constitute the promising future of PC ***,this study aims to elucidate the main mechanisms of resistance to immunotherapy in PC and new ways of manipulating thi

关键词： Pancreatic cancer Immunotherapy Resistance Tumor microenvironment manipulation Combined immunotherapy

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腐植酸促进候选细菌丰富植物微生物群以抑制病原体

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腐植酸 2022年第3期 103-115页

作者： Maura santos reis de andradeda silva Orlando Carlos Huertas Tavares Thiago Gonçalves Ribeiro camilla santos reis de andradeda silva Carolina santos reis de andradeda silva JoséMaria García-Mina Vera Lúcia Divan Baldani Andrés Calderín García Ricardo Luiz Louro Berbara Ederson da Conceição Jesus 李子东(译) 熊传教(译) 周欣(译) 余玲玲(译) 刘可星(译) 巴西农业研究公司里约热内卢联邦农村大学弗洛米嫩塞联邦大学西班牙纳瓦拉大学华南农业大学资源环境学院

腐植酸(HA)通过调节植物的激素和氧化还原代谢来刺激几种植物种类的生长,然而,关于HA与植物相关菌群的关系鲜有报道。本文中,我们假设HA效应与植物相关细菌群落的调控同时发生,水稻在施用或不施用HA(80 mg/L)的营养液中生长264 h,每24 ... 详细信息

腐植酸(HA)通过调节植物的激素和氧化还原代谢来刺激几种植物种类的生长,然而,关于HA与植物相关菌群的关系鲜有报道。本文中,我们假设HA效应与植物相关细菌群落的调控同时发生,水稻在施用或不施用HA(80 mg/L)的营养液中生长264 h,每24 h评价1次植株生长,施用240 h后取样品进行16S rRNA基因测序。第1次施用HA后,从100 h到264 h植株净同化率、绝对生长率和相对生长率增加,根系体积和其他生长变量在植物生长周期的不同时间受到刺激。宏基因组分类揭示,使用HA后细菌群落结构和组成受到影响,HA处理的根部,群落成员间的相互作用增强,显示更多关联更密切的细菌群落,鞘氨醇菌属(Chitinophaga)和粘液杆菌属(Mucilaginibacter)是HA处理后根系的优势菌属。据报道,这些细菌能产生酶,降解真菌、卵菌和线虫卵壁中的化合物。铁载体产生者和植物生长促进者——假单胞菌(Pseudomonas)和酸杆菌Gp1(Acidobacteria Gp1)均富集,虽然丰度较低。鉴于这些结果,我们认为植物组建这些微生物是为了应对HA—根互作引起的胁迫。我们的研究结果首次表明,受HA刺激的植物可能采用组建细菌群落成员的生态策略,这些细菌群落成员是抑制病原体的候选者,因而参与植物防御.

关键词：腐殖质宏基因组分类植物微生物群植物生长促进植物-微生物互作植物防御

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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel silva Luz Gabriel reis Rocha Gabriel Lima Correa santos Luís Guilherme de Oliveira silva Mariana santos Calmon Cláudio Lima Souza Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio silva Neto Claudio Avelino Rodrigues santos Paolo Lucas Rodrigues-silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos santos Rosangela Vieira Andrade Jonato Prestes Thiago dos santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of ded concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning ***:Several variables were associated with elevated levels of D-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

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Response to Commentary by Dr. Matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena reis Thais Branquinho de Araújo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinésio silva Neto Cláudio Avelino Rodrigues santos Paolo Lucas Rodrigues-silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho Rafael Lavarini dos santos Rosangela Vieira Andrade Jonato Prestes Thiago dos santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

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Immune pathway through endometriosis to ovarian cancer

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World Journal of Clinical Oncology 2024年第4期15卷 496-522页

作者： Mariana santos Calmon Fabian Fellipe Bueno Lemos Marcel silva Luz Samuel Luca Rocha Pinheiro Luis Guilherme de Oliveira silva Gabriel Lima Correa santos Gabriel reis Rocha Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Endometriosis is an estrogen-dependent inflammatory disease,defined by the presence of functional endometrial tissue outside of the uterine *** disease is one of the main gynecological diseases,affecting around 10%-15%women and girls of reproductive age,being a common gynecologic *** endometriosis is a benign disease,it shares several characteristics with invasive *** support that it has been linked with an increased chance of developing endometrial ovarian cancer,representing an earlier stage of neoplastic *** is particularly true for women with clear cell carcinoma,low-grade serous carcinoma and ***,the carcinogenic pathways between both pathologies remain poorly *** studies suggest a connection between endometriosis and endometriosis-associated ovarian cancers(EAOCs)via pathways associated with oxidative stress,inflammation,and *** article aims to review current data on the molecular events linked to the development of EAOCs from endometriosis,specifically focusing on the complex relationship between the immune response to endometriosis and cancer,including the molecular mechanisms and their *** recent developments in immunotherapy and their potential to boost the effectiveness of future treatments.

关键词： Ovarian neoplasms Endometriosis Endometriosis-associated ovarian cancers Immune response Immunotherapy

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Variations in productivity and wood properties of Amazonian tachi-branco trees planted at diff erent spacings for bioenergy purposes

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Journal of Forestry Research 2021年第1期32卷 211-224页

作者： Marilene Olga dos santos silva Marcela Gomes da silva Lina Bufalino Maíra reis de Assis delman de Almeida Goncalves Paulo Fernando Trugilho Thiago de Paula Protásio Rural Federal University of Amazonia/UFRA Perimetral Ave.Terra FirmeBelémPA 66077-830Brazil Federal University of Lavras/UFLA Francisco Sales St.CentroLavrasMG 37200-000Brazil Brazilian Agricultural Research Corporation/Eastern Amazonia Embrapa Dr.Enéas Pinheiro BySt.MarcoBelémPA 66095-903Brazil Rural Federal University of Amazonia/UFRA PA-275 Rd.Zona RuralParauapebasPA 68515-000Brazil

Marilene Olga dos santos silva 1·Marcela Gomes da silva 1·LTachi-branco(Tachigali vulgaris,*** da silva&***)is a leguminous tree species native to the Amazon rainforest that has drawn attention for its remarkably fast growth,a required trait for biomass/bioenergy *** evaluations of biomass production and wood properties of *** planted in homogeneous plantations at diff erent spacings in the Amazonian state of Pará,Brazil,biomass of 7-year-old trees was quantifi ed for individual trees and the entire *** was also sampled to assess properties relevant to bioenergy *** choice for spacing dimension for planting nonclonal *** should consider whether the priority is greater productivity per tree,achieved with greater spacings(9.0 m 2 and 12.0 m 2),or productivity per area,achieved with closerina Bufalino 1·Maíra reis de Assis 2·delman de Almeida Goncalves 3·Paulo Fernando Trugilho 2·Thiago de Paula Protásio 4 spacings(6.0 m 2 and 7.5 m 2).Genetic variability of the *** seed stand and/or high heritability of wood traits overcame the eff ect of diff erent spacing on all morphological,physical,chemical and energetic properties of *** *** species has moderate basic density when cultivated at spacings larger than 6 m 2 and net heating value above 7.95 MJ/kg,which is suitable for bioenergy *** high variation in wood properties within tree spacing is strongly indicative of great potential for genetic *** fast growth and the suitable moderate wood basic density confi rm the outstanding potential of homogeneous plantations of *** for providing wood for bioenergy.

关键词： Basic density Heating value Planting density Tachigali vulgaris

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Hepatocellular carcinoma staging systems: Hong Kong liver cancer vs Barcelona clinic liver cancer in a Western population

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World Journal of Hepatology 2019年第9期11卷 678-688页

作者： Laura Bainy Rodrigues de Freitas Larisse Longo deivid santos Ivana Grivicich Mário reis Alvares-da-silva Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto AlegreRS 90035-003Brazil Experimental Hepatology and Gastroenterology Laboratory Center for Experimental ResearchHospital de Clínicas de Porto AlegrePorto AlegreRS 90035-003Brazil School of Medicine Universidade Federal do Rio Grande do SulPorto AlegreRS 90035-003Brazil Graduate Program in Health-Applied Cellular and Molecular Biology ULBRA.CanoasRS 92425-900Brazil department of Gastroenterology Hospital de Clínicas de Porto AlegrePorto AlegreRS 90035-003Brazil

BACKGROUND despite being the world’s most widely used system for staging and therapeutic guidance in hepatocellular carcinoma(HCC)treatment,the Barcelona clinic liver cancer(BCLC)system has limitations,especially regarding intermediate-grade(BCLC-B)*** recently proposed Hong Kong liver cancer(HKLC)staging system appears useful but requires validation in Western *** To evaluate the agreement between BCLC and HKLC staging on the management of HCC in a Western population,estimating the overall patient *** This was a retrospective study of HCC patients treated at a university hospital in southern Brazil between 2011 and ***,clinical,and laboratory data were *** staging was carried out according to the HKLC and BCLC systems to assess treatment *** survival was estimated based on the treatment proposed in each *** A total of 519 HCC patients were *** these,178(34.3%)were HKLC-I;95(18.3%)HKLC-IIA;47(9.1%)HKLC-IIB;29(5.6%)HKLC-IIIA;30(5.8%)HKLCIIIB;75(14.4%)HKLC-IV;and 65(12.5%)*** to the BCLC,25(4.9%)were BCLC-0;246(47.4%)BCLC-A;107(20.6%)BCLC-B;76(14.6%)BCLCC;and 65(12.5%)*** general agreement between the two systems was 80.0%-BCLC-0 and HKLC-I(100%);BCLC-A and HKLC-I/HKLC-II(96.7%);BCLC-B and HKLC-III(46.7%);BCLC-C and HKLC-IV(98.7%);BCLC-D and HKLC-V(41.5%).When sub-classifying BCLC-A,HKLC-IIB,HKLC-IIIA and HKLC-IIIB stages according to the up-to-7 in/out criterion,13.4,66.0,100 and 36.7%,respectively,of the cases were classified as up-to-7 *** In a Western population,the general agreement between the two systems was 80.0%,although in BCLC-B cases the agreement was low,suggesting that some individuals could be candidates for the curative treatment recommended by the *** authors suggest that the BCLC system should be routinely employed,although for BCLC-B cases it should be associated with the HKLC system.

关键词： Barcelona clinic liver cancer staging system Hepatocellular carcinoma Hong Kong liver cancer staging system

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Transmission of severe acute respiratory syndrome coronavirus 2 via fecal-oral:Current knowledge

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World Journal of Clinical Cases 2021年第28期9卷 8280-8294页

作者： Filipe Antônio França da silva Breno Bittencourt de Brito Maria Luísa Cordeiro santos Hanna santos Marques Ronaldo Teixeira da silva Júnior Lorena Sousa de Carvalho Samuel de Sousa Cruz Gabriel reis Rocha Gabriel Lima Correa santos Kathlen Coutinho de Souza Rebeca Gabrielle Almeida Maciel Daiana silva Lopes Natália Oliveira e silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45002175BahiaBrazil departamento de Ciências Naturais Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45002175BahiaBrazil departamento de Bioquímica e Biofísica Universidade Federal da BahiaSalvador 40.110-100BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 93 million cases and 2 million deaths in the ***-CoV-2 respiratory tract infection and its main clinical manifestations such as cough and shortness of breath are well known to the scientific ***,a growing number of studies have reported SARS-CoV-2-related gastrointestinal involvement based on clinical manifestations,such as diarrhea,nausea,vomiting,and abdominal pain as well as on the pathophysiological mechanisms associated with coronavirus disease ***,current evidence suggests SARS-CoV-2 transmission via the fecal-oral route and aerosol ***,studies have shown a high risk of contamination through hospital surfaces and personal ***,viable SARS-CoV-2 specimens can be obtained from aerosols,which raises the possibility of transmission through aerosolized viral particles from ***,the infection by SARS-CoV-2 via fecal-oral route or aerosolized particles should *** addition,a possible viral spread to sources of drinking water,sewage,and rivers as well as the possible risk of viral transmission in shared toilets become a major public health concern,especially in the least developed *** authors have emphasized the presence of viral RNA and even viable SARS-CoV-2 in human feces,studies on the possible fecal-oral coronavirus disease 2019 transmission become essential to understand better the dynamics of its transmission and,then,to reinforce preventive measures against this infection,leading to a more satisfactory control of the incidence of the infection.

关键词： COVID-19 SARS-CoV-2,Transmission Via fecal-oral

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Production and quality of eucalyptus mini-cuttings using kaolin-based particle films

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Journal of Forestry Research 2021年第3期32卷 953-965页

作者： Maria de Fátima de Castro Oliveira Diego Pereira santos Karolline Sena Figueredo Fabrício de Oliveira reis Tiago Massi Ferraz Heder Braun Eliemar Campostrini Fábio Afonso Mazzei Moura de Assis Figueiredo Graduate Program in Agriculture and Environment Centro de Estudos Superiores de BalsasState University of MaranhaoPraca Goncalves Diass/nCentro65800-000 BalsasMABrazil Enraize-E.M.Figueredo Ind.e Com.de Produtos Florestais Br 222Km 09Lote 52Margem Esquerda S/n:Chac.Belo HorizonteZona RualAcailandiaMABrazil Centro de Ciências Agrárias State University of MaranhaoAv.Lourenco Vieira da Silva1000Jardim Sao Cristovao65055-310 Sao LuísMABrazil CCTA Northern Rio de Janeiro State UniversityAv.Alberto Lamego200028013-602 Campos dos GoytacazesRJBrazil

Considering the expansion of forest plantations over the Brazilian territory and the imminent increase in air temperatures due to global warming,the search for technologies that ensure high levels of productivity and high quality plants in clonal nurseries is *** kaolin-based particle films(KBPF)has been used as a physical barrier to reduce the negative effects of excessive solar radiation and adverse *** effects of KBPF on production and physiological quality of eucalyptus mini-cuttings were evaluated during two different seasons.A randomized block design was used,consisting of five treatments and four *** concentrations(0,3%,5%,7%,and 10%)were tested here and six weekly replicates of each concentration was *** different kaolin concentrations and seasonal variations resulted in a quadratic response of the leaf SPAD reading during both daily evaluation *** applications resulted in a quadratic response of photochemical efficiency in the morning period,and an increasing specific leaf weight linear response,and during the dry season,the different kaolin concentrations resulted in a bud length quadratic *** results indicated that the kaolin application maintained the production and yield index statistically equal between weekly KBPF applications,improving photochemical efficiency,leaf thickness,SPAD reading,and bud *** use of KBPF could reduce the intervals between collections of mini-cuttings and increase nursery yields in environments that present high temperatures.

关键词： Photoprotector Ecophysiology Forestry Clonal propagation

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