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Human Beta Defensins 1,2 and 3 Produced by Amniochorion Membranes Is Similar in Term and Preterm Delivery

Open Journal of Obstetrics and Gynecology 2017年第8期7卷 846-857页

作者： Nathália Mayumi Noda-Nicolau Jossimara Polettini camila Marconi José Carlos Peracoli Hélio Amante Miot Márcia Guimaraes da silva Department of Pathology Botucatu Medical School UNESP—Universidade Estadual Paulista Sao Paulo Brazil The University of Western Sao Paulo (UNOESTE) Presidente Prudente Brazil Department of Basic Pathology Setor de Ciências Biológicas UFPR—Universidade Federal do Paraná Curitiba Brazil Department of Gynecology and Obstetrics Botucatu Medical School UNESP—Universidade Estadual Paulista Sao Paulo Brazil Department of Dermatology Botucatu Medical School UNESP—Universidade Estadual Paulista Sao Paulo Brazil

Amniochorion membranes were collected from 25 pregnant women at preterm labor, in the presence or not of Preterm Premature Rupture of Membranes (PPROM) and 27 pregnant women at term in the presence at labor, in order to quantify the expression and to evaluate the immunoreactivity of human beta defensins (HBD)1, HBD2, HBD3 and HBD4 in amniochorion membranes from pregnancies complicated by spontaneous prematurity. The HBDs were evaluated by immunohistochemistry, real time quantitative PCR and ELISA. Statistical analyses were performed using Chi-squared and Mann Whitney tests. There was no significant difference in HBDs expression between study and control groups: HBD1 (Md = 0.62 (0.0 - 105.0) vs Md = 0.80 (0.02 - 25.0);p = 0.85), HBD2 (Md = 0.17 (0.0 - 5.2) vs Md = 0.0 (0.0 - 43.2);p = 0.16), HBD3 (Md = 0.11 (0.0 - 140.5) vs Md = 0.06 (0.0 - 972.1);p = 0.91). Also, HBD1, HBD2 and HBD3 protein expression was not significant different between the groups: HBD1 (1.32 pg/mL (0.0 - 1.85) vs 1.08 pg/mL (0.04 - 2.22);p = 0.67), HBD2 (0.00 pg/mL (0.0 - 1.74) vs 0.02 pg/mL (0.0 - 1.24);p = 0.69), HBD3 (0.04 pg/mL (0.0 - 1.05) vs 0.09 pg/mL (0.0 - 1.05);p = 0.63). The immunoreactivity of HBD1, HBD2 and HBD3 was observed in amnion, chorion and decidua cells from preterm and term pregnancies. Amniochorion membranes are sources of HBD1, HBD2 and HBD3 and their expressions are similar in term and preterm pregnancies.

关键词： Preterm Birth Amniochorion Membranes Human Beta Defensins

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Occurrence of Delirium and Length of Stay of Patients in the Intensive Care Unit

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Journal of Biosciences and Medicines 2021年第8期9卷 1-9页

作者： Aparecida Sátira da silva Machado Mayara Rabello Teixeira Alves daniella Nogueira vieira Sara Ellias de Sousa Felipe Rodrigues Maia daniel Almeida da Costa Leandro Raider The Medical School at the Center of Higher Education of Valenç a Unifaa Brazil

Introduction: The delirium has received little attention from professionals working in the intensive care unit, mainly due to the fact that this is, rarely, the primary reason for patient admission. Given the high prevalence of delirium in an intensive care environment, the current guidelines recommend the daily assessment of delirium and a multidisciplinary approach. Delirium is a frequent and severe form of acute brain dysfunction, as well as an important source of concern in critical care. Objective: To assess the occurrence of delirium and time of stay in the intensive care unit. Method: This is a quantitative, descriptive study, with a cross-sectional design, which was carried out in a university hospital located in the interior of the State of Rio de Janeiro. The sample consisted of 89 patients, of both sexes, aged between 24 and 92 years. The RASS and CAM-ICU scales were used to assess delirium. The data were collected every 12 hours, for 3 months, 7 days a week and in an uninterrupted manner. Results: Were evaluated 89 patients, of which 16 were excluded according to the scale criteria, leaving 73 patients. After evaluation, 22 patients were diagnosed with delirium and 51 patients without delirium. Of the patients who presented delirium, 13 deaths and 9 had high to the nursery. Of the patients who did not have delirium, 40 had high to the nursery and 11 deaths. Patients with delirium had an average hospital stay of 23.25 days and patients who did not have delirium had an average of 4.5 days hospitalization. Conclusion: We can infer that the longer the patient spends in the intensive care unit, the greater the chance of delirium occurring. Therefore, preventive and interventional measures are necessary to decrease the mortality rate in patients with delirium and early detection is an excellent tool to improve this outcome.

关键词： Delirium Intensive Care Unit Time of Hospitalization

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Risk stratification and geographical mapping of Brazilian inflammatory bowel disease patients during the COVID-19 outbreak:Results from a nationwide survey

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World Journal of Gastroenterology 2021年第12期27卷 1226-1239页

作者： Natália Sousa Freitas Queiroz Fábio vieira Teixeira Marina Pamponet Motta Liliana Andrade Chebli Adriano Akira Ferreira Hino Camilla de Almeida Martins Abel Botelho Quaresma Alexandre Augusto de Paula da silva Adérson Omar Mourão Cintra damião Rogerio Saad-Hossne Paulo Gustavo Kotze Department of Gastroenterology University of São Paulo School of MedicineSão Paulo 05403-000SPBrazil IBD Unit Gastroenterology DepartmentGastrosaúde ClinicMarilia 17509190SPBrazil School of Medicine Federal University of BahiaSalvador 40020-025BHBrazil IBD Outpatient Clinics Universidade Federal de Juiz de ForaJuiz de Fora 36010-010MGBrazil Health Sciences Postgraduate Program Pontifícia Universidade Católica do Paraná(PUCPR)Curitiba 80440-220PRBrazil Departamento de Ciências da Saúde Universidade do Oeste de Santa Catarina(UNOESC)Joaçaba 89600-000SCBrazil Botucatu Medical School Paulista State University(UNESP)Botucatu 18600-050SPBrazil IBD Outpatient Clinics Pontificia Universidade Católica do Paraná(PUCPR)Curitiba 80440-220PRBrazil

BACKGROUND Coronavirus disease 2019(COVID-19)pandemic is still evolving globally,and Brazil is currently one of the most affected *** is still debated whether patients with inflammatory bowel disease(IBD)are at a higher risk for developing COVID-19 or its *** To assess geographical distribution of IBD patients at the highest risk and correlate these data with COVID-19 mortality rates in *** The Brazilian IBD Study Group(Grupo de Estudos da Doença Inflamatória Intestinal do Brasil)developed a web-based survey adapted from the British Society of Gastroenterology *** included categories were demographic data and inquiries related to risk factors for complications from *** were categorized as highest,moderate or lowest individual *** Spearman correlation test was used to identify any association between highest risk and mortality rates for each state of the *** A total of 3568 patients(65.3%females)were *** participants were from the southeastern and southern regions of Brazil,and 84.1%were using immunomodulators and/or *** patients(55.1%)were at moderate risk,23.4%were at highest risk and 21.5%were at lowest risk of COVID-19 *** association between the proportion of IBD patients at highest risk for COVID-19 complications and higher mortality rates was identified in different Brazilian states(r=0.146,P=0.467).CONCLUSION This study indicates a distinct geographical distribution of IBD patients at highest risk for COVID-19 complications in different states of the country,which may reflect contrasting socioeconomic,educational and healthcare *** association between high risk of IBD and COVID-related mortality rates was identified.

关键词： Crohn’s disease Colitis,Ulcerative COVID-19 Inflammatory bowel disease Brazil

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Hemoglobin Values in the First Six Months of Life in Exclusively Breastfed Children

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Open Journal of Blood Diseases 2013年第4期3卷 130-135页

作者： Rosa de Fatima da silva vieira Marques Jose Augusto de Aguiar Carrazedo Taddei Fabio Ancona Lopez Josefina Aparecida Pellegrini Braga Department of Integral Health State University of Para(UEPA)BelemBrazil Department of Pediatrics Sao Paulo Medical SchoolFederal University of Sao Paulo(EPM/UNIFESP)Sao PauloBrazil.

Objective: The inexistence of publications on hemoglobin values in the first six months of life gave us the objective of describing these values, month by month in healthy, iron sufficient exclusively breastfed infants. Methods: This was a cross-sectional descriptive study in 306 infants stratified according to age from one to six months, full-term births, weighing ≥2500 g, without intercurrences at birth, serum ferritin levels ≥10 ng/mL, followed by the public health service encouraging and supporting exclusive breastfeeding. An automated counter was used for measuring hemoglobin, and serum ferritin was determined using immunoenzymatic method. Student’s t-test was used to analyze differences between means, and Mann-Whitney test when distribution was non-normal. Level of statistical significance was p 0.05. Results: The hemoglobin values, according to gender, did not differ statistically in the different months;the results are presented without sample division according to gender. Hemoglobin means and standard deviations in g/dL were: 11.7(±1.6), 10.7(±1.5), 10.8(±1.3), 11.6(±1.5), 11.7(±1.7), and 11.8(±1.6), from the first to sixth month respectively. Conclusion: The hemoglobin values obtained in all the first six months of life, based on a healthy, exclusively breastfed infant population, may contribute to the reassessment of reference levels for the diagnosis of anemia in the studied age range.

关键词： Hemoglobin Ferritin Infant Exclusive Breastfeeding Nutrition

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Learning Disorder Secondary Epilepsy: A Case Report

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World Journal of Neuroscience 2016年第4期6卷 303-309页

作者： A.R. de Albuquerque Sarmento Omena José Cláudio da silva camila Maria Beder Ribeiro Euclides Maurício Trindade Filho Terezinha Rocha Almeida Cesmac. Clínica Guri Maceió Brazil Universidade Estadual de Ciências da Saúde de Alagoas-UNCISAL Maceió Brazil Universidade Estadual de Ciências da Saúde de Alagoas (NUCIB-UNCISAL) Maceió Brazil Clínica Guri Maceió Brazil

Introduction: Epilepsy is a syndrome characterized by the presence of seizures that can affect the cognitive performance of the individual. Neuropsychology has studied the idiopathic epilepsies to understand if the behavioral and cognitive impairments are associated with electrical discharges in the brain, and not with an injury itself. Objective: To identify cognitive impairments of a child with epilepsy associated with diagnosis of learning disorder. Method: The sample consists of a child diagnosed with epilepsy, nine years old, from Maceió-AL. The methodology applied is a qualitative and descriptive study of a case report. Neuropsychological tests are applied for that purpose. Results: The results of the tests show cognitive deficits, impaired attention, memory and slowness of reasoning. Conclusion: Despite the results, it cannot be said in this case that epilepsy was the only factor that triggered the learning disorder, because the child had related comorbidities.

关键词： Epilepsy Learning Disorder Cognitive Functions

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Analysis of the evidence of related factors,associated conditions and at-risk populations of the NANda-I nursing diagnosis insomnia

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International Journal of Nursing Sciences 2020年第4期7卷 466-476,I0008页

作者： Lidia Santiago Guandalini Eduarda Ferreira da silva Juliana de Lima Lopes Vinicius Batista Santos camila Takao Lopes Alba Lúcia Bottura Leite de Barros Escola Paulista de Enfermagem Universidade Federal de Sao PauloSao PauloBrazil Sao Paulo Hospital Sao PauloBrazil

Objectives:To summarize evidence in the literature on the predictors of insomnia in adults and to determine correspondences with diagnostic indicators of the NANda-I diagnosis ***:An integrative review performed in Pubmed,Virtual Health Library and ***-eight articles published in Portuguese,English or Spanish from 2011 to 2018 were *** analysis of correspondence between the predictors and the NANda-I related factors and associated conditions for Insomnia was ***:There was a correspondence of the predictors found in this review with NANda-I related factors and associated conditions,except for grieving and frequent naps during the ***,caffeine intake,dysfunctional sleep beliefs,obesity and caregiver role strain are possible new related factors;chronic illness is a possible new associated condition and individuals going through changes in marital status,economically disadvantaged,female gender,increasing age and night shift worker are possible new at-risk ***:The predictors of insomnia that had a correspondence with the NANda-I elements can support the evidence base of the nursing *** predictors found without a correspondence with the diagnosis can be considered for inclusion in the NANda-I classification,thereby supporting the clinical reasoning of nurses and students.

关键词： Adult Insomnia Nursing diagnosis Sleep initiation and maintenance disorders

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COVID-19 Downgraded Already Impaired Mental Health of Medical Undergraduates during the Pandemic Years

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Journal of Biosciences and Medicines 2023年第5期11卷 166-180页

作者： Rodrigo Corrêa Falcão Rodrigues Alves Rodolffo da silva Fossa Vinicius de Calasans Timaco José Mariano Soares de Moraes Emilio Magalhães Martins Will Rinaldo Henrique Aguilar da silva Luiz Antonio Vane Joaquim Edson vieira Matheus Fachini Vane Faculdade de Ciências Médicas de Sã o José dos Campos S&atildeo José dos Campos Brazil Department of Anesthesiology Juiz de Fora Federal University Juiz de Fora Brazil Department of Anesthesiology Clinics Hospital University of S&atildeo Paulo Medical School S&atildeo Paulo Brazil Discipline of Anesthesiology Department of Surgery University of S&atildeo Paulo Medical School S&atildeo José dos Campos Brazil

Background: Measures to contain the COVID-19 transmission reached teaching routines of universities worldwide with possible mental health consequences for anxiety. This study assessed prevalence and risk factors for stress, depression, and anxiety (Sda) in medical students during quarantine by COVID-19. Methods: A cross-sectional observational study of medical students by means of the daSS-21 questionnaire. Risk factors for Sda were assessed based on epidemiologic questions related to COVID-19. Receiver Operating Characteristics (ROC) curves were calculated for each predictor, as well as sensitivity and specificity. Results: This survey reached 1009 responses. A prevalence of 77.5% for some Sda disorder was found, 63% being severe. Previous diagnosis of psychiatric disorder was a factor of risk for anxiety (OR 2.78 CI95% 1.44 - 14.25, p = 0.044), as well as for depression (OR 3.37 CI95% 1.98 - 6.02, p Conclusion: Psychiatric conditions as well as chronic illnesses were risk factors for high prevalence of anxiety, depression and stress during the COVID-19 pandemic among medical students.

关键词： Mental Health COVID-19 Students Medical Surveys and Questionnaires

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Methodology for ranking controllable parameters to enhance operation of a steam generator with a combined Artificial Neural Network and Design of Experiments approach

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能源与人工智能(英文) 2021年第1期3卷 9-21页

作者： Lara Werncke vieira Augusto Delavald Marques Paulo Smith Schneider Antônio Joseda silva Neto Felipe Antonio Chegury Viana Madhat Abdel-jawad Julian david Hunt Julio Cezar Mairesse Siluk Federal University of Rio Grande do Sul-UFRGS Porto AlegreBrazil State University of Rio de Janeiro-UERJ Nova FriburgoBrazil University of Central Florida OrlandoUCFUnited States Advanced Analysis Australia-AAA PerthAustralia International Institute for Applied Systems Analysis-IIASA ViennaAustria Federal University of Santa Maria-UFSM Santa MariaBrazil

The operation of complex systems can drift away from the initial design conditions,due to environmental condi-tions,equipment wear or specific *** generators are complex equipment and their proper opera-tion relies on the identification of their most relevant *** approach to rank the operational parameters of a subcritical steam generator of an actual 360 MW power plant is *** Artificial Neural Network-ANN delivers a model to estimate the steam generator efficiency,electric power generation and flue gas outlet temperature as a function of seven input *** ANN is trained with a two-year long database,with training errors of 0.2015 and 0.2741(mean absolute and square error)and validation errors of 0.32%and 2.350(mean percent and square error).That ANN model is explored by means of a combination of situations proposed by a Design of Experiment-DoE *** seven controlled parameters showed to be relevant to express both steam generator efficiency and electric power generation,while primary air flow rate and speed of the dynamic classifier can be neglected to calculate flue gas temperature as they are not statistically *** also shows the prominence of the primary air pressure in respect to the steam generator efficiency,electric power generation and the coal mass flow rate for the calculation of the flue gas outlet *** ANN and DoE combined methodology shows to be promising to enhance complex system efficiency and helpful whenever a biased behavior must be brought back to stable operation.

关键词： Coal-fired power plant Artificial Neural Network Design of Experiments Response surface methodology Steam generator

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Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus

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World Journal of Hepatology 2020年第4期12卷 137-148页

作者： Cliviany Borges da silva Diego Alves vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz silva Sciences Applied to Adult Health Care Post-Graduate Programme Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Outpatient Clinic of Viral Hepatitis Instituto Alfa de GastroenterologiaFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Medical undergraduate student Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Department of Internal Medicine Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Division of Endocrinology Department of Internal MedicineFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Epidemiology of Infectious and Parasitic Diseases Laboratory Department of ParasitologyInstitute of Biological SciencesUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil

BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes *** the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune *** serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C *** To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same *** between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC *** Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively *** 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes ***,biochemical,histological and radiological methods were used for the diagnosis of the liver ***-6 polymorphism was evaluated by Taqman SNP genotyping *** data were analysed by logistic regression *** Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,*** frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C *** identification of potential inflammatory mediato

关键词： Chronic Hepatitis C Type 2 diabetes mellitus Interleukin 6-174G/Cgenepromoter single nucleotide polymorphism Blood hypertension Healthy control subjects

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圣保罗大学的固体废料管理倡议(英文)

圣保罗大学的固体废料管理倡议(英文)

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北京论坛（2010）文明的和谐与共同繁荣——为了我们共同的家园：责任与行动

作者： camila Martins Oliveira da silva Nogueira University of Sao Paulo

*** The severity of the current levels of environmental degradation that we have witnessed has led to an environmental concern that is no more restricted to groups of environmental activists,but has

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