检索结果-南通市图书馆

Divergence and constraint in the thermal sensitivity of aquatic insect swimming performance

Current Zoology 2020年第5期66卷 555-564页

作者： Alisha A.SHAH Eva M.S.Bacmeister Juan G.Rubalcaba cameron k.ghalambor Department of Biology Colorado State UniversityFort CollinsCO80526USA Division of Biological Sciences University of MontanaMissoulaMT59812USA Department of Biology McGill University1205 Docteur PenfieldMontrealQCCanada Department of Biology Centre for Biodiversity DynamicsNorwegian University of Science and Technology(NTNU)TrondheimNorway

Environmental temperature variation may play a significant role in the adaptive evolutionary divergence of ectotherm thermal performance curves(TPCs).However,divergence in TPCs may also be constrained due to various ***,we measured TPCs for swimming velocity of temperate and tropical mayflies(Family:Baetidae)and their stonefly predators(Family:Perlidae)from different *** predicted that differences in seasonal climatic regimes would drive divergence in TPCs between temperate and tropical *** tropical temperatures should favor the evolution of"specialists"that perform well across a narrow range of ***,variable temperatures in temperate zones,however,should favor"generalists"that perform well across a broad range of *** phylogenetically paired comparisons of mayflies and stoneflies,swimming speed was generally unaffected by experimental temperature and did not differ among populations between latitudes,suggesting a maintenance of performance breadth across elevation and *** exception was found between temperate and tropical mayflies at low elevation where climatic differences between latitudes are *** addition,TPCs did not differ between mayflies and their stonefly predators,except at tropical low *** results indicate that divergence in TPCs may be con strai ned in aquatic in sects except under the most differe nt ther・mal regimes,perhaps because of trade-offs that reduce thermal sensitivity and increase performance breadth.

关键词： aquatic insects climate variability elevation latitude predator-prey swimming performance thermal performance curve

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbon storage and net primary productivity in Canadian boreal mixedwood stands

引用

Journal of Forestry Research 2019年第5期30卷 1667-1678页

作者： Nicholas J.Payne D.Allan cameron Jean-Denis Leblanc Ian k.Morrison Canadian Forest Service Great Lakes Forestry Centre

Canadian boreal mixedwood forests are extensive,with large potential for carbon sequestration and storage;thus,knowledge of their carbon stocks at different stand ages is needed to adapt forest management practices to help meet climate-change mitigation *** stocks were quantified at three Ontario boreal mixedwood sites.A harvested stand,a juvenile stand replanted with spruce seedlings and a mature stand had total carbon stocks(±SE)of 133±13 at age 2,130±13 at age 25,and 207±15 Mg C ha^-1 at age 81 *** the clear-cut site,stocks were reduced by about 40%or 90 Mg C ha^-1 at *** held 27,34 and 62%of stocks,while detritus held 34,29 and 13%of stocks at age 2,25 and 81,*** soil carbon stocks averaged 51 Mg C ha^-1,and held 38,37 and 25%of *** net primary productivity(±SE)in the harvested and juvenile stand was 2.1±0.2 and 3.7±0.3 Mg C ha^-1 per annum(p.a.),compared to 2.6±2.5 Mg C ha^-1 *** the mature *** mature canopies studied had typical boreal mixedwood composition and mean carbon densities of 208 Mg C ha^-1,which is above average for managed Canadian boreal forest ecosystems.A comparison of published results from Canadian boreal forest ecosystems showed that carbon stocks in mixedwood stands are typically higher than coniferous stands at all ages,which was also true for stocks in vegetation and ***,aboveground net primary productivity was typically found to be higher in mixedwood than in coniferous boreal forest stands over a range of *** from this study,together with those published from the other boreal forest stands demonstrate the potential for enhanced carbon sequestration through modified forest management practices to take advantage of Canadian boreal mixedwood stand characteristics.

关键词： Aboveground net primary productivity Boreal mixedwood forest Carbon stocks Mixedwood stand management Stand age

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Methylene blue enhances polyethylene glycol-fusion repair of completely severed rat sciatic nerves

引用

Neural Regeneration Research 2021年第10期16卷 2056-2063页

作者： cameron L.Ghergherehchi Jaimie T.Shores Joseph Alderete Erik k.Weitzel George D.Bittner Institute for Cellular and Molecular Biology University of Texas at AustinAustinTXUSA Department of Plastic and Reconstructive Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Surgery RESTOR LaboratorySan AntonioTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Complete transection of peripheral mixed nerves immediately produces loss of sensory perception,muscle contractions and voluntary behavior mediated by the severed distal *** contrast to natural regeneration(~1 mm/d)of proximal axons that may eventually reinnervate denervated targets,re-innervation is restored within minutes by PEG-fusion that consists of neurorrhaphy and a sequence of well specified hypo-and isotonic calcium-free or calcium-containing solutions,the anti-oxidant methylene blue(MB)and the membrane fusogen polyethylene glycol(PEG).In this study,we examined the relative efficacy of PEG-fusion with no MB(0%),0.5%MB,or 1%MB on the recovery of voluntary behaviors by female Sprague-Dawley rats with a complete mid-thigh severance of their sciatic nerve bathed in extracellular fluid or calcium-containing isotonic *** recovery of voluntary behaviors is the most relevant measure of success of any technique to repair peripheral nerve *** assessed recovery by the sciatic functional index,a commonly used measure of voluntary hindlimb behaviors following complete sciatic *** reported that both 1%MB and 0.5%MB in sterile distilled water in our PEG-fusion protocol with neurorrhaphy significantly increased the rate and extent of behavioral recovery compared to PEG plus neurorrhaphy ***,0.5%MB was as effective as 1%MB in voluntary behavioral recovery as assessed by the sciatic functional *** sterile 1%MB is no longer clinically available,we therefore recommend that 0.5%MB be included in upcoming human clinical trials to evaluate the safety and efficacy of *** animal procedures were approved by the University of Texas Institutional Animal Care and Use Committee(AUP-2019-00225)on September 9,2020.

关键词： axotomy methylene blue nerve repair neurorrhaphy peripheral nerve injury polyethylene glycol fusion sciatic nerve

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimizing oncolytic virus design:a“Swiss army knife”approach to create a systemically delivered therapeutic

引用

Signal Transduction and Targeted Therapy 2024年第5期9卷 1791-1792页

作者： Carolina S.Ilkow John cameron Bell Ottawa Hospital Research Institute 501 Smyth RoadOttawaONK1H 8L6Canada

In a recent paper published in Nature Biotechnology,Chen et al.1 describe a multiplex oncolytic virus platform that coupled with adoptive T cell therapy could solve the problem of repeat,systemic delivery of virus based *** is widely accepted that multi-targeted therapeutic approaches attacking several facets of cancer biology are necessary to effectively deal with the tumor heterogeneity that exists within and between patients.

关键词： therapeutic al. targeted

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Induction of Bone Matrix Protein Expression by Native Bone Matrix Proteins in C2C12 Culture

引用

Biomedical and Environmental Sciences 2009年第2期22卷 164-169页

作者： ZHEN-MING HU SEAN A. F. PEEL STEPHEN k. C. HO GEORGE k. B. SANDOR AND cameron M. L. CLOkIE Department of Orthopedic Surgery the First Affiliated Hospital Chongqing Medical University Chongqing 400016 China Orthobiologics Laboratory Discipline of Oral and Maxillofacial Surgery Faculty of Dentistry University of Toronto Toronto ON M5G 1G6 Canada

Objective To study the expression of bone matrix protein （BMP） induced by bovine bone morphogenetic proteins （BMPs） in vitro. Methods Type 1 collagen, osteopontin （OPN）, osteonectin （ON）, osteocalcin （OC）, and bone sialoprotein （BSP） were detected by immunohistochemistry in C2C12 cultured from day 1 to day 28. Results The signaling of bone matrix protein expression became weaker except for type I collagen, OC and BSP after 5 days. Fourteen days after culture, the positive signaling of type I collagen, OPN, ON, OC, and BSP was gradually declined, and could be detected significantly as compared with that of the negative control on day 28. BMP assay showed that the lkaline phosphatase （ALP） activity was higher in C2C12 culture than in the control during the 14-day culture. Also, total protein and DNA significantly increased during the 14-day culture. High levels of ALP were seen in preosteoblasts and osteoblsts in vivo and in differentiating osteoblasts in vitro. ALP was well recognized as a marker reflecting osteoblastic activity. Conclusion Native bovine BMP induces conversion of myoblasts into osteoblasts, produces type I collagen, and plays significantly role in osteoinduction and bone matrix mineralization of C2C 12 in vitro.

关键词： Bone matrix proteins Bone morphogenetic proteins Immunohistochemistry C2C12

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular therapeutic strategies targeting pancreatic cancer induced cachexia

引用

World Journal of Gastrointestinal Surgery 2018年第9期10卷 95-106页

作者： Anastasiya Yakovenko Miles cameron Jose Gilberto Trevino University of Florida College of Medicine GainesvilleFlorida 32610United States Department of Surgery University of Florida Health Sciences CenterGainesvilleFlorida 32610United States

Pancreatic cancer(PC) induced cachexia is a complex metabolic syndrome associated with significantly increased morbidity and mortality and reduced quality of life. The pathophysiology of cachexia is complex and poorly understood. Many molecular signaling pathways are involved in PC and cachexia. Though our understanding of cancer cachexia is growing, therapeutic options remain limited. Thus, further discovery and investigation of the molecular signaling pathways involved in the pathophysiology of cachexia can be applied to development of targeted therapies. This review focuses on three main pathophysiologic processes implicated in the development and progression of cachexia in PC, as well as their utility in the discovery of novel targeted therapies. Skeletal muscle wasting is the most prominent pathophysiologic anomaly in cachectic patients and driven by multiple regulatory pathways. Several known molecular pathways that mediate muscle wasting and cachexia include transforming growth factor-beta(TGF-β), myostatin and activin, IGF-1/PI3 k/AkT, and JAk-STAT signaling. TGF-β antagonism in cachectic mice reduces skeletal muscle catabolism and weight loss, while improving overall survival. Myostatin/activin inhibition has a great therapeutic potential since it plays an essential role in skeletal muscle regulation. Overexpression of insulin-like growth factor binding protein-3(IGFBP-3) leads to increased ubiquitination associated proteolysis, inhibition of myogenesis, and decreased muscle mass in PC induced cachexia. IGFBP-3 antagonism alleviates muscle cell *** component of cachexia is profound systemic inflammation driven by pro-cachectic cytokines such as interleukin-6(IL-6), tumor necrosis factoralpha(TNF-α), and interferon gamma(INF-γ). IL-6 antagonism has been shown to reduce inflammation, reduce skeletal muscle loss, and ameliorate cachexia. While TNF-α inhibitors are clinically available, blocking TNF-α signaling is not effective in the treatment of c

关键词： Cachexia Muscle wasting Pancreatic cancer Cachexia therapies Molecular signaling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress of Pb-Sn Mixed Perovskites for Photovoltaics: A Review

引用

Energy & Environmental Materials 2022年第2期5卷 370-400页

作者： Rajapakshe Mudiyanselage Indrachapa Bandara Shashini M.Silva cameron C.L.Underwood k.D.G.Imalka Jayawardena Radu A.Sporea S.Ravi P.Silva Advanced Technology Institute Faculty of Engineering and Physical SciencesUniversity of SurreyGuildford Surrey GU27XHUnited Kingdom

Pb-Sn mixed perovskites are becoming increasingly popular as narrowbandgap(1.2–1.3 eV)light absorbers in single-junction perovskite solar cells(PSCs)and as bottom cells for all-perovskite tandem solar cells,for highefficiency,low-cost,lightweight,roll-to-roll printable photovoltaic(PV)*** the first report of planar Pb:Sn mixed PSCs in 2014,the power conversion efficiencies(PCE)have increased from 10%to 21%by the end of 2020 with an exponential growth in research conducted in this *** much effort,the performance and stability of Pb-Sn mixed PSCs are still limited,which constrains their long-term use in all-perovskite tandem *** review highlights the avenues explored in improving different aspects of Pb-Sn mixed PSCs and provides a comprehensive discussion of the interdependent factors affecting the device *** includes compositional engineering of the perovskite crystal,absorber layer fabrication and crystallization methods,bandgap tuning,Sn4+reduction,and surface passivation of the absorber layer,as well as the selection of interlayers and electrodes of the final PSC.

关键词： inorganic-organic hybrids lead-tin mixed perovskites perovskites photovoltaics solution-processed

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of internal COI primers to improve and extend barcoding of fruit flies (Diptera: Tephritidae: Dacini)

引用

Insect Science 2020年第1期27卷 143-158页

作者： Matt N.krosch Francesca Strutt Mark J.Blacket Jana Batovska Melissa Starkie Anthony R.Clarke Stephen L.cameron Mark k.Schutze School of Earth Environmental&Biological SciencesQueensland University of TechnologyBrisbaneQueenslandAustralia Plant Biosecurity Co-operative Research Centre BruceAustralian Capital TerritoryAustralia Agriculture Victoria AgriBioCentre for AgriBioscienceBundooraVictoriaAustralia Department of Entomology Purdue UniversityWest LafayetteIndianaUSA Department of Agriculture&Fisheries Queensland Primary Industries Insect Collection(QDPC)Dutton ParkQueenslandAustralia

Accurate species-level identifications underpin many aspects of basic and applied biology;however,identifications can be hampered by a lack of discriminating morphological characters,taxonomic expertise or *** approaches,such as DNA"barcoding"of the cytochrome c oxidase(COI)gene,are argued to overcome these ***,nuclear encoding of mitochondrial genes(numts)and poor amplification success of suboptimally preserved specimens can lead to erroneous *** insect group for which these molecular and morphological problems are significant are the dacine fruit flies(Diptera:Tephritidae:Dacini).We addressed these issues associated with COI barcoding in the dacines by first assessing several"universal"COI primers against public mitochondrial genome and numt sequences for dacine *** then modified a set of four primers that more closely matched true dacine COI sequence and amplified two overlapping portions of the COI barcode *** new primers were tested alongside universal primers on a selection of dacine species,including both fresh preserved and decades-old dry ***,Bactrocera tiyoni mitochondrial and nuclear genomes were compared to identify putative *** numt clades were identified,three of which were amplified using existing universal *** contrast,our new primers preferentially amplified the"true"mitochondrial COI barcode in all dacine species *** new primers also successfully amplified partial barcodes from dry specimens for which full length barcodes were *** we recommend these new primers be incorporated into the suites of primers used by diagnosticians and quarantine labs for the accurate identification of dacine species.

关键词： Bactrocera biosecurity Dacus\minibarcodes pseudogene Zeugodacus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Validation of SNP markers for fruit quality and disease resistance loci in apple (Malus × domestica Borkh.) using the OpenArray® platform

引用

Horticulture Research 2019年第1期6卷 1348-1363页

作者： David Chagné Stijn Vanderzande Chris kirk Natalie Profitt Rosemary Weskett Susan E.Gardiner cameron P.Peace Richard k.Volz Nahla V.Bassil The New Zealand Institute for Plant&Food Research Ltd(Plant&Food Research) Palmerston North Research CentrePalmerston NorthNew Zealand Department of Horticulture Washington State UniversityPullmanWAUSA Plant&Food Research Hawke’s Bay Research CentreHavelock NorthNew Zealand USDA-ARS National Clonal Germplasm RepositoryCorvallisORUSA

Genome mapping has promised much to tree fruit breeding during the last 10 ***,one of the greatest challenges remaining to tree fruit geneticists is the translation of trait loci and whole genome sequences into diagnostic genetic markers that are efficient and cost-effective for use by breeders,who must select genetically optimal parents and subsequently select genetically superior individuals among their *** take this translational step,we designed the apple International RosBREED SNP Consortium OpenArray v1.0(IRSCOA v1.0)assay using a set of 128 apple single nucleotide polymorphisms(SNPs)linked to fruit quality and pest and disease resistance trait *** Thermo Fisher Scientific OpenArray®technology enables multiplexed screening of SNP markers using a real-time PCR instrument with fluorescent probe-based Taqman®*** validated the apple IRSCOA v1.0 multitrait assay by screening 240 phenotyped individuals from the Plant&Food Research apple cultivar breeding *** set of individuals comprised commercial and heritage cultivars,elite selections,and families segregating for traits of importance to *** total,33 SNP markers of the IRSCOA v1.0 were validated for use in marker-assisted selection(MAS)for the scab resistances Rvi2/Vh2,Rvi4/Vh4,Rvi6/Vf,fire blight resistance MR5/RLP1,powdery mildew resistance Pl2,fruit firmness,skin colour,flavour intensity,and *** availability of this set of validated trait-associated SNP markers,which can be used individually on multiple genotyping platforms available to various apple breeding programmes or re-designed using the flanking sequences,represents a large translational genetics step from genomics to crop improvement of apple.

关键词： Open resistance breeding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimizing the solar energy capture of residential roof design in the southern hemisphere through Evolutionary Algorithm

引用

Energy and Built Environment 2021年第4期2卷 406-424页

作者： Saleh kaji Esfahani Ali karrech Robert cameron Mohamed Elchalakani Rosangela Tenorio Fernando Jerez The Faculty of Arts BusinessLaw and EducationSchool of DesignUniversity of Western Australia6009 PerthWestern AustraliaAustralia Faculty of Engineering and Mathematical Sciences School of EngineeringUniversity of Western Australia6009 PerthWestern AustraliaAustralia The Australian Urban Design Research Centre University of Western Australia6000 PerthWestern AustraliaAustralia

Australia’s national energy system is heavily reliant on coal-fired power plants and requires quick action to de-crease CO_(2)emissions in order to meet the Paris climate change agreement by *** a good alternative to coal power,renewable resources can produce the required energy for Australia while keeping the environment *** annual amount of falling solar irradiation in Australia is a few thousand times higher than its energy consumption,but the amount of the collected solar energy is *** Perth,the sunniest city in Aus-tralia,one-third of the residential dwellings have roof-mounted solar collector ***,there have been limited studies into the integration of these systems in building design and it is still unknown which roof design can deliver maximum efficiency based on the local environmental ***,the aims of this study are to determine the optimum residential roof design in Perth,Western Australia and to maximise extracted solar power throughout a *** reach this aim,a combination of analytical modelling,numerical simulation,and evolutionary algorithm methods have been *** first,a series of detailed mathematical calculations were performed in Excel to find the optimum solar collector mounting *** the numerical simulation,the exam-ination was repeated in the Rhino-Grasshopper interface to verify the earlier findings and calibrate the chosen simulation package with the help of parametric *** the last step,a wide range of housing roof shapes has been tested by evolutionary algorithm plugin-Galapagos,to find the optimum roof shape design in the given *** results show that,unlike the traditional approach and common belief,a roof shape with a 25-degree tilt angle,170-175 azimuth angle,and aspect ratio of 1:1.2 is optimum to gain maximum solar gaining ***,this study advances the knowledge of solar capturing by suggesting a new parameter-oblique angle-in finding the op

关键词： Parametric architecture Solar gaining Roof form optimization Evolutionary algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：