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Mastering the craft:Creating an insightful and widely-cited literature review

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世界干细胞杂志:英文版(电子版) 2023年第8期15卷 781-786页

作者： shengwen calvin Li Neuro-oncology and stem Cell Research Laboratory Children’s Hospital of Orange CountyDepartment of NeurologyUniversity of California-Irvine School of MedicineOrangeCA 92868-3874United States

The art of constructing an insightful literature review manuscript has witnessed an exemplar in the work of Oz et al(2023),wherein concept progression harmoniously merges with figures and *** on retrospective data science,it is evident that well-cited articles can wield a transformative influence on the Journal Citation Reports Impact Factor score,as exemplified by Robert Weinberg’s landmark on cancer(hanahan and Weinberg,2011).here,we aim to spotlight a commendable contribution by Tuba Oz,Ajeet Kaushik,and Małgorzata Kujawska in this issue while pivoting towards identifying the hallmarks of a subpar literature review-elements that hinder rather than promote *** hurdles and roadblocks encountered within subpar literature reviews are *** of emerging trends,identification of challenges,and exploration of solutions remain conspicuously *** Contributions fail to surface amidst the vast sea of pre-existing literature,with noticeable gaps amplified by the lack of illustrative figures and *** manuscript,at times,assumes a skeletal form,reflecting an attempt to accommodate an excess of references,leading to convoluted sentences laden with *** contrast,a potent solution lies in adopting a comprehensive approach.A nuanced and critical evaluation of sources can culminate in a robust discussion,surpassing the mere summarization of conclusions drawn by *** approach,often dismissed,holds the potential to elevate clarity,coherence,and logical flow,ultimately inviting engaged readership and coveted *** critical necessity of integrating visionary insights is underscored and achieved through a rigorous analysis of pivotal concepts and innovative *** can be harnessed to elucidate the application of these *** advocate a paradigm shift,urging literature review writers to embrace the readers’perspective.A literature review’s purpose extends beyond providing a comprehensive panor

关键词： Literature review Concept progression Data science Journal Citation Reports Impact Factor Original contributions Comprehensive approach Clarity and coherence Visionary insights Reader engagement Concept development

Weaning stress and gastrointestinal barrier development:Implications for lifelong gut health in pigs

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Animal Nutrition 2017年第4期3卷 313-321页

作者： Adam J.Moeser calvin s.Pohl Mrigendra Rajput Gastrointestinal stress Biology Laboratory Department of Large Animal Clinical SciencesCollege of Veterinary MedicineMichigan State University Neuroscience Program Michigan State University Department of Physiology Michigan State University

The gastrointestinal(GI) barrier serves a critical role in survival and overall health of animals and humans. several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions(e.g., digestion,absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease *** stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed.

关键词： Intestinal barrier Pigs stress Weaning Gut health Mast cells

Assessment of sulf hydryl Group in Individual Rat Lens Protein subunits During Galactose Cataract Development

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眼科学报 1994年第1期10卷 21-26页

作者： haroldI.calvin s.C.JosephFu Depts.of Ophthalmology and of Biochemistry & Molecular Biology UND-N.J.Medical SchoolNewarkN.J.07103 U.S.A.Depts.of Ophthalmology and of Biochemistry & Molecular BiologyUND-N.J.Medical SchoolNewarkN.J.07103 U.S.A.

A specific reagent DACM [N-( 7-Dimethylamino-4-methyl-3-coumarinyl) maleimide] is used to study the -sh groups in lens proteins of normal and galactose cataractous rats. DACM when reacts readily with -sh groups form strong fluorescent adducts. The two -dimensional electrophoresis with DACM pre-labeled proteins is a simple and sensitive method for detecting -sh groups of protein subunit. In the present study, based on IEF/sDs-PAGE electrophoretically characterized soluble crystallins, describes specific ...

关键词： sh group DACM pre-labeled protein-labeled protein gel-electrophoresis fluorrescence cataract

Esophageal squamous papilloma lacks clear clinicopathological associations

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World Journal of Clinical Cases 2017年第4期5卷 134-139页

作者： Bilel Jideh Martin Weltman Yang Wu calvin h Y Chan Department of Gastroenterology and hepatology Nepean Hospital

AIM To determine the prevalence of esophageal squamous papillomas(EsPs) in a tertiary teaching hospital and to assess for any clinical associations, including relations with esophageal squamous cell carcinomas(sCCs). METhODs Data from a total of 6962 upper gastrointestinal endoscopies over a five year period were retrospectively obtained and analysed. REsULTs EsP was found in sixteen patients(0.23%). Eight(50%) patients had a high body mass index, seven(44%) had history of cigarette smoking. Reflux esophagitis was found in four(25%) patients. All EsPs were solitary with a mean endoscopic size of 3.8 mm and located in the mid to lower esophagus. human papilloma virus(hPV) was tested in three(19%) patients and was negative. Esophageal sCC was found in seven patients(0.10%) during the same period. None of the specimens were tested for hPV, and none had associated papillomatous changes. CONCLUsION EsP is an uncommon tumour with unclear clinical associations and malignant potential.

关键词： Esophagus Papilloma Gastroesophageal reflux disease human papilloma virus squamous cell carcinoma

hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective

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World Journal of stem Cells 2020年第8期12卷 706-720页

作者： Lisa X Lee shengwen calvin Li Division of hematology/Oncology Department of MedicineChao Family Comprehensive Cancer CenterUCI HealthOrangeCA 92868United States Neuro-oncology and stem Cell Research Laboratory CHOC Children's Research InstituteChildren's Hospital of Orange CountyOrangeCA 92868United States Department of Neurology University of California-Irvine School of MedicineOrangeCA 92868United States

The development of single-cell subclones,which can rapidly switch from dormant to dominant subclones,occur in the natural pathophysiology of multiple myeloma(MM)but is often"pressed"by the standard treatment of *** emerging subclones present a challenge,providing reservoirs for chemoresistant *** advancement is required to track MM subclonal changes,as understanding MM's mechanism of evolution at the cellular level can prompt the development of new targeted ways of treating this *** methods to study the evolution of subclones in MM rely on technologies capable of phenotypically and genotypically characterizing plasma cells,which include immunohistochemistry,flow cytometry,or ***,all of these technologies may be limited by the sensitivity for picking up rare *** contrast,more incisive methods such as RNA sequencing,comparative genomic hybridization,or whole-genome sequencing are not yet commonly used in clinical *** we introduce the epidemiological diagnosis and prognosis of MM and review current methods for evaluating MM subclone evolution,such as minimal residual disease/multiparametric flow cytometry/next-generation sequencing,and their respective advantages and *** addition,we propose our new single-cell method of evaluation to understand MM's mechanism of evolution at the molecular and cellular level and to prompt the development of new targeted ways of treating this disease,which has a broad prospect.

关键词： Multiple myeloma single cells single-cell transcriptome subclonal evolution Cancer stem cells systemic tracking of single-cell landscape Artificial intelligence medicine

A transmission dynamics model of COVID-19:Case of Cameroon

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Infectious Disease Modelling 2022年第2期7卷 211-249页

作者： calvin Tadmon severin Foko Department of Mathematics and Computer science Faculty of ScienceUniversity of DschangP.O.Box:67DschangCameroon The Abdus salam International Centre for Theoretical Physics Strada Costiera 1134151TriesteItaly

In this work,we propose and investigate an ordinary differential equations model describing the spread of COVID-19 in *** model takes into account the asymptomatic,unreported symptomatic,quarantine,hospitalized individuals and the amount of virus in the environment,for evaluating their impact on the transmission of the *** establishing the basic properties of the model,we compute the control reproduction number Rc and show that the disease dies out whenever Rc1 and is endemic whenever Rc>***,an optimal control problem is derived and investigated theoretically by mainly relying on Pontryagin's maximum *** illustrate the theoretical analysis by presenting some graphical results.

关键词： COVID-19 ODE model Global stability Lyapunov function Optimal control

Urban growth dynamics and expansion forms in 11 Tanzanian cities from 1990 to 2020

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International Journal of Digital Earth 2023年第1期16卷 1985-2001页

作者： Neema simon sumari Fanan Ujoh calvin samwel swai Muchen Zheng Department of Informatics and Information TechnologyCollege of Natural and Applied Sciences(CoNAS)Sokoine University of AgricultureMorogoroTanzania Center for sustainability and Resilient Infrastructure and Communities(saRIC) London South Bank UniversityLondonUnited Kingdom Department of Water Resources and Environmental Management Faculty of GeoInformation Science and Earth Observation(ITC)University of TwenteEnschedeThe Netherlands school of Resource and Environmental sciences Wuhan UniversityWuhanPeople’s Republic of China

With rapid urban expansion across Tanzania,there is a need to institute steps to address factors and forms as well as impacts and challenges associated with the observed *** study’s aim is to use spatial urban landscape indices to analyze the spatial changes in urban forms,patterns,and rates across 11 urban centers in Tanzania over a 30-year study period(1990–2020).During the past three decades,urban lands of 11 cities and town in Tanzania have grown by a total of 480 *** growth was found as the most dominant form of urban expansion in Tanzania while Dodoma,the capital city of Tanzania,had the highest rate of urban expansion when compared to all other individual *** most robust and significant interaction of the AWMLEI and MLEI was found in Kigoma,Arusha,Mtwara,Mafinga,and Tunduma *** contrast,Mbeya agricultural city,Arusha the tourist city,Tabora,and Geita Lake zone areas did show their own peculiarities revealing an interesting spatial temporal variation in rate and form of *** outcome of this study reveals that the influence and management of economic and socio-cultural opportunities will be an effective tool for the determination of the rapidly expanding cities and towns of Tanzania.

关键词： Urban growth indices drivers of urban forms urban forms and patterns landscape metrics Tanzania

Beclin 1-Vps34 complex architecture： Understanding the nuts and bolts of therapeutic targets

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Frontiers in Biology 2015年第5期10卷 398-426页

作者： Deanna h. Morris calvin K. Yip Yi shi Brian T. Chait Qing Jun Wang Department of Molecular and Cellular Biochemistry University of Kentucky Lexington KY 40536 USA Department of Biochemistry and Molecular Biology The University of British Columbia Vancouver BC V6TIZ3 Canada Laboratory of Mass spectrometry and Gaseous Ion Chemistry The Rockefeller University New York NY 10065 USA Department of Toxicology and Cancer Biology University of Kentucky Lexington KY 40536 USA Markey Cancer Center University of Kentucky Lexington KY 40536 USA

Autophagy is an important lysosomal degradation pathway that aids in the maintenance of cellular homeostasis by breaking down and recycling intracellular contents. Dysregulation of autophagy is linked to a growing number of human diseases. The Beclin 1-Vps34 protein-protein interaction network is critical for autophagy regulation and is therefore essential to cellular integrity. Manipulation of autophagy, in particular via modulation of the action of the Beclin I-Vps34 complexes, is considered a promising route to combat autophagy-related diseases. here we summarize recent findings on the core components and structural architecture of the Beclin 1-Vps34 complexes, and how these findings provide valuable insights into the molecular mechanisms that underlie the multiple functions of these complexes and for devising therapeutic strategies.

关键词： Beclin 1 Vps34 Nrbf2 complex structure CX-Ms EM inhibitor drag design

Anthropogenic impacts to the sediment budget of são Francisco River navigation channel using sWAT

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International Journal of Agricultural and Biological Engineering 2015年第3期8卷 140-157页

作者： calvin T.Creech Rafael Brito siqueira James P.selegean Carol Miller Wayne state University DetroitMichigan 48202United States Com panhia de Desenvolvimento dos Vales do são Francisco e do Parnaíba(CODEVAsF) Brasília 70830Brazil United states Army Corps of Engineers Detroit DistrictDetroitMichigan 48226United States United states Army Corps of Engineers Mobile Di strictMobile 36628AlabamaUnited States

The são Francisco River Basin,located in eastern Brazil,has undergone a significant amount of anthropogenic changes in the last several decades,such as agricultural expansion,irrigation activities,mining,and the construction of large ***,these changes have altered the historic sediment budget and have led to an aggradation of sediments in the navigation channel,impacting the ability to efficiently ship agricultural commodities to regional *** an effort to aid decision makers in future waterway navigation planning,an international partnership between the Brazilian government agency CODEVAsF and the Us Army Corps of Engineers(UsACE)was *** this partnership a sWAT model of the 630000 km2 são Francisco River basin was developed to better understand both the historic and current sediment budget within the navigation *** sWAT model of the são Francisco River Basin was calibrated for hydrology and sediment *** discharges were calibrated at 17 Agência Nacional deÁguas(ANA)gages,with Nash-sutcliffe efficiency(NsE)values ranging from 0.42 to 0.75 for an eleven year *** loads were calibrated to an ANA sediment gage located in the Middle são Francisco River Navigation Channel,with a PBIAs(Percent Bias)of *** on model results,the aggradation rate of sediment in the são Francisco River and major tributaries has increased by approximately 20 Mt since Pre-European settlement of the basin(from approximately 7 Mt/a to 27 Mt/a).This increase has contributed to an impaired navigation channel due to shoaling of sandy sediments in the navigation channel.

关键词： sediment budget aggradation rate são Francisco River anthropogenic impact sWAT