Weaning stress and gastrointestinal barrier development:Implications for lifelong gut health in pigs

作     者：Adam J.Moeser Calvin S.Pohl Mrigendra Rajput 

作者机构：Gastrointestinal Stress Biology LaboratoryDepartment of Large Animal Clinical SciencesCollege of Veterinary MedicineMichigan State University Neuroscience ProgramMichigan State University Department of PhysiologyMichigan State University 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2017年第3卷第4期

页      面：313-321页

核心收录：

学科分类：0710[理学-生物学] 0905[农学-畜牧学] 0906[农学-兽医学] 09[农学] 

基　　金：supported by a grant from the National Institutes of Health HD072968 Agriculture and Food Research Initiative Competitive Grant No. 2017-67015-26673 from the USDA National Institute of Food and Agriculture 

主　　题：Intestinal barrier Pigs Stress Weaning Gut health Mast cells 

摘      要：The gastrointestinal(GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions(e.g., digestion,absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease *** stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed.