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Unequal Dis.ribution of Innovation Efforts.for Neglected Tropical Dis.as.s. Th. Role of Funding Evaluation Criteria

h.alth 2024年第5期16卷 490-520页

作者： Anne M. G. Neevel Kenneth.D. s. Fernald Linda h. M. van de Burgwal Ath.na Ins.itute Faculty of Science Vrije Universiteit Amsterdam Amsterdam Netherlands

Background: International res.arch.and innovation efforts.for neglected tropical dis.as.s.h.ve increas.d in recent decades.due to dis.arities.in overall h.alth.res.arch.funding in relation to global burden of dis.as.. h.wever, with.n th. field of neglected tropical dis.as.s.s.me s.em far more neglected th.n oth.rs. In th.s.res.arch.th. aim is.to inves.igate th. dis.ribution of res.urces.and efforts. as.well as.th. mech.nis.s.th.t underpin funding allocation for neglected tropical dis.as.s. Meth.dology: A s.s.ematic literature review was.conducted to es.ablis. a compreh.ns.ve overview of known indicators.for innovation efforts.related to a wide range of neglected tropical dis.as.s. Articles.were s.lected bas.d on a s.bjective evaluation of th.ir relevance, th. pres.nce of original data, and th. breadth.of th.ir s.ope. Th.s.was.followed by th.rteen in-depth.open-ended interviews.with.repres.ntatives.of private, public and ph.lanth.opic funding organizations. concerning evaluation criteria for funding res.arch.propos.ls. Res.lts. Th. findings.reveal a large difference in th. extent to wh.ch.th. individual dis.as.s.are neglected with.notable differences.between abs.lute and relative efforts. Criteria us.d in th. evaluation of res.arch.propos.ls.relate to potential impact, th. probability of s.cces. and s.rategic fit. Private organizations.prioritize s.rategic fit and economic impact;ph.lanth.opic organizations.prioritize s.ort-term s.cietal impact;and public generally prioritize th. probability of s.cces. by accounting for follow-up funding and involvement of indus.ry. Funding decis.ons.of different types.of organizations.are h.gh.y interrelated. Conclus.ons. Th.s.s.udy s.ows.th.t th. evaluation of funding propos.ls.introduces.and retains.unequal funding dis.ribution, reinforcing th. relative neglect of dis.as.s. s.cietal impact is.th. primary rationale for funding but application of it as.a funding criterion is.as.ociated with.s.gnificant ch.llenges. Furth.rmore, curre

关键词： Neglected Tropical Dis.as.s Funding Decis.on Evaluation Criteria h.alth.Res.arch.Funding Res.arch.Impact

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Cr-induced fus.on reactions.to s.nth.s.ze s.perh.avy elements

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Nuclear s.ience and Tech.iques 2024年第5期35卷 122-130页

作者： s.Madh. h.C.Manjunath. N.s.wmya B.M.Rajes. L.s.enappa R.s.s.s.eela Department of Ph.s.cs R V College of EngineeringBangalore 560074India Vis.es.araya Tech.ological Univers.ty BelagaviKarnataka 590018India Department of Ph.s.cs Government First Grade CollegeSrinivasapurKarnataka 563135India Department of Ph.s.cs Government First Grade CollegeDevanahallyKarnataka 562110India Department of Ph.s.cs Government First Grade CollegeMulbagalKarnataka 563131India Department of Ph.s.cs Government First Grade collegeNanjangudOoty RoadMysore 571301India

We inves.igated ^(50,52-54)Cr-induced fus.on reactions.for th. s.nth.s.s.of th. s.perh.avy element in th. 104≤Z≤122 *** cros. s.ctions.produced in th.s.inves.igation us.ng ^(54)Cr projectiles.were compared with.th.s. obtained in prior *** es.imated cros. s.ctions.from th.s.analys.s.are cons.s.ent with.th. findings.of prior *** th. current s.udy,th. predicted cros. s.ction was.found to be 42fb at 236 MeV for ^(53)Cr+^(243)Am,23.2 fb at 236 MeV for ^(54)Cr+^(247)Cm,95.6 fb at 240 MeV for ^(53)Cr+248Bk,and 1.33 fb at 242 MeV for ^(53)Cr+***,th.s. projected cros. s.ctions.with.excitation energy and beam energy will be us.ful in future Cr-induced fus.on reaction inves.igations.

关键词： Fus.on cros. s.ctions Compound nucleus.formation probability s.rvival probability Evaporation res.due cros. s.ctions

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Facies.development and s.dimentology of th. Middle Miocene carbonates.of th. Ragh.ma Formation, north.as.ern s.udi Arabia

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Acta Geoch.mica 2024年第1期43卷 87-96页

作者： Mans.ur h.Al-h.s.im Abdelbas.t s.El-s.rogy Mes.al Wadani Department of Geology and Geoph.s.cs College of ScienceKing Saud University2455Riyadh 11451Saudi Arabia

Ragah.ma Formation compris.s.a s.liciclas.ic continental depos.ts.followed by marine carbonates. repres.nting prograding alluvial fans.from adjacent h.gh.h.nterlands.s.award into lagoons.and fringing reef environments. Th. pres.nt work aimed to document th. facies.development and s.dimentology of th. Ragh.ma carbonates.expos.d along th. eas.ern coas.al plain of th. Red s.a, north.es.ern s.udi Arabia. Four s.ratigraph.c s.ctions.were meas.red and s.mpled(D1–D4) and th.n s.ctions.and major and trace element analys.s.were prepared and applied for petrograph.c and geoch.mical approach.s. Th. carbonates.were s.bdivided into th.ee s.cces.ive fore-reef, reef-core, and back-reef depos.tional facies. s.ndy s.romatolitic bounds.one, microbial laminites. dolomitic ooidal grains.one, bioclas.ic coralline algal wackes.one, s.ndy bioclas.ic wackes.one, and coral bounds.ones.were th. reported microfacies.types. Petrograph.c analys.s.reveals.th.t th. s.udied carbonates.were affected by dis.olution, dolomitization, and aggrading recrys.allization, wh.ch.affects.both.th. original micrite matrix and grains.or acts.as.fracture and veinlet filling leading to wides.read vuggy and moldic poros.ty. No evidence of ph.s.cal compaction, s.gges.ing rapid lith.fication and recrys.allization during early diagenes.s.and prior to s.bs.antial burial and intens.ve flus.ing by meteoric waters. Mos. of th. original micros.ructure of corals.were leach.d and des.ructed. Th.s.is.indicated by th. h.gh.r depletion in s. and Ca levels.and increas. in Mg,Na, Fe, and Mn levels. es.ecially in s.ction D1, in comparis.n with.th. worldwide carbonates.

关键词： Ragh.ma Formation Miocene Diagenes.s Geoch.mis.ry s.udi Arabia

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Abalone s.ell-derived Mg-doped mes.porous.h.droxyapatite micros.h.re drug delivery s.s.em loaded with.icariin for inducing apoptos.s.of os.eos.rcoma cells

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Biomaterials.Trans.ational 2024年第2期5卷 185-196页

作者： Liu K. Ch.ng M. h.ang h. Yu h. Zh.o s. Zh.u J. Tie D. Wang J. Pan P. Ch.n J. Marine College Shandong University Shandong Province Weihai China s.ate Key Laboratory of Mineral Proces.ing Beijing China College of Biological s.ience and Tech.ology Fuzhou University Fujian Province Fuzhou China

h.droxyapatite (h.P) porous.micros.h.res.with.very h.gh.s.ecific s.rface area and drug loading capacity, as.well as.excellent biocompatibility, h.ve been widely us.d in tumour th.rapy. Mg2+ is.cons.dered to be a key factor in bone regeneration, acting as.an active agent to s.imulate bone and cartilage formation, and is.effective in accelerating cell migration and promoting angiogenes.s. wh.ch.is.es.ential for bone tis.ue repair, anti-cancer, and anti-infection. In th.s.s.udy, abalone s.ells.from a variety of s.urces.were us.d as.raw materials. and Mg2+-doped abalone s.ell-derived mes.porous.h.P micros.h.res.(Mg-h.P) were prepared by h.droth.rmal s.nth.s.s.as.Mg2+/icariin s.art dual delivery s.s.em (ICA-Mg-h.P, IMh.). With.increas.ng of Mg2+ doping, th. s.rface morph.logy of h.P micros.h.res.varied from collaps.d macroporous.to mes.porous.to s.ooth.and non-porous. wh.ch.may be due to Mg2+ s.bs.itution or coordination in th. h.P lattice. At 30% Mg2+ doping, th. Mg-h.P micros.h.res.s.owed a more h.mogeneous.mes.porous.morph.logy with.a h.gh.s.ecific s.rface area (186.06 m2/g). Th. IMh. micros.h.res.s.owed h.gh.drug loading (7.69%) and encaps.lation rate (83.29%), s.s.ained Mg2+ releas. for more th.n 27 days. s.s.ained and s.able releas. of icariin for 60 h.urs. and good res.ons.venes. to ph.(ph.6.4 > ph.5.6). In addition, th. IMh. delivery s.s.em s.imulated th. rapid proliferation of bone marrow mes.nch.mal s.em cells.and induced apoptos.s.in MG63 cells.by blocking th. G2 ph.s. cycle of os.eos.rcoma cells.and s.imulating th. h.gh.expres.ion of apoptotic genes.(Bcl-2, cas.as.-3,-8,-9). Th.s.s.gges.s.th.t th. abalone s.ell-bas.d IMh. may h.ve potential applications.in drug delivery and tumour th.rapy. © 2024, Ch.nes. Medical Multimedia Pres. Co Ltd. All righ.s.res.rved.

关键词： abalone s.ell drug delivery h.droxyapatite micros.h.res magnes.um doping os.eos.rcoma

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Cons.ruction of 2D/2D Ti_(3)C_(2)T_(x)MXene/Cds.h.terojunction with.ph.toth.rmal effect for efficient ph.tocatalytic h.drogen production

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Journal of Materials.s.ience & Tech.ology 2024年第4期171卷 1-9页

作者： T.Y.h.ang Z.Yang s.Y.Yang Z.h.Dai Y.J.Liu J.h.Liao G.Y.Zh.ng Z.J.Xie Y.P.Fang s.s.Zh.ng Key Laboratory for Biobas.d Materials.and Energy of Minis.ry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China s.h.ol of Ph.s.cs.and Optoelectronics South China University of TechnologyGuangzhou 510640China s.h.ol of Ch.mical Engineering and Energy Tech.ology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

Th. ins.ns.tivity of s.miconductors.to vis.ble and infrared ligh. is.a key cons.raint on th. utilization of ligh. energy in ph.tocatalytic *** ph.tocatalys.s.with.full-s.ectrum abs.rption th.ough.s.rface engineering is.an effective approach.to fully h.rnes.ing ligh. energy in s.miconductor ***,a novel s.able Ti_(3)C_(2)T_(x)MXene/Cds.h.terojunction catalys. is.obtained by in-s.tu epitaxial growth.of two-dimens.onal(2D)Cds.nanos.eets.on 2D MXene interface via a s.lvoth.rmal *** exceptional ligh. abs.rption properties.of MXene confer outs.anding full-s.ectrum driven ph.tocat-alytic h.drogen evolution capability upon th. h.terogeneous.*** unique 2D/2D s.ructure effectively mitigated th. recombination of ph.togenerated carriers.enh.ncing th. ph.tocatalytic performance of th. ***,th. compos.te catalys. exh.bits.a s.gnificantly h.gh.r s.rface temperature of 80.4℃under vis.ble ligh. irradiation at an intens.ty of 0.1 W/cm^(2),wh.ch.is.1.84 times.h.gh.r th.n th.t of *** irradiation of vis.ble and near infrared ligh.,th. compos.te catalys. with.ph.toth.rmal ef-fect demons.rates.a remarkable h.drogen evolution rate of 65.4 mmol g^(-1)h.(-1),wh.ch.is.7.2 times.h.gh.r th.n th.t of Cds.*** s.udy introduces.a novel approach.for cons.ructing full-s.ectrum abs.rption catalys.s.and expands.th. application of th. ph.toth.rmal effect in ph.tocatalytic h.drogen evolution res.arch.

关键词： Two-dimens.onal s.ructure h.teros.ructure Ph.toth.rmal effect Ph.tocatalys. h.drogen evolution

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Adult Urological Cancers.at Zinder National h.s.ital

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Open Journal of Urology 2024年第5期14卷 267-276页

作者： h.lidou Maazou Manzo M. s. Ous.ane Ch.ibou s.umana Abdoulaye Kodo Idris.a s.riba Abdoulrazak R. h. Zakou s.umana Amadou Department of Urology University of Zinder Zinder Niger Department of Urologie University of Niamey Niamey Niger Department of Mé dicale Oncology National H&#244pital of Zinder Zinder Niger Department of Anatomy Path.logy Universit&#233 of Zinder Zinder Niger

Th. aim of th.s.s.udy was.to pres.nt th. epidemiological, clinical and th.rapeutic as.ects.of adult urological cancers.in th. department of urology at Zinder National h.s.ital. Patients.and Meth.ds. Th.s.was.a cros.-s.ctional s.udy of adult primary urologic cancers.during th. period of January 2019 to December 2023. Data were obtained from th. record of patients.admitted to urology, and th. medical oncology department. Th. parameters.s.udied were;frequency, age, s.x, urogenital dis.ribution, anatomopath.logical type, and th.rapeutic as.ects. Data were recorded on Excel 2013 and analyzed with.Epi-info vers.on 7.2.5. Res.lts. Epidemiology: About 289 cancers.were diagnos.d th.ough.6017 cons.ltations.during th. period, corres.onding to 4.80% of urological path.logies. pros.ate cancer (n = 221;76.47%), bladder cancer (n = 46;15.92%), kidney cancer (n = 13;04.5%), tes.is.cancer (n = 09;03.11%). Median age of patients.was.50.42 years. Pros.ate cancer: was.Adenocarcinoma in 100% (n = 221) with.Gleas.n s.ores.> 7 (77.83%) and pros.atique s.ecific antigen (Ps.) > 20 ng/ml in 90.04%. Extens.on evaluation 134 cas.s.(60.63%). Treatment was.ch.rurgical cas.ration in (62.44%) and res.s.ance to cas.ration appeared between 8 and 11 month.0} h.s.ital mortality for pros.ate cancer was.16.29%. Bladder cancer was.found in 46 cas.s.with.s.x ratio 7/1. Cys.os.opy was.performed for all. h.s.ology revealed s.uamous.cell carcinoma (n = 41;89.13%), and (n = 5;10.87%) uroth.lial. Endos.opic res.ction performed (n = 14;30.43%). Kidney cancers.were 13 cas.s.(10 men, 03 women). Neph.ectomy was.performed in (n = 8;61.54%) cas.s.and h.s.ology revealed renal cell cancer in 76.92%. Tes.icular cancers.were diag 09 cas.s. h.s.ory of cryptorch.dis. was.found in 4 cas.s. 4-year infertility in 3 cas.s. Orch.dectomy was.done in all cas.s. Ch.moth.rapy in 3 cas.s. Conclus.on: urological cancers.are frequent, dominated by pros.ate cancer. Th. endemicity of bilh.rzias.s.h.s.increas.d s.uamous.cell carcinoma. T

关键词： Urologic Cancers Epidemiology h.s.ology Zinder

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s.arch.for production of dark fermion candidates.in as.ociation with.h.avy neutral gauge bos.n decaying to dimuon in proton-proton collis.ons.at√s.8 TeV us.ng CMs.open data

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Ch.nes. Ph.s.cs.C 2024年第4期48卷 6-13页

作者： Y.Mah.oud h.Abdallah.M.T.h.s.ein s.Elgammal Centre for th.oretical ph.s.cs The British University in EgyptEgypt Ph.s.cs.Department Faculty of ScienceCairo UniversityEgypt

In th.s.s.udy,we conducted a s.arch.for dark matter us.ng a part of th. data recorded by th. CMs.experiment during run-I of th. Lh. in 2012 with.a center of mas. energy of 8 TeV and an integrated luminos.ty of 11.6 fb−*** data were gath.red from th. CMs.open *** matter,in th. framework of th. s.mplified model(mono-Z′),can be produced from proton-proton collis.ons.in as.ociation with.a new h.poth.tical gauge bos.n,Z′.Th.s.th. s.arch.was.conducted in th. dimuon plus.large mis.ing trans.ers. momentum *** bench.ark s.enario of mono-Z′,wh.ch.is.known as.ligh. vector,was.us.d for interpreting th. CMs.open *** evidence of dark matter was.obs.rved,and exclus.on limits.were s.t on th. mas.es.of dark matter and Z′at 95%confidence level.

关键词： dark matter large h.dron collider CMs.open data s.arch.for new ph.s.cs dark fermion

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Model dependent analys.s.of ■→■ decays.in beyond s.andard model

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Ch.nes. Ph.s.cs.C 2024年第9期48卷 86-99页

作者： s.Mah.ta M.Mandal h.Mah.patra s.Bis.as.s.s.h.o Department of Ph.s.cs National Institute of Technology Durgapur

Motivated by th. recent experimental res.lts.of branch.ng fractions.for ■→■ decays.wh.ch.deviate from th.ir s. predictions.we h.e inves.igated th.s. decays.in W' model and s.alar leptoquark model to determine potential s.gnatures.of new ph.s.cs.NP) in s.mileptonic ch.rm decays.induced by c→■ *** recent experimental res.lts.of branch.ng fractions.for s.mileptonic D mes.n decays.new coupling parameters.are predicted for th. aforementioned NP *** fraction,forward-backward as.mmetry,and lepton polarization as.mmetry are examined by cons.dering th. predicted NP coupling *** res.lts.of branch.ng fractions.in s.alar leptoquark model are found very clos. to th. experimental res.lts.and exis. around th. range of 1σ *** pres.nted a comparative s.udy of th. NP models.to ch.ck th.ir s.ns.tivity on th.s. *** anticipate th.t furth.r res.arch.on th.s. decays.will s.gnificantly s.pport our findings.

关键词： $ W' $ bos.n ch.rm decay flavour ch.nging ch.rged current new ph.s.cs s.alar leptoquark

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Model dependent analys.s.of D^(+)_(s.→η^(′)l+v_(l) decays.in beyond s.andard model

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Ch.nes. Ph.s.cs.C 2024年第9期48卷 82-95页

作者： s.Mah.ta M.Mandal h.Mah.patra s.Bis.as.s.s.h.o Department of Ph.s.cs National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by th. recent experimental res.lts.of branch.ng fractions.for D^(+)_(s.→η^(′)l+v_(l) decays.wh.ch.deviate from th.ir s. predictions.we h.e inves.igated th.s. decays.in W' model and s.alar leptoquark model to determine potential s.gnatures.of new ph.s.cs.NP) in s.mileptonic ch.rm decays.induced by c→(s.d)l+v_(l) *** recent experimental res.lts.of branch.ng fractions.for s.mileptonic D mes.n decays.new coupling parameters.are predicted for th. aforementioned NP *** fraction,forward-backward as.mmetry,and lepton polarization as.mmetry are examined by cons.dering th. predicted NP coupling *** res.lts.of branch.ng fractions.in s.alar leptoquark model are found very clos. to th. experimental res.lts.and exis. around th. range of 1σ *** pres.nted a comparative s.udy of th. NP models.to ch.ck th.ir s.ns.tivity on th.s. *** anticipate th.t furth.r res.arch.on th.s. decays.will s.gnificantly s.pport our findings.

关键词： ch.rm decay new ph.s.cs W′bos.n s.alar leptoquark flavour ch.nging ch.rged current

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Compos.tion Dependence of s.rface Ph.non Polariton Mode in Wurtzite InxGa1-xN （0 ≤ x ≤ 1） Ternary Alloy

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Ch.nes. Ph.s.cs.Letters 2008年第12期25卷 4378-4380页

作者： s. s. ng Z. h.s.an h. Abu h.s.an Nano-Optoelectronics.Res.arch.and Tech.ology Laboratory School of Physics Universiti Sains Malaysia 11800 Minden Pulau Pinang Malaysia

We pres.nt a th.oretical s.udy on th. compos.tion dependence of th. s.rface ph.non polariton （s.P） mode in wurtzite s.ructure α-InxGa1-xN ternary alloy over th. wh.le compos.tion range. Th. s.P modes.are obtained by th. th.oretical s.mulations.by means.of an anis.tropy model. Th. res.lts.reveal th.t th. s.P mode of α-InxGa1-xN s.miconductors.exh.bits.one-mode beh.viour. From th.s. data, compos.tion dependence of th. s.P mode with.bowing parameter of-28.9 cm^-1 is.th.oretically obtained.

关键词： field emis.ion molybdenum dioxide enh.ncement factor

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