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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 67-88页

作者： Manickam Ashokkumar Wenwen Mei jackson j.Peterson Yuriko Harigaya David M.Murdoch David M.Margolis caleb Kornfein Alex Oesterling Zhicheng Guo Cynthia D.Rudin Yuchao jiang Edward P.Browne Department of Medicine University of North Carolina at Chapel HillChapel HillNC 27599USA HIV Cure Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Biostatistics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Microbiology and Immunology University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Genetics University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Medicine Duke UniversityDurhamNC 27708USA Department of Computer Science Duke UniversityDurhamNC 27708USA Department of Statistics Texas A&M UniversityCollege StationTX 77843USA Department of Biology Texas A&M UniversityCollege StationTX 77843USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA

Despite the success of antiretroviral therapy,human immunodeficiency virus(HIV)cannot be cured because of a reservoir of latently infected cells that evades *** understand the mechanisms of HIV latency,we employed an integrated single-cell RNA sequencing(scRNA-seq)and single-cell assay for transposase-accessible chromatin with sequencing(scATAC-seq)approach to simultaneously profile the transcriptomic and epigenomic characteristics of~125,000 latently infected primary CD4^(+)T cells after reactivation using three different latency reversing *** expressed genes and differentially accessible motifs were used to examine transcriptional pathways and transcription factor(TF)activities across the cell *** identified cellular transcripts and TFs whose expression/activity was correlated with viral reactivation and demonstrated that a machine learning model trained on these data was 75%-79%accurate at predicting viral ***,we validated the role of two candidate HIV-regulating factors,FOXP1 and GATA3,in viral *** data demonstrate the power of integrated multimodal single-cell analysis to uncover novel relationships between host cell factors and HIV latency.

关键词： HIV latency reversal Primary CD4þT cell Single-cell multiomics HIV-regulating factor Machine learning

Remote ischemic conditioning: the brain’s endogenous defense against stroke

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Neural Regeneration Research 2020年第12期15卷 2249-2250页

作者： caleb j.Heiberger Tej Mehta jae Kim Divyajot SSANDhu University of South Dakota Sanford School of MedicineSioux FallsSDUSA

Introduction to ischemic conditioning:In 1986,Murray built upon a series of accumulated works to demonstrated that brief ischemic"training"episodes fortified cardiac tissue against impending prolonged infarction(Murry et al.,1986).This discovery altered the dogmatic understanding of ischemia,highlighting that time-dependent tissue compromise during infarction was bimodal,not linear,in *** of being invariably deleterious,an organ’s response to ischemia is dependent upon both the duration of the infarction as well as adaptions from previous,transient ischemic episodes.

关键词： endogenous ischemia conditioning

Control of Cell Wall Extensibility during Pollen Tube Growth

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Molecular Plant 2013年第4期6卷 998-1017页

作者： Peter K. Hepler caleb M. Rounds Lawrence j. Winship Biology Department University of Massachusetts Amherst MA 01003 USA School of Natural Science Hampshire College Amherst MA 01002 USA

In this review, we address the question of how the tip-growing pollen tube achieves its rapid rate of elongation while maintaining an intact cell wall. Although turgor is essential for growth to occur, the local expansion rate is controlled by local changes in the viscosity of the apical wall. We focus on several different structures and underly- ing processes that are thought to be major participants including exocytosis, the organization and activity of the actin cytoskeleton, calcium and proton physiology, and cellular energetics. We think that the actin cytoskeleton, in particular the apical cortical actin fringe, directs the flow of vesicles to the apical domain, where they fuse with the plasma mem- brane and contribute their contents to the expanding cell wall. While pH gradients, as generated by a proton-ATPase located on the plasma membrane along the side of the clear zone, may regulate rapid actin turnover and new polymeri- zation in the fringe, the tip-focused calcium gradient biases secretion towards the polar axis. The recent data showing that exocytosis of new wall material precedes and predicts the process of cell elongation provide support for the idea that the intussusception of newly secreted pectin contributes to decreases in apical wall viscosity and to cell expansion. Other prime factors will be the localization and activity of the enzyme pectin methyl-esterase, and the chelation of calcium by pectic acids. Finally, we acknowledge a role for reactive oxygen species in the control of wall viscosity.

关键词： cell expansion cell walls cytoskeleton dynamics polarity pollen development.

Biobehavioral assessment of the anxiety disorders:Current progress and future directions

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World journal of Psychiatry 2017年第3期7卷 133-147页

作者： Deah Abbott Yasmin Shirali j Kyle Haws caleb W Lack Department of Psychology University of Central Oklahoma

It is difficult to accurately assess and differentially diagnose the anxiety *** current system of assessment relies heavily on the subjective measures of client self-report,clinical observation,and clinical ***,recent technological advances may enable practitioners to utilize objective,biobehavioral measures of assessment in a clinical *** current body of literature on two of these biobehavioral tools(eyetracking and electrocardiogram devices) is promising,but more validation and standardization research is needed to maximize the utility of these ***-tracking devices are uniquely capable of providing data that can be used to differentially diagnose anxiety disorders from both other commonly comorbid and misdiagnosed *** eye-tracking and electrocardiogram devices are able to provide change-sensitive assessment *** objective,real-time feedback can assist clinicians and researchers in assessing treatment efficacy and symptom *** developed wearable and highly portable electrocardiogram devices,like the wearable fitness and behavior tracking devices used by many consumers,may be particularly suited for providing this feedback to *** these biobehavioral devices would supply an objective,dimensional component to the current categorical diagnostic assessment *** posit that if adequate funding and attention are directed at this area of research,it could revolutionize diagnostic and on-going assessment practices and,in doing so,bring the field of diagnosis out of the 20 th century.

关键词： Biobehavioral Assessment Diagnosis Anxiety Electrocardiogram Electrocardiogram Eyetracker

Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： j.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke jacqueline Proszynski Braden Tierney caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman jangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor julian C.Schmidt Michael A.Schmidt Kelly Blease juan Moreno Andrew Boddicker junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

Efficient VLSI Implementation of the C-MANTEC Conn Algorithm by Using PID Controllers

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Circuits and Systems 2017年第11期8卷 253-260页

作者： j. jeya caleb M. Kannan Department of ECE Saveetha Engineering College Chennai India Department of ECE MIT Campus Anna University Chennai India

Through the research on the existing C-MANTEC neural network and PID control technology, this paper presents an improved C-MANTEC algorithm based on PID control system. The combining of the artificial neural networks with conventional PID control helps in exploring their respective advantages to forming the intelligent PID control. From UCI Repository cancer dataset, the developed system is tested. The results show that the scheme can not only improve the speed of the algorithm in the training process but also improve the generalization capability of the network, which further enhances the performance of PID controllers. The overall power consumed is also reduced to a greater extent.

关键词： C-MANTEC PID Generalization Capability Cancer Intelligent Control

Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin

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Acta Pharmaceutica Sinica B 2014年第3期4卷 217-226页

作者： Huiyi Wu Xiaoying Long Fei Yuan Li Chen Sujing Pan Yunjun Liu Yoshiko stowell Xiaoling Li School of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Department of Pharmaceutics Thomas J Long School of Pharmacy&Health SciencesUniversity of the PacificCA 95211USA

The aim of this study was to develop a formulation to improve the oral absorption of baicalin(BA)by combining a phospholipid complex(PC)and self-emulsifying microemulsion drug delivery system(SMEDDS),termed BA–PC–***–PC was prepared by a solvent evaporation method and evaluated by complexation percentage(CP).The physicochemical properties of BA–PC were *** synergistic effect of PC and SMEDDS on permeation of BA was studied in vitro with Caco-2 cells and in situ with a single pass intestinal perfusion *** improved bioavailability of BA in BA–PC–SMEDDS was confirmed in an in vivo rat *** CP of BA–PC reached 100%when the molar ratio of drug to phospholipid(PP)was Z1:*** solubility of BA–PC increased in both water and octanol,and the log P o/w of BA–PC was increased ***–PC–SMEDDS could be dispersed more evenly in water,compared to BA and BA–*** the Caco-2 cell uptake and single-pass intestinal perfusion models illustrated that transport of BA in BA–PC was lower than that of free BA,while improved significantly in BA–PC–*** relative bioavailability of BA–PC(1:2)–SMEDDS was 220.37%.The combination system of PC and SMEDDS had a synergistic effect on improving the oral absorption of BA.

关键词： Baicalin SMEDDS Phospholipid complex Caco-2 cell Single-pass intestinal per-fusion Bioavailability

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棉织物的低甲醛耐久阻燃整理

国外纺织技术（纺织针织服装化纤染整） 2003年第6期 30-32页

作者： j.K.stowell 徐鹏

目前有多种化学方法用于纤维素的阻燃整理,但仅有少数方法整理后织物经多次水洗和干洗后依然保持优良的阻燃性能,这些整理称之为耐久阻燃整理.其中大多数整理采用氮羟甲基磷酸酯和预缩氨焙烘.很难相信这些方法已问世30年并一直占据棉织... 详细信息

目前有多种化学方法用于纤维素的阻燃整理,但仅有少数方法整理后织物经多次水洗和干洗后依然保持优良的阻燃性能,这些整理称之为耐久阻燃整理.其中大多数整理采用氮羟甲基磷酸酯和预缩氨焙烘.很难相信这些方法已问世30年并一直占据棉织物阻燃整理主导地位,但其在整理技术方面也有不尽人意的地方.

关键词：棉织物低甲醛耐久阻燃整理含羟基有机磷化物整理剂

从大学到社区:美国田纳西大学花园园艺疗法项目实践

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园林 2023年第4期40卷 41-50页

作者： [美]Derrick R.stowell [美]P j Snodgrass 李同予(译) 郭思远美国田纳西大学植物科学系诺克斯维尔37996 哈尔滨工业大学建筑学院寒地城乡人居环境科学与技术工业和信息化部重点实验室哈尔滨150006

园艺疗法作为一种促进健康和福祉的有效疗法,日益得到全世界的认可,而大学校园则是一个实施园艺疗法项目的绝佳场所。作为赠地大学的一员,美国田纳西大学具备良好的开展园艺疗法的基础。以田纳西大学花园(UTG)园艺疗法项目为例,从教育... 详细信息

园艺疗法作为一种促进健康和福祉的有效疗法,日益得到全世界的认可,而大学校园则是一个实施园艺疗法项目的绝佳场所。作为赠地大学的一员,美国田纳西大学具备良好的开展园艺疗法的基础。以田纳西大学花园(UTG)园艺疗法项目为例,从教育培训、科学研究和技术推广三个方面,详细阐述UTG园艺疗法项目的发展历程和具体开展环节,以及园艺疗法与大学校园和社区公园共建的重要性。此外,还讨论了UTG园艺疗法项目未来的发展计划,为其他大学校园、社区公园开展园艺疗法事业进而促进人们健康与福祉提供借鉴。

关键词：园艺疗法大学校园项目实践健康福祉美国田纳西大学