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Has OpenStreetMap a role in Digital Earth applications?

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International Journal of Digital Earth 2014年第7期7卷 534-553页

作者： Peter mooney Padraig Corcoran Department of Computer Science National University of IrelandMaynoothIreland School of Computer Science and Informatics University College DublinBelfieldIreland

Volunteered geographic information(VGI),as a special subset of crowdsourcing,has provoked interest from many scientific disciplines and industry in the past few ***(OSM)is the most famous and well supported example of a VGI project on the Internet *** a technology,Digital Earth(DE)offers immediate access to enormous quantities of data and information,referenced by locations on the surface of the *** of DE’s goals is to make global spatial information ubiquitously available as an essential component of ***’s mission is well positioned within this goal where OSM aims to create a freely available editable map database of the *** paper explores the characteristics of the collaborative,crowd-based,editing of spatial data in OSM and the crowd *** provide some conclusions on how OSM can be best integrated into the fabric of DE.

关键词： OpenStreetMap Digital Earth volunteers spatial data crowdsourcing

Extensive adhesion formation in a total knee replacement in the setting of a gastrointestinal stromal tumor:A case report

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World Journal of Orthopedics 2022年第5期13卷 538-543页

作者： Steven Mitchell Anderson Lee Ryan Stenquist David YatsonskyⅡ Megan L mooney Vithal B Shendge Department of Orthopaedic Surgery The University of Toledo Medical CenterToledoOH 43614United States

BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare primary neoplasms of the gastrointestinal tract,accounting for 1%to 2%of all gastrointestinal neoplasms *** are frequently discovered incidentally during workup for other diagnosis or intestinal obstruction,as they can present with few or no ***,GISTs confer a high degree of malignant transformation,with a progression in about 10%to 30%of *** SUMMARY A 63-year-old healthy female presented to our institution with complaints of right knee pain and limited passive and active motion in the setting of a previous right total knee arthroplasty(TKA).One year after TKA,the patient was incidentally diagnosed with a GIST,which was successfully *** removal,the patient continued to have limited range of motion of the right knee and subsequently underwent revision *** significant fibrotic adhesions were found encapsulating the femoral and tibial *** patient’s pain improved postoperatively,however,she continued to have decreased range of motion with difficulty *** We propose that this case may demonstrate a proinflammatory milieu arising from a GIST,which had a direct influence on the outcome of recent total knee *** proposed mechanism between neoplastic cytokinetic activity and adhesion formation could have implications on preoperative and postoperative orthopedic management of total knee arthroplasty.

关键词： Gastrointestinal stromal tumor Adhesion formation Total knee arthroplasty Inflammatory response Decreased range of motion Case report

Quantification of changes in zero valent iron morphology using X-ray computed tomography

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Journal of Environmental Sciences 2013年第11期25卷 2344-2351页

作者： Ping Luo Elizabeth H.Bailey Sacha J.mooney Division of Agricultural and Environmental Sciences School of Biosciences University of Nottingham Sutton Bonington CampusSutton Bonington

Morphological changes within the porous architecture of laboratory scale zero valent iron （ZVI） permeable reactive barriers （PRBs）, after exposure to different groundwater conditions, have been quantified experimentally for different ZVI/sand ratios （10%, 50% and 100%, W/W） with the aim of inferring porosity changes in field barriers. Column studies were conducted to simulate interaction with different water chemistries, a synthetic groundwater, acidic drainage and deionised （DI） water as control. Morphological changes, in terms of pore size and distribution, were measured using X-ray computed tomography （CT）. CT image analysis revealed significant morphological changes in columns treated with different water chemistries. For example, 100% ZVI （W/W） columns had a higher frequency of small pores （0.6 mm） was observed in ZVI grains reacted with typical groundwater, resulting in a porosity of 27%, compared to 32% when exposed to DI water. In comparison, ZVI grains treated with the acidic drainage had higher porosity （44%） and larger average pore size （2.8 mm）. 10% ZVI PRB barrier material had the highest mean porosity （56%） after exposure to any water chemistry whilst 100% ZVI （W/W） columns always had the lowest （34%） with the 50% ZVI （W/W） in between （40%）. These results agree with previously published PRB field data and simultaneously conducted geochemical monitoring and mass balance calculation, indicating that both the geochemical and hydraulic environment of the PRB play an important role in determining barrier lifespan. This study suggests that X-ray CT image analysis is a powerful tool for studying the detailed inter pores between ZVI grains within PRBs.

关键词： porosity change X-ray computer tomography mass balance permeable reactive barrier zero valent iron acidic drainage typical groundwater pore-clogging

A Novel System for Moving Object Detection Using Bionic Compound Eyes

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Journal of Bionic Engineering 2011年第3期8卷 313-322页

作者： Huabo Sun Haimeng Zhao Peter mooney Hongying Zhao Daping Liu Lei Yan Beoing Key Lab of Spatial information Integration and lts Applications Peking University Beijing 100871 P. R. China Department of Computer Science National University of Ireland Maynooth Co. Kildare Ireland

Conventional moving target detection focuses on algorithms to improve detection efficiency. These algorithms pay less attention to the image acquisition means, and usually solve specific problems. This often results in poor flexibility and reus- ability. Insect compound eyes offer unique advantages for moving target detection and these advantages have attracted the attention of many researchers in recent years. In this paper we proposed a new system for moving target detection. We used the detection mechanism of insect compound eyes for the simulation of the characteristics of structure, control, and function. We discussed the design scheme of the system, the development of the bionic control circuit, and introduced the proposed mathe- matical model of bionic cqmpound eyes for data acquisition and object detection. After this the integrated system was described and discussed. Our paper presents a novel approach for moving target detection. This approach effectively tackles some of the well-known problems in the field of view, resolution, and real-time processing problems in moving target detection.

关键词： moving target detection bionic compound eyes mechanical structure control circuit detection model

HLA and lung transplantation

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Frontiers of Medicine 2019年第3期13卷 298-313页

作者： Liya Ju Caroline Suberbielle Xiaofan Li Nuala mooney Dominique Charron HLA et Medecine "Jean Daus set" Laboratory NetworkHopital Saint-LouisParisFrance Laboratoire Histocompatibilité Hopital Saint-LouisParisFrance INSERM U1160 Hopital Saint-LouisUniversité Paris DiderotSorbonne Paris CitéFrance Labex Transplantex StrasbourgFrance Shanghai Jiao Tong University School of Medicine Shanghai 200025China

Lung transplantation is increasingly practiced for patients with end-stage lung *** successful outcome of solid organ transplantation today is severely impeded by the production of alloantibodies,mainly directed against the protein products of the HLA complex of the organ *** the association between antibody mediated rejection and ailograft damage has been well established in renal and heart transplantation,it has not yet been well characterized in lung *** review addresses the question of HLA matching in lung transplantation and current knowledge of the allogenicity of different HLA class Ⅰ and Ⅱ *** role of the antibody mediated immune response is discussed as well as the importance of pre-transplant or de novo posttransplant circulating ***,potential mechanisms,which may act individually or in combination,of antibody mediated damage to solid organ transplants are considered.

关键词： human leukocyte antigen class I and II lung transplantation mismatch obliterans bronchiolitis alloantibody antibody mediated rejection

Phenotypic plasticity in prostate cancer： role of ntrinsically disordered proteins

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Asian Journal of Andrology 2016年第5期18卷 704-710页

作者： Steven M mooney Mohit Kumar Jolly Herbert Levine Prakash Kulkarni Department of Biology University of Waterloo Waterloo ON N2L 3G1 Canada Center for Theoretical Biological Physics Rice University Houston TX 77005 USA Department of Bioengineering Rice University Houston TX 77005 USA Department of Physics and Astronomy Rice University Houston TX 77005 USA institute for Bioscience and Biotechnology Research University of Maryland Rockville Maryland 20850 USA

A striking characteristic of cancer ceLls is their remarkable phenotypic plasticity, which is the ability to switch states or phenotypes in response to environmental fluctuations. Phenotypic changes such as a partial or complete epithelial to mesenchymal transition （EMT） that play important roles in their survival and proliferation, and development of resistance to therapeutic treatments, are widely believed to arise due to somatic mutations in the genome. However, there is a growing concern that such a deterministic view is not entirely consistent with multiple lines of evidence, which indicate that stochasticity may also play an important role in driving phenotypic plasticity. Here, we discuss how stochasticity in protein interaction networks （PINs） may play a key role in determining phenotypic plasticity in prostate cancer （PCa）. Specifically, we point out that the key players driving transitions among different phenotypes （epithelial, mesenchymal, and hybrid epithelial/mesenchymal）, including ZEB1, SNAIl, OVOL1, and OVOL2, are intrinsically disordered proteins （IDPs） and discuss how plasticity at the molecular level may contribute to stochasticity in phenotypic switching by rewiring PINs. We conclude by suggesting that targeting iDPs implicated in EMT in PCa may be a new strategy to gain additional insights and develop novel treatments for this disease, which is the most common form of cancer in adult men.

关键词： epithelial to mesenchymal transition intrinsically disordered proteins prostate cancer state-switching

Identification of the Early Jurassic mylonitic granitic pluton and tectonic implications in Namling area,southern Tibet

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Geoscience Frontiers 2021年第1期12卷 13-28页

作者： Yuanku Meng Walter D.mooney Runlong Fan Jinqing Liu Youqing Wei College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China U.S.Geological Survey Menlo ParkCA 94025USA SHRIMP Center Institute of GeologyChinese Academy of Geological SciencesBeijing 102206China

A number of studies revealed that the Gangdese magmatic belt of southern Tibet was closely related to the northward subduction of the Neo-Tethys oceanic lithosphere and Indo-Asian ***,pre-Cretaceous magmatism is still poorly constrained in the Gangdese magmatic belt,southern ***,we conducted systematically geochronology and geochemistry studies on a newly-identified granitic pluton in the middle Gangdese magmatic belt(Namling area),southern *** SHRIMPⅡU-Pb dating for one representative sample gives a weighted age of 184.2±1.8 Ma(MSWD=±1.11),corresponding to emplacement and crystallization age of the granitic pluton in the Early Jurassic(Pliensbachian).High SiO2(68.9-72.1 wt.%)contents and intermediate Mg#values(35-38)together suggest that the newly-identified granitic pluton was probably formed by partial melting of crustal material with minor injection of mantle-derived magma,precluding an origin from melting of metasedimentary rocks that are characterized by low Mg#and high zirconδ^18O values(>8‰).Geochemically,the newly-identified granitic pluton belongs to typical I-type granitic affinity,whereas this is inconsistent with aluminium saturation index(ASI=A/CNK ratios)and geochemical *** suggests that zircon oxygen isotopes(4.30‰-5.28‰)and mineral features(lacking Al-rich minerals)are reliable indicators for discriminating granitic *** depleted whole-rock Sr-Nd-Hf isotopic compositions and zirconεHf(t)values indicate that the granitic pluton was derived from partial melting of depleted arc-type *** addition,the granitic pluton shows zirconδ^18O values ranging from 4.30‰to 5.28‰(with a mean value of 4.77‰)that are consistent with mantle-derived zircon values(5.3‰±0.6‰)within the uncertainties,indicating that the granitic pluton might have experienced weak short-living high-temperature hydrous fluid-rock *** with the Sr-Nd-Hf-O isotopes and geochemical signatures,we propose that the newl

关键词： Sr-Nd-Hf-O isotopes SHRIMP U-Pb dating Early Jurassic Mylonitic granitic pluton Gangdese belt

Cancer/testis antigens and obligate participation in multiple hallmarks of cancer： an update

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Asian Journal of Andrology 2016年第5期18卷 711-712页

作者： Steven M mooney Krithika Rajagopalan Govindan Rangarajan Prakash Kulkarni Department of Biology University of Waterloo Waterloo ON N2L 3G1 Canada Department of Biological Sciences Columbia University NY 10027 USA Department of Mathematics and Centre for Neuroscience Indian Institute of Science Bengaluru Karnataka India Institute for Bioscience and Bietechnology Research University of Maryland Rockville. Marvland 20850. USA.

The Cancer/Testis Antigens （CTAs） are a group of so-called tumor antigens that exhibit provocative expression patterns in most types of cancer. However, because most CTAs appear to be intrinsically disordered, they ... 详细信息

关键词： INTRINSICALLY DISORDERED PROTEINS C-JUN TRANSACTIVATION PHOSPHORYLATION NOISE

Application of an Improved 2-Dimensional High-Throughput Soybean Root Phenotyping Platform to Identify Novel Genetic Variants Regulating Root Architecture Traits

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Plant Phenomics 2023年第4期5卷 728-745页

作者： Rahul Chandnani Tongfei Qin Heng Ye Haifei Hu Karim Panjvani Mutsutomo Tokizawa Javier Mora Macias Alma Armenta Medina Karine C.Bernardino Pierre-Luc Pradier Pankaj Banik Ashlyn mooney Jurandir V.Magalhaes Henry T.Nguyen Leon V.Kochian Global Institute for Food Security University of SaskatchewanSaskatoonSKCanada NRGene Canada 110 Research Dr Suite 101SaskatoonSKCanada Division of Plant Sciences and Technology University of MissouriColumbiaM065211USA School of Biological Sciences The University of Western AustraliaCrawleyWA 6009Australia Rice Research Institute Guangdong Academy of Agricultural Sciences&Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China(Co-construction by Ministry and Province)Ministry of Agriculture and Rural Affairs&Guangdong Key Laboratory of New Technology in Rice Breeding&Guangdong Rice Engineering LaboratoryGuangdongChina Embrapa Maize and Sorghum Sete LagoasBrazil

Nutrient-efficient root system architecture(RSA)is becoming an important breeding objective for generating crop varieties with improved nutrient and water acquisition *** variants shaping soybean RSA is key in improving nutrient and water ***,we report on the use of an improved 2-dimensional high-throughput root phenotyping platform that minimizes background noise by imaging pouch-grown root systems submerged in *** also developed a background image cleaning Python pipeline that computationally removes images of small pieces of debris and filter paper fibers,which can be erroneously quantified as root *** platform was used to phenotype root traits in 286 soybean lines genotyped with 5.4 million single-nucleotide *** was a substantially higher correlation in manually counted number of root tips with computationally quantified root tips(95%correlation),when the background was cleaned of nonroot materials compared to root images without the background corrected(79%).Improvements in our RSA phenotyping pipeline significantly reduced overestimation of the root traits influenced by the number of root ***-wide association studies conducted on the root phenotypic data and quantitative gene expression analysis of candidate genes resulted in the identification of 3 putative positive regulators of root system depth,total root length and surface area,and root system volume and surface area of thicker roots(DOF1-like zinc finger transcription factor,protein of unknown function,and C2H2 zinc finger protein).We also identified a putative negative regulator(gibberellin 20 oxidase 3)of the total number of lateral roots.

关键词： Python Root submerged