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Herpetological Diversity of Timor-Leste: Updates and a Review of Species Distributions

Asian Herpetological Research 2015年第2期6卷 73-131页

作者： Mark O'SHEA caitlin sanchez Andrew KATHRINER Sven MECKE Venancio LOPES CARVALHO Agivedo VARELA RIBEIRO Zito AFRANIO SOARES Luis LEMOS DE ARAUJO Hinrich KAISER Faculty of Science and Engineering University of Wolverhampton Wulfruna Street Wolverhampton WV1 1LY United Kingdom and West Midland Safari Park Bewdley Worcestershire DY12 LF United Kingdom Department of Biology Victor Valley College Department of Biology Villanova University 800 East Lancaster Avenue Villanova Pennsylvania 19085 USA Department of Herpetology Bronx Zoo 2300 Southern Boulevard Bronx New York 10460 USA Department of Animal Evolution and Systematics Faculty of Biology Philipps Universit?t Marburg Universidade National Timor-Lorosa’e Faculdade de Ciencias da Educa?ao Departamentu da Biologia Avenida Cidade de Lisboa Liceu Dr. Francisco Machado Dili Timor-Leste Department of Vertebrate Zoology National Museum of Natural History Smithsonian Institution

We report the results of five herpetological surveys during 2011-2013 that included visits to all districts of Timor-Leste （Aileu, Ainaro, Baucau, Bobonaro, Dili, Covalima, Ermera, Laut6m, Liquiga, Manatuto, Manufahi, Viqueque） except the Oecusse exclave. Our fieldwork culminated in the discovery of one putative new frog species （genus Kaloula）, at least five putative new lizard species （genera Cyrtodactylus, Cryptoblepharus, and Sphenomorphus）, and two putative new snake species （genera Stegonotus and Indotyphlops）. In addition, we present new distribution records of amphibians and reptiles for 11 of the country＇s 12 contiguous districts, along with additional natural history data. Results from our surveys increase the number of amphibian and reptiles known to occur in Timor-Leste from 22 species before our surveys began to over 60, including over 20 as yet undescribed species.

关键词： Timor-Leste Kaloula Cyrtodactylus Eremiascincus Stegonotus

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First Update to Herpetofaunal Records from Timor-Leste

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Asian Herpetological Research 2012年第2期3卷 114-126页

作者： Mark O'SHEA caitlin sanchez Scott HEACOX Andrew KATHRINER Venancio LOPES CARVALHO Agivedo VARELA RIBEIRO Zito AFRANIO SOARES Luis LEMOS DE ARAUJO Hinrich KAISER West Midland Safari Park Bewdley Worcestershire DY12 1LF United Kingdom and Australian Venom Research Unit Department of Pharmacology University of MelbourneVictoria 3010 Australia Department of Biology Victor Valley College 18422 Bear Valley Road VictorvilleCalifornia 92395 USA Department of Ecology and Evolution Stony Brook University Stony Brook New York 11794 USA Present Address: Department of Biology Villanova University 800 Lancaster Avenue VillanovaPennsylvania 19085 USA Universidade National Timor-Lorosa’e Faculdade de Ciencias da Educa ao Departamentu da Biologia Avenida Cidade de Lisboa Liceu Dr. Francisco MachadoDili Timor-Leste

Herpetological surveys of locations in six districts of Timor-Leste(Dili, Baucau, Ermera, Liqui a, Manatuto, Viqueque) during 2010 led to the discovery of a new, high-altitude species of Cryptoblepharus from Ermera District, a new country record(Hemidactylus cf. tenkatei), and the recording of two previously unvouchered species(Python r. reticulatus and Liasis m. mackloti). In this article, we summarize these new records and present numerous new district records for Timor-Leste and four records for road-killed snakes seen in West Timor(Indonesia). With the addition of the results from our 2009 survey, the update presented herein increases the confirmed number of amphibian and reptile species for Timor-Leste to 47.

关键词： herpetofauna biodiversity Timor-Leste West Timor Wallacea Cryptoblepharus Hemidactylus cf.tenkatei

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Serum ferritin and the risk of early-onset colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3496-3506页

作者： Adam L Urback Kylee Martens Hannah Stowe McMurry Emerson Y Chen caitlin Citti Anil Sharma Adel Kardosh Joseph J Shatzel Division of Internal Medicine Oregon Health&Science UniversityPortlandOR 97239United States Division of Hematology and Medical Oncology Knight Cancer InstituteOregon Health&Science UniversityPortlandOR 97239United States Division of Gastroenterology&Hepatology Oregon Health&Science UniversityPortlandOR 97239United States

BACKGROUND The incidence of early-onset colorectal cancer(EO-CRC)is rising in the United States,and is often diagnosed at advanced *** serum ferritin is often incidentally discovered in young adults,however,the indication for endoscopy in EO-CRC is *** To compare serum ferritin between patients with EO-CRC and healthy controls(HCs),and examine the association of serum ferritin in EO-CRC with patient-and disease-specific *** A retrospective study of patients<50 years with newly-diagnosed EO-CRC was conducted from 1/2013-12/*** were included if serum ferritin was measured within 2 years prior to 1 year following CRC histologic *** supplement the analysis,a cohort of HCs meeting similar inclusion and exclusion criteria were identified for comparison.A sensitivity analysis including only patients with serum ferritin obtained at or before diagnosis was separately performed to minimize risk of *** Among 85 patients identified with EO-CRC(48 females),the median serum ferritin level was 26 ng/mL(range<1-2759 ng/mL).Compared to HCs(n=80211),there were a higher proportion of individuals with EO-CRC with serum ferritin<20 ng/mL(female 65%,male 40%)versus HCs(female 32.1%,male 7.2%)age 29-39 years(P=0.002 and P<0.00001,respectively).Stage IV disease was associated with significantly higher serum ferritin compared to less advanced stages(P<0.001).Serum ferritin obtained before or at the time of diagnosis was lower than levels obtained after *** findings were confirmed in the sensitivity *** Severe iron deficiency may indicate an increased risk of EO-CRC,particularly at earlier *** studies defining the optimal serum ferritin threshold and routine incorporation of serum ferritin in screening algorithms is essential to develop more effective screening strategies for EO-CRC.

关键词： Early-onset Young-onset Colorectal cancer Age Ferritin Iron deficiency

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Social and Economic Considerations for Creating Sustainable Climate Change Haven Communities

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Journal of Environmental Protection 2024年第1期15卷 76-93页

作者： Elizabeth C. Hirschman William Bourgin Angel Castilla caitlin Glover Caitlyn Justice Manuel Munoz Braydon Thompson Justin Snider Olivia Toomer Department of Business and Economics University of Virginia-Wise Wise USA

As Climate Change Haven Communities are constructed across the Northern Hemisphere, it will be necessary to attract two types of migrants to populate them. The first group consists of professionals and companies in eco-sustainable businesses, such as law firms, insurance companies, investment firms, banking, technological innovation, mass media, medical research and pharmaceutical research. The second group will consist of persons engaged in organic/eco-sustainable agriculture whose crops and animal husbandry practices can be transferred successfully to Climate Change Haven regions. The present research focuses on the social and economic variables that must be taken into account to insure that each new Climate Change Haven Community becomes successfully integrated with the local population and forms a cohesive, harmonious social structure. Examples are given from the United States, France, Spain, Portugal and Italy.

关键词： Climate Change Haven Community Sustainability Organic/Eco Farming Internal Migration Social Integration

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PNPLA8是调控三阴性乳腺癌磷脂代谢并促进肿瘤增殖和转移的关键分子（英文）

PNPLA8是调控三阴性乳腺癌磷脂代谢并促进肿瘤增殖和转移的关键分...

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2024中国肿瘤标志物学术大会暨CACA整合肿瘤学高峰论坛暨第十七届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者：谭哲琼 Pragney Deme Keerti Boyapati Annet A.M.Duivenvoorden Ron M.A.Heeren caitlin M.Tressler Norman James Haughey Kristine Glunde

Background Triple-negative breast cancer(TNBC) is the most aggressive breast cancer subtype and leads to the poorest patient outcomes despite surgery and chemotherapy treatment. Exploring new molecular mechanisms of TNBC that could lead to the development of novel molecular targets are critically important for improving therapeutic options for treating *** We sought to identify novel therapeutic targets in TNBC by combining genomic and functional studies with lipidomic analysis, which included mechanistic studies to elucidate the pathways that tie lipid profile to critical cancer cell properties. Our studies were performed in a large panel of human breast cancer cell lines and patient *** Comprehensive lipid profiling revealed that phospholipid metabolism is reprogrammed in TNBC cells. We discovered that patatin-like phospholipase domain-containing lipase 8(PNPLA8)is overexpressed in TNBC cell lines and tissues from breast cancer patients. Silencing of PNPLA8disrupted phospholipid metabolic reprogramming in TNBC, particularly affecting the levels of phosphatidylglycerol(PG), phosphatidylcholine(PC), lysophosphatidylcholine(LPC) and glycerophosphocholine(GPC). We showed that PNPLA8 is essential in regulating cell viability,migration and antioxidation in TNBC cells and promoted arachidonic acid and eicosanoid production, which in turn activated PI3K/Akt/Gsk3β and MAPK *** Our study highlights PNPLA8 as key regulator of phospholipid metabolic reprogramming and malignant phenotypes in TNBC, which could be further developed as a novel molecular treatment target.

关键词： PNPLA8 Breast cancer Triple negative Phospholipid Metabolism reprogramming Eicosanoids Migration Invasion Proliferation

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CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman caitlin M.James Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of Technology BostonMA 02139USA Present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKM2

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Female sex in experimental traumatic brain injury research:forging a path forward

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Neural Regeneration Research 2022年第3期17卷 550-552页

作者： Theresa Currier Thomas caitlin E.Bromberg Gokul Krishna Department of Child Health University of Arizona College of Medicine-Phoenix BARROW Neurological Institute at Phoenix Children’s Hospital PhoenixAZUSA Phoenix VA Health Care System PhoenixAZUSA Arizona State University TempeAZUSA

Traumatic brain injury(TBI) is a leading cause of death and disability worldwide,with estimates indicating that -50% of the world's population will acquire a head injury at some point in their lifetime(Maas et al.,2017).Mild TBIs account for -80% of all reported cases,with up to 43% of all TBI patients reporting symptoms beyond 2 weeks *** of 2016,only 7% of preclinical TBI experiments included both male and female sexes,and fewer studies analyzed the data using sex as a biological variable(Spani et al.,2018).

关键词： injury death

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Evaluating provincial-level employment challenge during the coal transition in China

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Advances in Climate Change Research 2022年第5期13卷 729-737页

作者： caitlin HAMILTON Jiawei SONG Ryna CUI Colin OLSON Diyang CUI Center for Global Sustainability School of Public PolicyUniversity of MarylandCollege Park 20742USA

As China works to move away from coal in its energy system as a critical strategy to achieve carbon neutrality before 2060,there are several challenges which will affect the coal *** challenge that has not been fully explored is the impact on coal *** are millions of people employed in various sectors along the coal supply chain,including mining,processing,transport,and power *** this study,we developed a framework to understand the magnitude and characteristics of the employment challenges associated with the coal transition across ***,the magnitude and characteristics of the challenges are evaluated from multiple dimensions,including existing coal sector employment,coal production,coal consumption,GDP contribution from the coal industry,and coal mining productivity,to explore how the transition of the coal industry will likely affect different *** results showed that provinces with large total coal employment today are often those with high coal production and consumption,high GDP contribution from the coal industry,and low productivity of coal *** found that employment impacts of a coal transition will not be equally distributed in China,as both the magnitude and characteristics of the employment challenges vary substantially across all *** is therefore important to develop a tailored strategy to tackle specific needs for each province.

关键词： Coal transition Just transition Coal employment Province China

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Bayesian modeling of dynamic behavioral change during an epidemic

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Infectious Disease Modelling 2023年第4期8卷 947-963页

作者： caitlin Ward Rob Deardon Alexandra M.Schmidt Division of Biostatistics University of MinnesotaMinneapolisMNUSA Faculty of Veterinary Medicine University of CalgaryCalgaryABCanada Department of Mathematics and Statistics University of CalgaryCalgaryABCanada Department of Epidemiology Biostatisticsand Occupational HealthMontrealQCCanada

For many infectious disease outbreaks,the at-risk population changes their behavior in response to the outbreak severity,causing the transmission dynamics to change in *** change is often ignored in epidemic modeling efforts,making these models less useful than they could *** address this by introducing a novel class of datadriven epidemic models which characterize and accurately estimate behavioral *** proposed model allows time-varying transmission to be captured by the level of“alarm”in the population,with alarm specified as a function of the past epidemic *** investigate the estimability of the population alarm across a wide range of scenarios,applying both parametric functions and non-parametric functions using splines and Gaussian *** model is set in the data-augmented Bayesian framework to allow estimation on partially observed epidemic *** benefit and utility of the proposed approach is illustrated through applications to data from real epidemics.

关键词： Bayesian inference Compartmental model SIR SEIR Transmission modeling

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The Endoplasmic Reticulum: A Social Network in Plant Cells

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Journal of Integrative Plant Biology 2012年第11期54卷 840-850页

作者： caitlin Doyle Department of Biology McGill University 1205 Dr. Penfield Avenue Montreal Quebec H3A 1B1 Canada

The endoplasmic reticulum （ER） is an interconnected network comprised of ribosome-studded sheets and smooth tubules. The ER plays crucial roles in the biosynthesis and transport of proteins and lipids, and in calci... 详细信息

关键词： ER Golgi reticulons Yopl RHD3.

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