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Pembrolizumab-induced Guillain-Barrésyndrome in triple-negative breast cancer:A case report

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World Journal of Clinical Oncology 2025年第2期16卷 144-151页

作者： Phani Bhavana Cherukuri Muhammad Tayyeb Sai Rakshith Gaddameedi Doantrang du Trishala Meghal Department of Internal Medicine Monmouth Medical CenterLong BranchNJ 07740United States Department of Hematology Oncology Monmouth Medical CenterLong BranchNJ 07740United States

BACKGROUND The programmed cell death protein 1 inhibitor pembrolizumab has become a key treatment for various cancers,including triple-negative breast ***,it is associated with immune-related adverse events,including rare but serious neurological complications such as Guillain-Barrésyndrome(GBS).GBS is a potentially life-threatening autoimmune disorder characterized by muscle weakness and *** present a unique case of pembrolizumab-induced GBS to highlight the importance of recognizing this complication and managing it promptly in patients receiving immune checkpoint *** SUMMARY A 69-year-old woman with a medical history of hypertension,anxiety,depression,and stage IIIB triple-negative breast cancer treated with pembrolizumab,carboplatin,and paclitaxel,presented to the emergency department with a 1-month history of tingling,lower extremity weakness,and shooting *** progressed to global weakness,ascending paralysis,and double *** examination revealed significant lower extremity weakness and sensory *** resonance imaging of the lumbar spine and cerebrospinal fluid analysis confirmed *** treatment with intravenous immunoglobulin led to relapse,requiring additional intravenous immunoglobulin and high-dose *** patient’s condition improved,pembrolizumab therapy was permanently discontinued,and she was discharged to a rehabilitation *** Pembrolizumab can induce GBS,necessitating early recognition,prompt diagnosis,and multidisciplinary management to prevent serious complications.

关键词： Pembrolizumab Guillain-Barrésyndrome Triple-negative breast cancer Immune-related adverse events Intravenous immunoglobulin therapy High-dose steroids Case report

Improved non-negative tensor Tucker decomposition algorithm for interference hyper-spectral image compression

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Science China(Information Sciences) 2015年第5期58卷 112-120页

作者： WEN Jia ZHAO JunSuo MA CaiWen WANG cailing Science and Technology on Integrated Information System Laboratory Institute of SoftwareChinese Academy of Sciences Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences College of Computer Science Xi'an Shiyou University

The compression method, first proposed in 2012, is based on the non-negative tensor decomposition for interference hyper-spectral image data. As a tensor is generated by a huge amount of interference hyper-spectral images, the multiplicative update algorithm is made extremely complicated, and even *** reduce the computational cost and speed up the convergence, this paper, based on the characteristics of interference hyper-spectral images, develops a new algorithm using different down-sampling factors for different non-negative wavelet sub-band tensors. The experimental results showed that this algorithm could significantly shorten the running time, while maintaining a good compression performance compared with the conventional methods.

关键词： interference hyper-spectral images LASIS three-dimensional lifting wavelet transform non-negative tensor decomposition image com

Many—Body Contributions to Cohesive Energy of Highly Compressed Solid ^4He^＊

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Chinese Physics Letters 2003年第5期20卷 706-708页

作者： TIANChun-Ling LIUFu-Sheng cailing-Cang JINGFu-Qian InstituteofPhysics SouthwestJiaotongUniversityChengdu610031 LaboratoryofShockWaveandDetonationPhysicsResearch ChineseAcademyofEngineeringPhysicsMianyang621900

A many-body expansion of cohesive energy of solid 4He is made up to five-body term, and short-range two-, three-, four- and five-body contributions have been computed by using the Hartree-Fock self-consistent-field technique and the same atomic basis set (6311G). At high densities the Hartree-Fock part of two- and four-body contributions are repulsive, whereas the three- and five-body ones are attractive. The four-body term increases as much as 15% repulsion of two-body term, and at the same time the five-body term reduces 4% of two-body repulsion at 2.5 cm3/mol. The four- and five-body terms are found to be important to describe short-range inter-atomic interaction correctly and to compute the cohesive energy accurately in a wide compression range from 2.5 to 7.5 cm3/mol.

关键词： ~4He 氦离子粘着能量高压缩固体相互作用数值计算

Halogenated benzothiadiazole-based conjugated polymers as efficient photocatalysts for dye degradation and oxidative coupling of benzylamines

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Chinese Chemical Letters 2022年第5期33卷 2736-2740页

作者： Chu Chu Yuancheng Qin cailing Ni Jianping Zou Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China

Donor-acceptor(D-A)conjugated polymers are widely used in photovoltaic applications and heteroge-neous catalysis due to their tunable building block and pre-designable ***,a series of ad-justable Donor-acceptor(D-A)benzothiodiazole-based conjugated polymers were designed and *** photocatalytic performance could be improved by fine-tuning the chemical structure by halo-gen substitution(F or Cl).The polymers exhibited excellent optoelectronic properties and were effective photocatalysts for the degradation of RhB and MO dyes,as well as promoting the oxidative coupling of *** degradation of RhB and MO occurred in 30 min under visible light radiation,while the yield of benzylamine coupling mediated by superoxide anion was as high as 82%.Systematic characterization methods were used to gain insights on the unique photocatalytic performance of the *** findings provide further insights into the design and synthesis of benzothiadiazole-based conjugated polymers as promising organic photocatalysts for solar energy conversion.

关键词： Conjugated polymer Band gap Dye degradation Photocatalysis Benzylamine oxidation

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Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第01期 226-232页

作者： Rongrong du Senmiao Xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第01期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Preparation,applications,and challenges of functional DNA nanomaterials

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Nano Research 2023年第3期16卷 3895-3912页

作者： Lei Zhang Mengge Chu cailing Ji Jie Tan Quan Yuan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

As a carrier of genetic information,DNA is a versatile module for fabricating nanostructures and *** molecules could be integrated into DNA by precise base complementary pairing,greatly expanding the functions of DNA *** functions endow DNA nanomaterials with great potential in the application of biomedical *** recent years,functional DNA nanomaterials have been rapidly investigated and *** have been reviews that classified DNA nanomaterials from the perspective of functions,while this review primarily focuses on the preparation methods of functional DNA *** review comprehensively introduces the preparation methods of DNA nanomaterials with functions such as molecular recognition,nanozyme catalysis,drug delivery,and biomedical material ***,the latest application progress of functional DNA nanomaterials is systematically ***,current challenges and future prospects for functional DNA nanomaterials are discussed.

关键词： DNA nanomaterial function preparation biomedical application

Three Semi-empirical Analytic Expressions for the Radial Distribution Function of Hard Spheres

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Communications in Theoretical Physics 2004年第3期41卷 400-404页

作者： SUNJiu-Xun cailing-Gang WUQiang JINGFu-Qian DepartmentofAppliedPhysics UniversityofElectronicScienceandTechnologyChengdu610054China LaboratoryforShockWave＆DetonationPhysicsResearch SouthwestInstituteofFluidPhysicsP.O.Box919-102Mianyang621900China

Three simple analytic expressions satisfying the limitation condition at low densities for the radial distribution function of hard spheres are developed in terms of a polynomial expansion of nonlinear base functions and the Carnahan-Starling equation of state. The simplicity and precision for these expressions are superior to the well-known Percus Yevick expression. The coefficients contained in these expressions have been determined by fitting the Monte Carlo data for the first coordination shell, and by fitting both the Monte Carlo data and the numerical results of PercusYevick expression for the second coordination shell. One of the expressions has been applied to develop an analytic equation of state for the square-well fluid, and the numerical results are in good agreement with the computer simulation data.

关键词： radial distribution function hard spheres equation of state square-well fluids

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Traction rheological properties of simulative soil for deep-sea sediment

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Journal of Oceanology and Limnology 2019年第1期37卷 62-71页

作者： QI cailing RAO Qiuhua LIU Qi MA Wenbo College of Civil Engineering and Mechanics Xiangtan University Hunan Key Laboratory of Geomechanics and Engineering Safety Xiangtan University School of Civil Engineering Central South University

The traction capacity of the mining machine is greatly in?uenced by the traction rheological properties of the deep-sea sediments. The best simulative soil was prepared for substituting the deep-sea sediment based on the deep-sea sediment collected from the Paci?c C-C mining area. Traction rheological properties of the simulative soil were studied by a home-made test apparatus. In order to accurately describe the traction rheological properties and determine traction rheological parameters, the Newtonian dashpot in Maxwell body of Burgers model was replaced by a self-similarity spring-dashpot fractance and a new rheological constitutive model was deduced by fractional derivative theory. The results show the simulative soil has obvious non-attenuate rheological properties. The transient creep and stable creep rate increase with the traction, but they decrease with ground pressure. The fractional derivative Burgers model are better in describing non-attenuate rheological properties of the simulative soil than the classical Burgers model. For the new traction rheological constitutive equation of the simulative soil, the traction rheological parameters can be obtained by ?tting the tested traction creep data with the traction creep constitutive equation. The ground contact length of track and walking velocity of the mining machine predicted by the traction rheological constitutive equation can be used to take full advantages of the maximum traction provided by the soil and safely improve mining effciency.

关键词： simulative soil traction rheological properties constitutive model rheological parameters ground contact length of track walking velocity

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