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Acceptance and Factors Associated With Participation in Functional Cure–Related Trials Among People Living With HIV: A Cross-sectional Study in Southern China

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Infectious Microbes & Diseases 2024年第1期6卷 11-19页

作者： Zhaomin Deng Minjuan Shi Yue Yuan GuangjinCao Chunyan Wen Lijuan Chen Xueying Fan Linan Wu Jianhui Yuan Huachun Zou Linghua Li caijun sun School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenChina Department of Diseases Control Panyu District Center for Disease Control and PreventionGuangzhouChina Infectious Disease Center Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Nanshan District Center for Disease Control and Prevention ShenzhenChina Key Laboratory of Tropical Disease Control(sun Yat-sen University) Ministry of EducationGuangzhouChina

HIV remains a global health challenge,and research efforts directed towards a functional cure require people living with HIV(PLHIV)in-volvement in clinical *** study assessed willingness to participate in HIV functional cure–related clinical trials and associated factors among PLHIV in Guangzhou,China,using a questionnaire survey *** analyzed responses from 718 questionnaires,finding that 71.2%were willing to participate in Phase Ⅲtrials,while 51.7%were willing to participate in Phase I trials and 42.9%expressed acceptability for analytic treatment *** logistic regression demonstrated that male PLHIV,those with awareness of functional cure,and PLHIV,who had been on antiretroviral therapy(ART)for less than 1 year,were more willing to partic-ipate in Phase Ⅲ*** with a body mass index greater than 24,and those without resistance to ART drug were more willing to participate in Phase I *** major motivations for participation in Phase Ⅲtrials were access to cutting-edge treatments(62.6%)and supporting research(55.3%).Safety was the main concern contributing to *** study revealed a high willingness to participate in HIV functional cure–related trials among PLHIV in Guangzhou,China,and willingness varied across different trial phases and was influenced by multiple *** study provides valuable references for future clinical trial recruitment strategies and public health policy formulation.

关键词： people living with HIV functional cure clinical trials willingness

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B cell engineering in vivo:Accelerating induction of broadly neutralizing antibodies against HIV-1 infection

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Signal Transduction and Targeted Therapy 2023年第2期8卷 327-328页

作者： caijun sun Teng Zuo Ziyu Wen School of Public Health(Shenzhen) Sun Yat-sen University518107ShenzhenChina Key Laboratory of Tropical Disease Control(sun Yat-sen University) Ministry of Education511400GuangzhouChina Laboratory of Immunoengineering Institute of Health and Medical TechnologyHefei Institutes of Physical ScienceChinese Academy of Sciences230031HefeiChina

In a recent study published in Nature Biotechnology,1 Nahmad and colleagues reported in vivo B-cell engineering to generate broadly neutralizing antibodies(bnAbs)against human immunodeficiency virus type 1(HIV-1)in *** proof-of-concept study suggests the possibility of in vivo B-cell engineering as a novel preventive or therapeutic approach against HIV-1 infection.

关键词： vivo antibodies neutral

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卫星互联网安全风险及应对措施分析

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天地一体化信息网络 2024年第1期5卷 95-101页

作者：谷欣单超孙才俊李珂田敏王瑞青中国星网网络创新研究院有限公司北京100029 之江实验室智能网络研究院浙江杭州311121 中电科网络安全科技股份有限公司北京100043

从阐述卫星互联网的系统组成和安全事件入手,综合分析卫星和载荷、卫星终端、信关站、运控中心、运营中心等实体对象的安全风险,接入链路、星间链路、馈电链路、测控链路、地面互联等通信链路安全风险,运营数据、通信内容监管、公众隐... 详细信息

从阐述卫星互联网的系统组成和安全事件入手,综合分析卫星和载荷、卫星终端、信关站、运控中心、运营中心等实体对象的安全风险,接入链路、星间链路、馈电链路、测控链路、地面互联等通信链路安全风险,运营数据、通信内容监管、公众隐私、数据违规出境等应用数据安全风险,以及新兴技术带来的安全风险挑战,并针对上述各种潜在的安全威胁提出相应的应对措施。最后对卫星互联网安全形势演变应关注的研究方向进行展望。

关键词：卫星互联网安全挑战安全风险应对措施

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HIV新近感染的检测技术现状及其在艾滋病防控中的作用

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中华实验和临床病毒学杂志 2024年第2期38卷 193-201页

作者：崔明婷李顺然王浩航袁建辉周毅孙彩军中山大学公共卫生学院(深圳) 深圳518107 深圳市南山区疾病预防控制中心深圳518054 珠海市疾病预防控制中心艾滋病防制所珠海519060 中山大学热带病防治研究教育部重点实验室广州510030

目前,艾滋病监测主要通过哨点监测和艾滋病病例报告系统来计算人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染率、艾滋病新报告病例数和HIV相关死亡率,以及开展全国性研究调查HIV耐药毒株特征,但这些措施不能估算HIV新近感染... 详细信息

目前,艾滋病监测主要通过哨点监测和艾滋病病例报告系统来计算人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染率、艾滋病新报告病例数和HIV相关死亡率,以及开展全国性研究调查HIV耐药毒株特征,但这些措施不能估算HIV新近感染率。HIV感染的病程隐蔽且具有长期潜伏感染的特性,急性期感染者难以被发现,常规监测手段难以确定感染者的感染时间,从而使得新近感染率的计算存在潜在偏倚,影响对疾病危险因素的深入探究以及评价干预措施的效果。近年来,使用HIV-1新近感染检测(test for recent infection,TRI)基于横断面样本估算HIV新近感染率已成为监测HIV传播、评估干预手段的重要方法之一,其可以将HIV-1感染者分为新近感染与长期感染,提高HIV新近感染率测量的准确性。TRI分为血清学检测与分子检测,其中血清学检测因其成本低、估算HIV新近感染率准确、发展历史较长而被广泛使用,近年来在准确度与简便性方面取得较大进展。本文通过对TRI的原理、准确度以及应用的介绍,系统综述TRI技术的最新研究进展及优缺点。

关键词：艾滋病人类免疫缺陷病毒新近感染新近感染检测

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基于石墨烯纳米材料的电化学传感器在传染病检测中的应用

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国际检验医学杂志 2024年第12期45卷 1511-1515页

作者：叶颖叶健忠张然朱丽何建安赵纯中(综述) 孙彩军(审校) 深圳国际旅行卫生保健中心(深圳海关口岸门诊部) 广东深圳518000 中山大学公共卫生学院(深圳) 广东深圳518107

石墨烯作为新型的二维纳米材料,其独特的理化特性,使其具有电阻率低、比表面积大、生物相容性好、化学稳定性高等特点,有望发展为高灵敏电化学传感器的理想材料。随着电化学传感器技术的发展,高灵敏度、高特异度、快速、便捷的石墨烯电... 详细信息

石墨烯作为新型的二维纳米材料,其独特的理化特性,使其具有电阻率低、比表面积大、生物相容性好、化学稳定性高等特点,有望发展为高灵敏电化学传感器的理想材料。随着电化学传感器技术的发展,高灵敏度、高特异度、快速、便捷的石墨烯电化学传感器可用于检测多种传染病病原体。本文总结了现有报道的基于石墨烯纳米材料的电化学传感器检测技术应用于呼吸道病原体、蚊媒传染病病原体、肠道传染病病原体等传染病病原体检测的情况,为实现传染病的早发现、早诊断的快速检测技术及方法提供新的思路。

关键词：石墨烯纳米材料电化学传感器传染病

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Safety and Immunogenicity of SARS-CoV-2 Vaccines in People Living With HIV:A Systematic Review and Meta-analysis of Real-World Studies

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Infectious Microbes & Diseases 2023年第4期5卷 159-166页

作者： Xueying Fan Yangguo Zhao Fan Wu Yue Yuan Bing Lang Di Yin Zhongliang Xu Shiqiang Jiang Huachun Zou Jianhui Yuan caijun sun School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenChina Nanshan District Center for Disease Control and Prevention ShenzhenChina School of Public Health(Shenzhen) Sun Yat-sen UniversityShenzhenChina Key Laboratory of Tropical Disease Control(sun Yat-sen University) Ministry of EducationGuangzhouChina

The safety and immunogenicity of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines in people living with HIV(PLWH)in real-world studies remain ***,we conducted a comprehensive systematic review and meta-analysis to address this *** search were conducted from PubMed,Web of Science and *** events following vaccination,the risk ratio(RR)of SARS-CoV-2–specific IgG seroconversion and the level of anti–SARS-CoV-2 neutralizing antibodies were compared between the PLWH group and a healthy control group.A total of 10,582 PLWH from 22 studies were *** our analysis,the incidence of local or systemic adverse events after the first SARS-CoV-2 vaccine dose was not statistically different between PLWH and healthy ***,there was a statistical difference after the second dose(RR,0.83;95%CI,0.71–0.98).The seroconversion rate of SARS-CoV-2 IgGantibodies in PLWH was significantly lower than that in the healthy control group(RR,0.94;95%CI,0.89–0.98;I2=80%,P<0.01).The anti–SARS-CoV-2 neutralizing antibody titers in PLWH after full immunization were also significantly lower than those in the healthy control group(RR,0.91;95%CI,0.85–0.98;I2=81%,P<0.01).The safety and tolerance of COVID-19 vaccines in PLWHare ***,their immunogenicitymay be impaired to a certain extent,characterized by a lower IgGseroconversion rate and neutralizing antibody titers compared with healthy *** findings should provide guidance for optimizing future COVID-19 vaccination strategies among PLWH.

关键词： COVID-19 HIV immunogenicity safety vaccination meta-analysis

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First clinical study of germline-targeting strategy: One step closer to a successful bnAb-based HIV vaccine

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The Innovation 2023年第1期4卷 36-37页

作者： caijun sun Teng Zuo Ziyu Wen School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Laboratory of Immunoengineering Institute of Health and Medical TechnologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Key Laboratory of Tropical Disease Control(sun Yat-sen University) Ministry of EducationGuangzhou 511400China

The epidemic of human immunodeficiency virus type 1(HIV-1)remains amajor threat to global public health,with approximately 38 million people living with HIV-1 ***,a prophylactic vaccine against HIV-1 is not available *** a recent study,1 Leggat and colleagues reported the first-in-human test of a germline-targeting HIV-1 vaccine candidate,eOD-GT860-mer adjuvanted with ***,this strategy effectively activated the B cell precursors(germlines)of VRC01-class broadly neutralizing antibodies(bnAbs)in 97%(35 of 36)of vaccine recipients.

关键词： vaccine closer clinical

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Antibody upstream sequence diversity and its biological implications revealed by repertoire sequencing

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Journal of Genetics and Genomics 2021年第10期48卷 936-945页

作者： Yan Zhu Xiujia Yang Cuiyu Ma Haipei Tang Qilong Wang Junjie Guan Wenxi Xie Sen Chen Yuan Chen Minhui Wang Chunhong Lan Deqiang sun Lai Wei caijun sun Xueqing Yu Zhenhai Zhang State Key Laboratory of Organ Failure Research National Clinical Research Center for Kidney DiseaseDivision of NephrologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Bioinformatics School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Center for Precision Medicine Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Key Laboratory of Mental Health of the Ministry of Education Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceSouthern Medical UniversityGuangzhou 510515China Department of Nephrology Hainan Affiliated Hospital of Hainan Medical CollegeHaikou 570311China Department of Nephrology Hainan General HospitalHaikou 570311China Department of Center Laboratory The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China School of Public Health Sun Yat-sen UniversityShenzhen 510006China Division of Nephrology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

The sequence upstream of the antibody variable region(antibody upstream sequence[AUS])consists of a 5′untranslated region(5′UTR)and a preceding leader *** sequence variations in AUS affect antibody engineering and PCR based antibody quantification and may also be implicated in mRNA transcription and ***,the diversity of AUSs remains *** 5′rapid amplification of cDNA ends and high-throughput antibody repertoire sequencing technique,we acquired full-length AUSs for human,rhesus macaque,cynomolgus macaque,mouse,and *** designed a bioinformatics pipeline and identified 3307 unique AUSs,corresponding to 3026 and 1457 unique sequences for 5′UTR and leader region,*** analysis indicated that 928(63.69%)leader sequences are novel relative to those recorded in the international ImMunoGeneTics information ***,leader sequences are more conserved than 5′UTR and seem to coevolve with their downstream V ***,single-nucleotide polymorphisms are position dependent for leader regions and may contribute to the functional reversal of the downstream V ***,the AUGs in AUSs were found to have little impact on gene *** together,our findings can facilitate primer design for capturing antibodies efficiently and provide a valuable resource for antibody engineering and molecule-level antibody studies.

关键词： Antibody upstream sequences 5′UTR Leader sequences Antibody repertoire sequencing Antibody repertoire

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Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques

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Virologica Sinica 2021年第5期36卷 1197-1209页

作者： Chunxiu Wu Jin Zhao Ruiting Li Fengling Feng Yizi He Yanjun Li Runhan Huang Guangye Li Heng Yang Genhong Cheng Ling Chen Feng Ma Pingchao Li caijun sun State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health(GIBH)Chinese Academy of SciencesGuangzhou 510530China School of Public Health(Shenzhen) Sun Yat-Sen UniversityGuangdong 518107China Key Laboratory of Tropical Disease Control Sun Yat-Sen UniversityMinistry of EducationGuangzhou 514400China University of Chinese Academy of Sciences Beijing 100049China Center for Systems Medicine Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Suzhou Institute of Systems Medicine Suzhou 215123China Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos Angeles 90095USA Guangdong Landau Biotechnology Co.Ltd Guangzhou 510700China

Cholesterol-25-hydroxylase(CH25 H)and its enzymatic product 25-hydroxy cholesterol(25 HC)exert broadly antiviral activity including inhibiting HIV-1 ***,their antiviral immunity and therapeutic efficacy in a nonhuman primate model are ***,we report that the regimen of 25 HC combined with antiretroviral therapy(ART),provides profound immunological modulation towards inhibiting viral replication in chronically SIVmac239-infected rhesus macaques(RMs).Compared to the ART alone,this regimen more effectively controlled SIV replication,enhanced SIVspecific cellular immune responses,restored the ratio of CD4/CD8 cells,reversed the hyperactivation state of CD4^(+)T cells,and inhibited the secretion of proinflammatory cytokines by CD4^(^(+))and CD8^(+)T lymphocytes in chronically SIVinfected ***,the in vivo safety and the preliminary pharmacokinetics of the 25 HC compound were assessed in this RM *** together,these assessments help explain the profound relationship between cholesterol metabolism,immune modulation,and antiviral activities by 25 *** results provide insight for developing novel therapeutic drug candidates against HIV-1 infection and other related diseases.

关键词： 25-hydroxycholesterol(25HC) HIV SIV Antiretroviral therapy(ART) Macaque

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利用马赛克策略设计靶向神经氨酸酶抗原的广谱流感疫苗

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病毒学报 2022年第3期38卷 543-553页

作者：李瑞婷李敏超李彦君舒跃龙孙彩军中山大学公共卫生学院(深圳) 广州510006 中山大学热带病防治研究教育部重点实验室广州510030

季节性流感病毒仍对全球公共卫生安全构成巨大威胁,对老人、儿童以及免疫功能低下人群的危害尤其严重。疫苗接种是目前应对季节性流感疫情重要手段,然而由于抗原转换和抗原漂移,常出现疫苗株与实际病毒流行株的不匹配现象,因此迫切需要... 详细信息

季节性流感病毒仍对全球公共卫生安全构成巨大威胁,对老人、儿童以及免疫功能低下人群的危害尤其严重。疫苗接种是目前应对季节性流感疫情重要手段,然而由于抗原转换和抗原漂移,常出现疫苗株与实际病毒流行株的不匹配现象,因此迫切需要开发一种安全高效的广谱流感疫苗来对抗季节性流感病毒和潜在的流感大流行。抗原设计是研发新型疫苗的关键前提,我们利用马赛克(mosaic)遗传算法设计研发了一种具有广谱抗原表位覆盖率的靶向流感病毒神经氨酸酶(Neuraminidase,NA)的新型抗原(Mosaic-NA)。该抗原在最大程度上涵盖了所有已报道甲型流感病毒的NA1蛋白与NA2蛋白序列中的细胞毒性T淋巴细胞(Cytotoxic T lymphocyte,CTL)抗原表位,并保留了天然蛋白空间构象。因此,这种新型抗原预期可有效诱导出靶向保守表位的CTL反应和抗体反应,从而为研发通用流感疫苗提供新思路和理论基础。

关键词：流感病毒广谱疫苗抗原设计神经氨酸酶(NA) 马赛克策略

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