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南靖县布鲁氏菌病调查及其防控措施

福建畜牧兽医 2024年第5期46卷 24-25页

作者：严彩凤张松波南靖县农业农村局福建南靖363600

为了解南靖县布鲁氏菌病(简称布病)感染情况,南靖县农业农村局每年5~9月均对辖区内11个乡镇的生猪、羊养殖场进行布鲁氏菌病抗体检测,结合流行病学调查,结果显示南靖县猪群、羊群均未感染布鲁氏菌病。

关键词：布鲁氏菌病调查检测防控

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Retinol binding protein 4 correlates with and is an early predictor of carotid atherosclerosis in type 2 diabetes mellitus patients

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The Journal of Biomedical Research 2015年第6期29卷 451-455页

作者： Shangyong Feng yan Zhu caifeng yan yan Wang Zhenweng Zhang Department of Endocrinology the Affiliated Hospital of Yangzhou University

The association of retinol binding protein 4 （RBP4） with atherosclerosis of the carotid artery in type 2 diabetes mellitus （T2DM） remains undefined. We aimed to investigate the correlation of RBP4 expression with atherosclerosis of the carotid artery in T2DM. A total of 1,076 subjects were investigated for intima-media thickness of the bilateral common carotid arteries, and they were divided into three groups： in group Ⅰ, patients had normal neck vascular ultra- sound, in group Ⅱ, intimal carotid artery media thickness was equal to or more than 1 mm, and in group Ⅲ, carotid artery plaque was present. Height, weight, blood pressure （BP）, fasting plasma glucose （FPG）, hemoglobin Alc （HbA1c）, total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C）, high-density lipopro- tein cholesterol （HDL-C）, apolipoprotein A-1 （apoA-1）, apolipoprotein B （apoB） and lipoprotein （a） [Lp（a）] were determined by routine laboratory methods. RBP4 and high sensitivity C reactive protein （HsCRP） were measured by an enzyme-linked immuno-sorbent assay, and insulin concentration was measured by an electrochemiluminescence sandwich immunoassay. Duration of diabetes, waist and BP, FPG, HbAlc, TG, TC, LDL-C, APOB, Lp（a）, HsCRP, RBP4 and homeostasis model assessment insulin resistance index （HOMA-IR） were significantly lower in group I than in the other two groups （P〈0.01, P〈0.01）. Plasma levels of HbAlc, RBP4, LDL-C, TC, HOMA-IR, HsCRP and Lp（a）, waist and BP were significantly increased in group III than in group II （P〈0.01）. Multivariate logistic regression analysis showed that there were seven factors associated with the occurrence of carotid artery atherosclero- sis and its risks in descending order were： high LDL-C, high waist, high HsCRP, duration of diabetes, high HOMA-IR, HbAlc and high RBP4. Our finding supported that RBP4 was positively correlated with carotid atherosclerosis in patients with T2DM and could be used as an early predictor of cardiovascular di

关键词： type 2 diabetes mellitus retinol binding protein 4 subclinical atherosclerosis

Enhanced Anticancer Cells Effects of Optimized Suspension Stable As2O3-Loaded Poly（lactic-co-glycolic acid） Nanocapsules

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Chinese Journal of Chemistry 2015年第7期33卷 777-784页

作者： Xiaoli Song Juan You Chunlan Xu Aiping Zhu caifeng yan Rong Guo College of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu 225002 China Northern Jiangsu People's Hospital Yangzhou Jiangsu 225001 China

This study is to prepare a nanosuspension based on poly（lactic-co-glycolic acid）（PLGA） for delivery, controlled release and enhanced anti-solid tumor effects of As2O3. As2O3-1oaded PLGA nanocapsules （As2O3-PLGANCs） were prepared by double emulsion-solvent evaporation method and were optimized by univariate analysis in combination with orthogonal experimental according to several factors. The optimized As2O3-PLGA NCs presented suitable physical stability, favorable size of （200.2± 10.6） nm （PDI=0.117 ±0.008）, spherical shape, and high encapsulation efficiency （92.48%± 2.14%）. The in vitro suspension stability of the NCs was excellent. The release of As2O3 from the NCs showed pH responsive release characteristics. The NCs can be efficiently taken up by SMMC-7721 cell and showed excellent antitumor efficacy against SMMC-7721 cell line. Then, As2O3-PLGA NCs could be considered as a promising formulation for the pH dependent release of As2O3 in cancer cells and enhance the anti-solid tumor effects of As2O3.

关键词： As2O3-PLGA nanocapsules orthogonal experiment suspension stability drug delivery

Responses and sensitivity of N, P and mobile carbohydrates of dominant species to increased water, N and P availability in semi- arid grasslands in northern China

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Journal of Plant Ecology 2017年第3期10卷 486-496页

作者： Xue Wang Zhuwen Xu caifeng yan Wentao Luo Ruzhen Wang Xingguo Han Yong Jiang Mai-He Li Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesNo.72 Wenhua RoadShenhe DistrictShenyang 110016China College of Resources and Environment University of Chinese Academy of SciencesNo.19A Yuquan RoadShijingshan DistrictBeijing 100049China Forest dynamics Swiss Federal Research Institute WSlZuercherstrasse 111CH-8903 BirmensdorfSwitzerland

Aims We aimed to improve the understanding of the carbon and nutri-ent physiological responses and adaptation of semi-arid grassland plants to environmental *** We investigated plant leaf non-structural carbohydrate(NSC=solu-ble sugars+starch),nitrogen(N)and phosphorus(P)levels in an Inner Mongolian semi-arid grassland community treated with water,N and P additions for 8 *** dominant grasses(Agropyron cris-tatum(L.)Gaertn.,Stipa krylovii Roshev.)and two forbs(Artemisia frigida Willd.,Potentilla bifurca L.)were *** Findings Water addition decreased plant leaf N and P concentrations,whereas N and P addition increased them,indicating that the semi-arid grassland studied suffers from a shortage of N and P *** N and P addition decreased the levels of soluble sugars,starch and thus also NSC in plant leaves,which may be attributed to(i)increased carbohydrate consumption associated with a higher growth rate,and(ii)a dilution effect of greater plant size under N and P *** addition tended to increase the leaf NSC levels both in the grasses(+9.2%)and forbs(+0.6%only),which may be a result of increased photosynthesis of plants with increased water *** conditions of ambient and increased water supply in the present study,N addition resulted in an N/P ratio of>16 in the grasses but a significantly lower N/P ratio of<11 in the forb *** finding implies that growth of the two grass spe-cies will be limited mainly by P availability but the forbs will still be mainly limited by N supply if N deposition,alone or in combination with summer precipitation,continues to increase as predicted in Inner Mongolia.

关键词： climate change non-structural carbohydrates perennial grasses perennial forbs steppe

Sorafenib in hepatocellular carcinoma:efficacy and predictive factors

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Journal of Medical Colleges of PLA(China) 2011年第6期26卷 324-334页

作者： Li Jing Huang Liang yan Jianjun Zhou Feiguo Liu caifeng yan Yiqu Department of Hepatic Surgery I Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

Objective:To evaluate the efficacy and safety in patients with hepatocellular carcinoma treated with sorafenib and determine the predictive factors for ***:From April 2009 to December 2010,all patients with hepatocellular carcinoma treated with sorafenib were included in the *** data and survival time were *** analysis was conducted using the Kaplan-Meier method,and predictive factors for survival were analysed using the Cox's ***:A total of 51 patients were included in the study,the median time of follow-up was 10 months(range 1-22).All the 51 patients had one or more adverse events,of which 2 patients died of upper gastrointestinal bleeding and 6 patients discontinued *** mean survival time was 11 months and 1-year survival was 60.8%.On univariate analysis,the median survival time of patients with tumors of BCLC A,B and C were 17,12.5 and 8.5 months,and 1-year survival were 71.4%,61.1%,and 23.1%, respectively(P=0.006).Compared with those with mild and poor arterial supply tumors,patients with good arterial supply tumors had longer median survival time(12 months vs 8 months and 9 months) and higher 1-year survival(52.0%vs 30.8%and 38.5%)(P=0.037).Patients with portal invasion had shorter median survival time and lower 1-year survival(8.5 months vs 13 months and 57.6%vs 16.7%,respectively) than those without(P=0.012).Patients with prealbumin≥170 mg/L had longer median survival time and higher 1-year survival(13.5 months vs 9 months and 55.6%vs 36.4%,respectively) than those with prealbumin<170 mg/L(P=0.016).Early tumor BCLC staging and high level of prealbumin were independent predictive factors for survival on multivariate analysis using Cox's regression model,the hazard ratio were 3.69(95%CI:1.30-10.53,P=0.015) and 3.53(95%CI:1.40-8.91,P=0.008) ***:Upper gastrointestinal bleeding was a severe event need to be concerned in patients with hepatocellular carcinoma treated with ***

关键词： Hepatocellular carcinoma Sorafenib Adverse events Prealbumin

Synthesis, Characterization and Antibacterial Activity of New Ln(Ⅲ) Complexes with an Unsymmetrical Schiff Base Ligand

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Journal of Ocean University of China 2006年第3期5卷 235-238页

作者： BI caifeng yan Liangliang FAN Yuhua ZHANG Xia WANG Aidong College of Chemistry and Chemical Engineering Ocean University of China Qingdao 266003 P. R. China

A new unsymmetrical Schiff base ligand (H2LLi) was synthesized using L-lysine, salicylaldehyde and 2-hydroxy-1-naphthaldehyde. Three solid metal complexes of this ligand \[Ln(H2L)(NO3)\] NO3·2H2O (Ln=La, Sm, Ho) have been prepared and characterized by elemental analyses, IR spectra, UV spectra, TG-DTG and molar conductance. The antibacterial activities of the ligand and its complexes are also studied. The antibacterial experiments indicate that the ligand and its complexes possess antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis and that the complexes have higher activity than those of the ligand.

关键词： unsymmetrical Schiff base Ln(Ⅲ) complex synthesis characterization antibacterial action

Synthesis, Crystal Structure and Interactions with Different G-quadruplex DNA and ctDNA of Zn-CAP

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Journal of Chemistry and Chemical Engineering 2014年第5期8卷 444-452页

作者： caifeng Liu Yunfeng An yan Peng Qiping Qin Hui Zhong Chao Lu Guohai Zhang State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry &Pharmaceutical Sciences Guangxi Normal University Guilin 541004 China

In this study, one mononuclear zinc（II） complex with 1,2-bis CAP （（5-chlorosalicylidene amino）-phenylene）： C22C13N2035Znl5 H0125 （Zn-CAP） was synthesized. The binding properties of Zn-CAP with G-quadruplex DNA and ctDNA （calf thymus DNA） were examined by fluorescence, CD （circular dichroism） spectroscopic and FRET （fluorescence resonance energy transfer） assay. In the fluorescence emission spectral analysis, the addition of three series of G-quadruplex DNA （G4-HTG21, G4-Pu27 and G4-c-kit-l） into the Zn-CAP solution induced moderate or add hypochromicity with total quenching ratios of 10.73%, 15.07% and 8.59% in the presence of K＋ were achieved, respectively. While the addition of ctDNA under same condition only caused 7.08% quenching on the fluorescence emission of Zn-CAP. In the CD spectral analysis, the interaction with Zn-CAP could induce significant spectral changes on the CD absorption of G4-HTG21, G4-Pu27 and G4-c-kit-1, with 106.00%, 93.06%, 113.47% increment at 232 nm absorption, along with a 81.11%, 92.80%, 83.72% decrement at 295 nm or 270 nm absorption, which demonstrated that the antiparallel structure of G-quadruplex DNA is more stable in the presence of Zn-CAP. Comparatively, the addition of Zn-CAP could induce significant spectral changes on the CD absorption of double helix ctDNA, with 64.17% decrement on the positive peak absorption, along with a 90.91% increment on the negative peak absorption. On the other hand, in the FRET-melting assay analysis, it was clear that Zn-CAP at 0.5 equivalences could raise the melting temperature of G-quadruplex （F2 IT or FPul 8T） by 3.45℃ and 15.85℃, indicating an obvious stabilization effect of Zn-CAP on G-quadruplex in Pu27. All the results indicated that Zn-CAP exhibited higher binding affinity and binding intensity to G-quadruplex DNA than ctDNA, especially G-quadruplex Pu27.

关键词： Zn-CAP G-quadruplex DNA ctDNA spectroscopy FRET assay.

Analysis and Management of Adverse Drug Reactions after Injection of Amphotericin B in AIDS Patients with Fungal Infection

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Natural Science 2022年第2期14卷 62-70页

作者： caifeng yan Qing Lin Buqing Su Xiaoye Su Hanzhen Su Lida Mo Pharmacy Department/Laboratory Department of Nanning Fourth People’s Hospital Nanning China Nanning Infectious Disease Hospital Affiliated to Guangxi Medical University Nanning China Guangxi AIDS Clinical Treatment Center Nanning China Department of Infectious Diseases Debao People’s Hospital Debao China Nursing Department of Liaoning Hospital Vocational College Shenyang China Department of Nursing Graduate School Eternal University of the Philippines Las Pinas Philippines Department of Critical Medicine Fuzhou Second People’s Hospital Fuzhou China

Objective: To understand the condition of adverse drug reactions and the treatment procedures of amphotericin B for injection in patients with AIDS complicated with fungal infection. Methods: For the research object, a retrospective analysis of adverse reactions of amphotericin B injection in 121 patients of AIDS complicated with fungal infection was reported in our hospital from October 2017 to June 2021 to observe the adverse drug reactions of patients after treatment with amphotericin B for injection, 87 cases with general degree (regarded as the general group) and 34 cases with serious degree (regarded as the serious group), and analyze the general data, medication and course of disease of the two groups for symptomatic treatment. Results: Adverse reactions such as hypokalemia, abnormal liver function, renal impairment, leucopenia and drug fever were more common in the two groups, and there were also many adverse reactions such as bone marrow suppression, rash, anemia, thrombocytopenia, nausea, vomiting, fatigue, dizziness, pruritus, angina pectoris, vertigo, abdominal pain and diarrhea. The rates of leukopenia and drug fever in general group were significantly lower than those in severe group (P < 0.05);in the dose of amphotericin B used, the rate of using 25 mg and more than 25 mg in the general group was significantly lower than that in the severe group (P < 0.05). After symptomatic treat-ment, most patients have improved, and a few are unknown or have not improved. Con-clusion: Amphotericin B for injection has great side effects and will cause different degrees of adverse drug reactions. The dose of amphotericin B for clinical treatment should be ad-justed and disposed according to the adverse reactions to avoid serious consequences.

关键词： AIDS Fungus Amphotericin B for Injection Drugs Adverse Reaction

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定量CT对2型糖尿病性骨质疏松的诊断意义

中国骨质疏松杂志 2019年第11期25卷 1641-1644页

作者：谭璐闫彩凤中南大学湘雅二医院湖南长沙410000 江苏省苏北人民医院江苏扬州225001

2型糖尿病(type 2 diabetes mellitus,T2DM)通过多种因素影响骨微结构和骨密度,导致骨强度下降,骨折风险增加。定量CT(quantitative computed tomography,QCT)测定三维体积骨密度(volume bone mineral density,vBMD)优于双能X线吸收法(dual energy X-ray absorptiometry,DXA)测定的面积骨密度(area bone mineral density,aBMD)对T2DM患者骨折风险评估,还能发现松质骨的结构改变、皮质骨多孔性结构,对骨量细微改变具有高敏感性。将QCT与有限元分析法结合,通过骨密度、骨组织结构同时分析骨应力来评价骨强度,对T2DM患者骨折风险的预测更有价值。

关键词：定量CT 2型糖尿病骨质疏松有限元分析法