Enhanced Anticancer Cells Effects of Optimized Suspension Stable As2O3-Loaded Poly（lactic-co-glycolic acid） Nanocapsules

作     者：Xiaoli Song Juan You Chunlan Xu Aiping Zhu Caifeng Yan Rong Guo 

作者机构：College of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu 225002 China Northern Jiangsu People's Hospital Yangzhou Jiangsu 225001 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2015年第33卷第7期

页      面：777-784页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 0702[理学-物理学] 

基　　金：This research was supported by the National Natural Science Foundation of China (No. 21201149)  the Natural Science Foundation of Jiangsu Province (No. BK2012259)  the Project of the Testing Center of Yangzhou University (China)  the Postdoctoral Science Foundation and the Priority Academic Program Development of Jiangsu Higher Education Institutions 

主　　题：As2O3-PLGA nanocapsules orthogonal experiment suspension stability drug delivery 

摘      要：This study is to prepare a nanosuspension based on poly（lactic-co-glycolic acid） （PLGA） for delivery, controlled release and enhanced anti-solid tumor effects of As2O3. As2O3-1oaded PLGA nanocapsules （As2O3-PLGANCs） were prepared by double emulsion-solvent evaporation method and were optimized by univariate analysis in combination with orthogonal experimental according to several factors. The optimized As2O3-PLGA NCs presented suitable physical stability, favorable size of （200.2± 10.6） nm （PDI=0.117 ±0.008）, spherical shape, and high encapsulation efficiency （92.48%± 2.14%）. The in vitro suspension stability of the NCs was excellent. The release of As2O3 from the NCs showed pH responsive release characteristics. The NCs can be efficiently taken up by SMMC-7721 cell and showed excellent antitumor efficacy against SMMC-7721 cell line. Then, As2O3-PLGA NCs could be considered as a promising formulation for the pH dependent release of As2O3 in cancer cells and enhance the anti-solid tumor effects of As2O3.