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IMpower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 103-113页

作者： Yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang Amy cai Lilian Bu Jane Shi Jinjing xia Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Respiration Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Department of Thoracic Oncology and Surgery the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Department of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Product Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab *** as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian ***: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT ***: Median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82;95% CI, 0.66-1.03]. Median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel ***: IMpower210 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.

关键词： Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody

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Machine-learning-based models assist the prediction of pulmonary embolism in autoimmune diseases: A retrospective, multicenter study

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中华医学杂志(英文版) 2024年第15期137卷 1811-1822页

作者： Hu Ziwei Hu Yangyang Zhang Shuoqi Dong Li Chen xiaoqi Yang Huiqin Su Linchong Hou xiaoqiang Huang xia Shen xiaolan Ye Cong Tu Wei Chen Yu Chen Yuxue cai Shaozhe Zhong Jixin Dong Lingli Department of Rheumatology and Immunology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Rheumatology and Immunology Jingzhou Central Hospital Yangtze University Jinzhou Hubei China Department of Rheumatology and Immunology Zhongnan Hospital Wuhan University Wuhan Hubei China Department of Rheumatology Wuhan No.Hospital Wuhan Hubei China Department of Rheumatology Minda Hospital of Hubei Minzu University Enshi Hubei China Department of Rheumatology and Immunology The First College of Clinical Medical Science China Three Gorges University Yichang Hubei China

Background: Pulmonary embolism (PE) is a severe and acute cardiovascular syndrome with high mortality among patients with autoimmune inflammatory rheumatic diseases (AIIRDs). Accurate prediction and timely intervention play a pivotal role in enhancing survival rates. However, there is a notable scarcity of practical early prediction and risk assessment systems of PE in patients with ***: In the training cohort, 60 AIIRD with PE cases and 180 age-, gender-, and disease-matched AIIRD non-PE cases were identified from 7254 AIIRD cases in Tongji Hospital from 2014 to 2022. Univariable logistic regression (LR) and least absolute shrinkage and selection operator (LASSO) were used to select the clinical features for further training with machine learning (ML) methods, including random forest (RF), support vector machines (SVM), neural network (NN), logistic regression (LR), gradient boosted decision tree (GBDT), classification and regression trees (CART), and C5.0 models. The performances of these models were subsequently validated using a multicenter validation ***: In the training cohort, 24 and 13 clinical features were selected by univariable LR and LASSO strategies, respectively. The five ML models (RF, SVM, NN, LR, and GBDT) showed promising performances, with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.962-1.000 in the training cohort and 0.969-0.999 in the validation cohort. CART and C5.0 models achieved AUCs of 0.850 and 0.932, respectively, in the training cohort. Using D-dimer as a pre-screening index, the refined C5.0 model achieved an AUC exceeding 0.948 in the training cohort and an AUC above 0.925 in the validation cohort. These results markedly outperformed the use of D-dimer levels ***: ML-based models are proven to be precise for predicting the onset of PE in patients with AIIRD exhibiting clinical suspicion of *** Registration: ***: ChiCTR2200059599.

关键词： Autoimmune inflammatory rheumatic diseases Pulmonary embolism Predictive model Machine learning

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Interaction and coordinated development between desertification control and social economy in Xizang,China

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Ecological Economy 2024年第2期20卷 160-177页

作者： ZHU cai-xia ZHENG Yu-jie LIU Si-yu QIN Tao School of Economics and Management Beijing Forestry UniversityBeijing 100083CHINA

Based on the general requirements of the coordinated development of"ecological livable"and"affluent life"in the rural revitalization strategy,the evaluation index system of desertification control was constructed,the interaction between desertification control and regional social economy and the internal space-time coordination mechanism were explored,and the quality of desertification control and its coordination degree with regional economic development were quantitatively *** decoupling mechanism of desertification governance society economy system were analyzed,and the high level for the government to promote desertification governance,constructing ecological economy coordinated development pattern to provide decision basis to Xizang desertification governance-social economic system interaction and coupling coordination development as the research object,introducing the coupling decoupling model to measure the coupling coordination model and system coordination and decoupling *** control in Xizang shows a trend of gradual improvement,but the overall level is still not high and there is a lot of room for *** coupling coordination degree of desertification control-social and economic system is in a steady fluctuation trend,rising from D value less than 0.55 in 2004 to 0.87 in 2018,in a state of coordinated development(good),and grey prediction analysis shows that D value is in a continuous *** coupling coordination degree of the six prefecture-level cities in Xizang and Ngari region is different in time and space,but the overall development trend is *** development index of desertification control and the socio-economic development index show the interaction of strong decoupling,strong negative decoupling and weak decoupling,and there are interaction effects of desertification control,economic development and social development at different scales.

关键词： desertification control coupling coordination model decoupling model economic development

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水稻-雍菜间作系统中种间关系和水稻的硅、氮营养状况

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应用生态学报 2017年第2期28卷 474-484页

作者：宁川川杨荣双蔡茂霞王建武骆世明蔡昆争华南农业大学农业部华南热带农业环境重点实验室广州510642

间作是一种优良的生态农业模式,但以水稻为主的水生作物间作研究很少.本试验以水稻和雍菜为研究对象,开展了连续两年(2014—2015年)四季的大田试验,研究水稻和雍菜间作条件下产量、种间关系以及水稻的硅、氮营养状况.试验共设置5个处理... 详细信息

间作是一种优良的生态农业模式,但以水稻为主的水生作物间作研究很少.本试验以水稻和雍菜为研究对象,开展了连续两年(2014—2015年)四季的大田试验,研究水稻和雍菜间作条件下产量、种间关系以及水稻的硅、氮营养状况.试验共设置5个处理,包括水稻单作、雍菜单作、水稻-雍菜2∶2间作、3∶2间作、4∶2间作.结果表明:水稻和雍菜间作显著增加水稻的产量,其中2∶2间作、3∶2间作和4∶2间作在单位面积上的增产幅度分别为77.5%~120.6%、64.9%~80.9%、37.7%~56.0%,但间作显著降低了雍菜的产量.从土地当量比(LER)来看,水稻和雍菜间作可增加系统的综合产量,3种间作的LER全部大于1,其中3∶2间作模式最佳.从竞争指数来看,在间作系统中,水稻比雍菜有更强的竞争能力,特别是在早季.与水稻单作相比,水稻-雍菜间作显著增加水稻叶片对硅和氮的吸收量以及成熟期水稻叶片的硅含量,但是并没有增加水稻叶片的氮含量,甚至在成熟期略低于单作;而对土壤有效硅、铵态氮和硝态氮含量没有显著影响.在整个试验期间,与水稻单作和间作相比,雍菜单作始终有最高的土壤有效硅、铵态氮和硝态氮含量.本研究表明,水稻和雍菜间作可以促进水稻对硅和氮的吸收,增加水稻的竞争能力.

关键词：水稻雍菜间作竞争指数硅氮

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避而不谈抑或巧言令色?薪酬不公平与非财务信息的薪酬辩护效应

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中央财经大学学报 2024年第6期 76-88页

作者：王雄元胡彩霞中南财经政法大学会计学院香港理工大学会计与金融学院中国

价值相关性越来越高的非财务信息是否具有薪酬辩护效应?既有文献仅在文本可读性上找到了证据。本文基于“管理层讨论与分析”(MD&A)文本,从文本相似度角度探讨非财务信息的薪酬辩护效应。研究发现:(1)存在超额薪酬时,公司会提高MD&A文... 详细信息

价值相关性越来越高的非财务信息是否具有薪酬辩护效应?既有文献仅在文本可读性上找到了证据。本文基于“管理层讨论与分析”(MD&A)文本,从文本相似度角度探讨非财务信息的薪酬辩护效应。研究发现:(1)存在超额薪酬时,公司会提高MD&A文本相似度,即公司对普遍存在的超额薪酬采取了“避而不谈”的辩护策略,而且这种策略更可能发生在业绩辩护手段匮乏的情形下,会减少风险、人力资源以及薪酬主题的信息披露。(2)但当超额薪酬较极端时,公司会降低MD&A文本相似度,“巧言令色”地为其辩护,而且这种策略更可能发生在业绩辩护手段较为有效的情形下,会增加风险、人力资源以及薪酬主题的信息披露。这些结论有助于从非财务信息文本操纵角度丰富薪酬辩护假说,以及从薪酬披露角度丰富非财务信息文本操纵的经济后果。

关键词：超额薪酬薪酬辩护文本相似度文本主题

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运动疗法在慢性疼痛中的研究进展

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中国疼痛医学杂志 2024年第4期30卷 296-301页

作者：王彩霞黄媛馨王林贵州医科大学贵阳550025 贵州医科大学附属医院疼痛科贵阳550004

随着现代化生活方式的推进,慢性疼痛愈发普遍存在。由于致痛因素的复杂性和疼痛发病机制的不明确性,治疗后仍存在无法完全缓解和远期疗效欠佳的问题,这给慢性疼痛病人造成了较大的精神压力和失控感,使其生活质量下降和社会能力退缩。研... 详细信息

随着现代化生活方式的推进,慢性疼痛愈发普遍存在。由于致痛因素的复杂性和疼痛发病机制的不明确性,治疗后仍存在无法完全缓解和远期疗效欠佳的问题,这给慢性疼痛病人造成了较大的精神压力和失控感,使其生活质量下降和社会能力退缩。研究发现,运动可以通过减少炎症发作、增强痛觉下行抑制作用以及改善不良情绪来发挥镇痛作用。因此,运动作为一种低成本、低风险、长短期疗效结合的疗法对慢性疼痛的预防和治疗具有重要意义。本文综述近年来运动疗法在慢性疼痛中的作用和运动镇痛的机制,以期为慢性疼痛病人提供运动康复的依据。

关键词：运动疗法慢性疼痛运动诱发痛觉减退

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sl_(2)上的范畴O的广义Green环

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数学学报（中文版） 2024年第4期67卷 794-806页

作者：吕彩娥沈彩霞夏利猛江苏大学数学科学学院镇江212013

假设g是复数域C上的有限维半单李代数.范畴O是一个包含了BGG范畴O的张量范畴.本文首先介绍了广义Green环的定义,然后给出了g=sl_(2)时范畴O的具体结构.最后我们给出并证明了sl_(2)的包含O的最小阿贝尔张量范畴.

关键词：张量范畴广义Green环 BGG范畴

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原料种类对黄酒产品品质影响的研究

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保鲜与加工 2018年第2期18卷 80-85,93页

作者：沈馨戴彩霞王菲朱科帆王想郭壮湖北文理学院食品科学技术学院鄂西北传统发酵食品研究所湖北襄阳441053

分别采集了籼糯米、粳糯米和大米样品各5个,在同一发酵条件下酿造黄酒,同时使用电子舌、色度仪、高效液相色谱仪和常规理化分析相结合的方法对黄酒品质进行评价分析。结果表明,通过主成分分析、典型相关分析、聚类分析和多元方差分析发... 详细信息

分别采集了籼糯米、粳糯米和大米样品各5个,在同一发酵条件下酿造黄酒,同时使用电子舌、色度仪、高效液相色谱仪和常规理化分析相结合的方法对黄酒品质进行评价分析。结果表明,通过主成分分析、典型相关分析、聚类分析和多元方差分析发现不同原料酿造黄酒滋味品质存在显著差异(P<0.05),而籼糯米和粳糯米酿造黄酒滋味较为相似。通过方差分析发现,以大米为原料酿造的黄酒其涩味、后味A(涩的回味)和L*值均显著高于籼糯米和粳糯米酿造的黄酒(P<0.05)。使用高效液相色谱法检测发现,柠檬酸和乳酸为黄酒中的主要有机酸,且籼糯米酿造的黄酒样品中酒石酸含量显著偏低。由此可见,以籼糯米和粳糯米为原料酿造的黄酒其产品品质要优于大米。

关键词：黄酒大米籼糯米粳糯米品质评价

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基于等效电路模型和数据驱动模型融合的SOC和SOH联合估计方法

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电工技术学报 2024年第10期39卷 3232-3243页

作者：刘萍李泽文蔡雨思王文夏向阳长沙理工大学电气与信息工程学院长沙410114

针对电池SOC与SOH估计结果相互影响,单独估计准确度不高的问题,该文提出了一种基于等效电路模型和数据驱动模型融合的SOC和SOH联合估计方法。通过构建考虑老化和SOC的电池二阶RC等效电路模型,采用带遗忘因子的递推最小二乘法,在不同SOC... 详细信息

针对电池SOC与SOH估计结果相互影响,单独估计准确度不高的问题,该文提出了一种基于等效电路模型和数据驱动模型融合的SOC和SOH联合估计方法。通过构建考虑老化和SOC的电池二阶RC等效电路模型,采用带遗忘因子的递推最小二乘法,在不同SOC和SOH的情况下,对电池的参数进行在线辨识,实现电池参数在线辨识与电池SOC和SOH估计的耦合。以锂离子电池自SOC=20%到恒流充电阶段结束所需时间为输入,电池SOH值为输出,训练GPR模型,实现电池SOH估计。将输出的SOH估计值与电池的额定容量相乘,得到电池的实际容量,更新二阶RC状态空间方程,采用扩展卡尔曼滤波算法对电池进行SOC估计,实现电池SOH估计和SOC估计之间的联合。采用牛津大学电池退化数据集和NASA随机使用电池数据集进行算法验证,结果表明,所提联合估计方法能够在电池的生命周期内较准确地跟随锂离子电池SOC和SOH的真实值。

关键词：锂离子电池荷电状态健康状态高斯过程回归带遗忘因子的递推最小二乘法

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Correlation between Combined Urinary Metal Exposure and Grip Strength under Three Statistical Models:A Cross-sectional Study in Rural Guangxi

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Biomedical and Environmental Sciences 2024年第1期37卷 3-18页

作者： LIANG Yu Jian RONG Jia Hui wang Xue Xiu cai Jian Sheng QIN Li Dong LIU Qiu Mei TANG Xu MO xiao Ting WEI Yan Fei LIN Yin xia HUANG Shen xiang LUO Ting Yu GOU Ruo Yu CAO Jie Jing HUANG Chu Wu LU Yu Fu QIN Jian ZHANG Zhi Yong Department of Environmental and Occupational Health School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Tumor Immunology and Microenvironmental Regulation Guilin Medical UniversityGuilin 541199GuangxiChina Department of Environmental Health and Occupational Medicine School of Public HealthGuilin Medical UniversityGuilin 541199GuangxiChina Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Key Laboratory of Environment and Health Research Guangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care Guilin Medical UniversityGuilin 541199GuangxiChina

Objective This study aimed to investigate the potential relationship between urinary metals copper(Cu),arsenic(As),strontium(Sr),barium(Ba),iron(Fe),lead(Pb)and manganese(Mn)and grip *** We used linear regression models,quantile g-computation and Bayesian kernel machine regression(BKMR)to assess the relationship between metals and grip *** In the multimetal linear regression,Cu(β=−2.119),As(β=−1.318),Sr(β=−2.480),Ba(β=0.781),Fe(β=1.130)and Mn(β=−0.404)were significantly correlated with grip strength(P<0.05).The results of the quantile g-computation showed that the risk of occurrence of grip strength reduction was−1.007(95%confidence interval:−1.362,−0.652;P<0.001)when each quartile of the mixture of the seven metals was *** kernel function regression model analysis showed that mixtures of the seven metals had a negative overall effect on grip strength,with Cu,As and Sr being negatively associated with grip strength *** the total population,potential interactions were observed between As and Mn and between Cu and Mn(P_(interactions) of 0.003 and 0.018,respectively).Conclusion In summary,this study suggests that combined exposure to metal mixtures is negatively associated with grip ***,Sr and As were negatively correlated with grip strength levels,and there were potential interactions between As and Mn and between Cu and Mn.

关键词： Urinary metals Handgrip strength Quantile g-computation Bayesian kernel machine regression

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