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Hepatitis B surface antigen clearance in inactive hepatitis B surface antigen carriers treated with peginterferon alfa-2a

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World Journal of Hepatology 2016年第15期8卷 637-643页

作者： Ming-Hui Li Yao Xie Lu Zhang Yao Lu Ge Shen Shu-Ling Wu Min Chang cai-qin mu Lei-Ping Hu Wen-Hao Hua Shu-Jing Song Shu-Feng Zhang Jun Cheng Dao-Zhen Xu Liver Disease Center Beijing Ditan Hospital Capital Medical University Clinical Test Center Beijing Ditan Hospital Capital Medical University

AIM: To examine the association between interferon(IFN) therapy and loss of hepatitis B surface antigen(HBs Ag) in inactive HBs Ag carriers. METHODS: This was a retrospective cohort study in inactive HBs Ag carriers, who were treatment-naive, with a serum HBs Ag level < 100 IU/m L and an undetectable hepatitis B virus(HBV) DNA level(< 100 IU/m L). All the 20 treated patients received subcutaneous PEG-IFN alfa-2a 180 μg/wk for 72 wk and were then followed for 24 wk. There were 40 untreated controls matched with 96 wk of observation. Serum HBs Ag, HBV DNA, and alanine aminotransferases were monitored every 3 mo in the treatment group and every 3-6 mo in the control group. RESULTS: Thirteen(65.0%) of 20 treated patients achieved HBs Ag loss, 12 of whom achieved HBs Ag seroconversion. Mean HBs Ag level in treated patients decreased to 6.69 ± 13.04 IU/m L after 24 wk of treatment from a baseline level of 26.22 ± 33.00 IU/m L. Serum HBV DNA level remained undetectable(< 100 IU/m L) in all treated patients during the study. HBs Ag level of the control group decreased from 25.72 ± 25.58 IU/m L at baseline to 17.11 ± 21.62 IU/m L at week 96(P = 0.108). In the control group, no patient experienced HBs Ag loss/seroconversion, and two(5.0%) developed HBV ***: IFN treatment results in HBs Ag loss and seroconversion in a considerable proportion of inactive HBs Ag carriers with low HBs Ag concentrations.

关键词： Chronic hepatitis B surface antigen carriers Inactive hepatitis B surface antigen carriers Interferon Peginterferon alfa-2a Hepatitis B surface antigen loss/ seroconversion

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min qin Zhongliang Li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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The Predictive Value of On-treatment Virological Response for Sustained Virological Response in Patients with Chronic Hepatitis C Receiving a Personalized Treatment Program

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国际感染病学（电子版） 2013年第2期2卷 60-70页

作者： Ming-hui Li Yao Xie Yao Lu Guo-hua Qiu Lu Zhang Ge Shen Li-wei Zhuang Ju-long Hu Jian-ping Dong cai-qin mu Lei-ping Hu Li-jun Chen Xing-hong Li Min Yang Yun-zhong Wu Hui Zhao Shu-jing Song Jun Cheng Dao-zhen Xu Liver Diseases Center Beijing Ditan HospitalCapital Medical University Department of Infectious Diseases Beijing Haidian Hospital Medical Record Library Beijing Ditan HospitalCapital Medical University Clinical Test Center Beijing Ditan HospitalCapital Medical University

To investigate the effects of individualised treatment with peginterferon alpha-2a(40 kD)plus ribavirin in Chinese patients with *** Total of 297 consecutive Chinese patients were enrolled,including 250 nave cases and 47 cases who were previously *** duration was determined according to viral genotypes,prior treatment history and viral responses at week 4,12 and *** Totally,235 patients(79.1%)completed treatment and 186(87.3%)achieved *** 219 out of 289(75.8%)patients achieved HCV RNA negative at week 4(RVR)and 259 of 276(93.8%)at week *** the 164 patients with RVR who completed follow-up,158(96.3%)achieved *** with RVR had lower baseline viral loads than patients without RVR(P=0.034).The positive predictive value(PPV)of RVR for SVR was 90.7%(OR 2.10 ***-RVR,95%CI:0.50-8.7).Similar outcomes were observed among patients with HCV undetectable at week *** Viral suppression by week 4 is associated with a high rate of treatment success in treatment nave and experienced patients receiving individualized CHC therapy.

关键词： Chronic hepatitis C Early viral kinetics Pegylated interferon Ribavirin Sustained virological response Tailored regimen

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HMFI分子筛Bronsted酸性位点与碱性分子的作用机制

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原子与分子物理学报 2025年第4期42卷 1-7页

作者：郑健秦康秦玉才宋丽娟中石化石油化工科学研究院有限公司北京100083 辽宁石油化工大学辽宁省石油化工催化科学与技术重点实验室抚顺113001

采用密度泛函理论(DFT)方法,以单铝、双铝和三铝酸性位点HMFI分子筛为模型分子筛,计算去质子化能考察HMFI分子筛的本征酸性,以NH_(3)分子作为模型分子,计算NH_(3)分子在HMFI分子筛中的吸附能与去质子化能进行关联性分析,并进一步考察NH_... 详细信息

采用密度泛函理论(DFT)方法,以单铝、双铝和三铝酸性位点HMFI分子筛为模型分子筛,计算去质子化能考察HMFI分子筛的本征酸性,以NH_(3)分子作为模型分子,计算NH_(3)分子在HMFI分子筛中的吸附能与去质子化能进行关联性分析,并进一步考察NH_(3)分子与HMFI分子筛的作用机制.研究表明分子筛Bronsted酸(简称B酸)强度与B酸数量没有强相关性,在考虑B酸位数量的同时须考虑B酸位的分布.酸性位点数量和分布的差异均可以调控NH_(3)分子的吸附构象,并且可以通过调节HMFI分子筛孔道对分子施加相互作用的模式,解析分子的结构和电子性质,精准调控分子的进一步转化.此项工作可以为未来高效多孔材料有效物种活性位的构建提供新思路.

关键词：密度泛函理论 HMFI分子筛 Bronsted酸性质吸附性能

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Constructing cactus-like mixed dimensional MOF@MOF as sorbent for extraction of bisphenols from environmental water

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Chinese Chemical Letters 2023年第12期34卷 281-286页

作者： Peige qin Shiping Zhu Mengyao mu Yanmei Gao Zongwei cai Minghua Lu Henan International Joint Laboratory of Medicinal Plants Utilization School of Chemistry and Chemical EngineeringHenan UniversityKaifeng 475004.China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China

Metal-organic frameworks(MOFs)received considerable attention to adsorption and removal of various environmental pollutants because of some inherent ***,it is challenging but meaningful to design and fabricate hierarchical mixed-dimensional MOFs with synergistic effects to enhance the performance for removal and preconcentration of environmental ***,a new hierarchical two-dimensional(2D)-three-dimensional(3D)mixed-dimensional cactus-like MOF@MOF hybrid material(PCN-134@Zr-BTB)was prepared by in-situ growth of 2D MOF nanosheets(Zr-BTB)on the surface of 3D MOF(PCN-134).The PCN-134@Zr-BTB composites combine the advantages of 2D and 3D MOFs with extensive mesoporous structures and large surface area for effective removal and enrichment of bisphenols(BPs).In comparison with pristine PCN-134 and Zr-BTB materials,the PCN-134@Zr-BTB hybrid material presented excellent adsorption performance for *** adsorption isotherms are consistent with the Langmuir model,and the maximum adsorption capacity of four bisphenols(BPs)ranged from 135.1 mg/g to 628.9 mg/*** adsorption kinetics are in accordance with the pseudo-second-order *** recoveries ranged from 72.8%to 108%.The limits of detection were calculated at 0.02-0.03 ng/*** enrichment factors were calculated in the range of *** to FT-IR and XPS analysis,the main adsorption mechanisms are hydrogen bonding and π-π ***,this work provides a new and convenient strategy for the preparation of new hierarchical mixed-dimensional MOF@MOF(PCN-134@Zr-BTB)hybrid material for extraction and enrichment of BPs from aqueous matrix.

关键词： PCN-134@Zr-BTB composite Metal-organic frameworks(MOFs) Mixed-dimensional Dispersive solid-phase extraction Endocrine disrupting compounds(EDCs) High-performance liquid chromatography

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Pore-scale modeling of pore structure properties and wettability effect on permeability of low-rank coal

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International Journal of Mining Science and Technology 2023年第5期33卷 573-584页

作者： Xiangjie qin Jianchao cai Gang Wang State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China State Key Laboratory of Mining Disaster Prevention and Control Cofounded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and TechnologyQingdao 266590China

Permeability is a key parameter for coalbed methane *** the absolute permeability of coal has been extensively studied,wettability and pore structure properties continue to challenge the microscopic description of water-gas flow in *** this purpose,we reconstructed the microstructures of low-rank coal using micro-computed tomography(micro-CT)*** geometry and pore-throat parameters are introduced to establish a relationship with absolute permeability.A dual-porosity pore network model is developed to study water-gas displacement under different wetting and pore structure *** show that absolute permeability is significantly affected by pore geometry and can be described using a binary quadratic function of porosity and fractal ***-gas relative permeability varies significantly and the residual gas saturation is lower;the crossover saturation first decreased and then increased with increasing porosity under hydrophobic *** the water relative permeability is lower and a certain amount of gas is trapped in complex pore-throat networks;the crossover saturation is higher under hydrophilic *** with large percolating porosity and well-developed pore networks have high displacement efficiency due to low capillary resistance and avoidance of *** work provides a systematic description of absolute permeability and water-gas relative permeability in coal microstructure for enhanced gas recovery.

关键词： Micro-CT Permeability Wetting condition Pore structure properties Water-gas flow

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Magnetic resonance imaging focused on the ferritin heavy chain 1 reporter gene detects neuronal differentiation in stem cells

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Neural Regeneration Research 2023年第7期18卷 1563-1569页

作者： Xiao-Ya He Yi-Rui Zhou Tong mu Yi-Fan Liao Li Jiang Yong qin Jin-Hua cai Department of Radiology Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqingChina Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Nuclear Medicine The Second Hospital of the Army Medical UniversityChongqingChina Department of Neurology Children’s Hospital of Chongqing Medical UniversityChongqingChina

The neuronal differentiation of mesenchymal stem cells offers a new strategy for the treatment of neurological ***,there is a need to identify a noninvasive and sensitive in vivo imaging approach for real-time monitoring of transplanted stem *** previous study confirmed that magnetic resonance imaging,with a focus on the ferritin heavy chain 1 reporter gene,could track the proliferation and differentiation of bone marrow mesenchymal stem cells that had been transduced with lentivirus carrying the ferritin heavy chain 1 reporter ***,we could not determine whether or when bone marrow mesenchymal stem cells had undergone neuronal differentiation based on changes in the magnetic resonance imaging *** solve this problem,we identified a neuron-specific enolase that can be differentially expressed before and after neuronal differentiation in stem *** this study,we successfully constructed a lentivirus carrying the neuron-specific enolase promoter and expressing the ferritin heavy chain 1 reporter gene;we used this lentivirus to transduce bone marrow mesenchymal stem *** and animal studies showed that the neuron-specific enolase promoter effectively drove the expression of ferritin heavy chain 1 after neuronal differentiation of bone marrow mesenchymal stem cells;this led to intracellular accumulation of iron and corresponding changes in the magnetic resonance imaging *** summary,we established an innovative magnetic resonance imaging approach focused on the induction of reporter gene expression by a neuron-specific *** imaging method can be used to noninvasively and sensitively detect neuronal differentiation in stem cells,which may be useful in stem cell-based therapies.

关键词： ferric ammonium citrate ferritin heavy chain 1 gene magnetic resonance imaging mesenchymal stem cells molecular imaging neuronal differentiation neuron-like cells neurons neuron-specific enolase promoter

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High-Order Discontinuous Galerkin Solution of Compressible Flows with a Hybrid Lattice Boltzmann Flux

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第3期35卷 413-422页

作者： Sun Yongcheng cai Junwei qin Wanglong The 28th Research Institute of China Electronics Technology Group Corporation Nanjing 210007P.R.China

A discontinuous Galerkin(DG)-based lattice Boltzmann method is employed to solve the Euler and Navier-Stokes *** of adopting the widely used local Lax-Friedrichs flux and Roe Flux etc.,a hybrid lattice Boltzmann flux solver(LBFS)is employed to evaluate the inviscid flux across the cell *** main advantage of the hybrid LBFS is its flexibility for capturing both strong shocks and thin boundary layers through introducing a function which varies from zero to one to control the artificial *** results indicate that the hybrid lattice Boltzmann flux solver behaves very well combining with the high-order DG method when simulating both inviscid and viscous flows.

关键词： hybrid lattice Boltzmann flux solver discontinuous Galerkin(DG)method Euler equations Navier-Stokes equations

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Virtual Coupling Trains Based on multi-Agent System Under Communication Delay

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Chinese Journal of Electronics 2024年第6期33卷 1545-1554页

作者： Guodong qin Xiangxi MENG Tao WEN Baigen cai School of Automation and Intelligence Beijing Jiaotong University The Institute of System Research China Industrial Control Systems Cyber Emergency Response Team

With the rapid development of railway transportation, virtual coupling(VC) has become a popular research topic. VC can greatly reduce tracking distance and increase the line capacity. Under VC control, the train formation control not only considers the behavior and speed adjustment strategy of the leader train but also the communication delays between trains. The quality of data communication between trains is an important aspect of train tracking control. We consider a virtually coupled train set(VCTS) as a multi-agent system. The Luenberger observer is introduced to estimate the real-time state of the train, based on the estimation, the train control consistency protocol is designed to account for communication delays. The stability of the error system is proven by constructing a Lyapunov function. The consistency of the coordinated train control is verified through simulation.

关键词： Couplings Protocols Transportation Observers Stability analysis Real-time systems Formation control Delays multi-agent systems Lyapunov methods

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Output formation tracking for networked systems with limited energy and aperiodic silence

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Chinese Journal of Aeronautics 2022年第7期35卷 274-288页

作者： Jin JIN Junlong LI Donghao qin Ning cai School of Electrical Engineering Northwest Minzu UniversityLanzhou 730030China Key Laboratory of China’s Ethnic Languages and Information Technology for Ministry of Education Northwest Minzu UniversityLanzhou 730000China School of Missile Engineering Rocket Force University of EngineeringXi’an 710025China School of Artificial Intelligent Beijing University of Posts and TelecommunicationsBeijing 100876China

For leader-following networked systems with the topology switching and the aperiodic silence,limited-energy output formation tracking problems are ***,a new output formation tracking control protocol is proposed,which contains two components associated with the communication interactions between the leader and tracking intelligent agents and the communication interactions among tracking intelligent agents,respectively,and the aperiodic silence,the topology switching and the energy constraint index is introduced ***,a two-step transformation method is presented to separate the whole dynamics of a networked system into the relative dynamics between the leader and tracking intelligent agents and the dynamics of the leader,and sufficient conditions for limited-energy output formation tracking for networked systems with limited energy and aperiodic silence are presented,which are extended into networked systems without the aperiodic ***,a partition checking algorithm is presented to check limitedenergy output formation tracking design ***,a numerical example is illustrated to demonstrate the validness of theoretical results.

关键词： Energy calculations Formation Intermittent working Networked control system Tracking

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