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Jianqu,a traditional Chinese medicine,alleviates functional dyspepsia in high-calorie and high-protein diet mice

Traditional Medicine Research 2024年第6期9卷 42-54页

作者： Jing-Yan yang xiao-Xing Li Juan Chen Yan-Jun Liu Yue-Hong Wu Ning-Yu Luo cai-xia yang yang Li Si-Jing Liu Jin-Lin Guo College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137China Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chengdu 611137China Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China College of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China

Background:Jianqu has been used to alleviate symptoms in patients with functional dyspepsia,but its specific anti-functional dyspepsia effect is still ***,our study aimed to investigate the impact of Jianqu on functional dyspepsia in ***:The phytochemical profile of Jianqu was analyzed by ***,Kunming mice were fed a high-calorie or high-protein diet(HCHP)for 7 days,and then orally treated with vehicle or Jianqu(1.62 g/kg body weight(b.w.)and 3.25 g/kg b.w.)for 10 days.A carbon powder solution was used to detect the gastric emptying and intestinal transit *** pathological changes in stomach and duodenum were evaluated by hematoxylin-eosin *** occludin,claudin-1,ZO-1 and CD45 expression was measured by immunocytochemical ***,the serum gastrointestinal hormones were detected by *** addition,the gut microbiota composition was determined using 16S rRNA gene *** cecal short chain fatty acids were assessed by gas ***:In general,17 phytochemical compounds were identified from Jianqu,which significantly improved the gastric emptying rate and intestinal transit rate(p<0.01),increased the body weight and food intake(p<0.0001)in HCHP mice as *** HCHP did not cause significant pathological lesions in the gastrointestinal tract,increased the expression of CD45 in the duodenum(p<0.05)was ***,Jianqu attenuated this abnormal expression of CD45(p<0.05).The levels of serum gastrointestinal hormones were significantly normalized by Jianqu intervention(p<0.05).Moreover,Jianqu increased the relative abundance of Roseburia as well as short chain fatty acids levels in cecum(p<0.05).Conclusion:The present results showed that Jianqu alleviated dyspeptic symptoms in HCHP mice possibly through reducing the duodenal leukocyte infiltration,and regulating the expression of gastrointestinal *** effects may be partly related to the increasing cecal short ch

关键词： herbal formula dyspepsia gastrointestinal hormones gastric emptying intestinal transit

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Research on Evaluating the Efficiency of the Project Financing of the Energy Service Company

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Frontiers of Engineering Management 2016年第3期3卷 252-257页

作者： Bao-zhen Zhang Han-ding Guo cai-xia yang Lei Wang School of Economics & Management Tianjin Chengjian University Tianjin Institute China Academy of Building Research

The financing efficiency evaluation of the ESCO(Energy Service Company) is an important approach to improve the operation efficiency of existing building energy-saving projects. To scientifically and reasonably evaluate the financing efficiency of the ESCO,this paper puts forward a combination evaluation model based on the method set. Firstly, the method set is composed of different methods that meet the demand of statistical coherence, and KENALL-W coefficient test of concordance is used to check up the coherence of the ranking results of the different methods. Secondly, mean,Borda and Copeland are used separately for calculating the combination evaluation results and the circular combination method is used to ensure the coherence of evaluation results. Finally, the combination evaluation model is used to evaluate the 10 ESCO business project financing benefits, and the effectiveness of the models is verified accordingly.

关键词： ESCO project financing financing efficiency method set combination evaluation

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Association of stent thrombectomy and conventional treatment with neuroprotection, complications, anxiety, and depression in acute ischemic stroke patients

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World Journal of Psychiatry 2025年第1期15卷 72-82页

作者： Kai-Jie yang Jia-Jian Huang cai-xia Xuan Department of Neurology Qinzhou Second People's HospitalQinzhou 535000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Acute ischemic stroke(AIS)is an abrupt blood flow cessation to a specific brain region within a vascular zone,causing a subsequent decline in neurological *** thrombectomy is a recently established technique for treating *** provides the benefits of being a relatively simple and safe procedure,capable of partially enhancing a patient’s ***,some patients may experience endothelial damage and recurrent thrombosis,with clinical outcomes that are not always ***,the efficacy of this method remains *** To survey the association of stent thrombectomy vs standard treatment with neurological function protection,complications,and short-term prognosis in patients diagnosed with *** This study assigned 90 patients with AIS to the observation and control groups(n=45 patients)from December 2020 to December *** thrombectomy was conducted in the observation group,whereas routine treatment was provided to the control *** study assessed the therapeutic outcomes of two groups,including a comparison of their neurological function,living ability,anxiety and depression status,plaque area,serum inflammatory factors,serum Smur100βprotein,neuron-specific enolase(NSE),homocysteine(Hcy),and vascular endo-thelial ***,the incidence of complications was calculated and analyzed for each *** The total effective rate of treatment was 77.78%and 95.56%in the control and observation groups,*** 8 weeks of treatment,the scores on the National Institutes of Health Stroke Scale,Hamilton Anxiety Scale,and Hamilton Depression Scale decreased remarkably;the Barthel index increased remarkably,with better improvement effects of the scores in the observation group(P<0.05);total cholesterol,triglyceride,C-reactive protein,and plaque area lessened remarkably,with fewer patients in the observation group(P<0.05);S-100βprotein,NSE,and Hcy levels lessened remarkably,with fewer patients in

关键词： Stent thrombectomy Acute ischemic stroke Neurological function Complications Short-term prognosis

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Vitamin C promotes meiotic maturation and developmental competence of porcine oocytes through epigenetic modifications

Vitamin C promotes meiotic maturation and developmental comp...

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中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： xiao-xia Yu Yun-Hua Liu xiao-Man Liu Pei-Chao Wang Zhi-Qiang Du cai-xia yang College of Animal Science and Technology Northeast Agricultural University

Vitamin C(L-ascorbic acid;VC) plays an important role in many biological processes,through donating electrons to act as a potent water-soluble anti-oxidant and acting as a cofactor for the family of Fe(ll) 2-oxoglutarate dependent *** catalyze the demethylation of5-methylcytosine(5 mC) in DNA,N-methyladenosine(m A) in RNA and lysine residues in histone proteins,and thereby dynamically regulate epigenetic modification of local chromatin and RNA structures,including ten-eleven-translocation 1-3(Tet1-3) enzymes,fat mass and obesity-associated(Fto),AlkB homologue 5(Alkbh5) AlkB enzymes,and Jumonji C-domain-containing *** studies demonstrated that VC supplement during in vitro maturation enhances cytoplasmic maturation and developmental competence of porcine oocytes derived from cumulus-oocyte complexes(COCs),however,the underlying molecular mechanism remains *** the present study,we reported that addition of one derivative of VC,250μM magnesium ascorbyl phosphate(AA2 P),greatly enhanced the nuclear maturation(as indicated by higher rate of first polar body extrusion and increased mRNA level of Bmpl5),cytoplasmic maturation(reduced reactive oxygen species level) and developmental potency(higher cleavage and blastotocyst rates of parthenotes and decreased mRNA levels of Bax and Caspase3) of pig oocytes derived from COCs after 44 h in vitro *** found that 250 u.M AA2 P supplementation in maturation culture of porcine COCs induced dynamic erasure of 5 mC,m A and H3 K27 me3,but establishment of H3 K4 me3 and K3 K36 me3 in mature porcine *** then found that 250 u.M AA2 P could decrease mRNA and protein abundances of DNMT3 a,but increase levels of ***,we showed that mRNA abundance of HIF-1 alpha,HIF-2 alpha,TET3,METTL14,KDM5 b and EED were suppressed by 250μM AA2 P treatment,while elevating DNMT3 b to a higher level in mature *** findings show VC can regulate epigenetic maturation of oocytes,and thus

关键词： Oocytes Pig Vitamin C Maturation Embryo development

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Single Oocyte Transcriptome Sequencing Reveals Essential role of CDC5L for Maturation and Development Competence of Pig Oocytes

Single Oocyte Transcriptome Sequencing Reveals Essential rol...

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作者： xiao-Man Liu Yan-Kui Wang Yun-Hua Liu xiao-xia Yu Pei-Chao Wang Xuan Li Zhi-Qiang Du cai-xia yang Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province

Oocytes with better quality and development competence are highly demanded in both basic biological research and assisted reproduction *** brilliant cresyl blue(BCB) staining test is able to discern oocytes with better maturation and developmental competence in different mammalian ***,the underlying molecular mechanism remains *** the present study,we first confirmed that compared to BCB-negative oocytes,BCB-positive oocytes had higher rates of meiotic maturation,cleavage and blastocyst rates of parthenotes,but lower death rate,indicating the BCB staining could be used to select porcine immature oocytes with better potential for meiotic maturation and subsequent ***,using single oocyte RNA-seq technique,we profiled transcriptome of immature porcine oocytes positively and negatively stained by the BCB test,and identified significant abundance differences of 155 genes,including CDC5 L,LDHA,SPATA22,RGS2,PAIP1,WEE1 B and *** enrichment analysis on these differential expressed genes found functionally important signaling pathways,such as cell cycle,oocyte meiosis,spliceosome,and nucleotide excision repair *** of γH2 A.X validated more frequent occurrence of DNA double stand breaks in BCB-negative porcine GV *** blots validated CDC5 L protein level was significantly higher in BCB-positive GV *** of CDC5 L protein using antibody microinjection into oocytes indicated that CDC5 L is vital for porcine oocyte meiosis and early embryo *** investigations are still needed to study the molecular roles of identified genes and pathways in the regulation of oocyte meiotic maturation and developmental competence.

关键词： Oocytes Pig Brilliant cresyl blue Maturation Embryo development CDC5L Metabolic control

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恶性肿瘤患者化疗相关HBV再激活的防治进展

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世界华人消化杂志 2016年第7期24卷 1048-1053页

作者：杨彩霞赖维菊唐映梅昆明医科大学第二附属医院肝胆胰内科云南省肝病研究中心云南省昆明市650033

合并乙型肝炎病毒(hepatitis B virus,HBV)感染的恶性肿瘤患者接受化疗后HBV再激活的发生率较高,HBV再激活是致命性的,因此认识HBV再激活现象并了解其防治原则非常重要.目前对HBV再激活的相关研究很多,但数据分散,本文就合并HBV感染的... 详细信息

合并乙型肝炎病毒(hepatitis B virus,HBV)感染的恶性肿瘤患者接受化疗后HBV再激活的发生率较高,HBV再激活是致命性的,因此认识HBV再激活现象并了解其防治原则非常重要.目前对HBV再激活的相关研究很多,但数据分散,本文就合并HBV感染的恶性肿瘤患者接受化疗相关HBV再激活的预防和治疗进展作一综述,旨在对恶性肿瘤患者在化疗之前进行常规筛查及治疗,有效避免HBV再激活的发生,提高患者生存质量.

关键词：化学药物治疗乙型肝炎病毒再激活预防治疗

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Effect of CTNNAL1 on Human Bronchial Epithelial Cells Proliferation

Effect of CTNNAL1 on Human Bronchial Epithelial Cells Prolif...

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传承与发展，创湖南省生理科学事业的新高——湖南省生理科学会2011年度学术年会

作者： cai-xia Liu,yang xiang,Ying Liu,Hui-Jun Liu,and xiao-Qun Qin(xiangya School of Medicine,Central South University,Changsha 410078,Hunan,PR China)

Objective Our previous study indicated an alpha-catenin-related protein,catenin alpha-like 1(CTNNAL1)was downregulated in asthma patients and animal *** vitro experiments found that CTNNAL1 expression was explicitlyincreased on the cells in wound edges,which indicating that CTNNAL1 might involved in growth *** aim of this study is exploring the effect

关键词： CTNNAL1,human bronchial epithelian cells,proliferation,asthma

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利用SF_6分解产物及气相色谱分析断路器故障

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电气开关 2017年第3期55卷 95-97,108页

作者：吴彩霞杨震洋广东电网公司珠海供电局广东珠海519000

目前SF_6气体分解物检测在电气设备故障分析中应用比较广泛,而由于新气中含有一定量的CF4含量,所以分析重点一般集中于H_2S、SO_2、HF、SO_2F_2等几种特征气体组分含量。本文将SF_6分解物测试与气相色谱分析相结合的方法应用于一起110kV... 详细信息

目前SF_6气体分解物检测在电气设备故障分析中应用比较广泛,而由于新气中含有一定量的CF4含量,所以分析重点一般集中于H_2S、SO_2、HF、SO_2F_2等几种特征气体组分含量。本文将SF_6分解物测试与气相色谱分析相结合的方法应用于一起110kV SF_6气体断路器的故障诊断,结果表明除了对SF_6气体中SO_2、H_2S及HF等特征气体测试外,增加对CF_4含量组分的分析,可判断SF_6断路器内部固体绝缘情况,可确诊传统电气手段、单一分析分解产物不能发现的设备缺陷,确保设备安全运行。

关键词： SF6断路器分解物四氟化碳故障诊断

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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A locking-free anisotropic nonconforming rectangular finite element approximation for the planar elasticity problem

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Applied Mathematics(A Journal of Chinese Universities) 2008年第1期23卷 9-18页

作者： SHI Dong-yang WANG cai-xia Dept. of Math. Zhengzhou Univ. Zhengzhou 450052 China. Faculty of Math. and Inform. Sci. North China Univ. of Water Conservancy and Electric PowerZhengzhou 450011 China.

This paper deals with a new nonconforming anisotropic rectangular finite element approximation for the planar elasticity problem with pure displacement boundary condition. By use of the special properties of this element, and by introducing the complementary space and a series of novel techniques, the optimal error estimates of the energy norm and the L^2-norm are obtained. The restrictions of regularity assumption and quasi-uniform assumption or the inverse assumption on the meshes required in the conventional finite element methods analysis are to be got rid of and the applicable scope of the nonconforming finite elements is extended.

关键词： anisotropic mesh locking-free nonconforming finite element optimal error estimate complementary space.

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