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Stability of rat models of fluid percussion-induced traumatic brain injury: comparison of three different impact forces

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Neural Regeneration Research 2015年第7期10卷 1088-1094页

作者： Yun-peng Lin rong-cai jiang Jian-ning Zhang Department of Neurosurgery Tianjin Medical University General Hospital Tianjin Neurological Institute Key Laboratory of Post-trauma Neurorepair and Regeneration in Central Nervous System Ministry of Education Tianjin Key Laboratory of Injuries Variations and Regeneration of Nervous System Tianjin Medical University General Hospital

Fluid percussion-induced traumatic brain injury models have been widely used in experimental research for years. In an experiment, the stability of impaction is inevitably affected by factors such as the appearance of liquid spikes. Management of impact pressure is a crucial factor that determines the stability of these models, and direction of impact control is another basic element. To improve experimental stability, we calculated a pressure curve by generating repeated impacts using a fluid percussion device at different pendulum angles. A stereotactic frame was used to control the direction of impact. We produced stable and reproducible models, including mild, moderate, and severe traumatic brain injury, using the MODEL01-B device at pendulum angles of 6°, 11° and 13°, with corresponding impact force values of 1.0 ± 0.11 atm（101.32 ± 11.16 k Pa）, 2.6 ± 0.16 atm（263.44 ± 16.21 k Pa）, and 3.6 ± 0.16 atm（364.77 ± 16.21 k Pa）, respectively. Behavioral tests, hematoxylin-eosin staining, and magnetic resonance imaging revealed that models for different degrees of injury were consistent with the clinical properties of mild, moderate, and severe craniocerebral injuries. Using this method, we established fluid percussion models for different degrees of injury and stabilized pathological features based on precise power and direction control.

关键词： nerve regeneration traumatic brain injury fluid percussion impact force pressure curve head fixed impact peak animal models neural regeneration

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复合地层盾构机连续下穿高架桥梁施工技术研究

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建筑技术 2024年第8期55卷 950-954页

作者：梁宇李生光李森蔡荣江张恒北京建工土木工程有限公司北京100015 北京建工集团有限责任公司北京100055

以南京地铁某区间连续侧穿、下穿高架桥和高架桥路基段为基础,建立高架桥及周边土体的三维数值模型,在不同的施工参数下对盾构机下穿风险源期间情况进行模拟,根据模拟结果对施工进行指导,并将施工过程中的监测情况和数值模拟情况进行对... 详细信息

以南京地铁某区间连续侧穿、下穿高架桥和高架桥路基段为基础,建立高架桥及周边土体的三维数值模型,在不同的施工参数下对盾构机下穿风险源期间情况进行模拟,根据模拟结果对施工进行指导,并将施工过程中的监测情况和数值模拟情况进行对比、分析,验证数值模拟结果的可靠性。施工过程中盾构机优化掘进参数,隧道内部进行二次注浆和深孔注浆可以有效减小桥梁及路面的变形量,并降低桥桩之间的差异沉降值;通过合理设置盾构施工参数可将桥梁及路面的变形控制在允许范围之内,减小桥梁及路面的变形量,为类似工程提供参考依据和经验。

关键词：复合地层盾构机高架桥掘进参数

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Primordial black holes and curvature perturbations from false vacuum islands

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 58-72页

作者： rong-Gen cai Yu-Shi Hao Shao-jiang Wang School of Physical Science and Technology Ningbo UniversityNingbo 315211China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Asia Pacific Center for Theoretical Physics Pohang 37673Republic of Korea

Recently,much attention has been focused on the false vacuum islands that are flooded by an expanding ocean of true-vacuum bubbles slightly later than most of the other parts of the *** delayed decay regions will accumulate locally larger vacuum energy density by staying in the false vacuum longer than those already transited into the true vacuum.A false vacuum island with thus acquired density contrast of a super-horizon size will evolve locally from radiation dominance to vacuum dominance,creating a local baby Universe that can be regarded effectively as a local closed *** such density contrasts of super-horizon sizes can ever grow large enough to exceed the threshold of gravitational collapse,primordial black holes will form similar to those collapsing curvature perturbations on super-horizon scales induced by small-scale enhancements during *** not,such density contrasts can still induce curvature perturbations potentially observable *** this paper,we revisit and elaborate on the generations of primordial black holes and curvature perturbations from delayed-decayed false vacuum islands during asynchronous first-order phase transitions with fitting formulas convenient for future model-independent studies.

关键词： first-order phase transitions primordial black holes curvature perturbations

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Highly Soluble Polyimides Containing Di-tert-butylbenzene and Dimethyl Groups with Good Gas Separation Properties and Optical Transparency

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Chinese Journal of Polymer Science 2020年第7期38卷 759-768,I0007页

作者： Chen-Yi Wang cai-rong jiang Bin Yu Xiao-Yan Zhao Zhao-Liang Cui Jian Li Qiang Ren jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering Jiangsu Key Laboratory of Environmentally Friendly Polymeric MaterialsSchool of Materials Science and EngineeringChangzhou UniversityChangzhou 213164China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China

A rigid aromatic diamine monomer containing di-tert-butylbenzene and dimethyl groups,3,3'-dimethyl-4,4'-diaminophenyl-3",5"-di-tert-butyltoluene,was successfully synthesized by a simple coupling reaction using 3,5-di-tert-butylbenzaldehyde and o-toluidine as starting materials.A series of novel polyimides(PI 3a-3c)with large pendant groups were prepared with the obtained diamine monomer and three different commercial aromatic dianhydrides(3,3',4,4'-biphenyltetracarboxylic dianhydride,4,4'-oxydiphthalic anhydride,and 4,4'-(hexafluoroisopropylidene)diphthalic anhydride)by one-step high temperature *** prepared polyimides exhibited high solubility and good membrane forming ability:they could be dissolved not only in some high boiling solvents such as DMF,NMP,DMAc,and m-Cresol at room temperature,but also in some low boiling solvents such as CHCl3,CH2Cl2,and *** solubility in most solvents could exceed 10 wt%,and the flexible membranes could be obtained by casting their *** prepared membranes exhibited good gas separation *** permeability coefficients of PI 3c for CO2 and O2 were up to 124.6 and 42.8 barrer,respectively,and the selectivity coefficients for CO2/CH4 and O2/N2 were 14.7 and 3.3,*** membranes had light color and good optical *** optical transmittance at 450 nm wavelength was in the range of 67%-79%,and the cutoff wavelength was in the range of 310-348 *** also had good thermal properties with glass transition temperature(Tg)values in the range of 264-302℃.In addition,these membranes possessed good mechanical properties with tensile strength ranging between 77.8-87.4 MPa,initial modulus ranging between 1.69-1.82 GPa,and elongation at break ranging between 4.8%-6.1%.

关键词： Polyimides Di-tert-butyltoluene Gas separation performance Optical transparency

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Risk factors for corticosteroid insufficiency during the sub-acute phase of acute traumatic brain injury

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Neural Regeneration Research 2020年第7期15卷 1259-1265页

作者： Xin Chen Yan Chai Shao-Bo Wang Jia-Chong Wang Shu-Yuan Yue rong-cai jiang Jian-Ning Zhang Department of Neurosurgery General Hospital of Tianjin Medical UniversityTianjinChina Tianjin Neurological Institute Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous SystemTianjinChina Department of Neurosurgery Ordos Central HospitalOrdosInnerMongolia Autonomous RegionChina Department of Neurosurgery Affiliated Haikou Hospital of Xiangya Medical CollegeCentral South UniversityChangshaHunan ProvinceChina

Hypothalamic-pituitary-adrenal axis dysfunction may lead to the occurrence of critical illness-related corticosteroid *** illness-related corticosteroid insufficiency can easily occur after traumatic brain injury,but few studies have examined this occurrence.A multicenter,prospective,cohort study was performed to evaluate the function of the hypothalamic-pituitary-adrenal axis and the incidence of critical illness-related corticosteroid insufficiency during the sub-acute phase of traumatic brain *** hundred and forty patients with acute traumatic brain injury were enrolled from the neurosurgical departments of three tertiary-level hospitals in China,and the critical illness-related corticosteroid insufficiency incidence,critical-illness-related corticosteroid insufficiency-related risk factors,complications,and 28-day mortality among these patients was *** illness-related corticosteroid insufficiency was diagnosed in patients with plasma total cortisol levels less than 10μg/dL(275.9 nM)on post-injury day 4 or when serum cortisol was insufficiently suppressed(less than 50%)during a dexamethasone suppression test on post-injury day *** results demonstrated that critical illness-related corticosteroid insufficiency occurred during the sub-acute phase of traumatic brain injury in 5.6%of patients with mild injury,22.5%of patients with moderate injury,and 52.2%of patients with severe *** brain injury-induced critical illness-related corticosteroid insufficiency was strongly correlated to injury severity during the sub-acute stage of traumatic brain *** brain injury patients with critical illness-related corticosteroid insufficiency frequently presented with hemorrhagic cerebral contusions,diffuse axonal injury,brain herniation,and *** in the incidence of hospital-acquired pneumonia,gastrointestinal bleeding,and 28-day mortality were observed between patients with and without critical i

关键词： brain herniation corticosteroid critical illness-related corticosteroid dexamethasone suppression test diffuse axonal injury gastrointestinal bleeding hemorrhagic cerebral contusions hospital-acquired pneumonia insufficiency prognosis traumatic brain injury

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Atorvastatin combined with low-dose dexamethasone for vascular endothelial cell dysfunction induced by chronic subdural hematoma

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Neural Regeneration Research 2021年第3期16卷 523-530页

作者： Yue-Shan Fan Bo Wang Dong Wang Xin Xu Chuang Gao Ying Li Shu Zhang Gui-Li Yang Xiao Liu rong-cai jiang Jian-Ning Zhang Department of Neurosurgery General Hospital of Tianjin Medical UniversityTianjinChina Tianjin Neurological Institute Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Graduate School Tianjin Medical UniversityTianjinChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Atorvastatin has been shown to be a safe and effective non-surgical treatment option for patients with chronic subdural ***,treatment with atorvastatin is not effective in some patients,who must undergo further surgical *** has anti-inflammatory and immunomodulatory effects,and low dosages are safe and effective for the treatment of many diseases,such as ankylosing spondylitis and community-acquired ***,the effects of atorvastatin and low-dose dexamethasone for the treatment of chronic subdural hematoma remain poorly *** samples of patients with chronic subdural hematoma admitted to the General Hospital of Tianjin Medical University of China were collected and diluted in endothelial cell medium at 1:1 as the hematoma ***,dexamethasone,or their combination was added to the culture *** main results were as follows:hopping probe ion conductance microscopy and permeability detection revealed that the best dosages to improve endothelial cell permeability were 0.1μM atorvastatin and 0.1μM ***,dexamethasone,or their combination could markedly improve the recovery of injured endothelial *** subcutaneously injected with diluted hematoma solution and then treated with atorvastatin,dexamethasone,or their combination exhibited varying levels of rescue of endothelial cell *** probe ion conductance microscopy,western blot assay,and polymerase chain reaction to evaluate the status of human cerebral endothelial cell status and expression level of tight junction protein indicated that atorvastatin,dexamethasone,or their combination could reduce subcutaneous vascular leakage caused by hematoma ***,the curative effect of the combined treatment was significantly better than that of either single *** of Krüppel-like factor 2 protein in human cerebral endothelial cells was significantly increased,as was expression of the tight junctio

关键词： brain brain trauma cells central nervous system inflammation plasticity protein repair

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Differences in pathological changes between two rat models of severe traumatic brain injury

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Neural Regeneration Research 2019年第10期14卷 1796-1804页

作者： Yi-Ming Song Yu Qian Wan-Qiang Su Xuan-Hui Liu Jin-Hao Huang Zhi-Tao Gong Hong-Liang Luo Chuang Gao rong-cai jiang Department of Neurosurgery General HospitalTianjin Medical UniversityTianjinChina Key Laboratory of Injuries Variations and Regeneration of Nervous SystemTianjin Neurological InstituteTianjinChina

The rat high-impact free weight drop model mimics the diffuse axonal injury caused by severe traumatic brain injury in humans,while severe controlled cortical impact can produce a severe traumatic brain injury model using precise strike *** this study,we compare the pathological mechanisms and pathological changes between two rat severe brain injury models to identify the similarities and *** severe controlled cortical impact model was produced by an electronic controlled cortical impact device,while the severe free weight drop model was produced by dropping a 500 g free weight from a height of 1.8 m through a plastic *** temperature and mortality were recorded,and neurological deficits were assessed with the modified neurological severity *** edema and bloodbrain barrier damage were evaluated by assessing brain water content and Evans blue *** addition,a cytokine array kit was used to detect inflammatory *** apoptosis in the brain and brainstem was quantified by immunofluorescence *** the severe controlled cortical impact and severe free weight drop models exhibited significant neurological impairments and body temperature *** severe motor dysfunction was observed in the severe controlled cortical impact model,while more severe cognitive dysfunction was observed in the severe free weight drop *** edema,inflammatory cytokine changes and cortical neuronal apoptosis were more substantial and blood-brain barrier damage was more focal in the severe controlled cortical impact group compared with the severe free weight drop *** severe free weight drop model presented with more significant apoptosis in the brainstem and diffused blood-brain barrier damage,with higher mortality and lower repeatability compared with the severe controlled cortical impact *** brainstem damage was not found in the severe controlled cortical impact *** results indicate that the

关键词： nerve regeneration severe traumatic brain injury animal model comparison free weight drop controlled cortical impact neurological impairment neuroinflammation blood-brain barrier damage neuronal apoptosis diffuse axonal injury brainstem injury neural regeneration

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Decreased numbers of circulating endothelial progenitor cells are associated with hyperglycemia in patients with traumatic brain injury

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Neural Regeneration Research 2019年第6期14卷 984-990页

作者： Hui-Jie Wei Li Liu Fang-Lian Chen Dong Wang Liang Wang Zeng-Guang Wang rong-cai jiang Jing-Fei Dong Jie-Li Chen Jian-Ning Zhang Department of Neurosurgery Tianjin Medical University General HospitalTianjin Neurological InstituteKey Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous System Department of Neurosurgery Peking University International Hospital Thrombosis Research Section Department of MedicineBaylor College of Medicine Department of Neurology Henry Ford Health System

Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their ***, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients with traumatic brain injury is unclear. In this study, 101 traumatic brain injury patients admitted to the Department of Neurosurgery, Tianjin Medical University General Hospital or the Department of Neurosurgery, Tianjin Huanhu Hospital, China, were enrolled from April 2005 to March 2007. The number of circulating endothelial progenitor cells and blood glucose levels were measured at 1, 4, 7, 14 and 21 days after traumatic brain injury by flow cytometry and automatic biochemical analysis, respectively. The number of circulating endothelial progenitor cells and blood sugar levels in 37 healthy control subjects were also examined. Compared with controls, the number of circulating endothelial progenitor cells in traumatic brain injury patients was decreased at 1 day after injury, and then increased at 4 days after injury,and reached a peak at 7 days after injury. Compared with controls, blood glucose levels in traumatic brain injury patients peaked at 1 day and then decreased until 7 days and then remained stable. At 1, 4, and 7 days after injury, the number of circulating endothelial progenitor cells was negatively correlated with blood sugar levels(r =-0.147, P < 0.05). Our results verify that hyperglycemia in patients with traumatic brain injury is associated with decreased numbers of circulating endothelial progenitor cells. This study was approved by the Ethical Committee of Tianjin Medical University General Hospital, China(approval No. 200501) in January 2015.

关键词： nerve regeneration endothelial progenitor cells vascular repair vascular remodeling angiogenesis neovascularization blood glucose hyperglycemia traumatic brain injury mobilization suppression senescence alternative therapy brain damage neural regeneration

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Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membranedecorated nanoparticles

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3218-3231页

作者： Wen Zhang Yihui Zhai Ying cai Xiang Gong Yunxuan jiang rong rong Chao Zheng Binyu Zhu Helen He Zhu Hao Wang Yaping Li Pengcheng Zhang China State Institute of Pharmaceutical Industry Shanghai 201203China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Biomedical Engineering&State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech UniversityShanghai 201210China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Yantai Institute of Materia Medica Shandong 264000China State Key Laboratory of Oncogenes and Related Genes Renji-Med-X Stem Cell Research CenterDepartment of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127China University of Chinese Academy of Sciences Beijing 100049China

Current cytotoxic T lymphocyte(CTL)activating immunotherapy requires a major histocompatibility complex I(MHC-I)-mediated presentation of tumor-associated antigens,which malfunctions in around half of patients with triple-negative breast cancer(TNBC).Here,we create a LCL161-loaded macrophage membrane decorated nanoparticle(LMN)for immunotherapy of MHC-I-deficient *** on the macrophage membrane helps LMNs recognize CD47-expressing cancer cells for targeted delivery of LCL161,which induces the release of high mobility group protein 1 and proinflammatory cytokines from cancer *** released cytokines and high mobility group protein 1 activate antitumor immunity by increasing the intratumoral density of the phagocytic macrophage subtype by 15 times and elevating the intratumoral concentration of CTL lymphotoxin by 4.6 *** also block CD47-mediated phagocytosis *** inhibit the growth of MHC-I-deficient TNBC tumors,as well as those resistant to combined therapy of anti-PDL1 antibody and albumin-bound paclitaxel,and prolong the survival of animals,during which process CTLs also play important *** macrophage membrane-decorated nanoparticle presents a generalizable platform for increasing macrophagemediated antitumor immunity for effective immunotherapy of MHC-I-deficient cancers.

关键词： MHC-I deficiency Macrophage CD47 Immunotherapy Triple-negative breast cancer Phagocytosis Immune checkpoint Innate immunity

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Disentangling distinct Cu surface sites for electrocatalytic CO_(2)-to-CO and CO-to-C_(2+)conversion

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Science China Chemistry 2024年第4期67卷 1047-1048页

作者： Kun jiang Wen-Bin cai Interdisciplinary Science Research Centre School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryFudan UniversityShanghai 200438China

Electrochemical CO_(2)reduction reaction(CO_(2)RR)is a promising strategy to curb anthropogenic carbon emissions,for which intermittent renewable electricity could be stored as chemical energy within carbon-based fuel... 详细信息

关键词： carbon Electrochemical surface

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