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Three dimensional velocity model and its tectonic implications at China Seismic Experimental Site,eastern margin of the Tibetan Plateau

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Science China Earth Sciences 2024年第7期67卷 2268-2290页

作者： Jianping WU Yan cai Wei wang Weilai wang Changzai wang Lihua FANG Yaning LIU Jing LIU Institute of Geophysics China Earthquake AdministrationBeijing 100081China Beijing Baijiatuan Earth Science National Observation and Research Station Beijing 1095China Beijing Earthquake Agency Beijing 100080China

The China Seismic Experimental Site(CSES)is located at the intersection of the Tibetan Plateau,South China Block,and Indian Plate and has complex geological settings and intense crustal deformation,making it one of the most seismically active areas in Chinese mainland.A high-resolution,three-dimensional(3D)crust-mantle velocity structure is crucial for understanding seismotectonic environments,lithospheric deformation mechanisms,and deep dynamic *** first constructed a high-vertical-resolution 3D initial velocity model using the joint inversion of receiver functions and surface waves and then obtained a 3D P-and S-wave velocity model(CSES-VM1.0)with the highest lateral resolution of 0.25°for the CSES using double-difference *** to the limitations of the Sn observation data,the resolution of the S-wave velocity model in the lower crust and upper mantle was reduced,making it closer to the initial model provided by joint inversion.A comparison with explosive-source seismic data showed that the synthetic P-wave first-arrival travel times of the new model were closer to the observations than those of the previous velocity *** velocity cross-sections across the source areas of the 2022 Lushan MS6.1 and Ludian MS6.8 earthquakes reveal that the former earthquake occurred near a weak contact zone between the Tibetan Plateau and Sichuan Basin,and the rupture of the latter earthquake occurred in a granitic area,with the northern end blocked by rigid high-velocity bodies.A clear high-velocity anomaly zone is distributed along the western margin of the Yangtze Block,revealing the spatial distribution of Neoproterozoic intermediate-basic *** high-velocity zone significantly controls the morphology of fault zones and influences the rupture processes of major *** northeast-southwest and north-south trending high-velocity anomalies were found near Panzhihua,potentially related to Neoproterozoic and Middle-Late Permian intermediate

关键词： Eastern Tibetan Plateau China Seismic Experimental Site Yangtze Block Velocity model Double-difference tomography

Macrophage senescence in health and diseases

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1508-1524页

作者： Longling wang Wenxiang hong hong Zhu Qiaojun He Bo Yang Jiajia wang Qinjie Weng Center for Drug Safety Evaluation and Research Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Nanhu Brain-Computer Interface Institute Hangzhou 311100China Taizhou Institute of Zhejiang University Taizhou 318000China The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310009China

Macrophage senescence,manifested by the special form of durable cell cycle arrest and chronic low-grade inflammation like senescence-associated secretory phenotype,has long been consid-ered *** senescence of macrophages may lead to maladaptation,immune dysfunction,and finally the development of age-related diseases,infections,autoimmune diseases,and ***,it is a ubiquitous,multi-factorial,and dynamic complex phenomenon that also plays roles in remodeled processes,including wound repair and *** this review,we summarize some general molecular changes and several specific biomarkers during macrophage senescence,which may bring new sight to recognize senescent macrophages in different ***,we take an in-depth look at the functional changes in senescent macrophages,including metabolism,autophagy,polarization,phagocytosis,antigen presentation,and infiltration or ***,some degenerations and diseases associated with senescent macrophages as well as the mechanisms or relevant genetic regulations of senescent macrophages are integrated,not only emphasizing the possibility of regulating macrophage senescence to benefit age-associated diseases but also has an implication on the finding of potential tar-gets ordrugs clinically.

关键词： Macrophages Senescence Molecular changes Functional alterations Aging tissues Age-associated diseases Drug treatment Genetic regulation

Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by Directly Inhibiting E3 Ubiquitin Ligase

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Chinese Journal of Integrative Medicine 2024年第6期30卷 499-506页

作者： LI Qi KONG Zhao-di wang Huan GU hong-hui CHEN Zhong Li Shi-guang CHEN Yi-qi cai Yu YANG Zhen-jiang Department of Oncology and Hematology Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong Province518033China College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou510632China Guangdong Key Lab of Traditional Chinese Medicine Information Technology Jinan UniversityGuangzhou510632China

ObjectiveTo provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction(JP)and to explore its mechanism of anti-cancer *** mouse model of colon cancer(CT26)-induced cancer cachexia(CC)was used to investigate the anti-CC effect of JP combined with medroxyprogesterone acetate(MPA).Thirty-six mice were equally divided into 6 groups:normal control,CC,MPA(100 mg·kg^(−1)·d^(−1)),MPA+low-dose(20 mg·kg^(−1)·d^(−1))JP(L-JP),MPA+medium-dose(30 mg·kg^(−1)·d^(−1))JP(M-JP),and MPA+high-dose(40 mg·kg^(−1)·d^(−1))JP(H-JP)*** successful modeling,the mice were administered by gavage for 11 *** body weight and tumor volume were measured and recorded every 2 d starting on the 8th day after *** liver,heart,spleen,lung,kidney,tumor and gastrocnemius muscle of mice were collected and *** pathological changes of the tumor was observed,and the cross-sectional area of the gastrocnemius muscle was *** protein expressions of STAT3 and E3 ubiquitinase in the gastrocnemius muscle were measured by Western *** addition,an in vitro C2C12 myotube formation model was established to investigate the role of JP in hindering dexamethasone-induced muscle *** vitro experiments were divided into control,model,and JP serum *** 2-d administration,microscopic photographs were taken and myotube diameters were *** blot was performed to measure the protein expressions of STAT3 and E3 *** combined with MPA restored tumor-induced weight loss(P<0.05,***)and muscle fiber size(P<0.01,***).Mechanistically,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx in tumor-induced muscle atrophy in vivo(P<0.05,***).In addition,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx and p-STAT3 phosphorylation(P<0.05 or P<0.01 *** group)in C2C12 myotubes treated with dexamethasone in *** of JP combined with MPA restores t

关键词： cancer cachexia muscle atrophy Jianpi Decoction Chinese medicine E3 ubiquitin ligases

Research on Condenser Deterioration Evolution Trend Based on ANP-EWM Fusion Health Degree

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 679-698页

作者： hong Qian Haixin wang Guangji wang Qingyun Yan College of Automation Engineering Shanghai University of Electric PowerShanghai200090China Shanghai Key Laboratory of Power Station Automation Technology Shanghai200072China Empower Information Technology(Shanghai)Co. Ltd.Shanghai201508China China Nuclear Power Engineering Design Co. Ltd.Shenzhen518052China

This study presents a proposed method for assessing the condition and predicting the future status of condensers operating in seawater over an extended *** aim is to address the problems of scaling and corrosion,which lead to increased loss of cold *** method involves utilising a set of multivariate feature parameters associated with the condenser as input for evaluation and trend *** methodology offers a precise means of determining the optimal timing for condenser cleaning,with the ultimate goal of improving its overall *** proposed approach involves the integration of the analytic network process with subjective expert experience and the entropy weightmethod with objective big data analysis to develop a fusion health *** mathematical model is constructed quantitatively using the improved Mahalanobis ***,a comprehensive prediction model is developed by integrating the improved Informer model and Markov error *** model takes into account the health status of the equipment and several influencing factors,includingmultivariate feature *** model facilitates the objective examination and prediction of the progression of equipment deterioration *** present study involves the computation and verification of the field time series data,which serves to demonstrate the accuracy of the condenser health-related models proposed in this *** models effectively depict the real condition and temporal variations of the equipment,thus offering a valuable method for determining the precise cleaning time required for the condenser.

关键词： Condenser health degree improved Mahalanobis distance GC-Informer model Markov error correction

MMAE-loaded PLGA nanomedicine with improved biosafety to achieve efficient antitumor treatment

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 79-93页

作者： Changqiang Xie Yan wang Zhenzhen cai Jianghai Du Zhengyu Chen Junjie wang Xingzhou Peng State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering Hainan University Haikou 570228P.R.China Key Laboratory of Biomedical Engineering of Hainan Province One Health Institute Hainan University Haikou 570228P.R.China Key Laboratory of Hainan Trauma and Disaster Rescue The First Affiliated Hospital of Hainan Medical University Hainan Medical University Haikou 571199P.R.China Engineering Research Center for Hainan Bio.Smart Materials and Bio-Medical Devices Key Laboratory of Emergency and Trauma Ministry of EducationKey Laboratory of Hainan Functional Materials and Molecular ImagingCollege of Emergency and Trauma Hainan Medical UniversityHaikou 571199P.R.China

Monomethyl auristatin E(MMAE)is a derivative of the marine peptide Dolastatin 10,which has therapeutic effects against various cancers according to its antimitotic activity in multiple clinical *** antibody drug conjugate(ADC)of MMAE is currently used in clinical ***,the safety issues of MMAE-based ADC,such as high drug toxicity and poor bioavailability,still exist when using it for anticancer therapy.A sustained release of drug delivery approach should be used to reduce toxicity and achieve sufficient anticancer ***,PLGA-b-PEG 2000 with excellent biocompatibility and slow degradation ability was adopted to construct MMAE-loaded nanoparticles for safe and effective *** sustained release effect and the immunogenic cell death(ICD)effect of PLGA-MMAE nanoparticles were assessed by in vitro *** PLGA-MMAE nanoparticles effectively accumulated in the tumor through the enhanced permeability and retention(EPR)effect,inducing cell apoptosis and causing a certain degree of immune *** sustained drug release of PLGA-MMAE improved the bioavailability and effectively reduced the toxicity and development of the tumor compared to the effect of free MMAE or ***,this study provides a safe and effective chemotherapeutic approach,as well as a simple and effective synthetic process for MMAE-based nanoparticles,improving their therapeutic efficacy and safety.

关键词： Monomethyl auristatin E poly(lactic-co-glycolic acid)nanoparticles sustained release chemotherapy immunogenic cell death

Method of improving pedestrian navigation performance based on chest card

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Journal of Systems Engineering and Electronics 2024年第4期35卷 987-998页

作者： CHENG Hao GAO Shuang cai Xiaowen wang Yuxuan wang Jie School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China School of Automation and Electronic Information Xiangtan UniversityXiangtan 411105China Navigation Guidance and Control Graduate School of the Second Institute of China Aerospace Science and Industry CorporationBeijing 100854China

With the development of positioning technology,loca-tion services are constantly in demand by *** a primary location service pedestrian navigation has two main approaches based on radio and inertial *** pedestrian naviga-tion based on radio is subject to environmental occlusion lead-ing to the degradation of positioning *** pedestrian navigation based on micro-electro-mechanical system inertial measurement unit(MIMU)is less susceptible to environmental interference,but its errors dissipate over *** this paper,a chest card pedestrian navigation improvement method based on complementary correction is proposed in order to suppress the error divergence of inertial navigation *** suppress atti-tude errors,optimal feedback coefficients are established by pedestrian motion *** extend navigation time and improve positioning accuracy,the step length in subsequent movements is compensated by the first step *** experi-mental results show that the positioning accuracy of the pro-posed method is improved by more than 47%and 44%com-pared with the pure inertia-based method combined with step compensation and the traditional complementary filtering com-bined method with step *** proposed method can effectively suppress the error dispersion and improve the positioning accuracy.

关键词： pedestrian navigation micro-electro-mechanical sy-stem(MEMS) inertial navigation complementary filtering

Security of quantum key distribution with virtual mutually unbiased bases

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 13-21页

作者： hong-Wei Li Chen-Peng Hao Zhi-Jiang Chen Li Gong Yi-Fei Lu Yang wang Jia-Ji Li Chun-Mei Zhang Rong wang Zhen-Qiang Yin Qing-Yu cai Henan Key Laboratory of Quantum Information and Cryptography SSF IEUZhengzhou 450000China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Department of Physics University of Hong KongHong Kong 999077China Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China School of Information and Communication Engineering Hainan UniversityHaikou 570228China

In a perfect quantum key distribution(QKD)protocol,quantum states should be prepared and measured with mutually unbiased bases(MUBs).However,in a practical QKD system,quantum states are generally prepared and measured with imperfect MUBs using imperfect devices,possibly reducing the secret key rate and transmission *** analyze the security of a QKD system with imperfect MUBs,we propose virtual MUBs to characterize the quantum channel against collective attack,and analyze the corresponding secret key rate under imperfect state preparation and measurement *** generally,we apply the advantage distillation method for analyzing the security of QKD with imperfect MUBs,where the error tolerance and transmission distance can be sharply *** analysis method can be applied to benchmark and standardize a practical QKD system,elucidating the security analysis of different QKD protocols with imperfect devices.

关键词： quantum key distribution mutually unbiased bases advantage distillation

PAL-BERT:An Improved Question Answering Model

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2729-2745页

作者： Wenfeng Zheng Siyu Lu Zhuohang cai Ruiyang wang Lei wang Lirong Yin School of Automation University of Electronic Science and Technology of ChinaChengdu610054China Department of Geography and Anthropology Louisiana State UniversityBaton RougeLA70803USA

In the field of natural language processing(NLP),there have been various pre-training language models in recent years,with question answering systems gaining significant ***,as algorithms,data,and computing power advance,the issue of increasingly larger models and a growing number of parameters has ***,model training has become more costly and less *** enhance the efficiency and accuracy of the training process while reducing themodel volume,this paper proposes a first-order pruningmodel PAL-BERT based on the ALBERT model according to the characteristics of question-answering(QA)system and language ***,a first-order network pruning method based on the ALBERT model is designed,and the PAL-BERT model is ***,the parameter optimization strategy of the PAL-BERT model is formulated,and the Mish function was used as an activation function instead of ReLU to improve the ***,after comparison experiments with traditional deep learning models TextCNN and BiLSTM,it is confirmed that PALBERT is a pruning model compression method that can significantly reduce training time and optimize training *** with traditional models,PAL-BERT significantly improves the NLP task’s performance.

关键词： PAL-BERT question answering model pretraining language models ALBERT pruning model network pruning TextCNN BiLSTM

Boring holes in Au nanoplates by active surface etching

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Nano Research 2024年第9期17卷 8610-8617页

作者： Haiyang Hu Yuntao wang Qian wang Xudong Peng An Su hong wang hongyu Chen Institute of Advanced Synthesis(IAS)and School of Chemistry and Molecular Engineering Jiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing Tech UniversityNanjing 211816China Department of Environmental Science and Engineering University of Science and Technology of ChinaHefei 230026China Department of Chemistry School of Science and Key Laboratory for Quantum Materials of Zhejiang ProvinceResearch Center for Industries of the FutureWestlake UniversityHangzhou 310030China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

In contrast to the conventional etching that makes nanoparticles rounder and our previous sharpening etching mode that causes serrated edges,here,we developed a new boring etching mode that targets the faces of Au nanoplates to make *** critical factors are the pre-incubation step with the ligand 2-mercapto-5-benzimidazolecarboxylic acid(MBIA)and the subsequent removal of excess ligands in the ***,etching is focused onto the few sites with initial loss of ligands,which cannot be quickly *** choice of ligand MBIA is also of importance,as it carries negative charge and repels each *** inability of forming a dense layer probably plays a critical role in the site-selectivity for faces,because ligands at the higher curvature edges and corners are expected to have less *** etching results from the comproportionation reaction between Au3+and Au0 in the nanoplates,where Br-coordination to Au and the extra stabilization from cetyltrimethylammonium bromide(CTAB)are *** believe that the ability of boring holes is an important tool for future synthetic designs.

关键词： Au nanoplates active surface etching boring etching mode cetyltrimethylammonium bromide(CTAB)passivation holes