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In-flight Energy Calibration of the GECAM Gamma-ray Detectors

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Research in Astronomy and Astrophysics 2024年第10期24卷 48-57页

作者： Rui Qiao Dong-Ya Guo Wen-Xi Peng yan-Qiu Zhang shuo Xiao Shao-Lin Xiong Chao Zheng Chao-yang Li Jia-Cong Liu Wang-Chen Xue Jian-Jian He Zheng-Hua An Da-Li Zhang Xin-Qiao Li Li-ming Song Shi-Jie Zheng Ke Gong Ya-Qing Liu Xin-Ying Song Xiao-yun zhao Xiang-yang Wen yan-Bing Xu Xiang Ma Xiao-Bo Li Ping Wang Yue Huang Ce cai Qi-Bin Yi Yi zhao Chen-Wei Wang institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Beijing 100049China china West Normal University Nanchong 637002China Xiangtan University Xiangtan 411105China Beijing Normal University Beijing 100875China

The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)mission is designed to monitor the Gamma-Ray Bursts(GRBs)associated with gravitational waves and other high-energy transient *** mission consists of two microsatellites which are planned to operate at the opposite sides of the *** GECAM satellite could detect and localize GRBs in about 8 keV-5 MeV with its 25 Gamma-Ray Detectors(GRDs).In this work,we report the in-flight energy calibration of GRDs using the characteristic gamma-ray lines in the background spectra,and show their performance evolution during the commissioning ***,a preliminary cross-calibration of energy response with Fermi GBM data is also presented,validating the energy response of GRDs.

关键词： (stars:)gamma-ray burst:general instrumentation:detectors methods:data analysis

Research on the development methodology for clinical practice guidelines for organic integration of traditional chinese medicine and Western medicine

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Military Medical Research 2024年第3期11卷 313-322页

作者： Ying-Hui Jin yan-Ping Wang Ying-Lan Xie Gui-Hua Tian Xiao-Yu Zhang Nan-Nan Shi Ke-Hu yang Xin Sun Yao-Long Chen Da-Rong Wu Xin-Feng Guo Long Ge Chen zhao Cheng Lu Yin Jiang Jing Guo Si-Yu yan Yong-Bo Wang Qiao Huang Xiang-Ying Ren Ying-Yue Rao yun-yun Wang Meng-Qian Yuan Xian-Tao Zeng Hong-cai Shang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China china Center for Evidence Based Traditional chinese Medicine Beijing 100029China Hubei Provincial Hospital of Traditional chinese Medicine Wuhan 430074China Key Laboratory of chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China china Center for Evidence-Based Medicine West China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Dampness Syndrome of chinese Medicine the Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Evidence-based Medicine Team Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120China Nanjing University of chinese Medicine Nanjing 210023China Jiangsu Province Hospital of chinese Medicine Nanjing 210029China

Integrated traditional chinese medicine(TCM)and Western medicine(WM)is a new medical science grounded in the knowledge bases of both TCM and WM,which then forms a unique modern medical system in *** TCM and WM has a long history in china,and has made important achievements in the process of clinical diagnosis and ***,the methodological defects in currently published clinical practice guidelines(CPGs)limit its *** organic integration of TCM and WM is a deeper integration of TCM and *** realize the progression of"integration"to"organic integration",a targeted and standardized guideline development methodology is ***,the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.

关键词： Methodology Traditional chinese medicine Western medicine Organic integration Clinical practice guidelines(CPGs)

近三十年天津市地热大规模开发热储动态特征研究

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地质学报 2024年第1期98卷 297-313页

作者：殷肖肖赵苏民蔡芸闫佳贤许磊天津地热勘查开发设计院天津300250 地热资源开发利用技术创新基地天津300250

天津是我国较早大规模开发深层地热的地区之一,经过30多年的持续开采回灌,对深部热储特征有无影响,是否引起了资源枯竭、水质恶化以及热储温度下降等环境问题,一直是社会关注的焦点。本文系统收集了1992年以来天津市地热开发过程中的不... 详细信息

天津是我国较早大规模开发深层地热的地区之一,经过30多年的持续开采回灌,对深部热储特征有无影响,是否引起了资源枯竭、水质恶化以及热储温度下降等环境问题,一直是社会关注的焦点。本文系统收集了1992年以来天津市地热开发过程中的不同热储层热水开发利用量、回灌量、水位、水质、水温等近30年的时间序列监测资料,通过垂向及横向对比,对地热持续开发30年来天津市不同地区不同热储层的热水动态特征进行了分析。结果表明,天津市各热储层地热流体的主要化学组分基本稳定,多年来无明显变化,地热采灌系统尾水回灌不会从根本上改变地热流体的原始化学特征,但深大断裂作为热流通道引起的顶托补给,会对上层热储水质造成一定的影响;随着近年来天津市回灌工作力度不断加大,大部分热储水位下降幅度减缓或出现回升,热储的温度没有明显的升高或降低的趋势,但回灌井热储段经过非供暖期的恢复无法达到最初的温度,呈逐年下降趋势。未来持续采灌条件下,回灌井筒的“冷堆积”及采灌井的优化调配应是重点关注的问题。

关键词：地热开发水动力场化学场温度场天津

Recombinant Bivalent Vaccine against Foot-and-Mouth Disease Virus Serotype O/A Infection in Guinea Pig

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Acta Biochimica et Biophysica Sinica 2004年第9期36卷 589-596页

作者： Jian-Zhong YI1, ming-Qiu LIU1, cai-Zhu ZHU2, Qiang ZHANG1, Zu-Tian SHENG3, Qing-yun du3, Wei-Yao yan1, and zhao-Xin ZHENG1* State Key Laboratory of Genetics Engineering, Life Science School, Fudan University, Shanghai 200433, china 1The Veterinary institute of chinese academy of Agricultural sciences, Lanzhou 730046, china 2The Virus Research institute of Zhejiang academy of Agricultural sciences, Hangzhou 310021, china State Key Laboratory of Genetics Engineering Life Science School Fudan University The Veterinary institute of chinese academy of Agricultural sciences

In this study, two DNA fragments encoding amino acid (141–160)-(21–40)-(141–160) of the VP1 of FMDV (foot-and-mouth disease virus) serotype O and (138–160)-(21–40)-(138–160) of the serotype A FMDV were chemically synthesized. These two tandem-repeat fragments were ligated and transfected into prokaryotic expression vector pTrcHis A to construct pTH-O-A. The other vector called pTH-O-scIgG-A was constructed similarly only that the two tandem-repeat DNA fragments were linked by the bovine- IgG heavy chain coding sequence. Guinea pigs immunized with the two bivalent vaccines pTH-O-A and pTH-O-scIgG-A showed both specific antibody activity and T cell proliferation responses. FMDV challenge tests showed that 85% and 70% of guinea pigs vaccinated twice with 200 μg of the fusion protein of pTH-O-A were protected from FMDV serotype O and serotype A infection respectively. 70% and 57% of the guinea pigs immunized with the fusion protein of pTH-O-scIgG-A were protected from FMDV serotype O and serotype A infection respectively.

关键词： foot-and-mouth disease FMDV serotype O FMDV serotype A VP1 protein bivalent vaccine guinea pig

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang Li-Tao yang Qian Yue Ke-Jun Kang Yuan-Jing Li Hai-Peng An C.Greeshma Jian-Ping Chang yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo Li He Sheng-ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi Jiang S.Karmakar Hao-Bin Li Jian-Min Li Jin Li Qian-yun Li Ren-ming-Jie Li Xue-Qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan Liu shu-Kui Liu yan-Dong Liu Yu Liu Yuan-Yuan Liu Zhong-Zhi Liu Hao Ma Yu-cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang yang Tian Guang-Fu Wang Li Wang Qing Wang Yu-Feng Wang yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu yan Nan Yi Chun-Xu Yu Hai-Jun Yu Jian-Feng Yue ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang Kang-Kang zhao ming-Gang zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the china Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-yun zhao Shao-Lin Xiong Xiang-yang Wen Xin-Qiao Li Ce cai shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan Liao yan-Qiu Zhang Yue Huang Lu Li Xing Wen Fei Zhang Jing duan Chen-Wei Wang Dong-Li Shi Peng Zhang Qi-Bin Yi Chao-yang Li yan-Bing Xu Xiao-Hua Liang Ya-Qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu Wang Sheng yang Xiao-Jing Liu Min Gao Mao-shun Li Jin-Zhou Wang Xing Zhou Yi zhao Wang-Chen Xue Chao Zheng Jia-Cong Liu Xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-ming Song Shi-Jie Zheng Bing Li Hong-Mei Zhang Yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun Wang yan-Chao Hao Xiang-Yu Wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan du Rui Gao Xiao-Fei Lan yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang Yu-Peng Xu Jia-Wei yang Xue-Juan yang shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China chinese academy of sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice

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chinese Journal of Integrative Medicine 2018年第2期24卷 133-139页

作者： HE Xiao-li zhao Shi-hui YOU Wei cai Yu-ying WANG yan-yun YE Yong-ming JIA Bao-hui Research Center for Pharmacology and Toxicology Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193China Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China Beijing Hospital of Traditional chinese Medicine Capital Medical University Beijing100010 China

Objective： To investigate the preventive treatment effects of electroacupuncture（EA） on cognitive changes and brain damage in senescence-accelerated mouse prone 8（SAMP8） mice. Methods： The 5-month-old male SAMP8 and age-matched homologous normal aging mice（SAMR1） were adopted in this study. EA stimulation at Baihui（GV 20） and Yintang（EX-HN 3） was performed every other day for 12 weeks, 4 weeks as a course. Morris water maze test and Nissl-stained with cresyl violet were used for cognitive impairments evaluation and brain morphometric analysis. Amyloid-β（Aβ） expression in hippocampus and parietal cortex was detected by immunohistochemistry, and apoptosis was observed by TUNEL staining. Results： After 3 courses of EA preventive treatment, the escape latencies of 8-month-old SAMP8 mice in EA group were significantly shortened than those of un-pretreated SAMP8 mice. Compared with SAMR1 mice, extensive neuronal changes were visualized in the CA1 area of hippocampus in SAMP8 mice, while these pathological changes and attenuate cell loss in hippocampal CA1 area of SAMP8 mice markedly reduced after EA preventive treatment. Furthermore, Aβ expression in hippocampus and parietal cortex of SAMP8 mice decreased significantly after EA treatment, and neuronal apoptosis decreased as well. Conclusion： EA preventive treatment at GV 20 and EX-HN 3 might improve cognitive deficits and neuropathological changes in SAMP8 mice, which might be, at least in part, due to the effects of reducing brain neuronal damage, decreasing neuronal apoptosis and inhibiting Aβ-containing aggregates.

关键词： electroacupuncture senescence-accelerated mouse prone 8 mice prevention learning and memory cognitive impairment brain damage

Industrial Experiment of Reducing Superheat of Steel by Nozzle Cooling

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Journal of Iron and Steel Research International 2011年第6期18卷 22-25页

作者： yan Hui-cheng QIU Sheng-tao TONG Tai-qin cai yun-teng WANG Zhong-ying zhao Pei State Key Laboratory of Advanced Steel Processing and Products Central Iron and Steel Research Institute Beijing 100081 China National Engineering Research Center of Continuous Casting Technology Central Iron and Steel Research Institute Eeijing 100081 China Huai Special Steel Co L.td Shasteel Group Huaian 211600 Jiangsu China

Nozzle cooling equipment is developed to supervise and control the heat flux by changing water flux. An in- dustrial experiment is held in billet caster in Huaigang . The results show that cooling control system works stably and effectively to control the heat fluxes by the temperature of copper tube. The superheat of steel in mould is reduced and the equiaxed crystal ratio, as well as compact degree of steel is raised.

关键词： nozzle cooling low superheat industrial experiment

Identification of biomarkers for hepatocellular carcinoma by semiquantitative immunocytochemistry

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World Journal of Gastroenterology 2014年第19期20卷 5826-5838页

作者： Hong Mu Kai-Xuan Lin Hong zhao shu Xing Cong Li Fang Liu Hai-Zhen Lu Ze Zhang Yu-Lin Sun Xi-yun yan Jian-Qiang cai Xiao-Hang zhao State Key Laboratory of Molecular Oncology Cancer Institute HospitalChinese Academy of Medical Sciences and Peking Union Medical College Center of Basic Medical sciences Navy General Hospital of Chinese PLA Department of Abdominal Surgery Cancer Institute HospitalChinese Academy of Medical Science and Peking Union Medical College Key Laboratory of Protein and Peptide Pharmaceutical National Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences Department of Pathology Cancer Institute HospitalChinese Academy of Medical Sciences and Peking Union Medical College

AIM: To investigate the expression of key biomarkers in hepatoma cell lines, tumor cells from patients’ blood samples, and tumor tissues.

关键词： Hepatocellular carcinoma Biomarker Immunocytochemistry Semiquantitative analysis Three-dimensional reconstruction