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World Journal of Gastroenterology 2008年第28期14卷 4535-4539页

作者： Guo-Shuang Feng Jun-Ling Ma Benjamin cy Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You Department of Cancer Epidemiology Peking University School ofOncology Beijing Cancer Hospital & Institute Beijing 100036 China Department of Medicine University of Hong Kong Hong Kong China Department of Medical Oncology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100036 China Department of Pathology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100036 China Healthy Bureau of Linqu County Weifang 262600 Shandong Province China

AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled ***: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events.

关键词：十二指肠溃疡心血管疾病流行病学临床表现

椎体复位器治疗胸腰椎骨折过程中的生物力学参数变化

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中国组织工程研究与临床康复 2007年第51期11卷 10255-10259页

作者：董扬眭述平王桂英陈旸鲍琨江潮胤曾炳芳上海交通大学附属第六人民医院骨科上海市200233

目的:对胸腰椎压缩性骨折的复位目前主要是通过Harrington棒的撑开或Dick等器械压缩,间接地使压缩的椎体得到复位。但复位的力量不易掌握,效果往往也不够理想。因此,需要了解和掌握复位器未发生变形时所能承受的最大应力及椎体复位器在... 详细信息

目的:对胸腰椎压缩性骨折的复位目前主要是通过Harrington棒的撑开或Dick等器械压缩,间接地使压缩的椎体得到复位。但复位的力量不易掌握,效果往往也不够理想。因此,需要了解和掌握复位器未发生变形时所能承受的最大应力及椎体复位器在椎体内撑开复位的应力与位移的关系。方法:实验于1998-10/2003-04在上海市材料力学研究所、上海市第九人民医院生物力学研究室及上海第二医科大学解剖教研室市生物力学研究室完成。自行设计的椎体复位器为圆柱形,顶端的上下开启由尾端的圆形手柄控制。实验方法:①椎体复位器的抗压力实验:将椎体复位器撑开到最大后进行轴向压缩实验,当复位器刚好发生形变时的轴向压应力,即是复位器进行轴向撑开时所能承受最大应力。②新鲜小牛骨椎体抗轴向压力实验:在36个新鲜小牛骨椎体上制作压缩性骨折模型时,了解椎体形变时的应力形变的关系。实验前测出每个椎体的高度值,发生压缩形变后,再测量每个椎体的高度值,并在机器上测出相应的压应力值。③椎体复位器复位压缩性小牛骨椎体的生物力学实验:将20个新鲜小牛骨胸腰椎椎体分成2组,每组10个椎体。在轴向载荷下压缩椎体,制作压缩性骨折的模型,1/2椎体高度压缩组其压缩后高度接近原有椎体高度的1/2,2/3椎体高度压缩组其压缩后高度接近原有椎体高度的2/3。从椎体椎弓根两侧放入复位器,将压缩的椎体予以复位。了解复位器在椎体内的撑开应力与复位时位移关系。结果:①复位器未发生变形时所能承受的最大力为281N。②36个新鲜小牛骨椎体在承受轴向载荷发生变形时屈服点的平均应力为74.96kPa,各数据符合正态分布(t=16.044,P0.05)。结论:椎体压缩程度与椎体内撑开复位的力量没有直接关系,自行设计的椎体复位器在椎体内撑开复位的力量远小于复位器的屈服点应力。

关键词：胸椎腰椎正骨疗法生物力学组织构建

Outcome analysis of management of liver trauma: A 10-year experience at a trauma center

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World Journal of Hepatology 2016年第15期8卷 644-648页

作者： Wong Hoi She Tan To Cheung Wing Chiu Dai Simon HY Tsang Albert cy Chan Daniel KH Tong Gilberto KK Leung Chung Mau Lo Department of Surgery Queen Mary Hospital the University of Hong Kong

AIM: To review the outcomes of liver trauma in patients with hepatic injuries only and in patients with associated injuries outside the ***: Data of liver trauma patients presented to our center from January 2003 to October 2013 were reviewed. The patients were divided into two groups. Group 1 consisted of patients who had hepatic injuries only. Group 2 consisted of patients who also had associated injuries outside the ***: Seven(30.4%) patients in group 1 and 10(28.6%) patients in group 2 received non-operative management; the rest underwent operation. Blunt trauma occurred in 82.8%(48/58) of the patients and penetrative trauma in 17.2%(10/58). A higher injury severity score(ISS) was observed in group 2(median 45 vs 25, P < 0.0001). More patients in group 1 were hemodynamically stable(65.2% vs 37.1%, P = 0.036). Other parameters were comparable between groups. Group 1 had better 30-d survival(91.3% vs 71.4%, P = 0.045). On multivariate analysis using the logistic regression model, ISS was found to be associated with mortality(P = 0.004, hazard ratio = 1.035, 95%CI:CONCLUSION: Liver trauma patients with multiple injuries are relatively unstable on presentation. Despite a higher ISS in group 2, non-operative management was possible for selected patients. Associated injuries outside the liver usually account for morbidity and mortality.

关键词： Non-operative management Liver trauma Multiple injuries Penetrative trauma Liver laceration Blunt tr

改进的石墨烯基材料用作菜籽油转酯化反应制生物柴油的有效催化剂（英文）

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Chinese Journal of Catalysis 2018年第10期39卷 1633-1645页

作者： Justina Gaidukevic Jurgis Barkauskas Anna Malaika Paulina Rechnia-Goracy Aleksandra Mozdzynska Vitalija Jasulaitiene Mieczyslaw Kozlowski 维尔纽斯大学化学研究所化学与地学系立陶宛瑙加杜科24维尔纽斯LT-03225 波兹南密茨凯维奇大学化学系波兰乌穆托斯卡89b波茨纳61-614 物理科学技术国家研究中心立陶宛撒乌耳·特基奥3维尔纽斯LT-10257

本文研究了不同石墨烯基材料用作转酯化反应制备生物柴油催化剂的性能.将磺酸基或磷酸盐基嫁接到热还原的氧化石墨烯表面,制备了固体酸石墨烯基样品.并采用扫描电镜、X射线衍射、热重分析、X射线光电子能谱、N2吸附-脱附法、电位滴定法... 详细信息

本文研究了不同石墨烯基材料用作转酯化反应制备生物柴油催化剂的性能.将磺酸基或磷酸盐基嫁接到热还原的氧化石墨烯表面,制备了固体酸石墨烯基样品.并采用扫描电镜、X射线衍射、热重分析、X射线光电子能谱、N2吸附-脱附法、电位滴定法、元素分析以及红外光谱法对所制样品进行了全面表征.将所制样品用于130 oC带压力的条件下菜籽油与甲醇转酯化反应中,并将其催化活性与商用的多相酸催化剂Amberlyst-15的进行了比较.结果表明,所有改进的样品在转酯化反应中均表现出催化活性,但各样品上生物柴油产率差别较大.其中以苯二氮磺酸基功能化的热还原氧化石墨烯样品上脂肪酸甲酯产率最高,反应6 h后达70%,也明显高于商用催化剂Amberlyst-15.该样品也表现出良好的重复使用性能.

关键词：石墨烯表面官能团化酸催化剂磺酸基转酯化生物柴油

Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 350-355页

作者： Department of General Surgery ( Lu P, Wang cy and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) Department of General Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China. luliu@***

It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO_2^-) and this NO_2^--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO_2^--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, Pcyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-trea

关键词： nitrites nitric oxide ischemia-reperfusion injury

C6细胞中诱导体外培养大鼠神经干细胞迁移蛋白的初步分析

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中国组织工程研究与临床康复 2007年第46期11卷 9230-9233页

作者：高宜录李传友林社裕沈剑虹刘梅南通大学附属医院神经外科江苏省南通市226001 河南省新乡市中心医院神经外科河南省新乡市453000 南通大学江苏省神经再生重点实验室江苏省南通市226001

目的:许多体内实验表明神经干细胞具有向胶质瘤细胞迁移的特性,该特性使神经干细胞有可能成为基因治疗脑胶质瘤潜在的基因携带者。实验拟观察大鼠星形胶质瘤C6细胞诱导体外培养的大鼠神经干细胞的迁移作用,并初步分离C6细胞中诱导神经... 详细信息

目的:许多体内实验表明神经干细胞具有向胶质瘤细胞迁移的特性,该特性使神经干细胞有可能成为基因治疗脑胶质瘤潜在的基因携带者。实验拟观察大鼠星形胶质瘤C6细胞诱导体外培养的大鼠神经干细胞的迁移作用,并初步分离C6细胞中诱导神经干细胞迁移的蛋白。方法:实验于2005-01/2006-05在南通大学江苏省神经再生重点实验室完成。实验材料:C6细胞用含10%小牛血清的DMEM/F12培养基进行培养,使用时细胞处于对数生长期。清洁级的新生1周内的SD大鼠由南通大学实验动物中心提供,实验过程中对动物处置符合动物伦理学标准。实验方法:从新生5～7dSD大鼠大脑皮质分离培养、纯化神经干细胞。从SD新生红皮鼠大脑皮质分离、培养、纯化星形胶质细胞。采用"TranswellInserts"细胞培养室培养系统共培养36h,比较C6细胞和大鼠星形胶质细胞对体外培养的大鼠神经干细胞的迁移作用;自然系统聚丙烯酰胺凝胶蛋白电泳分离C6细胞和星形胶质细胞差异蛋白,观察各蛋白凝胶条带对神经干细胞的迁移作用。结果:体外培养C6细胞能诱导神经干细胞迁移,迁移细胞数目与星形胶质细胞相比,差异有显著意义(P<0.001)。将C6细胞中差异蛋白条带与神经干细胞共培养,与对应的星形胶质细胞蛋白条带相比,可观察到与相对分子质量约67000蛋白胶条共培养的神经细胞球在接近蛋白胶条的一侧细胞向胶条迁移生长。结论:C6细胞可以诱导体外培养的神经干细胞迁移,其总蛋白在自然系统聚丙烯酰胺凝胶电泳分离实验中获得的相对分子质量为67000的蛋白组分具有诱导神经干细胞迁移的活性。

关键词：神经干细胞 C6细胞星形胶质细胞细胞迁移

血压、认知障碍发生和慢性肾脏病严重程度:慢性肾功能不全队列研究的结果

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中华高血压杂志 2023年第11期31卷 1110-1110页

作者： Babroudi S Tighiouart H Schrauben SJ Cohen JB Fischer MJ Rahman M Hsu cy Sozio SM Weir M Sarnak M Yaffe K Tamura MK Drew D 刘青(译) 练桂丽(审校) 不详

高血压是痴呆和认知障碍的已知危险因素。关于成人慢性肾脏病(chronic kidney disease,CKD)患者收缩压和舒张压与认知障碍事件之间关系的数据有限。该研究旨在探讨成人CKD患者血压、认知障碍和肾功能下降严重程度之间的关系。方法:该纵... 详细信息

高血压是痴呆和认知障碍的已知危险因素。关于成人慢性肾脏病(chronic kidney disease,CKD)患者收缩压和舒张压与认知障碍事件之间关系的数据有限。该研究旨在探讨成人CKD患者血压、认知障碍和肾功能下降严重程度之间的关系。方法:该纵向队列研究纳入慢性肾功能不全队列(chronic renal insufficiency cohort,CRIC)研究的参与者3 768名。

关键词：慢性肾功能不全慢性肾脏病队列研究认知障碍肾功能下降危险因素

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超重及肥胖与脂肪肝关系的病例对照分析

中国组织工程研究与临床康复 2007年第39期11卷 7773-7776页

作者：钟朝晖程朝英何艳辉廖蓉徐小利重庆医科大学流行病学教研室重庆市400016 重庆市第八人民医院重庆市400010 重庆市第五人民医院重庆市400062

目的:分析超重及肥胖与脂肪肝的关系,探索肥胖与其他危险因素在脂肪肝发病中的交互作用。方法:选择2002-09/2004-12期间某社区人群,按分层多级整群抽样原则进行抽样调查,共调查2458例。根据1∶1配对病例对照研究的设计原理,选择其中确诊... 详细信息

目的:分析超重及肥胖与脂肪肝的关系,探索肥胖与其他危险因素在脂肪肝发病中的交互作用。方法:选择2002-09/2004-12期间某社区人群,按分层多级整群抽样原则进行抽样调查,共调查2458例。根据1∶1配对病例对照研究的设计原理,选择其中确诊的425例脂肪肝患者作为研究病例,纳入标准:要求所有病例均有B超诊断报告,且年龄≥18岁,并从该人群的非脂肪肝患者中选择425例条件相似的作为对照,病例与对照在年龄、性别、居住地区方面均衡可比。对全体调查对象进行当面访谈调查和体格检查。结果:纳入调查对象850例,均进入结果分析。超重及肥胖者比正常体重者有显著升高的脂肪肝患病危险(OR=4.07,OR95%CI为2.99～5.54),OR值随体质量指数的增大而增大,呈明显的剂量反应关系(趋势χ2=104.25,P<0.0001)。腰臀比偏高的腹型肥胖者比非腹型肥胖者脂肪肝的发病危险更大。交互作用分析提示,肥胖与饮酒同时存在能显著增加疾病的危险性,其超额相对危险度为8.16,归因比为0.5767。结论:超重及肥胖与脂肪肝的发病关系密切,肥胖与饮酒在脂肪肝的发病中存在协同交互作用,控制体质量是降低人群脂肪肝患病率的重要措施。

关键词：肥胖脂肪肝病例对照研究交互作用

文献快报(12):邻苯二甲酸酯可能通过增加Kisspeptin活性促进雌性青春期发育

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中国学校卫生 2014年第5期35卷 727-727页

作者： CHEN cy CHOU YY WU YM 苏普玉安徽医科大学公共卫生学院儿少卫生与妇幼保健学系合肥230032

越来越多的证据表明,儿童性成熟比过去提前,性早熟发生率在全球范围内呈上升趋势,特别是女童。为阐明邻苯二甲酸酯暴露与Kisspeptin分泌之间的关系,以及两者与青春发到提前的关联,台湾国立成功大学Chen等采用病例对照研究,收集71名青春... 详细信息

越来越多的证据表明,儿童性成熟比过去提前,性早熟发生率在全球范围内呈上升趋势,特别是女童。为阐明邻苯二甲酸酯暴露与Kisspeptin分泌之间的关系,以及两者与青春发到提前的关联,台湾国立成功大学Chen等采用病例对照研究,收集71名青春发动提前（CPP）女童和29名对照的血清标本和尿液,采用放射性免疫法检测了血清标本中LH、FSH和Kisspetion-54的含量,使用反相高效液相色谱-串联质谱法检测尿中邻苯二甲酸酯代谢物。

关键词：邻苯二甲酸酯青春期发育高效液相色谱-串联质谱法雌性活性文献病例对照研究放射性免疫法