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Chinese Journal of Chemistry 2024年第16期42卷 1901-1912页

作者： Ke-Xin Yang Tian-Ze Li yun-Bao Ma Yong-cui Wang Feng-Jiao Li Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Ten novel isocoumarins,including four pairs of enantiomers,were isolated from Artemisia dubia ***(Asteraceae).Compounds 1,2 and 3a/3b possessed a unique 6/6/6-tricyclic system comprising an unusual 1-(2-methylcyclohexyl)propan-1-one moiety fused with isocoumarin core *** 4a/4b were characterized as an unexpected 2,5-dimethylcyclohexan-1-one scaffold,and compounds 5a/5b and 6a/6b were rare 1,*** structures and absolute configurations were elucidated through spectroscopic data,X-ray crystallography,ECD and NMR calculations with DP4+*** biosynthetic pathways were proposed from the naturally occurring *** pharmacological analysis suggested that the targets of compound 1 were significantly enriched in the cell cycle and Pl3K-Akt signaling *** molecular docking revealed that compound 1 had high binding affinity with CDK2(total score:6.8717).Furthermore,compounds 1 and 2 exhibited inhibitory activity on three human hepatoma cell lines,with inhibitory ratios of 85.1% and 84.5%(HepG2),88.2% and 87.3%(Huh7),and 69.2% and 69.1%(SK-Hep-1)at 200μmol·L^(-1),respectively.

关键词： Artemisia dubia var.subdigitata Isocoumarins Antihepatoma activity Cancer Natural products X-ray diffraction

Optimization of the co-closing law of guide vanes and blades for bulb turbines based on CFD

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Journal of Hydrodynamics 2024年第2期36卷 363-377页

作者： Hui Liu yun-fa Lin Yong-guang cheng Song Xue Mao-jia Tang Jian Zhang Jia-yi Fan State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China Dongfang Electric Machinery Co. Ltd.Deyang618000China

The load rejection transient process of bulb turbine units is critical to safety of hydropower stations,and determining appropriate closing laws of guide vanes(GVs)and runner blades(RBs)for this process is of *** this study,we proposed a procedure to optimize the co-closing law of GVs and RBs by using computational fluid dynamics(CFD),combined with the design of experiment(DOE)method,approximation model,and genetic optimization *** sensitivity of closing law parameters on the histories of head,speed,and thrust was analyzed,and a two-stage GVs’closing law associating with a linear RBs’closing law was *** results show that GVs dominate the transient characteristics by controlling the change of *** GVs’first-stage closing speed while shortening first-stage closing time can not only significantly reduce the maximum rotational speed but also suppress the water hammer pressure;slowing GVs’second-stage closing speed is conducive to controlling the maximum reverse axial *** directly affect the runner *** RBs’closing speed can further reduce the rotational speed and the maximum reverse axial *** safety margin of each control parameter,flow patterns,and pressure pulsations of a practical hydropower station were all improved after optimization,demonstrating the effectiveness of this method.

关键词： Bulb turbine load rejection transient process double regulation closing law optimization computational fluid dynamics(CFD)

Inhalation of taraxasterol loaded mixed micelles for the treatment of idiopathic pulmonary fibrosis

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Chinese Chemical Letters 2024年第8期35卷 475-480页

作者： Tong Zhang Chao Sun Shubin Yang Zimin Cai Sifeng Zhu Wendian Liu yun Luan cheng Wang Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Central Research Laboratory Department of General Surgerythe Second Hospital of Shandong UniversityJi’nan 250033China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and TechnologyQingdao 266237China Orthopedics Dept.1 Rushan people’s hospitalRushan 264500China Department of Cardiology the Second Hospital of Shandong UniversityJi’nan 250033China

Idiopathic pulmonary fibrosis(IPF)is a chronic and fatal lung disease characterized by pulmonary inflam-mation,oxidative stress,and excessive extracellular matrix(ECM)*** anti-fibrotic drugs for IPF treatment in the clinic lack selectivity and demonstrate unsatisfactory efficacy,highlighting the urgent necessity for a novel therapeutic ***(TA),which has biological activities against lung injury induced by various factors,is a potential anti-IPF drug due to its anti-inflammatory,antiox-idant and lung-protective ***,the protective effect of TA on IPF has not been confirmed,and its clinical application is limited due to its poor aqueous *** this study,we demonstrated that TA could inhibit epithelial-mesenchymal transition(EMT)and migration of A549 cells by inhibiting the transforming growth factor-β1(TGF-β1)/Smad signaling *** improve the aqueous solubility and pulmonary administration performance of TA,we prepared TA loaded methoxy poly(ethylene glycol)-poly(d,l-lactide)(mPEG-PLA)/d-α-tocopheryl polyethylene glycol succinate(TPGS)mixed polymeric mi-celles(TA-PM).Then a MicroSprayer^(R) Aerosolizer was used to deliver TA-PM once every two days for three weeks to evaluate their therapeutic effects on bleomycin(BLM)-induced IPF *** results demonstrated that inhaled TA-PM significantly inhibited BLM-induced inflammation,oxidative stress and fibrosis in lung ***,TA-PM exhibited high pulmonary deposition and retention by pul-monary administration,along with a favorable safety ***,this study emphasizes the potential of inhaled TA-PM as a promising treatment for IPF,providing a new opportunity for their clinical appli-cation.

关键词： Taraxasterol Idiopathic pulmonary fibrosis Mixed polymeric micelles Pulmonary administration Bleomycin

Disposal of zinc extraction residues via iron ore sintering process:an innovative resource utilization

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Journal of Iron and Steel Research International 2024年第7期31卷 1636-1645页

作者： Chun-long Fan cheng-yi Ding Tao Yang yun-fei Luo Yi-fan Wang Qian Li Hong-ming Long School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243002AnhuiChina Zhongye Changtian International Engineering Co. Ltd.Changsha 410205HunanChina Key Laboratory of Metallurgical Emission Reduction and Resources Recycling(Ministry of Education) Anhui University of TechnologyMa'anshan 243002AnhuiChina

Zinc extraction residue,a solid waste generated from the treatment of zinc-containing dust in rotary kilns,is commonly stockpiled in steel companies for extended *** poses significant disposal challenges and environmental pollution *** far,research on the treatment of zinc extraction residues has been slow,inadequate,and *** this gap,a novel approach was proposed to effectively treat the zinc extraction residue via the iron ore sintering *** was feasible to add 1 wt.%of zinc extraction residues to the sintering raw *** more adequate mineralization reaction resulted in higher yield and tumbler indexes,despite a slight decrease in sintering *** this may result in a slight decrease in sintering speed,the more complete mineralization reaction leads to improved sintering yield and tumbler ***,the addition of zinc extraction residues reduced the CO and NO_(x) concentrations in the sintering flue ***,the iron ore sintering process provided a viable solution for resource utilization and environmentally friendly treatment of zinc extraction residues.

关键词： Zinc extraction residue Iron ore sintering Co-processing Waste utilization Gas pollutant reduction

Integrated Chinese and Western Medicine in Treatment of Bronchopleural Fistula with Mycobacterium abscessus:A Case Report

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Chinese Journal of Integrative Medicine 2024年第8期30卷 742-746页

作者： WANG Qian-yun cheng Miao BAN cheng-jun ZHANG Li-shan WANG Hong-wu YANG Bing ZOU Heng WANG Ming-zhe The First Clinical Medical College of Beijing University of Chinese Medicine Beijing100700China Department of Respiratory Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China

Bronchopleural fistula(BPF)is defined as a pathological connection between the trachea or bronchus and the pleural *** may occur as a serious complication after lung surgery.^((1))It has a low incidence of 1%-3%^((2.3... 详细信息

关键词： pleural lung surgery

Removal of kathon by UV-C activated hydrogen peroxide:Kinetics,mechanisms,and enhanced biodegradability assessment

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Chinese Journal of Chemical Engineering 2024年第1期65卷 178-187页

作者： Jinzhi cui Guiqiao Wang Xing Rong Wensu Gao Yaxin Lu Yawen Luo Lichao Zhang Zhongfa cheng Canzhu Gao School of Environmental Science and Engineering Shandong UniversityQingdao 266237China Shandong Taihe Technologies Co. Ltd.Zaozhuang 250031China

Kathon(CMI-MI),a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one(CMI)and 2-methyl-4-isothiazolin-3-one(MI),was extensively used in industry as a nonoxidizing biocide or ***,it would show adverse effects on aquatic life when it is discharged into surface *** this study,the removal performance,parameter influence,degradation products and enhancement of subsequent biodegradation of CMI-MI in UV/H_(2)O_(2)system were systematically *** degradation rate of CMI-MI could reach 90%under UV irradiation for 20 min when the dosage of H_(2)O_(2)was 0.3 mmol·L^(–1).The DOC(dissolved organic carbon)mineralization rate of CMI-MI could reach 35%under certain conditions([H_(2)O_(2)]=0.3 mmol·L^(–1),UV irradiation for 40 min).kobs was inversely proportional to the concentration of CMI-MI and proportional to the concentration of H_(2)O_(2).The degradation rate of CMIMI was almost unchanged in the pH range from 4 to *** the presence of CO_(3)^(2-)inhibited the removal rate of CMI-MI,SO_(4)^(2-),Cl^(-),NO_(3)^(-),and NH_(4)^(+) did not interfere with the degradation of CMI-MI in the *** was found that UV/H_(2)O_(2)system had lower energy consumption and more economic advantage compared with UV/PS system by comparing the EEO(electric energy per order)values under the same *** main organic products were identified,namely HCOOH and CH_(3)NH_(2).There’s also the formation of Cl^(-)and SO_(4)^(2-).After UV and UV/H_(2)O_(2)photolysis,the biochemical properties of CMI-MI solution were obviously improved,especially the UV/H_(2)O_(2)treatment effect was better,indicating that UV/H_(2)O_(2)technology is expected to combine with biotechnology to remove CMI-MI effectively and environmentally friendly from wastewater.

关键词： Kathon UV/H_(2)O_(2) Biological degradation Circulating cooling water

Biocatalytic stereoselective synthesis of methyl mandelates by engineering a cytochrome P450 hydroxylase

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第2期5卷 88-93页

作者： Lingzhi Xie yun Zhang Ruyue Zhang Haibo cui Baodong cui Wenyong Han Nanwei Wan Zhi Li Yongzheng Chen Key Laboratory of Biocatalysis&Chiral Drug Synthesis of Guizhou Province Generic Drug Research Center of Guizhou ProvinceGreen Pharmaceuticals Engineering Research Center of Guizhou ProvinceSchool of PharmacyZunyi Medical UniversityZunyi 563000China Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563000China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4Singapore 117585Singapore

Chiral methyl mandelates are useful synthons in organic transformation and pharmaceutical *** synthesis of these valuable compounds by direct C–H activating oxidative hydroxylation has attracted keen *** herein is achieving the stereoselective and efficient bio-hydroxylation of methyl 2-phenylacetates to the chiral methyl mandelates by directed evolution of the cytochrome P450DA *** the present study,a new colorimetric high-throughput screening assay was successfully developed based on a dualenzyme cascade for the engineering of the P450DA's hydroxylation *** beneficial variants with enhanced bio-hydroxylation activity were created by combining random mutagenesis and site-saturated/directed mutagenesis ***-cell bio-hydroxylation of various methyl 2-phenylacetates using the best septupletmutant P450DA-11 yielded the corresponding chiral methyl mandelates in up to 92%isolated yields and>99%ee.

关键词： Bio-hydroxylation Directed evolution Cytochrome P450 High-throughput screening Methyl mandelates

The auxin transporter OsAUX1 regulates tillering in rice(Oryza sativa)

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Journal of Integrative Agriculture 2024年第5期23卷 1454-1467页

作者： Luqi Jia Yongdong Dai Ziwei Peng Zhibo cui Xuefei Zhang Yangyang Li Weijiang Tian Guanghua He yun Li Xianchun Sang Chongqing Key Laboratory of Crop Molecular Improvement/Rice Research Institute Academy of Agricultural SciencesSouthwest UniversityChongqing400715China Rice and Sorghum Research Institute Sichuan Academy of Agricultural Sciences/Key Laboratory of Southwest Rice Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsDeyang 618000China

Tillering is an important agronomic trait of rice(Oryza sativa)that affects the number of effective panicles,thereby affecting *** phytohormone auxin plays a key role in *** we identified the high tillering and semi-dwarf 1(htsd1)mutant with auxin-deficiency root characteristics,such as shortened lateral roots,reduced lateral root density,and enlarged root ***1 showed reduced sensitivity to auxin,but the external application of indole-3-acetic acid(IAA)inhibited its *** identified the mutated gene in htsd1 as AUXIN1(OsAUX1,LOC_Os01g63770),which encodes an auxin influx *** promoter sequence of OsAUX1 contains many SQUAMOSA PROMOTER BINDING PROTEIN-LIKE(SPL)binding sites,and we demonstrated that SPL7 binds to the OsAUX1 *** BRANCHED1(OsTB1),a key gene that negatively regulates tillering,was significantly downregulated in *** was enhanced in the OsTB1 knockout mutant,and the external application of IAA inhibited tiller elongation in this *** OsTB1 restored the multi-tiller phenotype of *** results suggest that SPL7 directly binds to the OsAUX1 promoter and regulates tillering in rice by altering OsTB1 expression to modulate auxin signaling.

关键词： rice(Oryza sativa L.) tillering indole-3-acetic acid(IAA) OsAUX1 OsTB1

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浅谈《工程材料》实验教学的改革

教育教学论坛 2019年第2期 108-109页

作者：崔承云江苏大学江苏镇江212000

《工程材料》作为高校机械类专业一门重要的专业基础课,其实验教学环节虽然课时较少,但和课堂教学环节同等重要。实验教学环节的顺利开展和实验内容的与时俱进不但可以提高学生独立解决实际问题的能力与学习积极性,而且也能锻炼学生动... 详细信息

《工程材料》作为高校机械类专业一门重要的专业基础课,其实验教学环节虽然课时较少,但和课堂教学环节同等重要。实验教学环节的顺利开展和实验内容的与时俱进不但可以提高学生独立解决实际问题的能力与学习积极性,而且也能锻炼学生动手能力,让学生透过实验现象发现事物本质,是培养适应社会需求人才的有效方法和途径。

关键词：《工程材料》实验教学改革

Chromosome-level genome assembly of the Asian citrus psyllid,Diaphorina citri

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Insect Science 2024年第1期31卷 13-27页

作者： Shuang Lei Shi-Jiang Yu Qi Pan Li-Li Ding Si-Chen Li Lu-Yan cheng Shu-Qi Wang Bing-Hai Lou Jun He cui-yun Lei Lin Cong Hao-Qiang Liu Xue-Feng Wang Chun Ran Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina

Diaphorina citri is a global citrus *** a vector insect,it can transmit the causative agents of citrus huanglongbing,causing irreversible losses to the citrus *** acquisition of genomic information can provide a molecular genetic basis for effective control of ***,the DNBSEQ™,Oxford Nanopore Technologies,and Hi-C technologies are applied to generate a high-quality chromosome-level genome of *** genome size of *** was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes.A total of 250.64 Mb(47.85%)repeat sequences and 24048 protein-coding genes were *** resequencing of female and male individuals indicated that the sex chromosome system of *** is *** analysis demonstrated that *** and Pachypsylla venusta,which separated from their most recent common ancestor about 336.62 million years ago,were the most closely ***,we identified genes potentially involved in detoxification metabolism,pathogen transmission,and honeydew secretion for further *** high-quality genome provides an important reference for developing effective management strategies of ***.

关键词： Asian citrus psyllid chromosome-level genome comparative genomics cytochrome P450 detoxification Huanglongbing